Research Topics
Genomes and GenesSpecies | Lian HongSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteinsLian Hong
Department of Chemistry, Duke University, Durham, NC 27708, USA
Metallomics 3:262-6. 2011..This current review reconciles the disparate models presented in the literature...
Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregationLian Hong
Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
J Phys Chem B 114:11261-71. 2010..The differences in the coordination geometries for Cu(2+) by the human and rat Abeta are proposed to contribute to the variation in the ability of Cu(2+) to induce aggregation of Abeta peptides...
Physical and chemical characterization of iris and choroid melanosomes isolated from newborn and mature cowsLian Hong
Department of Chemistry, Duke University, Durham, NC 27708-0346, USA
Photochem Photobiol 81:517-23. 2005..These tissue-related and age-related chemical differences between samples affected the optic density and metal binding properties of melanosomes, which are believed to be closely associated with the biological functions of melanins...- Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyesYan Liu
Department of Chemistry, Duke University, Durham, NC 27708-0346, USA
Photochem Photobiol 81:510-6. 2005.... - Photoionization thresholds of melanins obtained from free electron laser-photoelectron emission microscopy, femtosecond transient absorption spectroscopy and electron paramagnetic resonance measurements of oxygen photoconsumptionTong Ye
Department of Chemistry, Duke University, Durham, NC, USA
Photochem Photobiol 82:733-7. 2006..The lower ionization potential observed for pheomelanin could be an important part of the explanation for the greater incidence rate of UV-induced skin cancers in red-haired individuals... - Human iridal stroma melanosomes of varying pheomelanin contents possess a common eumelanic outer surfaceDana N Peles
Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
J Phys Chem B 113:11346-51. 2009..This provides new insights into the potential contribution of iridal stroma melanosomes both to inducing oxidative stress and to accounting for the observed iris-color-dependent epidemiology of uveal melanoma... - Current understanding of the binding sites, capacity, affinity, and biological significance of metals in melaninLian Hong
Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
J Phys Chem B 111:7938-47. 2007..This article examines the current state of understanding of this field... - Age-dependent photoionization thresholds of melanosomes and lipofuscin isolated from human retinal pigment epithelium cellsLian Hong
Department of Chemistry, Duke University, Durham, NC, USA
Photochem Photobiol 82:1475-81. 2006..These data suggest that thin deposits of lipofuscin on the surface of retinal pigment epithelium melanosomes are common in the aged eye and that this renders the melanosomes more pro-oxidant... - Insight into the binding of divalent cations to Sepia eumelanin from IR absorption spectroscopyLian Hong
Department of Chemistry, Duke University, Durham, NC, USA
Photochem Photobiol 82:1265-9. 2006.... - Comparison of structural and chemical properties of black and red human hair melanosomesYan Liu
Department of Chemistry, Duke University, Durham, NC 27708, USA
Photochem Photobiol 81:135-44. 2005..Excellent agreement is observed between these spectral results and the chemical degradation data... - Surface elastic properties of human retinal pigment epithelium melanosomesSenli Guo
Department of Chemistry, Duke University, Durham, NC, USA
Photochem Photobiol 84:671-8. 2008..This suggestion indicates that part of the difference in photochemical properties between the old and young melanosomes originates from surface lipofuscin... - Quantification of the binding constant of copper(II) to the amyloid-beta peptideLanying Q Hatcher
Department of Chemistry, Duke University, Durham, NC 27708, USA
J Phys Chem B 112:8160-4. 2008..Several previously reported values can be reconciled with the current measurement by careful consideration of thermodynamics associated with the presence of competing ligands used to solubilize copper... - Insights into melanosomes and melanin from some interesting spatial and temporal propertiesJohn D Simon
Department of Chemistry, Duke University, Durham, NC, USA
J Phys Chem B 112:13201-17. 2008..The article concludes with a brief discussion of important unanswered research questions in this field... - Probing skin pigmentation changes with transient absorption imaging of eumelanin and pheomelaninDan Fu
Princeton University, Department of Chemistry, Princeton, New Jersey 08544, USA
J Biomed Opt 13:054036. 2008..This difference should enable us to map out their respective distribution in tissue samples with subcellular resolution. This technique could provide valuable information in diagnosing the malignant transformation of melanocytes... - Binding of Cu(II) to human alpha-synucleins: comparison of wild type and the point mutations associated with the familial Parkinson's diseaseLian Hong
Department of Chemistry, Duke University, Durham, NC 27708, USA
J Phys Chem B 113:9551-61. 2009..g., small oligomeric species, such as dimers and trimers) relative to WT and A53T. Thus, we propose that the high affinity site is attributed to the binding of Cu(II) to those small oligomeric species... - Spectroscopy and photoreactivity of trichochromes: molecular components of pheomelaninsJohn D Simon
Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
Photochem Photobiol 82:318-23. 2006..Both trichochromes are efficient quenchers of 1O2, exhibiting a bimolecular rate constant comparable with vitamin C. These results suggest that trichochromes could serve a protective role in pheomelanin pigments... - Binding of metal ions to melanin and their effects on the aerobic reactivityLian Hong
Department of Chemistry, Duke University, Durham, NC 27708-0346, USA
Photochem Photobiol 80:477-81. 2004..Cu(II)- and Fe(III)-enriched melanins induce the most damage. Hydroxyl radical, *OH, is proposed to be one of the reactive oxygen species responsible... - Oxidation potentials of human eumelanosomes and pheomelanosomesAlexander Samokhvalov
Department of Chemistry, Duke University, Durham, NC 27708, USA
Photochem Photobiol 81:145-8. 2005..The FEL-PEEM experiment offers to be an important new approach for quantifying the effects of age, oxidation and metal accumulation on the oxidation potentials of intact melanosomes... - Ion-exchange and adsorption of Fe(III) by Sepia melaninYan Liu
Department of Chemistry, Duke University, Durham, NC, USA
Pigment Cell Res 17:262-9. 2004..These observations imply the existence of channels within the melanin granules that can serve to transport metal ions...