Research Topics
| GLENN JAFFESummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Management of condensation on a foldable acrylic intraocular lens after vitrectomy and fluid-air exchangeG J Jaffe
Department of Ophthalmology, Duke University, Durham, NC 27710, USA
Am J Ophthalmol 124:692-3. 1997..To describe the management of condensation on the posterior surface of a foldable acrylic intraocular lens during vitrectomy and fluid-air exchange...- Long-term follow-up results of a pilot trial of a fluocinolone acetonide implant to treat posterior uveitisGlenn J Jaffe
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Ophthalmology 112:1192-8. 2005..To investigate the safety and efficacy of a fluocinolone acetonide intravitreal implant in the treatment of noninfectious posterior uveitis... - Uveitis in the elderly: epidemiological data from the National Long-term Care Survey Medicare CohortSherman W Reeves
Duke University Eye Center, Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina 27710, USA
Ophthalmology 113:307.e1. 2006..In this analysis, we use Medicare claims data to define the population-based incidence and prevalence of uveitis in the United States elderly population... - Optical coherence tomography to detect and manage retinal disease and glaucomaGlenn J Jaffe
Duke Eye Center, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 137:156-69. 2004..To review basic principles of optical coherence tomography, and to describe its use in the diagnosis and management of retinal diseases and glaucoma... - Reimplantation of a fluocinolone acetonide sustained drug delivery implant for chronic uveitisGlenn J Jaffe
Duke Eye Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 145:667-675. 2008..To determine the effects of a second fluocinolone implant inserted in eyes with uveitis in which recurrent inflammation developed after the original implant was placed... - Fluocinolone acetonide sustained drug delivery device to treat severe uveitisG J Jaffe
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Ophthalmology 107:2024-33. 2000..In this report, we describe a pilot safety and efficacy trial of a novel sustained drug delivery system containing fluocinolone acetonide to treat patients with severe uveitis... - Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery deviceG J Jaffe
Department of Ophthalmology, Duke University, Durham, North Carolina Control Delivery Systems, Watertown, Massachusetts, USA
Invest Ophthalmol Vis Sci 41:3569-75. 2000..To determine the safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained drug delivery device... - Fluocinolone acetonide sustained drug delivery device for chronic central retinal vein occlusion: 12-month resultsRajeev S Ramchandran
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Am J Ophthalmol 146:285-291. 2008..To determine treatment outcomes of a long-acting intravitreal fluocinolone acetonide sustained drug delivery implant in eyes with central retinal vein occlusion (CRVO) and chronic refractory macular edema... - Combined fluocinolone acetonide intravitreal insertion and glaucoma drainage device placement for chronic uveitis and glaucomaPaula E Malone
Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
Am J Ophthalmol 149:800-6.e1. 2010.... - Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical studyGlenn J Jaffe
Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Ophthalmology 113:1020-7. 2006..The most common side effects included increased intraocular pressure and cataract progression... - Combined fluocinolone acetonide intraocular delivery system insertion, phacoemulsification, and intraocular lens implantation for severe uveitisJanet J Chieh
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 146:589-594. 2008.... - Primary intraocular T-cell-rich large B-cell lymphomaThomas J Cummings
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Arch Pathol Lab Med 129:1050-3. 2005..This case highlights the importance of interpreting cytologic features in vitreous aspirates in the context of the clinical situation... - Retinal thickening in iridocyclitisChelsea G Castellano
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Am J Ophthalmol 148:341-9. 2009..To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity... - Infliximab to treat chronic noninfectious uveitis in children: retrospective case series with long-term follow-upStacy P Ardoin
Division of Pediatric Rheumatology, Duke University Medical Center, Durham, NC 27710, USA
Am J Ophthalmol 144:844-849. 2007..To assess a response to infliximab therapy in childhood uveitis... - Efficacy of low-release-rate fluocinolone acetonide intravitreal implants to treat experimental uveitisPrithvi Mruthyunjaya
Department of Ophthalmology, Duke University Eye Center, Erwin Road, Durham, NC 27710, USA
Arch Ophthalmol 124:1012-8. 2006..CLINICAL RELEVANCE: The efficacy demonstrated with the 0.1-microg/d implant provides the rationale for future human studies with lower-release-rate implants than are currently used in noninfectious uveitis clinical trials... - Demographic-related variations in posterior segment ocular sarcoidosisDara Khalatbari
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Ophthalmology 111:357-62. 2004..001) and worse (P = 0.002) eye. CONCLUSIONS: We have identified variations based on patient race, sex, and age in PSI, specific posterior segment signs, and visual acuity in cases of ocular sarcoidosis... - Evaluation of image artifact produced by optical coherence tomography of retinal pathologyRobin Ray
Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 139:18-29. 2005..Recognition of these artifacts will improve retinal thickness measurement accuracy, and will prevent faulty treatment decisions that are based on inaccurate retinal thickness measurements... - Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusionCarl H Park
