Ru Rong Ji

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Microglia and spinal cord synaptic plasticity in persistent pain
    Sarah Taves
    Pain Signaling and Plasticity Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Neural Plast 2013:753656. 2013
  2. ncbi request reprint Glia and pain: is chronic pain a gliopathy?
    Ru Rong Ji
    Department of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC, USA Electronic address
    Pain 154:S10-28. 2013
  3. pmc The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition
    Yong Jing Gao
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 148:309-19. 2010
  4. pmc Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1
    Chul Kyu Park
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Neurosci 31:15072-85. 2011
  5. ncbi request reprint Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
  6. pmc TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 122:2195-207. 2012
  7. pmc Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Medical Research Building, Room 604, Boston, Massachusetts 02115, USA
    Nat Med 14:331-6. 2008
  8. pmc Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury
    Marc R Suter
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pain 5:53. 2009
  9. pmc Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Medical Research Building, Boston, MA 02115, USA
    Brain Behav Immun 21:642-51. 2007
  10. ncbi request reprint A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    Zhi Ye Zhuang
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3551-60. 2006

Collaborators

Detail Information

Publications49

  1. pmc Microglia and spinal cord synaptic plasticity in persistent pain
    Sarah Taves
    Pain Signaling and Plasticity Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Neural Plast 2013:753656. 2013
    ..Insights into microglial-neuronal interactions in the spinal cord dorsal horn will not only further our understanding of neural plasticity but may also lead to novel therapeutics for chronic pain management...
  2. ncbi request reprint Glia and pain: is chronic pain a gliopathy?
    Ru Rong Ji
    Department of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC, USA Electronic address
    Pain 154:S10-28. 2013
    ..Thus, chronic pain could be a result of "gliopathy," that is, dysregulation of glial functions in the central and peripheral nervous system. In this review, we provide an update on recent advances and discuss remaining questions. ..
  3. pmc The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition
    Yong Jing Gao
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 148:309-19. 2010
    ..Our findings also reveal a unique role of JNK1 and astrocyte network in regulating tactile allodynia and contralateral pain...
  4. pmc Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1
    Chul Kyu Park
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Neurosci 31:15072-85. 2011
    ..Our findings demonstrate a novel role of NPD1 in regulating TRPV1/TNF-α-mediated spinal synaptic plasticity and identify NPD1 as a novel analgesic for treating inflammatory pain...
  5. ncbi request reprint Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
    ....
  6. pmc TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 122:2195-207. 2012
    ..Our findings demonstrate a critical role of TLR3 in regulating sensory neuronal excitability, spinal cord synaptic transmission, and central sensitization. TLR3 may serve as a new target for developing anti-itch treatment...
  7. pmc Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Medical Research Building, Room 604, Boston, Massachusetts 02115, USA
    Nat Med 14:331-6. 2008
    ..Inhibition of MMP may provide a novel therapeutic approach for the treatment of neuropathic pain at different phases...
  8. pmc Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury
    Marc R Suter
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pain 5:53. 2009
    ....
  9. pmc Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Medical Research Building, Boston, MA 02115, USA
    Brain Behav Immun 21:642-51. 2007
    ....
  10. ncbi request reprint A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    Zhi Ye Zhuang
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3551-60. 2006
    ..Targeting the JNK pathway in spinal astroglia may present a new and efficient way to treat neuropathic pain symptoms...
  11. ncbi request reprint Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model
    Yeong Ray Wen
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 107:312-21. 2007
    ..Nerve injury-induced ectopic spontaneous activity is essential for the generation of neuropathic pain. The authors examined whether peripheral neural activity is necessary for p38 activation in spinal microglia...
  12. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
    ..TNF-α is shown to play a critical role in regulating spinal cord synaptic plasticity and central sensitization, and TNFR1 and TNFR2 play a distinct role in regulating different phases of inflammatory pain...
  13. pmc Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance
    Yeong Ray Wen
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Formos Med Assoc 110:487-94. 2011
    ....
  14. pmc Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    Zhen Zhong Xu
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:592-7, 1p following 597. 2010
