Adrian F Hernandez

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Sex and racial differences in the use of implantable cardioverter-defibrillators among patients hospitalized with heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    JAMA 298:1525-32. 2007
  2. doi request reprint Clinical effectiveness of anticoagulation therapy among older patients with heart failure and without atrial fibrillation: findings from the ADHERE registry linked to Medicare claims
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    J Card Fail 19:401-7. 2013
  3. doi request reprint Associations between aldosterone antagonist therapy and risks of mortality and readmission among patients with heart failure and reduced ejection fraction
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    JAMA 308:2097-107. 2012
  4. pmc Clinical effectiveness of beta-blockers in heart failure: findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) Registry
    Adrian F Hernandez
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Am Coll Cardiol 53:184-92. 2009
  5. pmc Comparative effectiveness of angiotensin-converting-enzyme inhibitors: is an ACE always an ace?
    Adrian F Hernandez
    Duke Clinical Research Institute and the Division of Cardiovascular Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
    CMAJ 178:1316-9. 2008
  6. ncbi request reprint The need for multiple measures of hospital quality: results from the Get with the Guidelines-Heart Failure Registry of the American Heart Association
    Adrian F Hernandez
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 124:712-9. 2011
  7. doi request reprint Relationship between early physician follow-up and 30-day readmission among Medicare beneficiaries hospitalized for heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 303:1716-22. 2010
  8. pmc Relationships between emerging measures of heart failure processes of care and clinical outcomes
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Am Heart J 159:406-13. 2010
  9. pmc Long-term outcomes and costs of ventricular assist devices among Medicare beneficiaries
    Adrian F Hernandez
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 300:2398-406. 2008
  10. doi request reprint Rationale and design of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial (ASCEND-HF)
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 157:271-7. 2009

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Sex and racial differences in the use of implantable cardioverter-defibrillators among patients hospitalized with heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    JAMA 298:1525-32. 2007
    ..The influence of sex and race on ICD use among eligible patients is unknown...
  2. doi request reprint Clinical effectiveness of anticoagulation therapy among older patients with heart failure and without atrial fibrillation: findings from the ADHERE registry linked to Medicare claims
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    J Card Fail 19:401-7. 2013
    ..Patients with heart failure are at higher risk for thromboembolic events, even in the absence of atrial fibrillation, but the effect of anticoagulation therapy on outcomes is uncertain...
  3. doi request reprint Associations between aldosterone antagonist therapy and risks of mortality and readmission among patients with heart failure and reduced ejection fraction
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    JAMA 308:2097-107. 2012
    ..Aldosterone antagonist therapy for heart failure and reduced ejection fraction has been highly efficacious in randomized trials. However, questions remain regarding the effectiveness and safety of the therapy in clinical practice...
  4. pmc Clinical effectiveness of beta-blockers in heart failure: findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) Registry
    Adrian F Hernandez
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Am Coll Cardiol 53:184-92. 2009
    ..We sought to examine associations between initiation of beta-blocker therapy and outcomes among elderly patients hospitalized for heart failure...
  5. pmc Comparative effectiveness of angiotensin-converting-enzyme inhibitors: is an ACE always an ace?
    Adrian F Hernandez
    Duke Clinical Research Institute and the Division of Cardiovascular Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
    CMAJ 178:1316-9. 2008
  6. ncbi request reprint The need for multiple measures of hospital quality: results from the Get with the Guidelines-Heart Failure Registry of the American Heart Association
    Adrian F Hernandez
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 124:712-9. 2011
    ..Whether these quality measures correlate with one another and the degree to which hospital provider rankings shift on the basis of the performance metric is uncertain...
  7. doi request reprint Relationship between early physician follow-up and 30-day readmission among Medicare beneficiaries hospitalized for heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 303:1716-22. 2010
    ..However, there are limited data describing patterns of follow-up after heart failure hospitalization and its association with readmission rates...
  8. pmc Relationships between emerging measures of heart failure processes of care and clinical outcomes
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Am Heart J 159:406-13. 2010
    ..Previous studies have not confirmed associations between some current performance measures for inpatient heart failure processes of care and postdischarge outcomes. It is unknown if alternative measures are associated with outcomes...
