Elizabeth Hauser

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Ordered subset analysis for case-control studies
    Xuejun Qin
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 34:407-17. 2010
  2. pmc A general integrative genomic feature transcription factor binding site prediction method applied to analysis of USF1 binding in cardiovascular disease
    Tianyuan Wang
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genomics 3:221-35. 2009
  3. pmc Comparison of GIST and LAMP on the GAW15 simulated data
    Xuemei Lou
    Center for Human Genetics, Duke University Medical Center, 595 South Lasalle Street, Durham, North Carolina 27710, USA
    BMC Proc 1:S41. 2007
  4. pmc Visualizing genotype x phenotype relationships in the GAW15 simulated data
    Xuejun Qin
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    BMC Proc 1:S132. 2007
  5. pmc Searching for epistatic interactions in nuclear families using conditional linkage analysis
    Svati H Shah
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Genet 6:S148. 2005
  6. pmc Adjusting for covariates on a slippery slope: linkage analysis of change over time
    Evadnie Rampersaud
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    BMC Genet 4:S50. 2003
  7. pmc A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study
    Elizabeth R Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 75:436-47. 2004
  8. ncbi request reprint Ordered subset analysis in genetic linkage mapping of complex traits
    Elizabeth R Hauser
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 27:53-63. 2004
  9. pmc Haplotype-based analysis: a summary of GAW16 Group 4 analysis
    Elizabeth Hauser
    Center for Human Genetics, Duke University, Durham, North Carolina 27710, USA
    Genet Epidemiol 33:S24-8. 2009
  10. ncbi request reprint Effects of covariates: a summary of Group 5 contributions
    Elizabeth R Hauser
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 25:S43-9. 2003

