V Hasselblad

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Room 0311, Terrace Level, Box 3850, Durham, NC 27705, USA
    Trials 14:123. 2013
  2. ncbi request reprint Meta-analysis of multitreatment studies
    V Hasselblad
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    Med Decis Making 18:37-43. 1998
  3. ncbi request reprint Power calculations for large multi-arm placebo-controlled studies of dichotomous outcomes
    Vic Hasselblad
    Department of Biostatistics and Bioinformatics and Duke Clinical Research Institute, PO Box 17969, Duke University Medical Center, Durham, NC 27715, U S A
    Stat Med 22:1943-54. 2003
  4. ncbi request reprint Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 41:1452-7. 2003
  5. ncbi request reprint Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: observations from the IMPACT-HF registry
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Division of Cardiology, Duke University Medical Center and Clinical Research Institute, 2400 N Pratt Street, Durham, NC 27705, USA
    J Card Fail 11:200-5. 2005
  6. ncbi request reprint Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients
    Padma Kaul
    Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    J Am Coll Cardiol 41:371-80. 2003
  7. ncbi request reprint First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation
    Christopher K Dyke
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 105:2385-91. 2002
  8. ncbi request reprint Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis
    Michael P Hudson
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 147:546-52. 2004
  9. ncbi request reprint Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-Segment elevation acute coronary syndromes: a systematic overview
    John L Petersen
    Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 292:89-96. 2004
  10. ncbi request reprint Reactivation of ischemic events in acute coronary syndromes: results from GUSTO-IIb. Gobal Use of Strategies To Open occluded arteries in acute coronary syndromes
    M C Bahit
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 37:1001-7. 2001

Collaborators

Detail Information

Publications81

  1. pmc Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Room 0311, Terrace Level, Box 3850, Durham, NC 27705, USA
    Trials 14:123. 2013
    ..We evaluated alternative approaches to quantifying infarct size using CK-MB values, and the relationship between infarct size and clinical outcomes...
  2. ncbi request reprint Meta-analysis of multitreatment studies
    V Hasselblad
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    Med Decis Making 18:37-43. 1998
    ..The methods proposed in this article, a generalization of current meta-analytic methods, allow for any number of competing therapies and include both fixed- and random-effects models...
  3. ncbi request reprint Power calculations for large multi-arm placebo-controlled studies of dichotomous outcomes
    Vic Hasselblad
    Department of Biostatistics and Bioinformatics and Duke Clinical Research Institute, PO Box 17969, Duke University Medical Center, Durham, NC 27715, U S A
    Stat Med 22:1943-54. 2003
    ..These results remained nearly constant over a wide range of sample sizes, average event rates and average effect sizes...
  4. ncbi request reprint Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 41:1452-7. 2003
    ..We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated with acute coronary syndrome (ACS)...
  5. ncbi request reprint Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: observations from the IMPACT-HF registry
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Division of Cardiology, Duke University Medical Center and Clinical Research Institute, 2400 N Pratt Street, Durham, NC 27705, USA
    J Card Fail 11:200-5. 2005
    ....
  6. ncbi request reprint Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients
    Padma Kaul
    Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    J Am Coll Cardiol 41:371-80. 2003
    ....
  7. ncbi request reprint First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation
    Christopher K Dyke
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 105:2385-91. 2002
    ....
  8. ncbi request reprint Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis
    Michael P Hudson
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 147:546-52. 2004
    ..We assessed whether elevated TnT levels are associated with the severity, etiology, and prognosis of HF in stable, ambulatory patients...
  9. ncbi request reprint Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-Segment elevation acute coronary syndromes: a systematic overview
    John L Petersen
    Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 292:89-96. 2004
    ....
  10. ncbi request reprint Reactivation of ischemic events in acute coronary syndromes: results from GUSTO-IIb. Gobal Use of Strategies To Open occluded arteries in acute coronary syndromes
    M C Bahit
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 37:1001-7. 2001
    ..We sought to determine the incidence of and risk factors for thrombotic events early after discontinuing antithrombin therapy in patients with acute coronary syndromes...