  9. pmc Long-term outcomes and costs of ventricular assist devices among Medicare beneficiaries
    Adrian F Hernandez
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 300:2398-406. 2008
    ..In 2003, Medicare expanded coverage of ventricular assist devices as destination, or permanent, therapy for end-stage heart failure. Little is known about the long-term outcomes and costs associated with these devices...
  10. doi request reprint Rationale and design of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial (ASCEND-HF)
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 157:271-7. 2009
    ..However, the effect of nesiritide on dyspnea at 6 or 24 hours is unknown, and no clinical outcome trials have been done to provide a reliable estimate of the effect of nesiritide on morbidity and mortality...
  11. doi request reprint Variation in perioperative vasoactive therapy in cardiovascular surgical care: data from the Society of Thoracic Surgeons
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 158:47-52. 2009
    ..The appropriate use of vasoactive cardiovascular drugs in high-risk coronary artery bypass grafting (CABG) patients has not been well characterized...
  12. ncbi request reprint Outcomes associated with warfarin use in older patients with heart failure and atrial fibrillation and a cardiovascular implantable electronic device: findings from the ADHERE registry linked to Medicare claims
    Paul L Hess
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Clin Cardiol 35:649-57. 2012
    ..Warfarin use and associated outcomes in patients with heart failure and atrial fibrillation and a cardiovascular implantable electronic device have not been described previously...
  13. pmc Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure
    Robb D Kociol
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 6:240-5. 2013
    ....
  14. ncbi request reprint Trends in the use and outcomes of ventricular assist devices among medicare beneficiaries, 2006 through 2011
    Prateeti Khazanie
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina
    J Am Coll Cardiol 63:1395-404. 2014
    ..This study sought to examine trends in mortality, readmission, and costs among Medicare beneficiaries receiving ventricular assist devices (VADs) and associations between hospital-level procedure volume and outcomes...
  15. doi request reprint Early intravenous heart failure therapy and outcomes among older patients hospitalized for acute decompensated heart failure: findings from the Acute Decompensated Heart Failure Registry Emergency Module (ADHERE-EM)
    Yee Weng Wong
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 166:349-56. 2013
    ..We examined the association between time to first intravenous (IV) heart failure (HF) therapy and patient outcomes...
  16. doi request reprint Design and rationale of a retrospective clinical effectiveness study of aldosterone antagonist therapy in patients with heart failure
    Lesley H Curtis
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 163:946-953.e1. 2012
    ..Questions remain about its clinical effectiveness and safety for patients who are underrepresented in randomized trials and those at risk for hyperkalemia...
  17. doi request reprint Comparison of composite measure methodologies for rewarding quality of care: an analysis from the American Heart Association's Get With The Guidelines program
    Zubin J Eapen
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    Circ Cardiovasc Qual Outcomes 4:610-8. 2011
    ..We sought to conduct an observational analysis to determine the influence of the opportunity-based and all-or-none composite performance measures on hospital rankings...
  18. doi request reprint Quality of care for atrial fibrillation among patients hospitalized for heart failure
    Jonathan P Piccini
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 54:1280-9. 2009
    ..This study sought to examine quality of care and warfarin use at discharge in patients with atrial fibrillation (AF) and heart failure (HF)...
  19. doi request reprint Reperfusion strategies and quality of care in 5339 patients age 80 years or older presenting with ST-elevation myocardial infarction: analysis from get with the guidelines-coronary artery disease
    Hector M Medina
    Department of Medicine, Montefiore Medical Center, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York, USA
    Clin Cardiol 35:632-40. 2012
    ..The aim of this study was to determine current reperfusion trends, medical treatment, and in-hospital mortality during STEMI in older adults...
  20. pmc Outcomes of Medicare beneficiaries undergoing catheter ablation for atrial fibrillation
    Jonathan P Piccini
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Circulation 126:2200-7. 2012
    ..Atrial fibrillation is common among older persons. Catheter ablation is increasingly used in patients for whom medical therapy has failed...
  21. doi request reprint Pharmacologic prophylaxis for venous thromboembolism and 30-day outcomes among older patients hospitalized with heart failure: an analysis from the ADHERE national registry linked to Medicare claims
    Robb D Kociol
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    Clin Cardiol 34:682-8. 2011
    ..Although pharmacologic prophylaxis regimens have reduced VTE risk in medically ill patients, associations with early postdischarge adverse clinical outcomes among patients with heart failure are unknown...
