S A Huettel

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Sleep deprivation elevates expectation of gains and attenuates response to losses following risky decisions
    Vinod Venkatraman
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Sleep 30:603-9. 2007
  2. pmc What makes a pattern? Matching decoding methods to data in multivariate pattern analysis
    Philip A Kragel
    Department of Psychology and Neuroscience, Duke University Durham, NC, USA Center for Cognitive Neuroscience, Duke University Durham, NC, USA
    Front Neurosci 6:162. 2012
  3. pmc Nucleus accumbens mediates relative motivation for rewards in the absence of choice
    John A Clithero
    Department of Economics, Duke University Durham, NC, USA
    Front Hum Neurosci 5:87. 2011
  4. pmc Event-related fMRI in cognition
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA
    Neuroimage 62:1152-6. 2012
  5. pmc Identity economics and the brain: uncovering the mechanisms of social conflict
    Scott A Huettel
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Philos Trans R Soc Lond B Biol Sci 367:680-91. 2012
  6. ncbi request reprint Decisions under uncertainty: probabilistic context influences activation of prefrontal and parietal cortices
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 25:3304-11. 2005
  7. ncbi request reprint Modulation of prefrontal cortex activity by information toward a decision rule
    Scott A Huettel
    Brain Imaging and Analysis Center, Department of Psychiatry, Box 3918, Duke University Medical Center, Durham, NC 27710, USA
    Neuroreport 15:1883-6. 2004
  8. ncbi request reprint Behavioral, but not reward, risk modulates activation of prefrontal, parietal, and insular cortices
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cogn Affect Behav Neurosci 6:141-51. 2006
  9. ncbi request reprint The BOLD fMRI refractory effect is specific to stimulus attributes: evidence from a visual motion paradigm
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, 27710, USA
    Neuroimage 23:402-8. 2004
  10. ncbi request reprint Linking hemodynamic and electrophysiological measures of brain activity: evidence from functional MRI and intracranial field potentials
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
    Cereb Cortex 14:165-73. 2004

Research Grants

  1. Functional Neuroimaging of Executive Processing
    Scott Huettel; Fiscal Year: 2002
  2. Neuroimaging of Executive Processing
    Scott Huettel; Fiscal Year: 2006
  3. Neuroimaging of Executive Processing
    Scott Huettel; Fiscal Year: 2007
  4. Neural Compensation and Economic Decision Making in Aging
    Scott Huettel; Fiscal Year: 2007