  11. ncbi request reprint Benefit of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes and troponin t-positive status: the paragon-B troponin T substudy
    L K Newby
    Duke Clinical Research Institute, Durham, NC, USA
    Circulation 103:2891-6. 2001
    ..Troponin T (TnT) is valuable for short- and long-term risk stratification of patients with acute coronary syndromes (ACS). It also may predict which ACS patients will benefit from glycoprotein (GP) IIb/IIIa blockade...
  12. ncbi request reprint Clinical outcomes of bivalirudin for ischemic heart disease
    D F Kong
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 100:2049-53. 1999
    ..We conducted a systematic overview (meta-analysis) to assess the effect of bivalirudin on 4 end points: death, myocardial infarction, major hemorrhage, and the composite of death or infarction...
  13. ncbi request reprint Intensity and focus of heart failure disease management after hospital discharge
    Monica R Shah
    Division of Cardiology, Center for Advanced Cardiac Care, Columbia University Medical Center, Durham, NC, USA
    Am Heart J 149:715-21. 2005
    ..Although features of heart failure disease management programs are broadly outlined, little is known about which interventions are actually used in the outpatient setting or which patients are most likely to require interventions...
  14. ncbi request reprint The failure of orally administered glycoprotein IIb/IIIa inhibitors to prevent recurrent cardiac events
    L Kristin Newby
    Duke Clinical Research Institute, Durham, North Carolina 27707, USA
    Am J Med 112:647-58. 2002
    ..To understand these findings, we performed a meta-analysis of results from four phase 3 trials...
  15. ncbi request reprint The Cobalt chromium STent with Antiproliferative for Restenosis II (COSTAR II) trial study design: advancing the active-control evaluation of second-generation drug-eluting stents
    Tracy Y Wang
    Duke Clinical Research Institute, Duke University, Durham, NC, USA
    Am Heart J 153:743-8. 2007
    ..The results of COSTAR II will provide information about a novel coronary stent device as well as unique data regarding both control and test DES use in more complex "real-world" patients...
  16. ncbi request reprint Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial
    Wendy A Gattis
    Division of Cardiology, Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 43:1534-41. 2004
    ....
  17. doi request reprint Effect of nesiritide in patients with acute decompensated heart failure
    C M O'Connor
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    N Engl J Med 365:32-43. 2011
    ..Nesiritide is approved in the United States for early relief of dyspnea in patients with acute heart failure. Previous meta-analyses have raised questions regarding renal toxicity and the mortality associated with this agent...
  18. ncbi request reprint Time-based risk assessment after myocardial infarction. Implications for timing of discharge and applications to medical decision-making
    L K Newby
    The Duke Clinical Research Institute, Durham, NC 27715 7969, USA
    Eur Heart J 24:182-9. 2003
    ..We evaluated timing of adverse cardiac events after thrombolysis to guide length of stay after ST-segment elevation myocardial infarction...
  19. ncbi request reprint Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial
    Cynthia Binanay
    Duke Clinical Research Institute, Durham, NC, USA
    JAMA 294:1625-33. 2005
    ..Pulmonary artery catheters (PACs) have been used to guide therapy in multiple settings, but recent studies have raised concerns that PACs may lead to increased mortality in hospitalized patients...
  20. doi request reprint A randomized, double-blind, placebo-controlled, multicenter study to evaluate the cardioprotective effects of MC-1 in patients undergoing high-risk coronary artery bypass graft surgery: MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft
    Rajendra H Mehta
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 155:600-8. 2008
    ....
  21. doi request reprint Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: a meta-analysis of randomized, controlled trials
    Jonathan P Piccini
    Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Circ Arrhythm Electrophysiol 2:626-33. 2009
    ..The efficacy and safety of pulmonary vein isolation (PVI) compared with medical therapy remain in question...