  22. doi request reprint Associations of patient demographic characteristics and regional physician density with early physician follow-up among medicare beneficiaries hospitalized with heart failure
    Robb D Kociol
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
    Am J Cardiol 108:985-91. 2011
    ..Strategies are needed to ensure access among vulnerable populations to this supply-sensitive resource...
  23. doi request reprint QRS duration, bundle-branch block morphology, and outcomes among older patients with heart failure receiving cardiac resynchronization therapy
    Pamela N Peterson
    Division of Cardiology, Department of Medicine, Denver Health Medical Center, Denver, CO 80204, USA
    JAMA 310:617-26. 2013
    ..The benefits of cardiac resynchronization therapy (CRT) in clinical trials were greater among patients with left bundle-branch block (LBBB) or longer QRS duration...
  24. doi request reprint Transitional adherence and persistence in the use of aldosterone antagonist therapy in patients with heart failure
    Lesley H Curtis
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC Department of Medicine, Duke University School of Medicine, Durham, NC Electronic address
    Am Heart J 165:979-986.e1. 2013
    ..Aldosterone antagonist therapy is recommended for selected patients with heart failure and reduced ejection fraction. Adherence to therapy in the transition from hospital to home is not well understood...
  25. doi request reprint B-type natriuretic peptide level and postdischarge thrombotic events in older patients hospitalized with heart failure: insights from the Acute Decompensated Heart Failure National Registry
    Robb D Kociol
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Am Heart J 163:994-1001. 2012
    ..Associations between BNP level and thromboembolic events in patients with HF without atrial fibrillation (AF) are not well studied...
  26. doi request reprint Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator
    Ying Xian
    Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 307:2600-8. 2012
    ..7 or lower, there are few data on safety of intravenous tPA in warfarin-treated patients in clinical practice...
  27. pmc Postoperative inotrope and vasopressor use following CABG: outcome data from the CAPS-care study
    Judson B Williams
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Card Surg 26:572-8. 2011
    ..Limited clinical data exist to guide practice patterns and evidence-based use of inotropes and vasopressors following coronary artery bypass grafting (CABG)...
  28. ncbi request reprint Associations between atrial fibrillation and early outcomes of patients with heart failure and reduced or preserved ejection fraction
    Zubin J Eapen
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC Department of Medicine, Duke University School of Medicine, Durham, NC Electronic address
    Am Heart J 167:369-375.e2. 2014
    ..The relative impact of atrial fibrillation on early outcomes of patients with heart failure with reduced or preserved ejection fraction (EF) is unknown...
  29. ncbi request reprint Association between prophylactic implantable cardioverter-defibrillators and survival in patients with left ventricular ejection fraction between 30% and 35%
    Sana M Al-Khatib
    Duke Clinical Research Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina3Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
    JAMA 311:2209-15. 2014
    ..Because a large number of ICDs in the United States are implanted in such patients, it is important to study survival associated with this therapy...
  30. pmc Racial differences in the prevalence and outcomes of atrial fibrillation among patients hospitalized with heart failure
    Kevin L Thomas
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC
    J Am Heart Assoc 2:e000200. 2013
    ..We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as a function of race...
  31. doi request reprint Predictors of incident heart failure hospitalizations among patients with impaired glucose tolerance: insight from the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research study
    Yee Weng Wong
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Circ Heart Fail 6:203-10. 2013
    ..However, predictors associated with the increased risk of incident HF have not been well characterized. We aimed to identify independent predictors of incident HF hospitalization among patients with impaired glucose tolerance...
  32. pmc International variation in use of oral anticoagulation among heart failure patients with atrial fibrillation
    Jorge Suarez
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 163:804-11. 2012
    ..We sought to characterize patient factors and regional variations associated with vitamin K antagonist (VKA) use in patients with heart failure (HF) and atrial fibrillation (AF) in areas outside the United States and Europe...
  33. ncbi request reprint Long-term outcomes of medicare beneficiaries with worsening renal function during hospitalization for heart failure
    Robb D Kociol
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Am J Cardiol 105:1786-93. 2010
    ..12, 95% confidence interval 1.04 to 1.20) but not readmission or total inpatient costs. In conclusion, worsening RF in patients hospitalized with HF was independently associated with long-term mortality...
