Lian Hong

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Metallomics 3:262-6. 2011
  2. pmc Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregation
    Lian Hong
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 114:11261-71. 2010
  3. ncbi request reprint Physical and chemical characterization of iris and choroid melanosomes isolated from newborn and mature cows
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 81:517-23. 2005
  4. ncbi request reprint Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 81:510-6. 2005
  5. ncbi request reprint Photoionization thresholds of melanins obtained from free electron laser-photoelectron emission microscopy, femtosecond transient absorption spectroscopy and electron paramagnetic resonance measurements of oxygen photoconsumption
    Tong Ye
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:733-7. 2006
  6. doi request reprint Human iridal stroma melanosomes of varying pheomelanin contents possess a common eumelanic outer surface
    Dana N Peles
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 113:11346-51. 2009
  7. pmc Current understanding of the binding sites, capacity, affinity, and biological significance of metals in melanin
    Lian Hong
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 111:7938-47. 2007
  8. ncbi request reprint Age-dependent photoionization thresholds of melanosomes and lipofuscin isolated from human retinal pigment epithelium cells
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:1475-81. 2006
  9. ncbi request reprint Insight into the binding of divalent cations to Sepia eumelanin from IR absorption spectroscopy
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:1265-9. 2006
  10. ncbi request reprint Comparison of structural and chemical properties of black and red human hair melanosomes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Photochem Photobiol 81:135-44. 2005

Collaborators

Detail Information

Publications19

  1. doi request reprint Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Metallomics 3:262-6. 2011
    ..This current review reconciles the disparate models presented in the literature...
  2. pmc Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregation
    Lian Hong
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 114:11261-71. 2010
    ..The differences in the coordination geometries for Cu(2+) by the human and rat Abeta are proposed to contribute to the variation in the ability of Cu(2+) to induce aggregation of Abeta peptides...
  3. ncbi request reprint Physical and chemical characterization of iris and choroid melanosomes isolated from newborn and mature cows
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 81:517-23. 2005
    ..These tissue-related and age-related chemical differences between samples affected the optic density and metal binding properties of melanosomes, which are believed to be closely associated with the biological functions of melanins...
  4. ncbi request reprint Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 81:510-6. 2005
    ....
  5. ncbi request reprint Photoionization thresholds of melanins obtained from free electron laser-photoelectron emission microscopy, femtosecond transient absorption spectroscopy and electron paramagnetic resonance measurements of oxygen photoconsumption
    Tong Ye
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:733-7. 2006
    ..The lower ionization potential observed for pheomelanin could be an important part of the explanation for the greater incidence rate of UV-induced skin cancers in red-haired individuals...
  6. doi request reprint Human iridal stroma melanosomes of varying pheomelanin contents possess a common eumelanic outer surface
    Dana N Peles
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 113:11346-51. 2009
    ..This provides new insights into the potential contribution of iridal stroma melanosomes both to inducing oxidative stress and to accounting for the observed iris-color-dependent epidemiology of uveal melanoma...
  7. pmc Current understanding of the binding sites, capacity, affinity, and biological significance of metals in melanin
    Lian Hong
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 111:7938-47. 2007
    ..This article examines the current state of understanding of this field...
  8. ncbi request reprint Age-dependent photoionization thresholds of melanosomes and lipofuscin isolated from human retinal pigment epithelium cells
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:1475-81. 2006
    ..These data suggest that thin deposits of lipofuscin on the surface of retinal pigment epithelium melanosomes are common in the aged eye and that this renders the melanosomes more pro-oxidant...
  9. ncbi request reprint Insight into the binding of divalent cations to Sepia eumelanin from IR absorption spectroscopy
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:1265-9. 2006
    ....
  10. ncbi request reprint Comparison of structural and chemical properties of black and red human hair melanosomes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Photochem Photobiol 81:135-44. 2005
    ..Excellent agreement is observed between these spectral results and the chemical degradation data...
  11. doi request reprint Surface elastic properties of human retinal pigment epithelium melanosomes
    Senli Guo
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 84:671-8. 2008
    ..This suggestion indicates that part of the difference in photochemical properties between the old and young melanosomes originates from surface lipofuscin...
  12. doi request reprint Quantification of the binding constant of copper(II) to the amyloid-beta peptide
    Lanying Q Hatcher
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    J Phys Chem B 112:8160-4. 2008
    ..Several previously reported values can be reconciled with the current measurement by careful consideration of thermodynamics associated with the presence of competing ligands used to solubilize copper...
  13. doi request reprint Insights into melanosomes and melanin from some interesting spatial and temporal properties
    John D Simon
    Department of Chemistry, Duke University, Durham, NC, USA
    J Phys Chem B 112:13201-17. 2008
    ..The article concludes with a brief discussion of important unanswered research questions in this field...
  14. doi request reprint Probing skin pigmentation changes with transient absorption imaging of eumelanin and pheomelanin
    Dan Fu
    Princeton University, Department of Chemistry, Princeton, New Jersey 08544, USA
    J Biomed Opt 13:054036. 2008
    ..This difference should enable us to map out their respective distribution in tissue samples with subcellular resolution. This technique could provide valuable information in diagnosing the malignant transformation of melanocytes...
  15. doi request reprint Binding of Cu(II) to human alpha-synucleins: comparison of wild type and the point mutations associated with the familial Parkinson's disease
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    J Phys Chem B 113:9551-61. 2009
    ..g., small oligomeric species, such as dimers and trimers) relative to WT and A53T. Thus, we propose that the high affinity site is attributed to the binding of Cu(II) to those small oligomeric species...
  16. ncbi request reprint Spectroscopy and photoreactivity of trichochromes: molecular components of pheomelanins
    John D Simon
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 82:318-23. 2006
    ..Both trichochromes are efficient quenchers of 1O2, exhibiting a bimolecular rate constant comparable with vitamin C. These results suggest that trichochromes could serve a protective role in pheomelanin pigments...
  17. ncbi request reprint Binding of metal ions to melanin and their effects on the aerobic reactivity
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 80:477-81. 2004
    ..Cu(II)- and Fe(III)-enriched melanins induce the most damage. Hydroxyl radical, *OH, is proposed to be one of the reactive oxygen species responsible...
  18. ncbi request reprint Oxidation potentials of human eumelanosomes and pheomelanosomes
    Alexander Samokhvalov
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Photochem Photobiol 81:145-8. 2005
    ..The FEL-PEEM experiment offers to be an important new approach for quantifying the effects of age, oxidation and metal accumulation on the oxidation potentials of intact melanosomes...
  19. ncbi request reprint Ion-exchange and adsorption of Fe(III) by Sepia melanin
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC, USA
    Pigment Cell Res 17:262-9. 2004
    ..These observations imply the existence of channels within the melanin granules that can serve to transport metal ions...