Francis M Hughes
Affiliation: Duke University Medical Center
Inouye B, Hughes F, Jin H, Lütolf R, Potnis K, Routh J, et al
. Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria. Res Rep Urol. 2018;10:219-225 pubmed publisher
..Inflammation in the bladder of diabetic mice correlates with the development of DBD and is triggered by hyperglycemia, not polyuria. ..
Hughes F, Hirshman N, Inouye B, Jin H, Stanton E, Yun C, et al
. NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. Diabetes. 2018;: pubmed publisher
..Together, the results demonstrate the role of NLRP3 in the genesis of DBD and suggest specific NLRP3-mediated neuronal changes can produce specific DBD symptoms. ..
Hughes F, Turner D, Todd Purves J. The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells). Int Urol Nephrol. 2015;47:1953-64 pubmed publisher
..The results suggest that the bladder possesses the capacity to initiate an innate immune response to a wide array of uropathological agents and the MYP3 cells will provide an excellent investigational tool for this field. ..
Hughes F, Sexton S, Jin H, Govada V, Purves J. Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1?. Am J Physiol Renal Physiol. 2017;313:F603-F610 pubmed publisher
..In summary, NLRP3-derived-IL-1? triggers fibrosis during BOO, most likely through an autocrine loop in which IL-1? acts on urothelia to drive collagen production. ..