  34. ncbi request reprint Medical resource use, costs, and quality of life in patients with acute decompensated heart failure: findings from ASCEND-HF
    Shelby D Reed
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina Electronic address
    J Card Fail 19:611-20. 2013
    ..We compared medical resource use, costs, and health utilities between the treatment groups...
  35. doi request reprint Generalizability and longitudinal outcomes of a national heart failure clinical registry: Comparison of Acute Decompensated Heart Failure National Registry (ADHERE) and non-ADHERE Medicare beneficiaries
    Robb D Kociol
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Am Heart J 160:885-92. 2010
    ..Clinical registries are used increasingly to analyze quality and outcomes, but the generalizability of findings from registries is unclear...
  36. doi request reprint Troponin I in acute decompensated heart failure: insights from the ASCEND-HF study
    G Michael Felker
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur J Heart Fail 14:1257-64. 2012
    ..Circulating troponins are a prognostic marker in patients with ADHF. Contemporary assays with greater sensitivity require reassessment of the significance of troponin elevation in HF...
  37. doi request reprint Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes
    Benjamin A Steinberg
    Duke University Medical Center, Durham, NC, USA
    Circulation 126:65-75. 2012
    ..Heart failure with preserved ejection fraction (EF) is a common syndrome, but trends in treatments and outcomes are lacking...
  38. pmc Predicting costs among medicare beneficiaries with heart failure
    Melissa A Greiner
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
    Am J Cardiol 109:705-11. 2012
    ..In conclusion, a model based on variables from clinical registries can identify a group of patients with heart failure who on average will incur higher costs in the first year after hospitalization...
  39. pmc Trends in use of implantable cardioverter-defibrillator therapy among patients hospitalized for heart failure: have the previously observed sex and racial disparities changed over time?
    Sana M Al-Khatib
    MHS, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Circulation 125:1094-101. 2012
    ..The degree to which the overall use of ICD therapy and disparities in use have changed is unclear...
  40. pmc Characterization of heart failure patients with preserved ejection fraction: a comparison between ADHERE-US registry and ADHERE-International registry
    Ryenn West
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Eur J Heart Fail 13:945-52. 2011
    ..To characterize geographic differences in clinical characteristics and care of patients hospitalized with heart failure and preserved ejection fraction (HF-PEF)...
  41. doi request reprint The importance of consistent, high-quality acute myocardial infarction and heart failure care results from the American Heart Association's Get with the Guidelines Program
    Tracy Y Wang
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 58:637-44. 2011
    ..This study examined the degree to which hospital performance for acute myocardial infarction (AMI) and heart failure (HF) care processes are correlated...
  42. pmc Non-evidence-based ICD implantations in the United States
    Sana M Al-Khatib
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 305:43-9. 2011
    ....
  43. pmc Admission, discharge, or change in B-type natriuretic peptide and long-term outcomes: data from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) linked to Medicare claims
    Robb D Kociol
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 4:628-36. 2011
    ..It is unknown if admission, discharge, or change from admission to discharge BNP measure is the most important predictor of long-term outcomes...
  44. pmc Use of guideline-recommended therapies for heart failure in the Medicare population
    Lisa D DiMartino
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Clin Cardiol 33:400-5. 2010
    ..Most information about the use of guideline-recommended therapies for heart failure reflects what occurred at discharge after an inpatient stay...
  45. ncbi request reprint Use of cardiac resynchronization therapy in patients hospitalized with heart failure
    Jonathan P Piccini
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 118:926-33. 2008
    ....
  46. doi request reprint Clinical effectiveness of implantable cardioverter-defibrillators among medicare beneficiaries with heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 3:7-13. 2010
    ..The clinical effectiveness of implantable cardioverter-defibrillators (ICDs) in older patients with heart failure has not been established, and older patients have been underrepresented in previous studies...
  47. pmc Representativeness of a national heart failure quality-of-care registry: comparison of OPTIMIZE-HF and non-OPTIMIZE-HF Medicare patients
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 2:377-84. 2009
    ..Participation in clinical registries is nonrandom, so participants may differ in important ways from nonparticipants. The extent to which findings from clinical registries can be generalized to broader populations is unclear...
  48. ncbi request reprint Age differences in the use of implantable cardioverter-defibrillators among older patients hospitalized with heart failure
    Paul L Hess
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    J Cardiovasc Electrophysiol 24:664-71. 2013
    ..Practice guidelines recommend the use of ICDs in patients with heart failure (HF) and a left ventricular ejection fraction (LVEF) of ≤ 35% in the absence of contraindications...
