Hai Huang

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc SOD2 polymorphisms: unmasking the effect of polymorphism on splicing
    Jing Shao
    Department of Pathology, University of Washington, Seattle, Washington, USA
    BMC Med Genet 8:7. 2007
  2. ncbi request reprint The immune system in aging: roles of cytokines, T cells and NK cells
    Hai Huang
    Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA
    Front Biosci 10:192-215. 2005
  3. ncbi request reprint The role of oxidative damage in mitochondria during aging: a review
    Hai Huang
    Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA
    Front Biosci 9:1100-17. 2004
  4. ncbi request reprint Newborn screening for severe combined immunodeficiency (SCID): a review
    Hai Huang
    Center for Demographic Studies, Duke University 2117 Campus Drive Box 90408 Durham, North Carolina 27708, USA
    Front Biosci 10:1024-39. 2005
  5. ncbi request reprint Fuzzy set analyses of genetic determinants of health and disability status
    Kenneth G Manton
    Center for Demographic Studies, Duke University, 2117 Campus Drive, Durham, NC 27708, USA
    Stat Methods Med Res 13:395-408. 2004
  6. ncbi request reprint A novel mutation in the SCN5A gene is associated with Brugada syndrome
    Dong Jik Shin
    Cardiovascular Genome Center, Yonsei University Medical Center, Seoul, Republic of Korea
    Life Sci 80:716-24. 2007
  7. ncbi request reprint Genetic interactions between leaf polarity-controlling genes and ASYMMETRIC LEAVES1 and 2 in Arabidopsis leaf patterning
    Yanlei Fu
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    Plant Cell Physiol 48:724-35. 2007
  8. ncbi request reprint ASYMMETRIC LEAVES1, an Arabidopsis gene that is involved in the control of cell differentiation in leaves
    Yue Sun
    Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Planta 214:694-702. 2002
  9. ncbi request reprint ICOS/B7RP-1 interference in mouse kidney transplantation
    Jens Lutz
    Department of Nephrology, Klinikum rechts der Isar, Munich, Germany
    Transplantation 84:223-30. 2007
  10. ncbi request reprint Recombinant high-density lipoprotein complex as a targeting system of nosiheptide to liver cells
    Meiqing Feng
    School of Pharmacy, Fu Dan University, Shanghai, P R China
    J Drug Target 16:502-8. 2008

Collaborators

  • Kenneth G Manton
  • Dhavalkumar D Patel
  • Zheng Yuan
  • Hong Li
  • Yan Zhu
  • Wei Zhang
  • Lin Xu
  • Li Yang
  • Hua Wang
  • Ben Xu
  • Weihua Huang
  • Yanlei Fu
  • Meiqing Feng
  • Dong Jik Shin
  • Jens Lutz
  • Jing Shao
  • Qihua Ling
  • Peng Ru
  • Run Cai
  • Na Li
  • Hong Ma
  • Limin Pi
  • Jian Hua Wang
  • Mingjie Chen
  • Yue Sun
  • Qinsheng Cai
  • Xin Guo
  • Xunlong Shi
  • Pei Zhou
  • Mohamed Chahine
  • Jihye Han
  • Junko Oshima
  • Won Cheoul Jang
  • Nengtai Ouyang
  • Meihong Deng
  • Sung Soon Kim
  • Brian Marrs
  • Eunmin Kim
  • Matthias Strobl
  • Moon Hyoung Lee
  • Ruiyan Lu
  • Lin Lee
  • Uwe Heemann
  • Boyoung Joung
  • Minghui Wang
  • Yoonsun Bae
  • Lishan Chen
  • Sang Bum Park
  • Sungjoo Kim Yoon
  • George M Martin
  • Yangsoo Jang
  • Wan Qi Liang
  • Hai Sheng Liu
  • Da Luo
  • Tie Qiao Wen
  • Huang Wei Chu
  • Jia Wang
  • Qili Liu
  • Yuquan Xu
  • Da Bing Zhang
  • Xiao Xing Li
  • R Scott Poethig
  • Da Sheng Zhang
  • Chang Song Yin
  • Wanqi Liang
  • Siu Cheung Tam
  • Xiaoxiang Xia
  • Huiqiong Zheng
  • Yuan Yuan Wang
  • Yong Tang Zheng
  • Dong Yun Ouyang
  • Qingwen Zhou

