Cathrine Hoyo

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements
    Ying Liu
    School of Medicine, Duke University, Durham, NC, USA
    Epigenetics 7:735-46. 2012
  2. pmc Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a cross-sectional hospital-based study
    Olukemi Ogundipe
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    BMC Public Health 12:481. 2012
  3. pmc Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium
    Cathrine Hoyo
    Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC 27710, USA
    Int J Epidemiol 41:1706-18. 2012
  4. pmc Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, 2200 West Main Street, Ste 600, Durham, NC 27705, USA
    Cancer Causes Control 23:635-45. 2012
  5. pmc The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring
    A Soubry
    Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA
    Clin Epigenetics 3:2. 2011
  6. pmc Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Epigenetics 6:928-36. 2011
  7. pmc Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women
    Adriana C Vidal
    Department of Community and Family Medicine, and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC, USA
    Infect Agent Cancer 6:20. 2011
  8. pmc Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)
    Cathrine Hoyo
    Department of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University, PO Box 104006, Durham, NC 27710, USA
    BMC Public Health 11:46. 2011
  9. pmc Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, Box 2914, Durham, NC 27710, USA
    J Natl Med Assoc 101:711-6. 2009
  10. pmc Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites
    Cathrine Hoyo
    Department of Community and Family Medicine, Hanes House Room 347, Trent Drive, Box 2914, Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    J Natl Med Assoc 99:718-22. 2007