  49. pmc Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 15:456-64. 2013
    ..To examine the characteristics associated with early dyspnoea relief during acute heart failure (HF) hospitalization, and its association with 30-day outcomes...
  50. doi request reprint Comparative effectiveness of pharmacotherapies for prevention of atrial fibrillation following coronary artery bypass surgery
    Jonathan P Piccini
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina Electronic address
    Am J Cardiol 112:954-60. 2013
    ..In this high-risk population, we were unable to demonstrate that any of the commonly used preventive agents were associated with lower rates of AF compared with alternatives or no treatment. ..
  51. ncbi request reprint Heart failure with preserved left ventricular systolic function among patients with non-ST-segment elevation acute coronary syndromes
    Kyla M Bennett
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    Am J Cardiol 99:1351-6. 2007
    ..Guideline-recommended therapies and interventions are under-utilized in patients with NSTE ACS and HF, with and without preserved systolic function, compared with those without HF...
  52. doi request reprint Performance measures to promote quality improvement in sudden cardiac arrest prevention and treatment
    Sana M Al-Khatib
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 165:862-8. 2013
    ..In this article, we review the burden of SCA and highlight the need to develop performance measures related to the prevention and treatment of SCA...
  53. doi request reprint National survey of hospital strategies to reduce heart failure readmissions: findings from the Get With the Guidelines-Heart Failure registry
    Robb D Kociol
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 5:680-7. 2012
    ..Reducing 30-day heart failure readmission rates is a national priority. Yet, little is known about how hospitals address the problem and whether hospital-based processes of care are associated with reductions in readmission rates...
  54. doi request reprint Incremental value of clinical data beyond claims data in predicting 30-day outcomes after heart failure hospitalization
    Bradley G Hammill
    Duke Clinical Research Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
    Circ Cardiovasc Qual Outcomes 4:60-7. 2011
    ..As clinical data become more readily available, the incremental value of adding clinical data to claims-based models of mortality and readmission is unclear...
  55. ncbi request reprint A decade of short-term outcomes in post cardiac surgery ventricular assist device implantation: data from the Society of Thoracic Surgeons' National Cardiac Database
    Adrian F Hernandez
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Circulation 116:606-12. 2007
    ..We examined a large national clinical database to assess trends in the incidence of post-cardiac surgery shock requiring VAD implantation, survival rates, and risk factors for mortality...
  56. doi request reprint Resource use in the last 6 months of life among medicare beneficiaries with heart failure, 2000-2007
    Kathleen T Unroe
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 171:196-203. 2011
    ..Heart failure is a common cause of death among Medicare beneficiaries, but little is known about health care resource use at the end of life...
  57. pmc Quality of care and outcomes among patients with heart failure and chronic kidney disease: A Get With the Guidelines -- Heart Failure Program study
    Uptal D Patel
    Division of Nephrology, Duke University Medical Center, Durham, NC, USA
    Am Heart J 156:674-81. 2008
    ..Both heart failure (HF) and chronic kidney disease (CKD) are highly prevalent conditions that often coexist; however, the quality of care received by hospitalized patients with both is not known...
  58. doi request reprint Left ventricular assist device destination therapy versus extended criteria cardiac transplant
    Mani A Daneshmand
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:1205-9; discussion 1210. 2010
    ..The purpose of this study was to compare baseline characteristics and outcomes after EC-AL versus DT-LVAD...
  59. doi request reprint Hospital variation and characteristics of implantable cardioverter-defibrillator use in patients with heart failure: data from the GWTG-HF (Get With The Guidelines-Heart Failure) registry
    Bimal Shah
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 53:416-22. 2009
    ..The aim of this study was to describe hospital variation and factors associated with adherence to guidelines for implantable cardioverter-defibrillator (ICD) therapy...
  60. doi request reprint Ten-year experience with extended criteria cardiac transplantation
    Marc D Samsky
    Duke University Medical Center, and the Duke Clinical Research Institute, Durham, NC
    Circ Heart Fail 6:1230-8. 2013
    ..There is a paucity of data examining long-term outcomes with this strategy...