Detail Information

Publications19

  1. pmc SOD2 polymorphisms: unmasking the effect of polymorphism on splicing
    Jing Shao
    Department of Pathology, University of Washington, Seattle, Washington, USA
    BMC Med Genet 8:7. 2007
    ..The SOD2 gene encodes an antioxidant enzyme, mitochondrial superoxide dismutase. SOD2 polymorphisms are of interest because of their potential roles in the modulation of free radical-mediated macromolecular damage during aging...
  2. ncbi request reprint The immune system in aging: roles of cytokines, T cells and NK cells
    Hai Huang
    Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA
    Front Biosci 10:192-215. 2005
    ..In this review, age-related changes in inflammatory cytokines, T and NK cells, and the biology of IL-6 and TNF-alpha and their relevance to senescence are considered...
  3. ncbi request reprint The role of oxidative damage in mitochondria during aging: a review
    Hai Huang
    Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA
    Front Biosci 9:1100-17. 2004
    ..While oxidative events in other cell organelles are likely to contribute to the pathobiology of aging, this review highlights alterations in mitochondrial function that, due to accumulated oxidative damage, occur with age...
  4. ncbi request reprint Newborn screening for severe combined immunodeficiency (SCID): a review
    Hai Huang
    Center for Demographic Studies, Duke University 2117 Campus Drive Box 90408 Durham, North Carolina 27708, USA
    Front Biosci 10:1024-39. 2005
    ..Screening newborns for SCID would allow early diagnosis and treatment -- as well as genetic counseling for the family...
  5. ncbi request reprint Fuzzy set analyses of genetic determinants of health and disability status
    Kenneth G Manton
    Center for Demographic Studies, Duke University, 2117 Campus Drive, Durham, NC 27708, USA
    Stat Methods Med Res 13:395-408. 2004
    ..A number of interesting relations with APOE polymorphism were found where disability profiles were more predictive than specific diagnoses because they implicitly contained information on chronicity and severity of disease processes...
  6. ncbi request reprint A novel mutation in the SCN5A gene is associated with Brugada syndrome
    Dong Jik Shin
    Cardiovascular Genome Center, Yonsei University Medical Center, Seoul, Republic of Korea
    Life Sci 80:716-24. 2007
    ..No effect on activation and inactivation were observed with this heterozygous expression. The W1191X mutation is associated with BS and resulted in the loss of function of the cardiac sodium channel...
  7. ncbi request reprint Genetic interactions between leaf polarity-controlling genes and ASYMMETRIC LEAVES1 and 2 in Arabidopsis leaf patterning
    Yanlei Fu
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    Plant Cell Physiol 48:724-35. 2007
    ..Genetic interactions between the key regulators during leaf patterning are discussed...
  8. ncbi request reprint ASYMMETRIC LEAVES1, an Arabidopsis gene that is involved in the control of cell differentiation in leaves
    Yue Sun
    Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Planta 214:694-702. 2002
    ..High levels of AS1 expression were found in tissues with highly proliferative cells, which further suggests a role in cell division and early cell differentiation...
  9. ncbi request reprint ICOS/B7RP-1 interference in mouse kidney transplantation
    Jens Lutz
    Department of Nephrology, Klinikum rechts der Isar, Munich, Germany
    Transplantation 84:223-30. 2007
    ..The role of this signaling pathway during the early phases of kidney allograft rejection is not clear so far...
  10. ncbi request reprint Recombinant high-density lipoprotein complex as a targeting system of nosiheptide to liver cells
    Meiqing Feng
    School of Pharmacy, Fu Dan University, Shanghai, P R China
    J Drug Target 16:502-8. 2008
    ..v. injection to male Wistar rats. Together, this report provides early evidence that it is feasible to develop efficient, HDL-based drug delivery systems against HBV, utilizing apolipoprotein A-I as the targeting moiety...
  11. pmc The rice tapetum degeneration retardation gene is required for tapetum degradation and anther development
    Na Li
    Shanghai Jiao Tong University Shanghai Institutes for Biological Sciences Pensylvania State University Joint Center for Life Sciences, Shanghai 200240, China
    Plant Cell 18:2999-3014. 2006
    ..These results indicate that TDR is a key component of the molecular network regulating rice tapetum development and degeneration...
  12. pmc The proteolytic function of the Arabidopsis 26S proteasome is required for specifying leaf adaxial identity
    Weihua Huang
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, Shanghai 200032, China
    Plant Cell 18:2479-92. 2006
    ..Together, our findings reveal that posttranslational regulation is essential in proper leaf patterning...
  13. ncbi request reprint Characterizations of a hypomorphic argonaute1 mutant reveal novel AGO1 functions in Arabidopsis lateral organ development
    Li Yang
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, China
    Plant Mol Biol 61:63-78. 2006
    ..Our results demonstrate several important AGO1 functions in plant lateral organ development...
  14. ncbi request reprint Plant fertility defects induced by the enhanced expression of microRNA167
    Peng Ru
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, 300 Fenglin Road, Shanghai 200032, China
    Cell Res 16:457-65. 2006
    ..Our results provide an important link between the miRNA-mediated regulatory pathway of gene expression and the auxin signaling network promoting plant reproductive development...
  15. ncbi request reprint Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis
    Lin Xu
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, PR China
    Plant Cell Physiol 47:853-63. 2006
    ..The RDR6-SGS3-AGO7 pathway was previously identified as regulating the plant vegetative phase change. Our results reveal a new function of the pathway, which is also required for normal leaf morphogenesis...
  16. pmc The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development
    Hong Li
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200032, China
    Plant Cell 17:2157-71. 2005
    ..Taken together, our data suggest that the Arabidopsis RDR6-associated epigenetic pathway and the AS1-AS2 pathway synergistically repress BP and MIR165/166 for proper plant development...
  17. ncbi request reprint The GAOLAOZHUANGREN2 gene is required for normal glucose response and development of Arabidopsis
    Mingjie Chen
    National Laboratory of Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Graduate School of Chinese Academy of Sciences, 200032 Shanghai, People s Republic of China
    J Plant Res 117:473-6. 2004
    ..Taken together, our results suggest that the GLZ2 gene is required for normal glucose response and development of Arabidopsis...
  18. ncbi request reprint Site-directed PEGylation of trichosanthin retained its anti-HIV activity with reduced potency in vitro
    Jian Hua Wang
    Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China
    Biochem Biophys Res Commun 317:965-71. 2004
    ..The in vitro study showed that the anti-HIV activity of PEGylated TCS was retained with reduced potency. The in vivo activity is expected to have only slightly changed due to other beneficial effects like prolonged half-life...
  19. doi request reprint Subcellular localizations of AS1 and AS2 suggest their common and distinct roles in plant development
    Yan Zhu
    State Key Laboratory of Genetic Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China
    J Integr Plant Biol 50:897-905. 2008
    ..Our data suggest that AS1, AS2 and the AS1-AS2 protein complex may have distinct functions, which are all required for normal plant development...