    ..Given the potency of resolvins and the well-known side effects of opioids and COX inhibitors, resolvins may represent new analgesics for treating inflammatory pain...
  15. pmc Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5189-94. 2008
    ..PICs may further induce long-term synaptic plasticity through CREB-mediated gene transcription. Blockade of PIC signaling could be an effective way to suppress central sensitization and alleviate chronic pain...
  16. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
    ..Inhibition of the JNK/MCP-1 pathway may provide a new therapy for neuropathic pain management...
  17. ncbi request reprint Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 24:8300-9. 2004
    ..Therefore, PI3K induces heat hyperalgesia, possibly by regulating TRPV1 activity, in an ERK-dependent manner. The PI3K pathway also appears to play a role that is distinct from ERK by regulating the early onset of inflammatory pain...
  18. pmc Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia
    Yong Jing Gao
    Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurochem 115:505-14. 2010
    ....
  19. pmc Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1
    Yong Jing Gao
    Sensory Plasticity Laboratory, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Pain Research Center, Boston, Massachusetts 02115, USA
    Glia 58:1871-80. 2010
    ..Taken together, our results suggest that activated astrocytes are sufficient to produce persistent pain symptom in naïve mice by releasing MCP-1...
  20. pmc Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma
    Zhen Zhong Xu
    Pain Signaling and Plasticity Laboratory, Department of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Ann Neurol 74:490-5. 2013
    ..Thus, NPD1/PD1 and related mimetics might serve as a new class of analgesics for preventing and treating neuropathic pain...
  21. ncbi request reprint Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Pharmacol Exp Ther 316:601-7. 2006
    ....
  22. pmc Emerging roles of resolvins in the resolution of inflammation and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Trends Neurosci 34:599-609. 2011
    ..Resolvins may offer novel therapeutic approaches for preventing and treating pain conditions associated with inflammation...
  23. pmc p38 MAPK, microglial signaling, and neuropathic pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Pain 3:33. 2007
    ..Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management...
  24. ncbi request reprint Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord
    Helene Beloeil
    Department of Anesthesiology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 105:139-45. 2006
    ....
  25. ncbi request reprint Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1
    Chul Kyu Park
    Pain Signaling and Plasticity Laboratory, Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 82:47-54. 2014
    ..Thus, secreted extracellular miRNAs may serve as novel pain mediators via activating TLR7/TRPA1 in nociceptor neurons. ..
  26. pmc New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?
    Tong Liu
    Pain Signaling and Plasticity Laboratory, Department of Anesthesiology and Neurobiology, Duke University Medical Center, 595 LaSalle Street, GSRB I, Room 1027A, DUMC 3094, Durham, NC, 27710, USA
    Pflugers Arch 465:1671-85. 2013
    ..g., atopic dermatitis), and some drugs for treating chronic pain are also effective in chronic itch. Thus, itch and pain have more similarities in pathological and chronic conditions. ..
  27. pmc Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury
    Zhen Zhong Xu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Neuroimmune Pharmacol 8:37-41. 2013
    ..Our data suggest that RvE1 may attenuate neuropathic pain via inhibiting microglial signaling. Targeting the anti-inflammatory and pro-resolution lipid mediators may offer new options for preventing and treating neuropathic pain...
  28. pmc Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels
    Promila Pagadala
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 33:13425-30. 2013
    ..Our results also call attention to potential opposing effects of NMDAR antagonists as a treatment for pain and other neurological disorders. ..
  29. ncbi request reprint Mitogen-activated protein kinases as potential targets for pain killers
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Medical Research Building, Room 604, 75 Francis Street, Boston, MA 02115, USA
    Curr Opin Investig Drugs 5:71-5. 2004
    ..Inhibition of ERK or p38 alleviates inflammatory pain and neuropathic pain in animal models. Development of specific inhibitors for these two MAPKs may lead to new therapies for pathological pain...
  30. pmc Targeting astrocyte signaling for chronic pain
    Yong Jing Gao
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 7:482-93. 2010
    ..Therefore, interventions in specific signaling pathways in astrocytes may offer new approaches for the management of chronic pain...
  31. pmc Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9
    Temugin Berta
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 8:18. 2012
    ..We examined acute morphine-induced activation of satellite glial cells (SGCs) and up-regulation of IL-1β in dorsal root ganglia (DRGs), and further investigated the involvement of MMP-9 in these opioid-induced peripheral changes...
  32. ncbi request reprint A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief
    Jun Ho Lee
    Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Cell 157:1393-404. 2014