Research Grants

Detail Information

Publications45

  1. pmc Ordered subset analysis for case-control studies
    Xuejun Qin
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 34:407-17. 2010
    ..In summary, we have demonstrated that OSACC is a useful method for improving SNP association signals in genetically heterogeneous datasets...
  2. pmc A general integrative genomic feature transcription factor binding site prediction method applied to analysis of USF1 binding in cardiovascular disease
    Tianyuan Wang
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genomics 3:221-35. 2009
    ..This method can be extended to other transcription factors identified in human disease studies to help further our understanding of the biology of complex disease...
  3. pmc Comparison of GIST and LAMP on the GAW15 simulated data
    Xuemei Lou
    Center for Human Genetics, Duke University Medical Center, 595 South Lasalle Street, Durham, North Carolina 27710, USA
    BMC Proc 1:S41. 2007
    ..We conclude that LAMP is more flexible and reliable to use in practice...
  4. pmc Visualizing genotype x phenotype relationships in the GAW15 simulated data
    Xuejun Qin
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    BMC Proc 1:S132. 2007
    ..The generated plots provide information about genetic models for the simulated continuous covariates and may help identify the single-nucleotide polymorphisms associated with the underlying quantitative trait loci...
  5. pmc Searching for epistatic interactions in nuclear families using conditional linkage analysis
    Svati H Shah
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Genet 6:S148. 2005
    ..Ordered subsets analysis (OSA) is a method for conditional linkage analysis using continuous covariates...
  6. pmc Adjusting for covariates on a slippery slope: linkage analysis of change over time
    Evadnie Rampersaud
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    BMC Genet 4:S50. 2003
    ....
  7. pmc A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study
    Elizabeth R Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 75:436-47. 2004
    ..These data provide initial areas of the human genome where further investigation may reveal susceptibility genes for early-onset CAD...
  8. ncbi request reprint Ordered subset analysis in genetic linkage mapping of complex traits
    Elizabeth R Hauser
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 27:53-63. 2004
    ..We illustrate this method by analyzing data on breast cancer age of onset and chromosome 17q [Hall et al., 1990, Science 250:1684-1689]. We evaluate OSA using simulation studies under a variety of genetic models...
  9. pmc Haplotype-based analysis: a summary of GAW16 Group 4 analysis
    Elizabeth Hauser
    Center for Human Genetics, Duke University, Durham, North Carolina 27710, USA
    Genet Epidemiol 33:S24-8. 2009
    ....
  10. ncbi request reprint Effects of covariates: a summary of Group 5 contributions
    Elizabeth R Hauser
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 25:S43-9. 2003
    ..Finally, the results of Group 5 studies show that inclusion of covariates can increase the power to detect genes for complex traits, and has the potential to advance an understanding of the role of genes in these complex traits...
  11. pmc SNPselector: a web tool for selecting SNPs for genetic association studies
    Hong Xu
    The Duke Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Bioinformatics 21:4181-6. 2005
    ..SNPselector outputs result in compressed Excel spreadsheet files for review by the user...
  12. pmc Ordered-subset analysis (OSA) for family-based association mapping of complex traits
    Ren Hua Chung
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 32:627-37. 2008
    ..Finally, we applied APL-OSA to a family study of age-related macular degeneration, where cigarette smoking was used as a covariate...
  13. ncbi request reprint Interpretation of simultaneous linkage and family-based association tests in genome screens
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27710, USA
    Genet Epidemiol 31:134-42. 2007
    ..We concluded that when linkage and association tests are applied in the same data, the type I error rate of neither test will be affected and that power can be increased by applying tests conditionally...
  14. pmc GATA2 is associated with familial early-onset coronary artery disease
    Jessica J Connelly
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States
    PLoS Genet 2:e139. 2006
    ....
  15. pmc Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 59:220-7. 2005
    ..Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies...
  16. pmc Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family
    Daniel Nolan
    Center for Human Genetics, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 8:e71779. 2013
    ..1). Identifying the causal variation underlying each linkage score will help to unravel the genetic architecture of these quantitative traits and, by extension, the genetic architecture of cardiovascular risk. ..
  17. pmc Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease
    Liyong Wang
    Center for Human Genetics, Department of Medicine, Duke Univeristy Medical Center, Durham, NC, USA
    Am J Hum Genet 80:650-63. 2007
    ..KALRN and two other associated genes identified in this study (CDGAP and MYLK) belong to the Rho GTPase-signaling pathway. Our data suggest the importance of the KALRN gene and the Rho GTPase-signaling pathway in the pathogenesis of CAD...
  18. doi request reprint Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease
    Svati H Shah
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 160:371-379.e2. 2010
    ..Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification...
  19. pmc Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 70:953-9. 2008
    ..To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery...
  20. ncbi request reprint Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage
    Michael A Hauser
    Center for Human Genetics, Duke University, Durham, NC 27710 2903, USA
    Hum Mol Genet 12:671-7. 2003
    ..These genes represent excellent candidates for PD susceptibility alleles and further genomic convergence and analyses...
  21. pmc A new locus for familial FSGS on chromosome 2p
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 21:1390-7. 2010
    ..These data support a new gene locus for familial FSGS on chromosome 2p15. Identification of the mutated gene at this locus may provide further insight into the disease mechanisms of FSGS...
  22. pmc Genetic and functional association of FAM5C with myocardial infarction
    Jessica J Connelly
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Med Genet 9:33. 2008
    ..59, D1S1589/D1S518). The overlap of genetic screens in independent data sets provides evidence for the existence of a gene or genes for CAD in this region...
  23. pmc Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis
    David R Crosslin
    Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, Durham, NC 27710, USA
    Hum Genet 125:217-29. 2009
    ....
  24. doi request reprint Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events
    Svati H Shah
    Department of Medicine, Duke University, Durham, NC, USA
    Circ Cardiovasc Genet 3:207-14. 2010
    ..Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events...
