Dora Il'yasova

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Racial differences in urinary F2-isoprostane levels and the cross-sectional association with BMI
    Dora Il'yasova
    Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA
    Obesity (Silver Spring) 20:2147-50. 2012
  2. doi request reprint Urinary F2-isoprostanes, obesity, and weight gain in the IRAS cohort
    Dora Il'yasova
    Duke University Medical Center, Duke Cancer Institute, Durham, North Carolina, USA
    Obesity (Silver Spring) 20:1915-21. 2012
  3. pmc Urinary biomarkers of oxidative status
    Dora Il'yasova
    Duke Cancer Institute, Duke University Medical Center, Box 2715, Durham, NC 27710, USA
    Clin Chim Acta 413:1446-53. 2012
  4. pmc Human exposure to selected animal neurocarcinogens: a biomarker-based assessment and implications for brain tumor epidemiology
    Dora Il'yasova
    Preston Robert Tisch Brain Tumor Center at Duke and Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Toxicol Environ Health B Crit Rev 12:175-87. 2009
  5. pmc Markers of oxidative status in a clinical model of oxidative assault: a pilot study in human blood following doxorubicin administration
    Dora Il'yasova
    Duke Comprehensive Cancer Center, Durham, NC 27710, USA
    Biomarkers 14:321-5. 2009
  6. pmc Urinary biomarkers of oxidative status in a clinical model of oxidative assault
    Dora Il'yasova
    Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 19:1506-10. 2010
  7. pmc Individual responses to chemotherapy-induced oxidative stress
    Dora Il'yasova
    Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC, 27710, USA
    Breast Cancer Res Treat 125:583-9. 2011
  8. pmc What can we learn from the age- and race/ethnicity- specific rates of inflammatory breast carcinoma?
    Dora Il'yasova
    Duke Cancer Institute, DUMC Box 2715, Durham, NC 27710, USA
    Breast Cancer Res Treat 130:691-7. 2011
  9. pmc Urinary F2-isoprostanes as a biomarker of reduced risk of type 2 diabetes
    Dora Il'yasova
    Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA
    Diabetes Care 35:173-4. 2012
  10. pmc Total dietary antioxidant index and survival in patients with glioblastoma multiforme
    Dora Il'yasova
    Department of Community and Family Medicine, Duke University Medical Center, P O Box 2949, Durham, NC 27710, USA
    Cancer Causes Control 20:1255-60. 2009