  22. ncbi request reprint Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot
    J H Alexander
    Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    J Thromb Haemost 2:234-41. 2004
    ..Direct factor (F)Xa inhibition is an attractive method to limit thrombotic complications during percutaneous coronary intervention (PCI)...
  23. pmc Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis
    J S Li
    Office of Pediatric Therapeutics, Office of the Commissioner, US Food and Drug Administration, Rockville, Maryland, USA
    Clin Pharmacol Ther 84:315-9. 2008
    ..This study evaluated the results of six trials of ACE inhibitors in children, using meta-analytic techniques to estimate the effect of race on blood pressure response...
  24. ncbi request reprint Prognostic usefulness of the six-minute walk in patients with advanced congestive heart failure secondary to ischemic or nonischemic cardiomyopathy
    M R Shah
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Am J Cardiol 88:987-93. 2001
    ..This may be a simple, noninvasive, objective way to risk-stratify these patients and standardize their treatment...
  25. ncbi request reprint Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis
    K Nanda
    Center for Health Services Research in Primary Care, Durham Veterans Administration Medical Center, North Carolina, USA
    Obstet Gynecol 93:880-8. 1999
    ..To review systematically the association between hormone replacement therapy (HRT) and the risk of developing or dying from colorectal cancer...
  26. ncbi request reprint Diagnostic efficiency of home pregnancy test kits. A meta-analysis
    L A Bastian
    Department of Internal Medicine, Duke University Medical Center, Durham, NC, USA
    Arch Fam Med 7:465-9. 1998
    ..To assess the diagnostic efficiency of home pregnancy test (HPT) kits...
  27. pmc Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patients
    J K Inrig
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    Kidney Int 71:454-61. 2007
    ..Further research should attempt to elucidate the mechanisms behind these findings...
  28. doi request reprint A novel bioresorbable polymer paclitaxel-eluting stent for the treatment of single and multivessel coronary disease: primary results of the COSTAR (Cobalt Chromium Stent With Antiproliferative for Restenosis) II study
    Mitchell W Krucoff
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 51:1543-52. 2008
    ....
  29. ncbi request reprint A perspective on trials comparing enoxaparin and unfractionated heparin in the treatment of non-ST-elevation acute coronary syndromes
    Robert M Califf
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 149:S91-9. 2005
    ..Contemporary guidelines from the American College of Cardiology/American Heart Association call for use of low-molecular-weight heparin or unfractionated heparin (UFH)...
  30. ncbi request reprint Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: a systematic overview
    Kenneth W Mahaffey
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 152:291-6. 2006
    ....
  31. doi request reprint Surgical Maze procedure as a treatment for atrial fibrillation: a meta-analysis of randomized controlled trials
    Melissa H Kong
    Duke University Medical Center, Durham, NC 27710, USA
    Cardiovasc Ther 28:311-26. 2010
    ..Large RCTs defining rates of freedom from AF without AADs postprocedure, are still needed to evaluate outcomes and determine the appropriate role for surgical Maze procedures in the management of AF...
  32. pmc Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation
    David A Rizzieri
    Duke University Medical Center, Department of Medicine, Division of Cellular Therapy, Durham, North Carloina, 27705, USA
    Biol Blood Marrow Transplant 16:1107-14. 2010
    ..Future studies must assess whether the improved outcomes are the direct result of the high doses and improved NK cell function or other aspects of immune recovery...
  33. doi request reprint Comparative efficacy of dronedarone and amiodarone for the maintenance of sinus rhythm in patients with atrial fibrillation
    Jonathan P Piccini
    Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 54:1089-95. 2009
    ..We sought to compare the efficacy and safety of dronedarone versus amiodarone for the prevention of recurrent atrial fibrillation (AF)...
  34. doi request reprint Rationale and design of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial (ASCEND-HF)
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 157:271-7. 2009
    ..However, the effect of nesiritide on dyspnea at 6 or 24 hours is unknown, and no clinical outcome trials have been done to provide a reliable estimate of the effect of nesiritide on morbidity and mortality...
