A H James

..The hematologist or hemostasis expert has the opportunity to make the difference between life and death for the patient experiencing massive PPH...

..Since administration of desmopressin may result in hyponatremia, whenever available, virally inactivated or recombinant clotting factor concentrates should be used for replacement as opposed to fresh frozen plasma or cryoprecipitate...

..The incidence of these disorders and the complications of pregnancy are discussed with particular reference to a case-control study conducted by the U.S. Centers for Disease Control and Prevention...

..Because current recommendations rely on case series and expert opinion, additional studies including randomized trials might enhance our ability to prevent recurrent thromboembolism in pregnancy...

..Women who do not require lifelong anticoagulation, but require anticoagulation during pregnancy, will still require anticoagulation for the first 6 weeks postpartum...

..Nonetheless, large trials demonstrate low-dose aspirin's relative safety and generally positive effects on reproductive outcomes...

..The purpose of this review is to summarize the epidemiology of thromboembolism in pregnancy and describe strategies to prevent and treat it...

..In the absence of strong evidence to direct practice, government agencies and hemophilia organizations have developed consensus guidelines. This paper summarizes existing recommendations from these guidelines...

..Nonetheless, anticoagulants are believed to improve the outcome of pregnancy for women who have or have had VTE...

..After proper evaluation, most abnormal reproductive tract bleeding in adolescents can be managed hormonally, with the addition of hemostatic therapies when necessary...

..Nonetheless, for women who have completed childbearing, the risks of hysterectomy may be acceptable...

..The purpose of this study was to examine blood component therapy in the treatment of postpartum hemorrhage...

..level of evidence: iii...

..Adequate prophylaxis during surgery and childbirth may help to prevent bleeding complications in women with VWD...

..Therefore, after a discussion of the maternal and foetal risks with planned vaginal delivery versus planned caesarean delivery, haemophilia carriers should be offered the option of an elective caesarean delivery...

..Optimal management involves the combined expertise of haemostasis experts and obstetrician-gynaecologists...

..Case reports and case series suggest that women with von Willebrand disease (VWD) are at an increased risk of bleeding complications during pregnancy and delivery...

..The risk of thrombosis is higher postpartum than during pregnancy, so anticoagulation therapy is usually continued for at least 6 weeks after delivery...

..An approach to screening for thrombophilia is outlined and strategies for thromboprophylaxis are provided...

..To estimate the incidence, mortality, and risk factors for pregnancy-related stroke in the United States...

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..To describe the circumstances surrounding deep vein thrombosis among pregnant or postpartum patients enrolled in a large multicenter registry...

..The purpose of this study was to determine the incidence, mortality, and risk factors for pregnancy-related acute myocardial infarction in the United States...

..While women with bleeding disorders are at risk for the same obstetrical and gynaecological problems that affect all women, they appear to be disproportionately affected by conditions that manifest with bleeding...

..There are no large trials of anticoagulation in pregnancy and recommendations are based on case series and the opinion of experts. Nonetheless, anticoagulation is believed to improve the outcome of pregnancy for women at risk...

..The purpose of this study was to assess the usefulness of a new platelet function analyzer in the detection of von Willebrand disease and platelet dysfunction in women with menorrhagia...

..The purpose of this study was to estimate the incidence, risk factors, and mortality from pregnancy-related venous thromboembolism...

..Unfortunately, fatal thromboses have occurred with low-molecular-weight heparin as well...

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..Combined deficiency of vitamin K-dependent coagulation factors (II, VII, IX, X) is an uncommon challenge for the expectant gravida...

..Women with hepatitis have an increased risk for complications during pregnancy. Research to determine the efficacy and cost-effectiveness of counselling patients about potential risks for adverse outcomes is warranted...

..An intrauterine foetal demise was averted. The clinical scenario in this case raises the issue of how often a stillbirth with intracranial haemorrhage may result from unrecognized factor deficiency...

..Ultrasonography and magnetic resonance imaging (MRI) have been used to identify and evaluate this condition. We present the first reported case of epidural hematoma diagnosed prenatally...

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..This consensus is intended to allow physicians to better recognize bleeding disorders as a cause of menorrhagia and consequently offer effective disease-specific therapies...

..This study was undertaken to determine the risk of rare complications during pregnancy for women with systemic lupus erythematosus...

..The purpose of this study was to identify morbidity that is associated with sickle cell disease (SCD) in pregnancy...

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..This study demonstrated that the PFA-100 analyzer can accurately assess vWF-dependent platelet function and detect other platelet defects under high shear stress in complex patient populations...

..The purpose of this study was to compare maternal soluble Flt-1 and PlGF levels in the second trimester with a marker of abnormal placentation, abnormal uterine artery Doppler (UAD)...

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..To estimate the incidence of maternal cardiovascular and pulmonary events and the prevalence of other comorbid conditions among pregnant smokers...

..Given the susceptibility of these subjects to obstetric emergencies, patients with PPROM at a viable gestational age should be considered for management as inpatients in a tertiary-care facility...

..Although the incidence of pulmonary embolism has decreased over time, the incidence of deep venous thrombosis remains unchanged, indicating the need to better identify pregnant women at increased risk...