  61. ncbi request reprint Contemporary performance of surgical ventricular restoration procedures: data from the Society of Thoracic Surgeons' National Cardiac Database
    Adrian F Hernandez
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 152:494-9. 2006
    ..We sought to characterize the performance of SVR nationally and describe the acute risks of mortality and major morbidity plus predictors of adverse outcomes...
  62. pmc Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007
    Jonathan P Piccini
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Circ Cardiovasc Qual Outcomes 5:85-93. 2012
    ..The frequency of AF increases with age, but representative national data about incidence and prevalence are limited. We examined the annual incidence, prevalence, and mortality associated with AF among older persons...
  63. doi request reprint Data quality in the American Heart Association Get With The Guidelines-Stroke (GWTG-Stroke): results from a national data validation audit
    Ying Xian
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 163:392-8, 398.e1. 2012
    ..Get With The Guidelines (GWTG)-Stroke is a national stroke registry and quality improvement program. We examined the accuracy and reliability of data entered in GWTG-Stroke...
  64. doi request reprint Infectious complications in extended criteria heart transplantation
    Keshava Rajagopal
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Heart Lung Transplant 27:1217-21. 2008
    ..We hypothesized that other adverse outcomes, principally determined by recipient characteristics, occur at a higher rate in extended criteria recipients...
  65. doi request reprint The dissociation between door-to-balloon time improvement and improvements in other acute myocardial infarction care processes and patient outcomes
    Tracy Y Wang
    Department of Medicine, Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    Arch Intern Med 169:1411-9. 2009
    ..However, DTB time is only one of several important AMI care processes. It is unclear whether quality efforts targeted to a single process will facilitate concomitant improvement in other quality measures and outcomes...
  66. ncbi request reprint Quality of care for sudden cardiac arrest: Proposed steps to improve the translation of evidence into practice
    Zubin J Eapen
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 162:222-31. 2011
    ..This article summarizes the discussions held at this meeting...
  67. pmc Linking inpatient clinical registry data to Medicare claims data using indirect identifiers
    Bradley G Hammill
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 157:995-1000. 2009
    ..We present a method to link hospitalization records from registries with Medicare inpatient claims data, without using direct identifiers, to create a unique data source that pairs rich clinical data with long-term outcome data...
  68. ncbi request reprint Sex differences in the use of implantable cardioverter-defibrillators for primary and secondary prevention of sudden cardiac death
    Lesley H Curtis
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
    JAMA 298:1517-24. 2007
    ..Previous studies of sex differences in the use of implantable cardioverter-defibrillators (ICDs) predate recent expansions in Medicare coverage and did not provide patient follow-up over multiple years...
  69. ncbi request reprint Implantable left ventricular assist devices: new hope for patients with end-stage heart failure
    Carmelo A Milano
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    N C Med J 67:110-5. 2006
    ..Recently, the Food and Drug Administration approved implantable left ventricular assist devices (LVAD) as destination therapy (DT) for end-stage heart failure patients who are ineligible for cardiac transplantation...
  70. doi request reprint Association of race/ethnicity with clinical risk factors, quality of care, and acute outcomes in patients hospitalized with heart failure
    Kevin L Thomas
    Duke Clinical Research, Durham, NC, USA
    Am Heart J 161:746-54. 2011
    ..Yet, there have been insufficient data characterizing the clinical presentation, quality of care, and outcomes of patients hospitalized with HF as a function of race/ethnicity...
  71. pmc Patient and implanting physician factors associated with mortality and complications after implantable cardioverter-defibrillator implantation, 2002-2005
    Sana M Al-Khatib
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
    Circ Arrhythm Electrophysiol 1:240-9. 2008
    ..We examined patient and implanting physician factors associated with outcomes of ICD therapy in Medicare beneficiaries from 2002 through 2005...
  72. doi request reprint Impact of heart failure on patients undergoing major noncardiac surgery
    Bradley G Hammill
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, North Carolina, USA
    Anesthesiology 108:559-67. 2008
    ..The authors evaluated short-term outcomes among patients with heart failure, coronary artery disease (CAD), or neither who underwent major noncardiac surgery...
  73. pmc Pharmacotherapy in Medicare beneficiaries with atrial fibrillation
    Jonathan P Piccini
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
    Heart Rhythm 9:1403-8. 2012
    ..There are limited data regarding national patterns of pharmacotherapy for atrial fibrillation (AF) among older patients. Drug exposure data are now captured for Medicare beneficiaries enrolled in prescription drug plans...