  35. doi request reprint Association of weight change with subsequent outcomes in patients hospitalized with acute decompensated heart failure
    Rajendra H Mehta
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 103:76-81. 2009
    ..e., death and/or rehospitalization) in patients with HF in the design of treatment strategies for novel therapeutic agents in randomized controlled clinical trials...
  36. doi request reprint Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial
    John H Alexander
    Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    JAMA 299:1777-87. 2008
    ..Phase 2 trial data suggest that MC-1 may reduce death or MI in high-risk patients undergoing CABG surgery...
  37. pmc Pediatric antihypertensive trial failures: analysis of end points and dose range
    Daniel K Benjamin
    Office of Pediatric Therapeutics, US Food and Drug Administration, Rockville, MD, USA
    Hypertension 51:834-40. 2008
    ..More importantly, our ability to combine data across trials allowed us to evaluate and potentially improve trial design...
  38. doi request reprint Biomarker-guided therapy in chronic heart failure: a meta-analysis of randomized controlled trials
    G Michael Felker
    Duke Clinical Research Institute and the Division of Cardiology, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 158:422-30. 2009
    ..We performed a quantitative meta-analysis of available randomized controlled trials to determine whether titration of therapy based on natriuretic peptide measurements improves mortality in chronic heart failure...
  39. pmc Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patients
    Jula K Inrig
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 50:108-18, 118.e1-4. 2007
    ..This study seeks to define the relationship between IDWG and BP in prevalent hemodialysis subjects...
  40. pmc Triage after hospitalization with advanced heart failure: the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) risk model and discharge score
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, 2400 North Pratt Street, Box 3356, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 55:872-8. 2010
    ..Identifying high-risk heart failure (HF) patients at hospital discharge may allow more effective triage to management strategies...
  41. ncbi request reprint Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a randomized controlled trial
    Michael A Blazing
    Duke Clinical Research Institute, Durham, NC, USA
    JAMA 292:55-64. 2004
    ..It is not clear if combining enoxaparin with glycoprotein IIb/IIIa inhibitors is as safe or as effective as the current standard combination of unfractionated heparin with glycoprotein IIb/IIIa inhibitors...
  42. ncbi request reprint Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial)
    Wendy A Gattis
    Duke Clinical Research Institute, Duke University Medical Center, 2400 N Pratt Street, Box 17969, Durham, NC 27710, USA
    Am J Cardiol 93:1436-7, A10. 2004
    ..One hundred ninety-two patients were enrolled in this study. Patients with baseline cTnI values were included in this analysis, and the relation between cTnI and the composite clinical primary end point of RITZ-4 was evaluated...
  43. pmc Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial
    Vic Hasselblad
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur J Heart Fail 9:1064-9. 2007
    ..We examined the relation of maximal in-hospital diuretic dose to weight loss, changes in renal function, and mortality in hospitalised heart failure (HF) patients...
  44. pmc Benefits of smoking cessation for longevity
    Donald H Taylor
    Center for Health Policy, Law and Management, Terry Sanford Institute of Public Policy Studies, Duke University, Durham, NC 27708, USA
    Am J Public Health 92:990-6. 2002
    ..This study determined the life extension obtained from stopping smoking at various ages...
  45. ncbi request reprint Comparison of 30-day outcome, resource use, and coronary artery disease severity in patients with suspected coronary artery disease with and without diabetes mellitus assigned to chest pain units
    Carlos D Sánchez
    Duke University School of Medicine and Duke Clinical Research Institute, Durham, North Carolina 27715 7969, USA
    Am J Cardiol 91:1228-30. 2003
  46. ncbi request reprint Dissociation between hemodynamic changes and symptom improvement in patients with advanced congestive heart failure
    Monica R Shah
    Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
    Eur J Heart Fail 4:297-304. 2002
    ..Changes in hemodynamic measures often serve as surrogate end points in efficacy trials for advanced heart failure, although there are few objective data to support this practice...