Duke University Eye Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 136:419-25. 2003..This reduction often corresponded to an improvement in visual acuity. Further evaluation is warranted to assess its safety and efficacy in these eyes... - Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancyPrithvi Mruthyunjaya
Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina 27710, USA
Ophthalmology 109:1123-9. 2002..This procedure is a valuable adjunct in cases that cannot be diagnosed by less invasive methods... - Evaluation of artifacts associated with macular spectral-domain optical coherence tomographyIan C Han
Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA
Ophthalmology 117:1177-1189.e4. 2010.... - Prevalence and risk factors for proliferative vitreoretinopathy in eyes with rhegmatogenous retinal detachment but no previous vitreoretinal surgeryWendy Tseng
Department of Ophthalmology, Duke University, Durham, North Carolina 27710, USA
Am J Ophthalmol 137:1105-15. 2004..We have identified preventable risk factors associated with PVR that suggest a specific and significant need for better access to ophthalmologic care and patient education in this group of patients... - Comparison of spectral- and time-domain optical coherence tomography for retinal thickness measurements in healthy and diseased eyesIan C Han
Duke Eye Center, Durham, North Carolina 27701, USA
Am J Ophthalmol 147:847-58, 858.e1. 2009..To compare retinal thickness (RT) measurements obtained by spectral-domain optical coherence tomography (SD-OCT) and time-domain OCT (TD-OCT) in eyes with and without posterior segment disease diagnoses... - B-scan ultrasonography for the detection of macular thickeningJames C Lai
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 136:55-61. 2003..B-scan ultrasonography is a potentially useful technique for assessing macular thickness when biomicroscopy is impossible or when patients cannot tolerate FA or OCT... - Modified external needle drainage procedure for rhegmatogenous retinal detachmentGlenn J Jaffe
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Retina 23:80-5. 2003..The retinal reattachment rate and complication rate compare favorably to alternative subretinal fluid drainage techniques... - Optical coherence tomography reader agreement in neovascular age-related macular degenerationNanfei Zhang
Duke University Eye Center and the OCT Reading Center at Duke, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 144:37-44. 2007..To determine the interreader and intrareader agreement at the Optical Coherence Tomography (OCT) Reading Center at Duke for images produced for an interventional neovascular age-related macular degeneration (AMD) clinical trial... - Caspase-8-mediated apoptosis in human RPE cellsPing Yang
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Invest Ophthalmol Vis Sci 48:3341-9. 2007..Herein, the authors investigated the role of caspase-8 in RPE cell resistance to TNF-alpha-mediated cell death... - Human RPE expression of cell survival factorsPing Yang
Departments of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
Invest Ophthalmol Vis Sci 46:1755-64. 2005..RPE cell survival factors may protect RPE cells from apoptosis normally and in diseases such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR)... - Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cellsPing Yang
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Invest Ophthalmol Vis Sci 45:2438-46. 2004..RPE cell resistance to apoptotic signals present in eyes with PVR, mediated by survival factors such as c-FLIP and c-IAP1, may help to explain unwanted and unchecked cell proliferation in this disease... - Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cellsPing Yang
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Invest Ophthalmol Vis Sci 44:1339-47. 2003..This technique will be useful to determine the role of NF-kappaB in experimental proliferative vitreoretinopathy (PVR), and may offer a novel approach to treatment of PVR with a gene therapy approach... - Treatment of posterior uveitis with a fluocinolone acetonide implant: three-year clinical trial resultsDavid G Callanan
Texas Retina Associates, 1001 N Waldrop Dr, Ste 512, Arlington, TX 76012, USA
Arch Ophthalmol 126:1191-201. 2008..To evaluate the safety and efficacy of 0.59-mg and 2.1-mg fluocinolone acetonide (FA) intravitreous implants in noninfectious posterior uveitis... - Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implantsDebra A Goldstein
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1905 W Taylor St, M C 648, Chicago, IL 60612, USA
Arch Ophthalmol 125:1478-85. 2007..To report the incidence and management of elevated intraocular pressure (IOP) in patients with uveitis treated with the fluocinolone acetonide (FA) intravitreal implant... - Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cellsBrian C Gilger
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
Am J Vet Res 63:942-7. 2002..1+/-298.3 pg/ml) and mRNA, compared with unstimulated samples. CONCLUSIONS AND CLINICAL RELEVANCE: Ciliary epithelium may play a role in recruitment and activation of leukocytes through expression of RANTES... - Diffuse unilateral subacute neuroretinitis in VenezuelaRafael Cortez
, Caracas, Venezuela
Ophthalmology 112:2110-4. 2005..CONCLUSIONS: In Venezuela, DUSN is seen primarily in young patients without a significant gender predilection. The vast majority of patients in this population presented with severe vision loss that was irreversible...
Research Grants
- Comparison of AMD Treatment Trials-OCT Reading CenterGLENN JAFFE; Fiscal Year: 2007....
- CYTOKINE MODULATION IN PROLIFERATIVE VITREORETINOPATHYGLENN JAFFE; Fiscal Year: 2005..Density-dependent effects of IL-1, TNFalpha, and specific NF-kappaB inhibitors on NF-kappaB-mediated RPE apoptosis will be quantified. IV) To determine whether specific in vivo NF-kappaB blockade inhibits PVR. ..
- CYTOKINE MODULATION IN PROLIFERATIVE VITREORETINOPATHYGLENN JAFFE; Fiscal Year: 2000....