Marcela Herrera

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein
    Marcela Herrera
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hypertension 61:253-8. 2013
  2. doi request reprint Aquaporins as gas channels
    Marcela Herrera
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA
    Pflugers Arch 462:623-30. 2011
  3. pmc Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 284:1454-60. 2009
  4. doi request reprint Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications
    Jeffrey L Garvin
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Annu Rev Physiol 73:359-76. 2011
  5. ncbi request reprint A high-salt diet stimulates thick ascending limb eNOS expression by raising medullary osmolality and increasing release of endothelin-1
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    Am J Physiol Renal Physiol 288:F58-64. 2005
  6. ncbi request reprint Novel role of AQP-1 in NO-dependent vasorelaxation
    Marcela Herrera
    Henry Ford Hospital, Division of Hypertension and Vascular Research, Wayne State University, Detroit, Michigan 48202, USA
    Am J Physiol Renal Physiol 292:F1443-51. 2007
  7. ncbi request reprint Recent advances in the regulation of nitric oxide in the kidney
    Marcela Herrera
    Division of Hypertension and Vascular Research, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Hypertension 45:1062-7. 2005
  8. doi request reprint The kidney and hypertension: novel insights from transgenic models
    Marcela Herrera
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Curr Opin Nephrol Hypertens 21:171-8. 2012
  9. ncbi request reprint Regulation of thick ascending limb transport: role of nitric oxide
    Marcela Herrera
    Hypertension and Vascular Research Div, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Am J Physiol Renal Physiol 290:F1279-84. 2006
  10. ncbi request reprint Aquaporin-1 transports NO across cell membranes
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202, USA
    Hypertension 48:157-64. 2006

Collaborators

Detail Information

Publications17

  1. pmc Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein
    Marcela Herrera
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hypertension 61:253-8. 2013
    ..We conclude that anti-AT(1)R antibodies available from commercial sources and commonly used in published studies exhibit nonspecific binding in mouse tissue that may lead to erroneous results...
  2. doi request reprint Aquaporins as gas channels
    Marcela Herrera
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA
    Pflugers Arch 462:623-30. 2011
    ..This review summarizes recent findings on the role of aquaporins as gas transporters as well as their physiological significance...
  3. pmc Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 284:1454-60. 2009
    ..We conclude that endothelin-1 stimulates THAL NO production by activating PI3K, stimulating Akt activity, and phosphorylating NOS3 at Ser1177. This enhances NO production and inhibits sodium transport...
  4. doi request reprint Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications
    Jeffrey L Garvin
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Annu Rev Physiol 73:359-76. 2011
    ..However, our understanding of how NO, endothelin, and ATP work, and of their role in pathology, is rudimentary at best...
  5. ncbi request reprint A high-salt diet stimulates thick ascending limb eNOS expression by raising medullary osmolality and increasing release of endothelin-1
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    Am J Physiol Renal Physiol 288:F58-64. 2005
    ..This may be an important regulatory mechanism of THAL NaCl absorption when dietary salt intake is increased...
  6. ncbi request reprint Novel role of AQP-1 in NO-dependent vasorelaxation
    Marcela Herrera
    Henry Ford Hospital, Division of Hypertension and Vascular Research, Wayne State University, Detroit, Michigan 48202, USA
    Am J Physiol Renal Physiol 292:F1443-51. 2007
    ....
  7. ncbi request reprint Recent advances in the regulation of nitric oxide in the kidney
    Marcela Herrera
    Division of Hypertension and Vascular Research, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Hypertension 45:1062-7. 2005
    ..Finally, other potential regulators of NOS such as endogenous L-arginine analogs may also be important. In this article, we summarize recent advances in the regulation of activity and expression of the NOS isoforms within the kidney...
  8. doi request reprint The kidney and hypertension: novel insights from transgenic models
    Marcela Herrera
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Curr Opin Nephrol Hypertens 21:171-8. 2012
    ..This review summarizes recent studies employing this technology to understand signaling pathways and specific cell lineages within the kidney that are involved in the regulation of sodium excretion impacting blood pressure homeostasis...
  9. ncbi request reprint Regulation of thick ascending limb transport: role of nitric oxide
    Marcela Herrera
    Hypertension and Vascular Research Div, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Am J Physiol Renal Physiol 290:F1279-84. 2006
    ..Although the effects of NO on thick ascending limb transport have received a great deal of attention recently, its effects on divalent ion absorption and many other issues remain unexplored...
  10. ncbi request reprint Aquaporin-1 transports NO across cell membranes
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202, USA
    Hypertension 48:157-64. 2006
    ..Disruption of NO transport by aquaporin-1 offers an alternate cause for diseases currently explained by inadequate NO bioavailability...
  11. pmc Angiotensin II stimulates thick ascending limb superoxide production via protein kinase C(α)-dependent NADPH oxidase activation
    Marcela Herrera
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 285:21323-8. 2010
    ..In tubules expressing dominant-negative PKC ß1, Ang II stimulated O2. by 2.080.69 nmol/min/mg (p < 0.002). We conclude that Ang II stimulates TAL O₂production via activation of AT₁receptors and PKC α-dependent NADPH oxidase...
  12. pmc Membrane-associated aquaporin-1 facilitates osmotically driven water flux across the basolateral membrane of the thick ascending limb
    Pablo D Cabral
    Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, Michigan, USA
    Am J Physiol Renal Physiol 303:F621-9. 2012
    ..AQP1 could play an important role in regulation of TAL cell volume during changes in interstitial osmolality, such as during a high-salt diet or water deprivation...
  13. ncbi request reprint Inhibition of Na-K-ATPase in thick ascending limbs by NO depends on O2- and is diminished by a high-salt diet
    Marisela Varela
    Division of Nephrology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Renal Physiol 287:F224-30. 2004
    ..NO donors do not inhibit Na-K-ATPase in THALs from rats on high salt due to decreased O(2)(-) production...
  14. pmc Angiotensin II stimulates thick ascending limb NO production via AT(2) receptors and Akt1-dependent nitric-oxide synthase 3 (NOS3) activation
    Marcela Herrera
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 285:14932-40. 2010
    ..01). Akt inhibition prevented NOS3 phosphorylation. We concluded that Ang II enhances TAL NO production via activation of AT(2) and Akt1-dependent phosphorylation of NOS3 at serines 1177 and 633...
  15. pmc Nitric oxide produced by endothelial nitric oxide synthase promotes diuresis
    Jazmin M Pérez-Rojas
    Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, MI 48202, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1050-5. 2010
    ..We conclude that 1) NO produced by NOS 3 promotes water and Na(+) excretion and 2) the renal epithelial actions of NO produced by NOS 3 supersede the systemic and renal vascular actions...
  16. ncbi request reprint A high-salt diet dissociates NO synthase-3 expression and NO production by the thick ascending limb
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI 48202 2689, USA
    Hypertension 47:95-101. 2006
    ....
  17. ncbi request reprint Endothelin stimulates endothelial nitric oxide synthase expression in the thick ascending limb
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI 48202 2689, USA
    Am J Physiol Renal Physiol 287:F231-5. 2004
    ..05; n = 5). Taken together, these data suggest that ET-1 stimulates THAL eNOS, activating ET(B) receptors and PI3K and thereby increasing NO production...