  25. pmc High heritability of metabolomic profiles in families burdened with premature cardiovascular disease
    Svati H Shah
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Mol Syst Biol 5:258. 2009
    ..27). We report a novel finding of high heritabilities of metabolites in premature CAD, establishing a possible genetic basis for these profiles. These results have implications for understanding CAD pathophysiology and genetics...
  26. pmc ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention
    Svati H Shah
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States
    Atherosclerosis 201:148-54. 2008
    ..There is no accurate way to predict in-stent restenosis, although risk factors for atherosclerosis overlap those for in-stent restenosis. Therefore, we evaluated atherosclerosis candidate genes for association with in-stent restenosis...
  27. pmc Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets
    Beth S Sutton
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:1318-28. 2008
    ..Further functional studies involving a combination of risk alleles are warranted...
  28. pmc Increased efficiency of case-control association analysis by using allele-sharing and covariate information
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 65:154-65. 2008
    ....
  29. ncbi request reprint Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 102:1121-30. 2003
    ..Thymic transplantation is efficacious, well tolerated, and should be considered as treatment for infants with complete DiGeorge syndrome...
  30. pmc Accounting for linkage in family-based tests of association with missing parental genotypes
    Eden R Martin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 73:1016-26. 2003
    ..As an example, we compare the performance of the tests in a candidate-gene study in families with Parkinson disease...
  31. pmc Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22
    William K Scott
    Department of Medicine, Duke University Medical Center, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Am J Hum Genet 73:1041-51. 2003
    ..These results indicate that linkage to chromosome 9p is strongest in late-onset AD and that regions on chromosome 2q34 and 15q22 are linked to early-onset AD and very-late-onset AD, respectively...
  32. pmc Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Genet 5:18. 2004
    ..Chromosome-wide significance of increases in nonparametric multipoint lod scores in covariate-defined subsets relative to the overall sample was assessed by permutation...
  33. pmc Statistical Viewer: a tool to upload and integrate linkage and association data as plots displayed within the Ensembl genome browser
    Judith E Stenger
    The Duke Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Bioinformatics 6:95. 2005
    ..We have developed a plug-in package for Ensembl called "Statistical Viewer" that facilitates the analysis of genomic features and annotation in the regions of interest defined by linkage analysis...
  34. pmc Early adult-onset POAG linked to 15q11-13 using ordered subset analysis
    R Rand Allingham
    Duke University Eye Center and the Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
    Invest Ophthalmol Vis Sci 46:2002-5. 2005
    ..Ordered subset analysis (OSA) is a recently described method that utilizes the variability of phenotypic traits to determine underlying genetic heterogeneity...
  35. ncbi request reprint Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 30:409-22. 2006
    ....
  36. ncbi request reprint Interpreting analyses of continuous covariates in affected sibling pair linkage studies
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 31:541-52. 2007
    ..They suggest that the side-by-side evaluation of OSA and QTL results may provide important information about the relationship of measured covariates with either disease risk or linkage heterogeneity...
  37. ncbi request reprint Maternal serum cytokines in preterm premature rupture of membranes
    Amy P Murtha
    Department of Obstetrics and Gynecology and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Obstet Gynecol 109:121-7. 2007
    ..To estimate whether maternal serum interleukin (IL)-6 or granulocyte colony-stimulating factor (G-CSF) obtained daily are elevated in women with preterm premature rupture of membranes who develop funisitis...
  38. pmc Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis
    Svati H Shah
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 5:e1000318. 2009
    ..We conclude that NPY contributes to atherosclerosis pathogenesis...
  39. ncbi request reprint Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study
    Elizabeth R Hauser
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 145:602-13. 2003
    ..Early onset (premature) coronary artery disease (EOCAD) is known to have a particularly strong genetic component. However, the actual genes leading to this increased risk of CAD remain obscure...
  40. pmc Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies
    Lisheng Zhang
    Department of Medicine Cardiology, Duke University Medical Center, Durham, NC, USA
    Hum Mol Genet 19:2754-66. 2010
    ..We conclude that TNFR1 polymorphisms associate with aging-related CAD in humans, and TNFR1 contributes to aging-dependent atherosclerosis in mice...
  41. ncbi request reprint Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth
    Amy P Murtha
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Obstet Gynecol 195:1249-53. 2006
    ..This study was undertaken to determine whether the interleukin-1 receptor antagonist (IL-1RN) variable number tandem repeat polymorphism is associated with preterm birth...
  42. pmc Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family
    Hsiang Cheng Chen
    Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Rheum 62:781-90. 2010
    ..The goal of the current study was to use OA-related biomarkers of severity and disease burden as quantitative traits to identify genetic susceptibility loci for OA...
  43. ncbi request reprint A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:821-9. 2004
    ....
  44. ncbi request reprint The APL test: extension to general nuclear families and haplotypes and examination of its robustness
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, N C, USA
    Hum Hered 61:189-99. 2006
    ..Furthermore, the robustness of APL in practice has not been examined. Here we present a generalization of the APL model and examination of its robustness under a variety of non-standard scenarios...
  45. ncbi request reprint Where the rubber meets the road in pharmacogenetics: assessment of gene-environment interactions
    Elizabeth R Hauser
    Am Heart J 146:929-31. 2003

Research Grants11

  1. SOFTWARE FOR INTEGRATED LINKAGE AND ASSOCIATION ANALYSIS
    Elizabeth Hauser; Fiscal Year: 2009
    ..We will continue to utilize this resource to develop realistic and practical guidelines for application of these methods. ..
  2. GENECARD-Gene Identification in Early-Onset CAD
    Elizabeth Hauser; Fiscal Year: 2007
    ..We strongly believe that a detailed study of genetic factors and gene-environment interactions is an essential step to identifying targeted preventive strategies and more effective treatments. ..
  3. SOFTWARE FOR INTEGRATED LINKAGE AND ASSOCIATION ANALYSIS
    Elizabeth Hauser; Fiscal Year: 2002
    ..abstract_text> ..