  47. ncbi request reprint Meta-analysis of survival with platelet glycoprotein IIb/IIIa antagonists for percutaneous coronary interventions
    David F Kong
    Division of Cardiology, Department of Medicine, Duke University Medical Center and Clinical Research Institute, Durham, NC 27710, USA
    Am J Cardiol 92:651-5. 2003
    ..There also is increasing evidence that mortality reductions are preserved at 6 months...
  48. ncbi request reprint Seeking the optimal aspirin dose in acute coronary syndromes
    David F Kong
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 90:622-5. 2002
  49. ncbi request reprint Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial)
    David E Kandzari
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am J Cardiol 92:660-4. 2003
    ..These results support the evaluation of MC-1 in pivotal trials of patients at risk for developing myocardial ischemia, infarction, or reperfusion injury...
  50. ncbi request reprint Revascularization in patients with coronary artery disease, left ventricular dysfunction, and viability: a meta-analysis
    Jamieson Macdonald Bourque
    Division of Cardiology, Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 146:621-7. 2003
    ..We provide an alternate meta-analysis of this primary literature, utilizing interaction statistical methodology on relevant data and factoring in multiple limitations...
  51. ncbi request reprint Prognostic value of isolated troponin elevation across the spectrum of chest pain syndromes
    Sunil V Rao
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Am J Cardiol 91:936-40. 2003
    ..This suggests that these patients should be admitted to the hospital and monitored in either an intensive care or step-down unit...
  52. ncbi request reprint Differential treatment benefit of platelet glycoprotein IIb/IIIa inhibition with percutaneous coronary intervention versus medical therapy for acute coronary syndromes: exploration of methods
    Karen S Pieper
    Duke Clinical Research Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27715, USA
    Circulation 109:641-6. 2004
    ..The assumption that these agents are useful only in conjunction with percutaneous coronary intervention is based primarily on inappropriate subgroup analyses performed across the glycoprotein IIb/IIIa inhibitor trials...
  53. ncbi request reprint Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure
    Karen E Joynt
    Department of Medicine Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 93:783-5. 2004
    ..Baseline angiotensin-converting enzyme inhibitor plus beta-blocker use were associated with lower levels of CRP; no relation was found between CRP levels and aspirin or statin use...
  54. ncbi request reprint Improved clinical outcomes with abciximab therapy in acute myocardial infarction: a systematic overview of randomized clinical trials
    David E Kandzari
    Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 147:457-62. 2004
    ....
  55. ncbi request reprint Assessing the clinical and economic burden of coronary artery disease: 1986-1998
    E L Eisenstein
    Outcomes Research and Assessment Group, The Duke Clincal Research Institute, Durham, NC, USA
    Med Care 39:824-35. 2001
    ..We compared the clinical and economic burden of CAD during the acute phase (first 30 days) with that in the postacute phase (31st day through 10 years)...
  56. ncbi request reprint Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study
    W A Gattis
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 159:1939-45. 1999
    ..The multidisciplinary approach to managing heart failure has been shown to improve outcomes. The role of a clinical pharmacist in treating heart failure has not been evaluated...
  57. ncbi request reprint Platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention: the ESPRIT trial: a randomized controlled trial
    G E Hafley
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27705, USA
    JAMA 285:2468-73. 2001
    ..6% of the eptifibatide group vs 9.4% of the placebo group (HR, 0.91; 95% CI, 0.68-1.22; P =.51). CONCLUSION: Adjunctive eptifibatide therapy during coronary stent implantation provides benefit through 6-month follow-up...
  58. ncbi request reprint Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE): design and rationale
    M R Shah
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Am Heart J 141:528-35. 2001
    ..However, there is no consensus regarding the true utility of this strategy. A randomized clinical trial is needed to test the safety, efficacy, and treatment benefit of pulmonary artery catheterization in patients with advanced CHF...