  74. doi request reprint Update on aldosterone antagonists use in heart failure with reduced left ventricular ejection fraction. Heart Failure Society of America Guidelines Committee
    Javed Butler
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, USA
    J Card Fail 18:265-81. 2012
    ..The efficacy of eplerenone in patients with mild HF symptoms translates into a unique opportunity to reduce morbidity and mortality earlier in the course of the disease...
  75. ncbi request reprint Outcomes with an alternate list strategy for heart transplantation
    G Michael Felker
    Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    J Heart Lung Transplant 24:1781-6. 2005
    ..The creation of an alternate list to match recipients with contraindications to traditional HT with sub-optimal donor organs has been implemented at some centers, but outcomes using this approach are uncertain...
  76. pmc Systematic review of the incidence of sudden cardiac death in the United States
    Melissa H Kong
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 57:794-801. 2011
    ..S. population...
  77. pmc Early and long-term outcomes of heart failure in elderly persons, 2001-2005
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 168:2481-8. 2008
    ..The treatment of chronic heart failure has improved during the past 2 decades, but little is known about whether the improvements are reflected in trends in early and long-term mortality and hospital readmission...
  78. doi request reprint Association of patient case-mix adjustment, hospital process performance rankings, and eligibility for financial incentives
    Rajendra H Mehta
    Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina 27715, USA
    JAMA 300:1897-903. 2008
    ..While most comparisons of hospital outcomes adjust for patient characteristics, process performance comparisons typically do not...
  79. pmc Process of care performance measures and long-term outcomes in patients hospitalized with heart failure
    Mark E Patterson
    Center for Clinical and Genetic Economics, Duke University School of Medicine, Durham, NC, USA
    Med Care 48:210-6. 2010
    ..Recent efforts to improve care for patients hospitalized with heart failure have focused on process-based performance measures. Data supporting the link between current process measures and patient outcomes are sparse...
  80. doi request reprint Impact of left ventricular assist device bridging on posttransplant outcomes
    Jay D Pal
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27705, USA
    Ann Thorac Surg 88:1457-61; discussion 1461. 2009
    ..However, referral for LVAD therapy may be limited secondary to reports of poor outcomes when mechanical circulatory support is required before transplantation...
  81. pmc Associations between worsening renal function and 30-day outcomes among Medicare beneficiaries hospitalized with heart failure
    Uptal D Patel
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Am Heart J 160:132-138.e1. 2010
    ..We examined associations between WRF and 30-day readmission, mortality, and costs among Medicare beneficiaries hospitalized with heart failure...
  82. ncbi request reprint End points for clinical trials in acute heart failure syndromes
    Larry A Allen
    Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Am Coll Cardiol 53:2248-58. 2009
    ....
  83. ncbi request reprint Recurrence of cardiac sarcoidosis in a heart transplant recipient
    Jonathan E E Yager
    Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    J Heart Lung Transplant 24:1988-90. 2005
    ..He subsequently underwent uncomplicated heart transplantation. Nineteen months later, a routine surveillance endomyocardial biopsy specimen demonstrated recurrence of sarcoidosis in the transplanted heart...
  84. doi request reprint Association between mortality and persistent use of beta blockers and angiotensin-converting enzyme inhibitors in patients with left ventricular systolic dysfunction and coronary artery disease
    Nancy M Allen LaPointe
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 103:1518-24. 2009
    ..We were unable to demonstrate a statistically significant association between persistent ACEI/ARB use and survival...
  85. doi request reprint Incidence and prevalence of heart failure in elderly persons, 1994-2003
    Lesley H Curtis
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 168:418-24. 2008
    ..We sought to estimate the annual incidence and prevalence of heart failure and associated survival in elderly persons from January 1, 1994, through December 31, 2003...
  86. doi request reprint Biomarker-guided therapy in chronic heart failure: a meta-analysis of randomized controlled trials
    G Michael Felker
    Duke Clinical Research Institute and the Division of Cardiology, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 158:422-30. 2009
    ..We performed a quantitative meta-analysis of available randomized controlled trials to determine whether titration of therapy based on natriuretic peptide measurements improves mortality in chronic heart failure...
