Research Topics
Species | Kathleen M HaydenSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County studyKathleen M Hayden
Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27705, USA
Alzheimer Dis Assoc Disord 20:93-100. 2006..Future studies should focus on specific causal pathways for each of these factors with regard to sex to determine if sex differences in the prevalence of vascular factors have an influence on sex differences in dementia risk...- Risk of mortality with vitamin E supplements: the Cache County studyKathleen M Hayden
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Am J Med 120:180-4. 2007..We sought to determine whether these mortality risks with vitamin E reflect adverse consequences of its use in the presence of cardiovascular disease... 
Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County StudyKathleen M Hayden
Department of Psychiatry and Behavioral Sciences and Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
Arch Neurol 66:1378-83. 2009..To evaluate the influences of a family history of Alzheimer dementia (FHxAD) and the apolipoprotein E epsilon4 genotype (APOE epsilon4) on cognitive decline...- Occupational exposure to pesticides increases the risk of incident AD: the Cache County studyK M Hayden
Duke University Medical Center, Durham, NC, USA
Neurology 74:1524-30. 2010..We sought to examine the association of occupational pesticide exposure and the risk of incident dementia and AD in later life... - Does NSAID use modify cognitive trajectories in the elderly? The Cache County studyK M Hayden
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Neurology 69:275-82. 2007..By contrast, clinical trials have not supported NSAID use to delay or treat AD. Few studies have evaluated cognitive trajectories of NSAID users over time... - Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over timeKathleen M Hayden
Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Alzheimer Dis Assoc Disord 25:128-37. 2011..In a range of cognition from normal to dementia, factor structures and factor loadings will vary little. Further work is needed to determine whether domains become more or less distinct in severely cognitively compromised individuals... - Cognitive decline in the elderly: an analysis of population heterogeneityKathleen M Hayden
Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Age Ageing 40:684-9. 2011..studies of cognitive ageing at the group level suggest that age is associated with cognitive decline; however, there may be individual differences such that not all older adults will experience cognitive decline... - Apolipoprotein E genotype and mortality: findings from the Cache County StudyKathleen M Hayden
Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina
J Am Geriatr Soc 53:935-42. 2005..To evaluate the association between apolipoprotein E (apo E) epsilon4 and mortality, the population attributable risk for mortality with epsilon4, and relative contributions of cardiovascular disease (CVD) and Alzheimer's disease (AD)... - Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory StudyKatheen A Welsh-Bohmer
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Clin Neuropsychol 23:77-99. 2009..Among elderly without dementia or other cognitive impairment, APOE does not appear to exert any major effects on cognition once other demographic influences are controlled... - A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in agingKathleen M Hayden
Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University, Durham, NC, USA
Alzheimers Dement 8:381-8. 2012..A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset... - Genome-wide scan of copy number variation in late-onset Alzheimer's diseaseErin L Heinzen
Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA
J Alzheimers Dis 19:69-77. 2010..In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation... - Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer diseaseChristine M Hulette
Department of Pathology Neuropathology, Joseph and Kathleen Price Bryan Alzheimer Disease Research Center, Duke University Medical Center, Durham, NC, USA
J Neuropathol Exp Neurol 68:417-24. 2009.... 
Genetic aspects of behavioral neurotoxicologyEdward D Levin
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States
Neurotoxicology 30:741-53. 2009....- Epidemiology of cognitive aging and Alzheimer's disease: contributions of the cache county utah study of memory, health and agingKathleen M Hayden
Department of Psychiatry, Joseph and Kathleen Bryan Alzheimer s Disease Research Center Division of Neurology, 2200 W Main Street, Suite A200, Durham, NC, 27705, USA
Curr Top Behav Neurosci 10:3-31. 2012..We also discuss hypotheses generated from this survey with respect to factors that may either accelerate or delay symptom onset in AD and the conditions that appear to be associated with successful cognitive aging... - Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County StudyMajid Fotuhi
Department of Neurology, Johns Hopkins University School of Medicine, and Center for Memory and Brain Health, LifeBridge Health Brain and Spine Institute, Baltimore, MD, USA
Alzheimers Dement 4:223-7. 2008..05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time... - Antihypertensive medication use and incident Alzheimer disease: the Cache County StudyAra S Khachaturian
Khachaturian and Associates Inc, Potomac, MD, USA
Arch Neurol 63:686-92. 2006..CONCLUSIONS: These data suggest that AH medications, and specifically potassium-sparing diuretics, are associated with reduced incidence of AD. Because the latter association is a new finding, it requires confirmation in further study... - Characteristics of a two-stage screen for incident dementiaKathleen M Hayden
Department of Menral Hygiene, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Clin Epidemiol 56:1038-45. 2003..CONCLUSIONS: The improved specificity of the two-stage approach offers economies that are attractive, particularly if sensitivity can be enhanced, for example, by examination of a high-risk validation sample... - Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County StudyPeter P Zandi
Department of Mental Hygiene, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Neurology 59:880-6. 2002..Recently initiated randomized trials of NSAID for primary prevention of AD are therefore unlikely to show effects with treatment until participants have been followed for several years...
Research Grants
- Cognitive Endophenotypes for Genetic Studies of Alzheimer's DiseaseKathleen Hayden; Fiscal Year: 2007..Ultimately the application of endophenotypes of AD will facilitate the identification of new genes, highlight potential causal pathways of disease, and suggest avenues for future treatment development. ..