Kathleen M Hayden

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study
    Kathleen M Hayden
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27705, USA
    Alzheimer Dis Assoc Disord 20:93-100. 2006
  2. ncbi request reprint Risk of mortality with vitamin E supplements: the Cache County study
    Kathleen M Hayden
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Med 120:180-4. 2007
  3. pmc Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study
    Kathleen M Hayden
    Department of Psychiatry and Behavioral Sciences and Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    Arch Neurol 66:1378-83. 2009
  4. pmc Occupational exposure to pesticides increases the risk of incident AD: the Cache County study
    K M Hayden
    Duke University Medical Center, Durham, NC, USA
    Neurology 74:1524-30. 2010
  5. ncbi request reprint Does NSAID use modify cognitive trajectories in the elderly? The Cache County study
    K M Hayden
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neurology 69:275-82. 2007
  6. pmc Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time
    Kathleen M Hayden
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Alzheimer Dis Assoc Disord 25:128-37. 2011
  7. pmc Cognitive decline in the elderly: an analysis of population heterogeneity
    Kathleen M Hayden
    Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Age Ageing 40:684-9. 2011
  8. ncbi request reprint Apolipoprotein E genotype and mortality: findings from the Cache County Study
    Kathleen M Hayden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina
    J Am Geriatr Soc 53:935-42. 2005
  9. pmc A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging
    Kathleen M Hayden
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University, Durham, NC, USA
    Alzheimers Dement 8:381-8. 2012
  10. pmc Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study
    Katheen A Welsh-Bohmer
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Clin Neuropsychol 23:77-99. 2009

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study
    Kathleen M Hayden
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27705, USA
    Alzheimer Dis Assoc Disord 20:93-100. 2006
    ..Future studies should focus on specific causal pathways for each of these factors with regard to sex to determine if sex differences in the prevalence of vascular factors have an influence on sex differences in dementia risk...
  2. ncbi request reprint Risk of mortality with vitamin E supplements: the Cache County study
    Kathleen M Hayden
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Med 120:180-4. 2007
    ..We sought to determine whether these mortality risks with vitamin E reflect adverse consequences of its use in the presence of cardiovascular disease...
  3. pmc Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study
    Kathleen M Hayden
    Department of Psychiatry and Behavioral Sciences and Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    Arch Neurol 66:1378-83. 2009
    ..To evaluate the influences of a family history of Alzheimer dementia (FHxAD) and the apolipoprotein E epsilon4 genotype (APOE epsilon4) on cognitive decline...
  4. pmc Occupational exposure to pesticides increases the risk of incident AD: the Cache County study
    K M Hayden
    Duke University Medical Center, Durham, NC, USA
    Neurology 74:1524-30. 2010
    ..We sought to examine the association of occupational pesticide exposure and the risk of incident dementia and AD in later life...
  5. ncbi request reprint Does NSAID use modify cognitive trajectories in the elderly? The Cache County study
    K M Hayden
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neurology 69:275-82. 2007
    ..By contrast, clinical trials have not supported NSAID use to delay or treat AD. Few studies have evaluated cognitive trajectories of NSAID users over time...
  6. pmc Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time
    Kathleen M Hayden
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Alzheimer Dis Assoc Disord 25:128-37. 2011
    ..In a range of cognition from normal to dementia, factor structures and factor loadings will vary little. Further work is needed to determine whether domains become more or less distinct in severely cognitively compromised individuals...
  7. pmc Cognitive decline in the elderly: an analysis of population heterogeneity
    Kathleen M Hayden
    Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Age Ageing 40:684-9. 2011
    ..studies of cognitive ageing at the group level suggest that age is associated with cognitive decline; however, there may be individual differences such that not all older adults will experience cognitive decline...
  8. ncbi request reprint Apolipoprotein E genotype and mortality: findings from the Cache County Study
    Kathleen M Hayden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina
    J Am Geriatr Soc 53:935-42. 2005
    ..To evaluate the association between apolipoprotein E (apo E) epsilon4 and mortality, the population attributable risk for mortality with epsilon4, and relative contributions of cardiovascular disease (CVD) and Alzheimer's disease (AD)...
  9. pmc A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging
    Kathleen M Hayden
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University, Durham, NC, USA
    Alzheimers Dement 8:381-8. 2012
    ..A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset...
  10. pmc Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study
    Katheen A Welsh-Bohmer
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Clin Neuropsychol 23:77-99. 2009
    ..Among elderly without dementia or other cognitive impairment, APOE does not appear to exert any major effects on cognition once other demographic influences are controlled...
  11. pmc Genome-wide scan of copy number variation in late-onset Alzheimer's disease
    Erin L Heinzen
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA
    J Alzheimers Dis 19:69-77. 2010
    ..In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation...
  12. pmc Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer disease
    Christine M Hulette
    Department of Pathology Neuropathology, Joseph and Kathleen Price Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, NC, USA
    J Neuropathol Exp Neurol 68:417-24. 2009
    ....
  13. ncbi request reprint Genetic aspects of behavioral neurotoxicology
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States
    Neurotoxicology 30:741-53. 2009
    ....
  14. doi request reprint Epidemiology of cognitive aging and Alzheimer's disease: contributions of the cache county utah study of memory, health and aging
    Kathleen M Hayden
    Department of Psychiatry, Joseph and Kathleen Bryan Alzheimer s Disease Research Center Division of Neurology, 2200 W Main Street, Suite A200, Durham, NC, 27705, USA
    Curr Top Behav Neurosci 10:3-31. 2012
    ..We also discuss hypotheses generated from this survey with respect to factors that may either accelerate or delay symptom onset in AD and the conditions that appear to be associated with successful cognitive aging...
  15. pmc Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study
    Majid Fotuhi
    Department of Neurology, Johns Hopkins University School of Medicine, and Center for Memory and Brain Health, LifeBridge Health Brain and Spine Institute, Baltimore, MD, USA
    Alzheimers Dement 4:223-7. 2008
    ..05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time...
  16. ncbi request reprint Antihypertensive medication use and incident Alzheimer disease: the Cache County Study
    Ara S Khachaturian
    Khachaturian and Associates Inc, Potomac, MD, USA
    Arch Neurol 63:686-92. 2006
    ..Recent reports suggest that antihypertensive (AH) medications may reduce the risk of dementing illnesses...
  17. ncbi request reprint Characteristics of a two-stage screen for incident dementia
    Kathleen M Hayden
    Department of Menral Hygiene, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Clin Epidemiol 56:1038-45. 2003
    ..Two-stage screening may offer improvements over single-stage methods. We therefore investigated a two-stage screening protocol for incident dementia among 3,308 elderly...
  18. ncbi request reprint Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Neurology 59:880-6. 2002
    ..The authors re-examined these associations using data on incident AD...

Research Grants2

  1. Cognitive Endophenotypes for Genetic Studies of Alzheimer's Disease
    Kathleen Hayden; Fiscal Year: 2007
    ..Ultimately the application of endophenotypes of AD will facilitate the identification of new genes, highlight potential causal pathways of disease, and suggest avenues for future treatment development. ..