  59. ncbi request reprint A randomized, placebo-controlled trial of enoxaparin after high-risk coronary stenting: the ATLAST trial
    W B Batchelor
    The Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 38:1608-13. 2001
    ..However, given its relative safety and potential to reduce the risk of subsequent infarction, a 14-day course of enoxaparin may be considered for carefully selected patients...
  60. ncbi request reprint Intradialytic blood volume monitoring in ambulatory hemodialysis patients: a randomized trial
    Donal N Reddan
    Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    J Am Soc Nephrol 16:2162-9. 2005
    ..The atypically low hospitalization and mortality rates for the conventional monitoring group suggest that these findings should be generalized to the US hemodialysis population with caution...
  61. ncbi request reprint Can one assess whether missing data are missing at random in medical studies?
    Richard F Potthoff
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Stat Methods Med Res 15:213-34. 2006
    ..If MAR+ is found to fail for a study whose data have already been gathered, extra caution may need to be exercised in the interpretation of the results...
  62. ncbi request reprint Effectiveness of Glycerol Mono-oleate as a Biosealant
    George L Adams
    Department of Medicine, Duke University Medical Center, Box 2622, Durham, NC, 27710, USA
    J Invasive Cardiol 20:29-34. 2008
    ..We assessed whether GMO would: 1) achieve hemostasis more effectively than control when injected into a swine liver biopsy tract; and 2) inhibit common percutaneous procedure pathogens...
  63. ncbi request reprint Hemodynamic profiles of advanced heart failure: association with clinical characteristics and long-term outcomes
    M R Shah
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Card Fail 7:105-13. 2001
    ..1% (n = 8); and dry/warm, 31.5%, P =.44 (n = 23). CONCLUSIONS: The patient's history and physical examination alone may lead to inaccurate estimation of hemodynamic status and thus suboptimal management for patients with advanced CHF...
  64. ncbi request reprint Diabetes-related knowledge, atherosclerotic risk factor control, and outcomes in acute coronary syndromes
    Carlos D Sánchez
    Duke University School of Medicine and Duke Clinical Research Institute, Durham, North Carolina, USA
    Am J Cardiol 95:1290-4. 2005
    ..New strategies must be developed to translate understanding of disease into better risk factor modification among patients who have diabetes and ACS...
  65. doi request reprint Acute in-vivo evaluation of bleeding with Gelfoam plus saline and Gelfoam plus human thrombin using a liver square lesion model in swine
    George L Adams
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Thromb Thrombolysis 28:1-5. 2009
    ..This study utilized a novel ordinal bleeding model to test whether a Gelfoam + human thrombin solution is superior at controlling bleeding when compared to Gelfoam + saline solution at different time intervals...
  66. ncbi request reprint Evaluation of an infrared/radiofrequency equipment-tracking system in a tertiary care hospital
    Truls Ostbye
    Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Med Syst 27:367-80. 2003
    ..Nursing staff and system users had positive impressions of the system and its potential. Tracking systems can successfully locate hospital equipment and may improve utilization...
  67. ncbi request reprint Coronary artery pattern and outcome of arterial switch operation for transposition of the great arteries: a meta-analysis
    Sara K Pasquali
    Pediatric Cardiovascular Program, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 106:2575-80. 2002
    ..This meta-analysis assesses the effect of coronary anatomy on post-ASO mortality, both overall and adjusted for time...
  68. ncbi request reprint Rapid assay brain natriuretic peptide and troponin I in patients hospitalized with decompensated heart failure (from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness Trial)
    Monica R Shah
    Washington Hospital Center, MedStar Research Institute, Washington, DC, USA
    Am J Cardiol 100:1427-33. 2007
    ..BNP decreased after hospitalization, but correlated modestly with PAC-derived hemodynamics. Rapid-assay BNP may provide information that helps physicians decide when to pursue more aggressive and invasive therapies...
  69. ncbi request reprint Metaanalysis and review of heart failure disease management randomized controlled clinical trials
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 149:722-9. 2005
    ..The aim of this study was to assess the effectiveness of DM programs in reducing hospitalization and mortality in patients with HF on the basis of the results of existing trials...