Detail Information

Publications46

  1. ncbi request reprint Sleep deprivation elevates expectation of gains and attenuates response to losses following risky decisions
    Vinod Venkatraman
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Sleep 30:603-9. 2007
    ..Using a gambling task, we investigated how 24 hours of sleep deprivation modulates the neural response to the making of risky decisions with potentially loss-bearing outcomes...
  2. pmc What makes a pattern? Matching decoding methods to data in multivariate pattern analysis
    Philip A Kragel
    Department of Psychology and Neuroscience, Duke University Durham, NC, USA Center for Cognitive Neuroscience, Duke University Durham, NC, USA
    Front Neurosci 6:162. 2012
    ..We conclude that for spatially localized analyses, such as searchlight and region of interest, multiple classification approaches should be compared in order to match fMRI analyses to the properties of local circuits...
  3. pmc Nucleus accumbens mediates relative motivation for rewards in the absence of choice
    John A Clithero
    Department of Economics, Duke University Durham, NC, USA
    Front Hum Neurosci 5:87. 2011
    ..These results demonstrate that neural idiosyncrasies in reward efficacy exist even in the absence of explicit choices, and extend the role of NAcc as a critical brain region for such choice-free motivation...
  4. pmc Event-related fMRI in cognition
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA
    Neuroimage 62:1152-6. 2012
    ..g., fewer articles plot the timing of activation). And, as event-related methods have become ubiquitous, they no longer represent a distinct category of fMRI research. In a real sense, event-related fMRI has now become, simply, fMRI...
  5. pmc Identity economics and the brain: uncovering the mechanisms of social conflict
    Scott A Huettel
    Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA
    Philos Trans R Soc Lond B Biol Sci 367:680-91. 2012
    ..And, we highlight the key questions that would be addressed by a new 'identity neuroeconomics'. Such research could serve as an important and novel link between the social and natural sciences...
  6. ncbi request reprint Decisions under uncertainty: probabilistic context influences activation of prefrontal and parietal cortices
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 25:3304-11. 2005
    ..The distinction between neural mechanisms subserving different forms of uncertainty resolution provides an important constraint for neuroeconomic models of decision making...
  7. ncbi request reprint Modulation of prefrontal cortex activity by information toward a decision rule
    Scott A Huettel
    Brain Imaging and Analysis Center, Department of Psychiatry, Box 3918, Duke University Medical Center, Durham, NC 27710, USA
    Neuroreport 15:1883-6. 2004
    ..This dissociation indicates that dlPFC supports modification of sets of stimulus-response contingencies while the striatum supports stimulus-specific learning...
  8. ncbi request reprint Behavioral, but not reward, risk modulates activation of prefrontal, parietal, and insular cortices
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cogn Affect Behav Neurosci 6:141-51. 2006
    ..Reward delivery, in comparison with omission, evoked increased activity in the ventromedial prefrontal cortex and the nucleus accumbens. We conclude that distinct brain systems are recruited for the resolution of different forms of risk...
  9. ncbi request reprint The BOLD fMRI refractory effect is specific to stimulus attributes: evidence from a visual motion paradigm
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, 27710, USA
    Neuroimage 23:402-8. 2004
    ..We conclude that the fMRI refractory effect predominantly reflects local stimulus-specific neuronal or neurovascular adaptation and is unlikely to be a nonspecific response of large vessels that support broad functional regions...
  10. ncbi request reprint Linking hemodynamic and electrophysiological measures of brain activity: evidence from functional MRI and intracranial field potentials
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
    Cereb Cortex 14:165-73. 2004
    ..We conclude that the relation between ERPs and fMRI differs across brain regions...
  11. ncbi request reprint What is odd in the oddball task? Prefrontal cortex is activated by dynamic changes in response strategy
    Scott A Huettel
    Brain Imaging and Analysis Center, Box 3918, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychologia 42:379-86. 2004
    ..We conclude that the dorsolateral prefrontal cortex (dlPFC) is associated with dynamic changes in the mapping of stimuli to responses (e.g. response strategies), independently of any changes in behavior...
  12. ncbi request reprint Dissociating the neural mechanisms of visual attention in change detection using functional MRI
    S A Huettel
    Duke University, Durham, NC 27710, USA
    J Cogn Neurosci 13:1006-18. 2001
    ..These results suggest that studies of change blindness can inform understanding of more general attentional processing...
  13. ncbi request reprint Neural signatures of economic preferences for risk and ambiguity
    Scott A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 49:765-75. 2006
    ....
  14. pmc Separate neural mechanisms underlie choices and strategic preferences in risky decision making
    Vinod Venkatraman
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 62:593-602. 2009
    ..We conclude that decision making reflects more than compensatory interaction of choice-related regions; in addition, specific brain systems potentiate choices depending on strategies, traits, and context...
  15. pmc Distinct value signals in anterior and posterior ventromedial prefrontal cortex
    David V Smith
    Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
    J Neurosci 30:2490-5. 2010
    ..We conclude that decisions are made by comparing neural representations of the value of different goods encoded in posterior VMPFC in a common, relative currency...