Research Grants

Collaborators

Detail Information

Publications44

  1. pmc Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements
    Ying Liu
    School of Medicine, Duke University, Durham, NC, USA
    Epigenetics 7:735-46. 2012
    ..9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed mood in pregnancy is associated with LBW, and that MEG3 and IGF2 plasticity may play important roles...
  2. pmc Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a cross-sectional hospital-based study
    Olukemi Ogundipe
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    BMC Public Health 12:481. 2012
    ..We assessed the use of prenatal folic acid and iron supplementation among women in a geographical area with a high prevalence of anaemia, in relation to socio-demographic, morbidity and health services utilization factors...
  3. pmc Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium
    Cathrine Hoyo
    Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC 27710, USA
    Int J Epidemiol 41:1706-18. 2012
    ..However, these studies have been limited in their ability to assess whether the effects of obesity vary by gender or by the presence of gastro-oesophageal reflux (GERD) symptoms...
  4. pmc Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, 2200 West Main Street, Ste 600, Durham, NC 27705, USA
    Cancer Causes Control 23:635-45. 2012
    ..We examined associations among DNA methylation at IGF2 differentially methylated regions (DMRs), circulating IGF2 protein concentrations in umbilical cord blood (UCB) and birth weight in newborns...
  5. pmc The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring
    A Soubry
    Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA
    Clin Epigenetics 3:2. 2011
    ..05%, p = 0.01). In conclusion, our findings suggest a race-dependent response related to maternal use of antidepressants at one of the IGF2 DMRs in the offspring...
  6. pmc Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Epigenetics 6:928-36. 2011
    ....
  7. pmc Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women
    Adriana C Vidal
    Department of Community and Family Medicine, and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC, USA
    Infect Agent Cancer 6:20. 2011
    ..abstract:..
  8. pmc Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)
    Cathrine Hoyo
    Department of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University, PO Box 104006, Durham, NC 27710, USA
    BMC Public Health 11:46. 2011
    ..The primary objective is to estimate the proportion of women taking folic acid (FA) doses exceeding the TUL before and during pregnancy, and to identify correlates of high FA use...
  9. pmc Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, Box 2914, Durham, NC 27710, USA
    J Natl Med Assoc 101:711-6. 2009
    ..Factors associated with variation in circulating levels of these peptide hormones remain unclear...
  10. pmc Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites
    Cathrine Hoyo
    Department of Community and Family Medicine, Hanes House Room 347, Trent Drive, Box 2914, Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    J Natl Med Assoc 99:718-22. 2007
    ..If confirmed in larger studies, these findings support the hypothesis that the association between IGFBP3 C allele and prostate cancer is grade specific in both ethnic groups...
  11. pmc Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke
    Susan K Murphy
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC 27708, USA
    Gene 494:36-43. 2012
    ..Our findings suggest that IGF2 DMR plasticity is an important mechanism by which in utero adjustments to environmental toxicants are conferred. Larger studies to replicate these findings are required...
  12. pmc Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children
    Ellen Perkins
    Department of Community and Family Medicine, Duke University, Durham, NC 27710, USA
    J Pediatr 161:31-9. 2012
    ..To determine whether aberrant DNA methylation at differentially methylated regions (DMRs) regulating insulin-like growth factor 2 (IGF2) expression in umbilical cord blood is associated with overweight or obesity in a multiethnic cohort...
  13. pmc IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University, Durham, NC 27710, USA
    Int J Cancer 125:2673-8. 2009
    ..5002G > A genotype and EGA was not evident. These findings suggest that nonsynonymous polymorphisms in M6P/IGF2R may contribute to the risks of EGA and noncardia adenocarcinomas. Larger studies are required to confirm these findings...
  14. pmc IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites
    Cathrine Hoyo
    Department of Community and Family Medicine, and Program of Cancer Detection, Prevention and Control, Duke University Medical Center, NC, USA
    Dis Markers 32:133-41. 2012
    ..5002 G>A modulates IGF2 circulating levels in a sex-specific manner, and while carrying the IGF2R c.901 C>G may increase cancer risk, the mechanism may not involve modulation of circulating IGF2...
  15. pmc Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study
    Adriana C Vidal
    Department of Biology and Cancer Research Program, JLC Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
    BMC Cancer 13:556. 2013
    ..Novel functional polymorphisms of the UGT2B17 and UGT2B15 genes have been recently characterized by in vitro assays but have not been evaluated in epidemiologic studies...
  16. pmc Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
    Adelheid Soubry