Detail Information

Publications31

  1. pmc Racial differences in urinary F2-isoprostane levels and the cross-sectional association with BMI
    Dora Il'yasova
    Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA
    Obesity (Silver Spring) 20:2147-50. 2012
    ....
  2. doi request reprint Urinary F2-isoprostanes, obesity, and weight gain in the IRAS cohort
    Dora Il'yasova
    Duke University Medical Center, Duke Cancer Institute, Durham, North Carolina, USA
    Obesity (Silver Spring) 20:1915-21. 2012
    ..37-0.87), respectively. The other three F(2)-IsoPs were consistently inversely associated with weight gain, although not significantly, suggesting that different F(2)-IsoPs vary in their ability to detect the association with weight gain...
  3. pmc Urinary biomarkers of oxidative status
    Dora Il'yasova
    Duke Cancer Institute, Duke University Medical Center, Box 2715, Durham, NC 27710, USA
    Clin Chim Acta 413:1446-53. 2012
    ..Promising urinary biomarkers include allantoin, acrolein-lysine, and dityrosine...
  4. pmc Human exposure to selected animal neurocarcinogens: a biomarker-based assessment and implications for brain tumor epidemiology
    Dora Il'yasova
    Preston Robert Tisch Brain Tumor Center at Duke and Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Toxicol Environ Health B Crit Rev 12:175-87. 2009
    ..Importantly, these chemicals are also carcinogenic in other organs; therefore, this discussion is useful for environmental epidemiologists studying all cancer types...
  5. pmc Markers of oxidative status in a clinical model of oxidative assault: a pilot study in human blood following doxorubicin administration
    Dora Il'yasova
    Duke Comprehensive Cancer Center, Durham, NC 27710, USA
    Biomarkers 14:321-5. 2009
    ....
  6. pmc Urinary biomarkers of oxidative status in a clinical model of oxidative assault
    Dora Il'yasova
    Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 19:1506-10. 2010
    ..We used doxorubicin-based chemotherapy as a clinical model of oxidative assault in humans...
  7. pmc Individual responses to chemotherapy-induced oxidative stress
    Dora Il'yasova
    Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC, 27710, USA
    Breast Cancer Res Treat 125:583-9. 2011
    ....
  8. pmc What can we learn from the age- and race/ethnicity- specific rates of inflammatory breast carcinoma?
    Dora Il'yasova
    Duke Cancer Institute, DUMC Box 2715, Durham, NC 27710, USA
    Breast Cancer Res Treat 130:691-7. 2011
    ..The number of critical transition carcinogenesis stages (m-stages) predicted by the model were 6.3 and 8.5 for IBC and non-inflammatory LABC, respectively, supporting different etiologies of these breast tumors...
  9. pmc Urinary F2-isoprostanes as a biomarker of reduced risk of type 2 diabetes
    Dora Il'yasova
    Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA
    Diabetes Care 35:173-4. 2012
    ..Here, we report the results from the study extended to the entire IRAS cohort...
  10. pmc Total dietary antioxidant index and survival in patients with glioblastoma multiforme
    Dora Il'yasova
    Department of Community and Family Medicine, Duke University Medical Center, P O Box 2949, Durham, NC 27710, USA
    Cancer Causes Control 20:1255-60. 2009
    ..No data on the relationships between antioxidant intake and survival of glioma patients are available. Our objective was to examine such association in a large series of cases...
  11. pmc Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls
    Dora Il'yasova
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 18:1232-8. 2009
    ..These controls seem to present a reasonable choice for clinic-centered case-control studies...
  12. pmc Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose
    D Il'yasova
    Department of Community and Family Medicine, Prevention Research Division, Duke University Medical Center, Box 2949, Durham, NC, 27710, USA
    Diabetologia 53:866-74. 2010
    ..To examine this assumption, we used cohort data from the Insulin Resistance Atherosclerosis Study (IRAS)...
  13. ncbi request reprint Correlation between two markers of inflammation, serum C-reactive protein and interleukin 6, and indices of oxidative stress in patients with high risk of cardiovascular disease
    Dora Il'yasova
    Duke Comprehensive Cancer Center, 2424 Erwin Rd, Hock Bldg, Ste 602, Box 2949, Durham, NC 27710, USA
    Biomarkers 13:41-51. 2008
    ..Urinary levels of F2-IsoP and serum levels of CRP represent appropriate biomarkers for future studies of inflammation and oxidative status in humans...
  14. ncbi request reprint Urinary F2-isoprostanes are not associated with increased risk of type 2 diabetes
    Dora Il'yasova
    Department of Community and Family Medicine Cancer Control and Prevention, Duke University Medical Center, Durham, NC 27710, USA
    Obes Res 13:1638-44. 2005
    ..Free radicals have been implicated in the etiology of type 2 diabetes. Cross-sectional studies have demonstrated associations between oxidative damage and type 2 diabetes. However, no prospective data on this association are available...
  15. ncbi request reprint Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort
    Dora Il'yasova
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 14:2413-8. 2005
    ..This study examined the relationships between circulating levels of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) and total as well as site-specific cancer incidence...
  16. pmc Systemic markers of oxidative status and colorectal adenomatous polyps
    Sharareh Siamakpour-Reihani
    Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA
    Ann Epidemiol 22:587-91. 2012
    ..Oxidative damage has been implicated in carcinogenesis. We hypothesized that elevated systemic oxidative status would be associated with later occurrence of colorectal adenomatous polyps, a precursor of colorectal cancer...
  17. pmc Association between body mass index and mortality in patients with glioblastoma mutliforme
    Lee W Jones
    Department of Radiation Oncology, Duke University Medical Center, Box 3085, Durham, NC 27710, USA
    Cancer Causes Control 21:2195-201. 2010