  16. pmc Resolving response, decision, and strategic control: evidence for a functional topography in dorsomedial prefrontal cortex
    Vinod Venkatraman
    Brain Imaging and Analysis Center, Durham, North Carolina 27710, USA
    J Neurosci 29:13158-64. 2009
    ..These results provide new insight into the functional organization of DMPFC and suggest how recent controversies about its role in complex decision making and response mapping can be reconciled...
  17. ncbi request reprint Regional differences in the refractory period of the hemodynamic response: an event-related fMRI study
    S A Huettel
    Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27710, USA
    Neuroimage 14:967-76. 2001
    ..We conclude that characteristics of the HDR, notably its amplitude, latency, and refractory properties, differ across visual cortical areas...
  18. ncbi request reprint Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging
    Deborah L Due
    Department of Psychological and Brain Sciences, Duke University, Durham, NC 27709, USA
    Am J Psychiatry 159:954-60. 2002
    ..The authors sought to increase understanding of the brain mechanisms involved in cigarette addiction by identifying neural substrates modulated by visual smoking cues in nicotine-deprived smokers...
  19. ncbi request reprint The effects of aging upon the hemodynamic response measured by functional MRI
    S A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Neuroimage 13:161-75. 2001
    ..Recovery measures were similar across the age groups...
  20. pmc The neural substrates of probabilistic and intertemporal decision making
    Bethany J Weber
    Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA
    Brain Res 1234:104-15. 2008
    ..These results indicate that there are differences in the patterns of brain activation evoked by risky and intertemporal choices, suggesting that the two domains utilize at least partially distinct sets of cognitive processes...
  21. ncbi request reprint The effects of single-trial averaging upon the spatial extent of fMRI activation
    S A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Box 3918, Durham, NC 27710, USA
    Neuroreport 12:2411-6. 2001
    ..Therefore, group or condition differences may result from differences in voxelwise noise exacerbated by averaging small numbers of trials...
  22. ncbi request reprint Perceiving patterns in random series: dynamic processing of sequence in prefrontal cortex
    Scott A Huettel
    Brain Imaging and Analysis Center, Box 3918, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 5:485-90. 2002
    ..Violations of repeating patterns, but not of alternating patterns, activated the basal ganglia...
  23. pmc Rule-dependent prefrontal cortex activity across episodic and perceptual decisions: an fMRI investigation of the criterial classification account
    Sanghoon Han
    Department of Psychology, Duke University, Durham, NC 27701, USA
    J Cogn Neurosci 21:922-37. 2009
    ..These data indicate that LPFC responses reflect the number of executed criterial classifications or judgments, independent of the number of competing stimuli and the overt response demands of the decision task...
  24. pmc Functional significance of striatal responses during episodic decisions: recovery or goal attainment?
    Sanghoon Han
    Department of Psychology, Yonsei University, Seoul 120 749, Korea
    J Neurosci 30:4767-75. 2010
    ..Instead, it is heavily dependent upon satisfaction of the subjective goals of the observer...
  25. pmc Scan-rescan reliability of subcortical brain volumes derived from automated segmentation
    Rajendra A Morey
    Duke UNC Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27705, USA
    Hum Brain Mapp 31:1751-62. 2010
    ..Thus, longitudinal research requires a careful analysis of sample size and choice of segmentation method combined with a consideration of the brain structure(s) of interest and the magnitude of the anticipated effects...
  26. ncbi request reprint Age-related changes in neural activity during visual target detection measured by fMRI
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
    Cereb Cortex 14:143-55. 2004
    ..Older adults may place relatively greater emphasis on the attentional control of response regulation, in compensation for the age-related decline in visual processing efficiency...
  27. pmc The effect of acute tryptophan depletion on emotional distraction and subsequent memory
    Lihong Wang
    Brain Imaging and Analysis Center, Duke University Medical Center, 2424 Erwin Road, Suite 501 Durham, NC 27705, USA
    Soc Cogn Affect Neurosci 4:357-68. 2009
    ..These findings highlight the importance of serotonin in negative memory with implications for mood disorders...
  28. ncbi request reprint Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time
    David J Madden
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 21:1174-81. 2004
    ....
  29. pmc Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Box 2980, Durham, NC 27710, USA
    Neurobiol Aging 28:459-76. 2007
    ....
  30. pmc Effects of aging on the neural correlates of successful item and source memory encoding
    Nancy A Dennis
    Center for Cognitive Neuroscience, Levine Science Research Center, Duke University, Durham, NC 27708, USA
    J Exp Psychol Learn Mem Cogn 34:791-808. 2008
    ..The functional connectivity findings are consistent with a posterior-anterior shift with aging previously reported in several cognitive domains and linked to functional compensation...
  31. pmc Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Neuropsychopharmacology 30:1940-7. 2005
    ....
  32. pmc Age-related preservation of top-down attentional guidance during visual search
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA
    Psychol Aging 19:304-9. 2004
    ..The authors conclude that under conditions that equate the physical structure of individual displays, top-down attentional guidance can be at least as effective for older adults as for younger adults...