    Duke Cancer Institute, Duke University Medical Center 2715, Durham, NC 27710, USA
    BMC Med 11:29. 2013
    ....
  17. pmc Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancer
    Monica D Nye
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS ONE 8:e56325. 2013
    ..6-fold increase ICC risk. Suggesting PEG3 methylation status may be useful as a molecular marker for CIN screening to improve prediction of cases likely to progress...
  18. pmc DNA methylation at imprint regulatory regions in preterm birth and infection
    Ying Liu
    Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA
    Am J Obstet Gynecol 208:395.e1-7. 2013
    ....
  19. doi request reprint Vitamin D receptor (VDR) polymorphisms and risk of ovarian cancer in Caucasian and African American women
    Delores J Grant
    Department of Biology and Cancer Research Program, JLC Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA
    Gynecol Oncol 129:173-8. 2013
    ..Polymorphisms in the vitamin D receptor (VDR) gene have been shown in some studies to be associated with the risk of epithelial ovarian cancer (EOC) in Caucasian women. There are no published reports among African Americans...
  20. doi request reprint Association between exercise and primary incidence of prostate cancer: does race matter?
    Abhay A Singh
    Duke Prostate Center, Duke University Medical Center, Durham, NC 27705, USA
    Cancer 119:1338-43. 2013
    ..However, whether this association is different as a function of race is unclear. In the current study, the authors attempted to characterize the link between exercise and prostate cancer (CaP) in white and black American men...
  21. pmc Dietary calcium and risk for prostate cancer: a case-control study among US veterans
    Christina D Williams
    Durham Veterans Affairs Medical Center, 508 Fulton St, HSRD 152, Durham, NC 27705, USA
    Prev Chronic Dis 9:E39. 2012
    ..The objective of this study was to examine the association between calcium intake and prostate cancer risk. We hypothesized that calcium intake would be positively associated with lower risk for prostate cancer...
  22. pmc Association of uridine diphosphate-glucuronosyltransferase 2B gene variants with serum glucuronide levels and prostate cancer risk
    Delores J Grant
    Cancer Research Program and Department of Biology, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina 27707, USA
    Genet Test Mol Biomarkers 17:3-9. 2013
    ..The functional significance of the UGT2B genetic variants has never been described in humans. We evaluated UGT2B variants in relation to plasma androstane-3α,17β-diol-glucuronide (AAG) levels and the prostate cancer risk...
  23. pmc Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa
    Adriana C Vidal
    Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, USA
    BMC Cancer 12:389. 2012
    ..However few studies have evaluated IGFBP-1 and C-peptide in relation to adenomatous polyps, the only known precursor for CRC...
  24. ncbi request reprint Anthropometric measurements and epithelial ovarian cancer risk in African-American and White women
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, 2424 Erwin Rd, Hock Plaza, Ste 602, Durham, NC 27710, USA
    Cancer Causes Control 16:955-63. 2005
    ..0; 95% CI = 0.7-1.4). These findings support the hypothesis that obesity is an important risk factor of ovarian cancer among African-Americans and Whites and also suggest that height may be a risk factor specific to African-Americans...
  25. ncbi request reprint Racial differences in enrolment in a cancer genetics registry
    Patricia G Moorman
    Cancer Prevention Detection and Control Research Program, Duke University Medical Center, 239 Hanes House, Trent Drive, Box 2949, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 13:1349-54. 2004
    ..Most studies have little information about nonparticipants, making it difficult to identify characteristics associated with enrolment and how they might vary by race...
  26. ncbi request reprint Pain predicts non-adherence to pap smear screening among middle-aged African American women
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, Box 2914, Durham, NC 27710, USA
    Prev Med 41:439-45. 2005
    ..Middle-aged African American women have the highest incidence and mortality of invasive cervical cancer in the United States and the lowest adherence to pap smear screening...
  27. pmc Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues
    Susan K Murphy
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e40924. 2012
    ..Similarity of inter-individual and intra-individual methylation at some, but not all of the DMRs analyzed supports the possibility that methylation of these regions can serve as useful biosensors of exposure...
  28. ncbi request reprint IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men
    Joellen M Schildkraut
    Program of Cancer Prevention, Detection and Control Research, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Cancer Epidemiol Biomarkers Prev 14:403-8. 2005
    ..Further research is needed to confirm these findings...
  29. ncbi request reprint The association between race and prostate cancer risk on initial biopsy in an equal access, multiethnic cohort
    Alexis R Gaines
    Global Health Institute, Duke University, Durham, NC, USA
    Cancer Causes Control 25:1029-35. 2014
    ..We investigated the association between race and risk of low- and high-grade PC in men undergoing initial prostate biopsy in an equal access medical center...