    ..5-24.9 kg/m(2); overweight, 25.0-29.9 kg/m(2); obese, ≥ 30.0 kg/m(2))...
  18. pmc Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome
    Adviye A Tolun
    Department of Pediatrics, Medical Genetics Division, Duke University Medical Center, Durham, NC 27710, USA
    Ann Epidemiol 22:892-4. 2012
    ..This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2α-III; these biomarkers have been previously validated in a clinical model of oxidative stress...
  19. ncbi request reprint Epidemiological marker for oxidant status: comparison of the ELISA and the gas chromatography/mass spectrometry assay for urine 2,3-dinor-5,6-dihydro-15-F2t-isoprostane
    Dora Il'yasova
    Wake Forest University School of Medicine, Departments of Cancer Biology and Public Health Sciences, Winston Salem, NC 27157, USA
    Ann Epidemiol 14:793-7. 2004
    ..However, this method is laborious and costly, which prohibits its use in large epidemiological studies...
  20. ncbi request reprint Choice of exposure scores for categorical regression in meta-analysis: a case study of a common problem
    Dora Il'yasova
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Cancer Causes Control 16:383-8. 2005
    ..This method requires the assignment of a single score to each exposure category. We examined how closely meta-analytical categorical regression approximates the results of analysis based on the individual-level continuous exposure...
  21. pmc Quantification of the oxidative damage biomarker 2,3-dinor-8-isoprostaglandin-F(2alpha) in human urine using liquid chromatography-tandem mass spectrometry
    Haoyue Zhang
    Department of Pediatrics, Medical Genetics Division, Duke University Medical Center, Durham, NC 27710, USA
    Anal Biochem 399:302-4. 2010
    ..5% or lower, and a lower limit of quantification of 0.5 microg/L, equivalent to 0.04 pmol injected onto the column. An analysis time of 6 min was shorter than previously published methods and amenable to large studies...
  22. pmc Allantoin in human urine quantified by ultra-performance liquid chromatography-tandem mass spectrometry
    Adviye A Tolun
    Department of Pediatrics, Duke University Medical Center, Durham NC 27709, USA
    Anal Biochem 402:191-3. 2010
    ..06pmol). Allantoin levels measured in control samples were comparable to literature values...
  23. ncbi request reprint The association between serum copper and anaemia in the adult Second National Health and Nutrition Examination Survey (NHANES II) population
    Mary Ann Knovich
    Section on Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Br J Nutr 99:1226-9. 2008
    ..On the other hand, the finding of hypocupraemia in a subset of adults with unexplained anaemia suggests that Cu deficiency may be a common reversible cause of anaemia in adults...
  24. pmc Effects of aerobic training on oxidative status in postsurgical non-small cell lung cancer patients: a pilot study
    Lee W Jones
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Lung Cancer 72:45-51. 2011
    ..We investigated the effects of supervised, moderate-intensity aerobic training on urinary markers of oxidative status in patients with postsurgical NSCLC...
  25. ncbi request reprint Cadmium and renal cancer
    Dora Il'yasova
    Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Toxicol Appl Pharmacol 207:179-86. 2005
    ..Cadmium, a widespread environmental pollutant, is a carcinogen that accumulates in the kidney cortex and is a cause of end-stage renal disease. Several observations suggest that cadmium may be a cause of renal cancer...
  26. ncbi request reprint Tea intake and risk of colon cancer in African-Americans and whites: North Carolina colon cancer study
    Dora Il'yasova
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Causes Control 14:767-72. 2003
    ..Tea polyphenols have been shown to exhibit anti-cancer activity, but the epidemiological findings are inconsistent. We examined the association between tea consumption and colon cancer in a population-based study in North Carolina...
  27. ncbi request reprint Exploring the association between melanoma and glioma risks
    Peter M Scarbrough
    Duke Cancer Institute, Duke University Medical Center, Durham, NC
    Ann Epidemiol 24:469-74. 2014
    ..Gliomas are one of the most fatal malignancies, with largely unknown etiology. This study examines a possible connection between glioma and melanoma, which might provide insight into gliomas' etiology...
  28. ncbi request reprint Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 26:468-70. 2003
    ....
  29. pmc Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps
    Adelheid Soubry
    Duke Cancer Institute, Duke University, Durham, NC 27710, USA
    Int J Cancer 131:512-7. 2012
    ..Our data suggest that an increase in circulating IGF-1 or IGF-1/IGFBP-3 may represent a disturbed GH/IGF1 homeostasis, which could favor the development of precancerous lesions such as colorectal adenoma...
  30. pmc Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Trent Drive, Box 90408, Durham, NC 27708, USA
    J Am Geriatr Soc 56:478-83. 2008
    ....
  31. pmc Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose
    Alexander V Kinev
    Creative Scientist, Inc, Durham, North Carolina, USA
    Cancer Invest 31:359-64. 2013
    ..This effect was evident at 48 hours and persisted up to 72 hr postirradiation. Such protracted cytostatic response of ECFCs to low-dose radiation suggests that ECFC primary cultures can be used to study low-dose radiation effects...

Research Grants2

  1. Urinary F2-isoprostanes as a new biomarker for the risk of type 2 diabetes
    DORA ILYASOVA; Fiscal Year: 2010
    ..Importantly, this biomarker is non-invasive and can be used in a clinical setting. We also believe that this biomarker can be used to predict weight gain, a very important characteristic for which no biomarkers are available. ..
  2. Urinary F2-isoprostanes as a new biomarker for the risk of type 2 diabetes
    DORA ILYASOVA; Fiscal Year: 2009
    ..Importantly, this biomarker is non-invasive and can be used in a clinical setting. We also believe that this biomarker can be used to predict weight gain, a very important characteristic for which no biomarkers are available. ..