  70. ncbi request reprint Prediction of rehospitalization and death in severe heart failure by physicians and nurses of the ESCAPE trial
    Laura M Yamokoski
    The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Card Fail 13:8-13. 2007
    ....
  71. ncbi request reprint Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study
    Jean Claude Tardif
    Montreal Heart Institute, Montreal, Canada
    J Thorac Cardiovasc Surg 133:1604-11. 2007
    ..The MEND-CABG trial tested the hypothesis that MC-1 reduces cardiovascular morbidity and mortality after coronary artery bypass graft...
  72. ncbi request reprint Prognostic significance of elevated troponin I after percutaneous coronary intervention
    Warren J Cantor
    Division of Cardiology, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    J Am Coll Cardiol 39:1738-44. 2002
    ..We sought to assess the incidence and clinical significance of elevated cardiac troponin I (cTnI) after percutaneous coronary intervention (PCI)...
  73. ncbi request reprint Evaluation of platelets in heart failure: is platelet activity related to etiology, functional class, or clinical outcomes?
    Paul A Gurbel
    Sinai Center for Thrombosis Research, Baltimore, MD 21215, USA
    Am Heart J 143:1068-75. 2002
    ..We sought to determine whether platelet activity in patients with heart failure is related to an ischemic versus nonischemic etiologic condition, clinical disease severity, or adverse clinical outcomes...
  74. ncbi request reprint Role of target vessel size and body surface area on outcomes after percutaneous coronary interventions in women
    Warren J Cantor
    St Michael s Hospital, Toronto, Ontario, Canada
    Am Heart J 144:297-302. 2002
    ..Differences in target vessel size may partially account for these differences. We set out to explore the effects of sex, body surface area (BSA), and target coronary vessel size on clinical outcomes after angioplasty...
  75. doi request reprint Cardiorenal interactions: insights from the ESCAPE trial
    Anju Nohria
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 51:1268-74. 2008
    ....
  76. ncbi request reprint Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma
    David J Samson
    Technology Evaluation Center, Blue Cross and Blue Shield Association, Washington, DC 20005, USA
    Cancer 95:361-76. 2002
    ..Outcomes of interest included overall, cancer specific, and progression-free survival; time to treatment failure; adverse events; and quality of life...
  77. ncbi request reprint Antibiotic therapy for the treatment of preterm labor: a review of the evidence
    John M Thorp
    Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill 27599 7570, USA
    Am J Obstet Gynecol 186:587-92. 2002
    ..The purpose of this study was to evaluate the evidence regarding antibiotics for the treatment of preterm labor...
  78. ncbi request reprint Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials
    Monica R Shah
    Department of Cardiology, Columbia University Medical Center, New York, NY, USA
    JAMA 294:1664-70. 2005
    ..Randomized clinical trials (RCTs) evaluating the pulmonary artery catheter (PAC) have been limited by small sample size. Some nonrandomized studies suggest that PAC use is associated with increased morbidity and mortality...
  79. pmc Interventions used in disease management programmes for patients with chronic illness-which ones work? Meta-analysis of published reports
    Scott R Weingarten
    Zynx Health, 9100 Wilshire Boulevard 665E, Beverly Hills, CA 90212, USA
    BMJ 325:925. 2002
    ..To systematically evaluate the published evidence regarding the characteristics and effectiveness of disease management programmes...
  80. ncbi request reprint A systematic review of diabetes disease management programs
    Kevin Knight
    PHAR, LLC, Los Angeles, CA 90025, USA
    Am J Manag Care 11:242-50. 2005
    ..To systematically evaluate and synthesize published evidence regarding the effect of disease management programs for patients with diabetes mellitus on processes and outcomes of care...
  81. ncbi request reprint Defining and utilizing surrogates in the evaluation of coronary stents: what do we really want and need to know?
    Robert A Harrington
    J Am Coll Cardiol 51:33-6. 2008