  30. doi request reprint The association of diabetes mellitus and high-grade prostate cancer in a multiethnic biopsy series
    Daniel M Moreira
    Division of Urologic Surgery, Department of Surgery and Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA
    Cancer Causes Control 22:977-83. 2011
    ..To analyze the association of diabetes mellitus (DM) with risk of prostate cancer and cancer grade among men undergoing prostate biopsy and to analyze how obesity and race modify these associations...
  31. pmc HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA
    Adriana C Vidal
    Program of Cancer Detection, Prevention and Control, Division of Clinical and Epidemiologic Research, Department of Obstetrics and Gynecology, Duke University School of Medicine, P O Box 104006, Durham, NC, 27710, USA
    Cancer Causes Control 25:1055-62. 2014
    ..The current study aimed at disentangling differences in HPV distribution among AA and EA women...
  32. pmc The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility
    David A Skaar
    Department of Oncology, Duke University Medical Center, Durham, North Carolina, USA
    ILAR J 53:341-58. 2012
    ..Ultimately, only the human will suffice to accurately define the human imprintome...
  33. doi request reprint A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer
    Christina D Williams
    Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Nutr Res 31:1-8. 2011
    ..In conclusion, our findings suggest that a high dietary ratio of n-6/n-3 fatty acids may increase the risk of overall prostate cancer among white men and possibly increase the risk of high-grade prostate cancer among all men...
  34. ncbi request reprint Barriers and strategies for sustained participation of African-American men in cohort studies
    Cathrine Hoyo
    Department of Health Education, North Carolina Central University, Durham 27707, USA
    Ethn Dis 13:470-6. 2003
    ....
  35. ncbi request reprint Improving the accuracy of syndromic diagnosis of genital ulcer disease in Malawi
    Cathrine Hoyo
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Sex Transm Dis 32:231-7. 2005
    ..However, the etiologic pathogens of GUD vary temporally and geographically, and current criteria may not reflect changes in the prevalence of specific pathogens...
  36. ncbi request reprint Reproducibility of self-reported pap test utilization in middle-aged African-American women
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ethn Dis 15:84-9. 2005
    ..Not using self-reports to base clinic decisions may still be prudent among those with less education...
  37. pmc Program prioritization to control chronic diseases in African-American faith-based communities
    Cathrine Hoyo
    Duke University Medical Center, Department of Community and Family Medicine, Durham, North Carolina, USA
    J Natl Med Assoc 96:524-32. 2004
    ..We assessed the effect of providing congregation leaders with skills on identifying their own health needs, planning, and implementing their own interventions...
  38. ncbi request reprint Perceptions of participation in an observational epidemiologic study of cancer among African Americans
    Kyna M Gooden
    Department of Epidemiology, University of North Carolina at Chapel Hill, 2101 McGavran Greenberg Hall, CB 7435, Chapel Hill, NC 26599, USA
    Ethn Dis 15:68-75. 2005
    ..We assessed perceptions and attitudes of African Americans towards participation in an observational epidemiologic study of cancer, and attitudes toward the data collection process...
  39. ncbi request reprint For the patient. Improving participation of African-American men in research studies
    Cathrine Hoyo
    Ethn Dis 13:547-8. 2003
  40. ncbi request reprint For the patient. Recruitment strategies for cancer research studies
    Kyna M Gooden
    Ethn Dis 15:151. 2005
  41. ncbi request reprint Key attributes of health ministries in African American churches: an exploratory survey
    Lori Carter-Edwards
    Institute for Health, Social and Community Research at Shaw University, USA
    N C Med J 67:345-50. 2006
    ..However it is unknown which program attributes they perceive as important and which program attributes exist in their congregations...
  42. ncbi request reprint The prevalence and correlates of urinary tract symptoms in Norwegian men: the HUNT study
    Arnfinn Seim
    Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    BJU Int 96:88-92. 2005
    ....

Research Grants8

  1. Insulin-like Growth Factors and Esophageal Cancer
    Cathrine Hoyo; Fiscal Year: 2007
    ..abstract_text> ..
  2. In-utero Exposure and Infant Loss of IGF2 Imprinting
    Cathrine Hoyo; Fiscal Year: 2007
    ..The proposed study also has the potential to provide a foundation for future studies investigating the etiology of chronic diseases, including diabetes, cardiovascular diseases and some cancers. ..
  3. Nutrition, Deregulation of Imprinted Genes
    Cathrine Hoyo; Fiscal Year: 2009
    ....
  4. Disparities in cervical cancer precursors and deregulation of imprinted genes
    Susan Kay Murphy; Fiscal Year: 2010
    ..Data from this study will elucidate the role of epigenetic deregulation in CIN2+ and inform triage decisions, reducing disparities in cervical cancer incidence and mortality. ..
  5. Nutrition, Deregulation of Imprinted Genes
    Cathrine Hoyo; Fiscal Year: 2010
    ....
  6. Nutrition, Deregulation of Imprinted Genes
    Cathrine Hoyo; Fiscal Year: 2009
    ....
  7. Obesity and deregulation of imprinted genes in early life
    Susan Kay Murphy; Fiscal Year: 2010
    ....