    ..Our studies reveal that NaV1.7 is a target for itch management, and the antibody has therapeutic potential for suppressing pain and itch. Our antibody strategy may have broad applications for voltage-gated cation channels. ..
  33. pmc Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice
    Yen Chin Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pain 8:19. 2012
    ..We examined MMP-9 expression and localization in dorsal root ganglia (DRGs) after acute morphine treatment and, furthermore, the role of MMP-9 in modulating acute morphine-induced analgesia and hyperalgesia in mice...
  34. ncbi request reprint Cell signaling and the genesis of neuropathic pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sci STKE 2004:reE14. 2004
    ....
  35. pmc Emerging role of Toll-like receptors in the control of pain and itch
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosci Bull 28:131-44. 2012
    ..Given the prevalence of chronic pain and itch and the suffering of affected people, insights into TLR signaling in the nervous system will open a new avenue for the management of clinical pain and itch...
  36. pmc Toll-like receptor 7 mediates pruritus
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:1460-2. 2010
    ..Our results indicate that TLR7 mediates itching and is a potential therapeutic target for anti-itch treatment in skin disease conditions...
  37. pmc Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    Neuron Glia Biol 2:259-69. 2006
    ..Investigation of signaling mechanisms in spinal astrocytes will identify new molecular targets for the management of chronic pain...
  38. pmc Intracellular signaling in primary sensory neurons and persistent pain
    Jen Kun Cheng
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 611, Boston, MA 02115, USA
    Neurochem Res 33:1970-8. 2008
    ..Targeting the critical signaling pathways in the periphery will tackle pain at the source...
  39. pmc Resolvins are potent analgesics for arthritic pain
    Zhen Zhong Xu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Br J Pharmacol 164:274-7. 2011
    ..LINKED ARTICLE This article is a commentary on Lima-Garcia et al., pp. 278-293 of this issue. To view this paper visit http://dx.doi.org/10.1111/j.1476-5381.2011.01345.x...
  40. ncbi request reprint Peripheral and central mechanisms of inflammatory pain, with emphasis on MAP kinases
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Drug Targets Inflamm Allergy 3:299-303. 2004
    ..Development of specific MAPK inhibitors will open a new avenue to the pharmacological intervention of inflammatory pain...
  41. pmc Do glial cells control pain?
    Marc R Suter
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron Glia Biol 3:255-68. 2007
    ..Investigating signaling mechanisms in microglia might lead to more effective management of devastating chronic pain...
  42. pmc MAP kinase and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
    Brain Res Rev 60:135-48. 2009
    ..Although it is well documented that MAPK pathways can increase pain sensitivity via peripheral mechanisms, this review will focus on central mechanisms of MAPKs, especially ERK...
  43. pmc Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurosci Bull 28:145-54. 2012
    ..To investigate the role of oxidative stress in itch-indicative scratching behavior in mice, and furthermore, to define the cellular and molecular mechanisms underlying oxidative stress-mediated itch...
  44. ncbi request reprint ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 114:149-59. 2005
    ..The sequential activation of ERK in dorsal horn microglia and then in astrocytes might reflect distinct roles for these two subtypes of glia in the temporal evolution of neuropathic pain...
  45. pmc Matrix metalloprotease regulation of neuropathic pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Trends Pharmacol Sci 30:336-40. 2009
    ..Inhibition of MMP-9 or MMP-2 might provide a new strategy for the prevention and treatment of neuropathic pain...
  46. pmc Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat
    Chi Fei Wang
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1397-405. 2008
    ..BLA has several potential targets, including voltage-gated Na+ channels. We tested whether BLA elicited long-lasting cutaneous analgesia, when co-injected with lidocaine and epinephrine, as a model for prolonged infiltration anesthesia...
  47. pmc Activation of JNK pathway in persistent pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurosci Lett 437:180-3. 2008
    ..Thus, targeting JNK pathway might be a useful strategy to treat both neurodegeneration and chronic pain...
  48. ncbi request reprint Emerging targets in neuroinflammation-driven chronic pain
    Ru Rong Ji
    Departments of Anesthesiology and Neurobiology, Duke University Medical Center, 595 LaSalle Street, Durham, North Carolina 27710, USA
    Nat Rev Drug Discov 13:533-48. 2014
    ..Targeting excessive neuroinflammation could offer new therapeutic opportunities for chronic pain and related neurological and psychiatric disorders. ..
  49. pmc Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Medical Research Building, Room 604, Boston, MA 02115, USA
    Exp Neurol 219:146-55. 2009
    ..Our data reveal a marked peripheral neuropathy in this skin cancer model and important roles of the JNK pathway in cancer pain development and tumor growth. JNK inhibitors such as D-JNKI-1 may be used to treat cancer pain...