  87. ncbi request reprint Outcomes in heart failure patients after major noncardiac surgery
    Adrian F Hernandez
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 44:1446-53. 2004
    ..The purpose of this study was to evaluate mortality and readmission rates of heart failure (HF) patients after major noncardiac surgery...
  88. doi request reprint A review of dyspnea in acute heart failure syndromes
    Ryenn L West
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 160:209-14. 2010
    ....
  89. ncbi request reprint Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial
    Dianne H Leloudis
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
    J Heart Lung Transplant 25:1164-6. 2006
    ..A better understanding of the factors affecting pain during EMBx could improve the comfort level of this procedure...
  90. doi request reprint Achieving rapid reperfusion with primary percutaneous coronary intervention remains a challenge: insights from American Heart Association's Get With the Guidelines program
    Rajendra H Mehta
    Duke Clinical Research Institute and Duke University Medical Center, Durham, NC, USA
    Am Heart J 155:1059-67. 2008
    ..Although preferably D2B times should be <or=90 minutes, it is unclear how consistently this is achieved in community practice, particularly in women, elderly people, and minorities...
  91. doi request reprint Efficacy and safety of nesiritide in patients with acute decompensated heart failure
    Tracy A Dewald
    Division of Clinical Pharmacology, Duke University Medical Center, Box 3943 Medical Center, Durham, NC 27710, USA
    Expert Rev Cardiovasc Ther 8:159-69. 2010
    ..However, the pathophysiology of acute decompensated heart failure is complex and the impact of nesiritide on important clinical end points, beyond symptomatic and hemodynamic improvement, is unknown...
  92. pmc Addressing disparities in sudden cardiac arrest care and the underutilization of effective therapies
    Melissa H Kong
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 160:605-18. 2010
    ..This article summarizes the discussions that occurred at the meeting...
  93. doi request reprint Do heart failure disease management programs make financial sense under a bundled payment system?
    Zubin J Eapen
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 161:916-22. 2011
    ..Whether a bundled payment approach can address the negative financial impact of DM programs is unknown...
  94. pmc Diuretic strategies in patients with acute decompensated heart failure
    G Michael Felker
    Duke University School of Medicine and Duke Heart Center, Durham, NC, USA
    N Engl J Med 364:797-805. 2011
    ..Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use...
  95. doi request reprint Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial
    Sunil V Rao
    Duke Clinical Research Institute, Durham, NC, USA
    Circulation 121:1713-21. 2010
    ..We performed a phase 2 randomized trial to evaluate the safety and feasibility of M118 in the setting of elective percutaneous coronary intervention...
  96. doi request reprint Device therapy in heart failure patients with chronic kidney disease
    Leon A Cannizzaro
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 58:889-96. 2011
    ..Given this lack of clear evidence, pragmatic clinical trials and comparative effectiveness studies are needed to help identify the appropriate use of ICD and CRT devices in this high-risk population of patients with HF and CKD...
  97. doi request reprint Mechanisms of bleeding and approach to patients with axial-flow left ventricular assist devices
    Jorge Suarez
    Duke Clinical Research Institute and the Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    Circ Heart Fail 4:779-84. 2011
    ....
  98. ncbi request reprint Preoperative evaluation for major noncardiac surgery: focusing on heart failure
    Adrian F Hernandez
    Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27710, USA
    Arch Intern Med 164:1729-36. 2004
    ..This review will summarize preoperative assessment and perioperative management with an emphasis on heart failure...
  99. doi request reprint Combination of loop diuretics with thiazide-type diuretics in heart failure
    Jacob C Jentzer
    Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    J Am Coll Cardiol 56:1527-34. 2010
    ..We provide considerations about prudent use of this therapy and review potential misconceptions about this long-used diuretic approach. Finally, we seek to highlight the need for pragmatic clinical trials for this commonly used therapy...
  100. ncbi request reprint Left ventricular assessment in myocardial infarction: the VALIANT registry
    Adrian F Hernandez
    Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 165:2162-9. 2005
    ..How often echocardiography and cardiac catheterization are used to evaluate left ventricular (LV) function in patients with myocardial infarction (MI) and how they are associated with quality of care is unknown...
  101. doi request reprint Translating evidence into practice: use of statins in real-world patients with heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Heart Fail Clin 4:217-23. 2008
    ..This article reviews the conceptual basis for driving evidence-based medicine by focusing on quality of care for heart failure patients...