  33. pmc Processing speed and memory mediate age-related differences in decision making
    Debra E Henninger
    Center for the Study of Aging and Human Development, Duke University Medical Center, NC, USA
    Psychol Aging 25:262-70. 2010
    ..The authors conclude that the reduction in decision quality and associated changes in risk preferences commonly ascribed to aging are instead mediated by age-related changes in underlying cognitive capacities...
  34. pmc Risky business: the neuroeconomics of decision making under uncertainty
    Michael L Platt
    Center for Neuroeconomic Studies, Room B243F LSRC Building, Duke University, Durham, North Carolina 27708 0999, USA
    Nat Neurosci 11:398-403. 2008
    ..Thus, understanding decision making-indeed, understanding behavior itself-requires knowing how the brain responds to and uses information about uncertainty...
  35. pmc Cerebral white matter integrity mediates adult age differences in cognitive performance
    David J Madden
    Duke University Medical Center, Durham, NC 27710, USA
    J Cogn Neurosci 21:289-302. 2009
    ..This result is the first demonstration that the integrity of specific white matter tracts is a mediator of age-related changes in cognitive performance...
  36. pmc Rapid electrophysiological brain responses are influenced by both valence and magnitude of monetary rewards
    Julia P Goyer
    Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA
    J Cogn Neurosci 20:2058-69. 2008
    ..These results indicate that early evaluation of feedback goes beyond simple identification of valence-it involves the consideration of multiple factors, including outcome magnitude, context of unchosen options, and prior history...
  37. pmc Local pattern classification differentiates processes of economic valuation
    John A Clithero
    Department of Economics, Duke University, USA
    Neuroimage 45:1329-38. 2009
    ..We conclude that the early valuation phases for these reward types differ on a fine spatial scale, suggesting the existence of computational topographies along the value construction pathway...
  38. ncbi request reprint Altruism is associated with an increased neural response to agency
    Dharol Tankersley
    Brain Imaging and Analysis Center, Box 3918, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 10:150-1. 2007
    ..Here, we demonstrate that differential activation of the human pSTC during action perception versus action performance predicts self-reported altruism...
  39. ncbi request reprint Males and females use different distal cues in a virtual environment navigation task
    N J Sandstrom
    Department of Psychology Experimental, Duke University, Durham, NC 27708 0086, USA
    Brain Res Cogn Brain Res 6:351-60. 1998
    ..We discuss these results as a possible link between recent human research reporting hippocampal activation in spatial tasks and animal work showing sex differences in both spatial ability and hippocampal development...
  40. ncbi request reprint Range effects of an irrelevant dimension on classification
    S A Huettel
    Department of Psychology, Duke University, Durham, NC 27708, USA
    Percept Psychophys 61:1624-45. 1999
    ..It is due to how subjects process successive stimulus differences. We call for more frequent reports of sequential analyses, because these can reveal information that is not available from data averages...
  41. ncbi request reprint Role of aerobic fitness and aging on cerebral white matter integrity
    Bonita L Marks
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA
    Ann N Y Acad Sci 1097:171-4. 2007
    ..There are only a few studies, however, investigating potential mechanisms for the improvements in aerobic fitness. Our study suggests that greater aerobic fitness may be related to greater WM integrity in select brain regions...
  42. pmc Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity
    Barbara Bucur
    Center for the Study of Aging and Human Development, Duke University Medical Center, USA
    Neurobiol Aging 29:1070-9. 2008
    ..These findings suggest that white matter integrity in prefrontal regions is one mechanism underlying the relation between individual differences in perceptual speed and episodic retrieval...
  43. ncbi request reprint Dynamic and strategic aspects of executive processing
    Scott A Huettel
    Brain Imaging and Analysis Center, Box 3918, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1000:78-84. 2004
    ..We conclude that dlPFC and related brain regions mediate both dynamic and strategic processing, through the preparation and selection of rules for behavior...
  44. pmc Cognitive and neural contributors to emotion regulation in aging
    Amy Winecoff
    Center for Cognitive Neuroscience, Box 90999, Duke University, Durham, NC 27708, USA
    Soc Cogn Affect Neurosci 6:165-76. 2011
    ..Thus, while older and younger adults use similar brain structures for emotion regulation and experience, the functional efficacy of those structures depends on underlying cognitive ability...

Research Grants6

  1. Functional Neuroimaging of Executive Processing
    Scott Huettel; Fiscal Year: 2002
    ..This research program will inform studies of executive processing, while providing proof-of-concept data for future applications for research support. ..
  2. Neuroimaging of Executive Processing
    Scott Huettel; Fiscal Year: 2006
    ..g., frontal lobe damage, schizophrenia, Parkinson's disease). ..
  3. Neuroimaging of Executive Processing
    Scott Huettel; Fiscal Year: 2007
    ..g., frontal lobe damage, schizophrenia, Parkinson's disease). ..
  4. Neural Compensation and Economic Decision Making in Aging
    Scott Huettel; Fiscal Year: 2007
    ..Better understanding of this brain-behavior relation could lead to interventions or clinical advances that remediate problems with decision making in the elderly, resulting in benefits to public health. ..