Mark A Hallen

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Expanding the scope of quantitative FRAP analysis
    Mark A Hallen
    Duke University, Department of Mathematics, Durham, NC 27708, USA
    J Theor Biol 262:295-305. 2010
  2. pmc Anastral spindle assembly: a mathematical model
    Mark A Hallen
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Biophys J 97:2191-201. 2009
  3. pmc Anastral spindle assembly and γ-tubulin in Drosophila oocytes
    Sharyn A Endow
    Department of Cell Biology and Structural Biology and Biophysics Program, Duke University, USA
    BMC Cell Biol 12:1. 2011
  4. pmc Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant
    Hong Lei Liu
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 7:e47148. 2012
  5. pmc Ncd motor binding and transport in the spindle
    Mark A Hallen
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 121:3834-41. 2008
  6. pmc Two-state displacement by the kinesin-14 Ncd stalk
    Mark A Hallen
    Department of Cell Biology, Structural Biology and Biophysics Program, Duke University Medical Center, Durham, NC 27710, USA
    Biophys Chem 154:56-65. 2011
  7. pmc Dead-end elimination with perturbations (DEEPer): a provable protein design algorithm with continuous sidechain and backbone flexibility
    Mark A Hallen
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA
    Proteins 81:18-39. 2013
  8. pmc Fluorescence recovery kinetic analysis of gamma-tubulin binding to the mitotic spindle
    Mark A Hallen
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biophys J 95:3048-58. 2008
  9. doi request reprint Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions
    Ying Xu
    Department of Chemistry, Duke University, Durham, North Carolina 27708, United States
    Anal Chem 83:3555-62. 2011

Detail Information

Publications9

  1. doi request reprint Expanding the scope of quantitative FRAP analysis
    Mark A Hallen
    Duke University, Department of Mathematics, Durham, NC 27708, USA
    J Theor Biol 262:295-305. 2010
    ..Numerical results show that using a model that represents the influential physical processes and that is formulated in the appropriate geometry can substantially improve the accuracy of FRAP calculations...
  2. pmc Anastral spindle assembly: a mathematical model
    Mark A Hallen
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Biophys J 97:2191-201. 2009
    ..These findings are consistent with spindle assembly in live wild-type and ncd mutant Drosophila oocytes...
  3. pmc Anastral spindle assembly and γ-tubulin in Drosophila oocytes
    Sharyn A Endow
    Department of Cell Biology and Structural Biology and Biophysics Program, Duke University, USA
    BMC Cell Biol 12:1. 2011
    ..Not only is the requirement for γ-tubulin to form anastral Drosophila oocyte meiosis I spindles controversial, but its presence in oocyte meiosis I spindles has not been demonstrated and is uncertain...
  4. pmc Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant
    Hong Lei Liu
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 7:e47148. 2012
    ..One possibility, based on our findings, is that movements by the residue and the loop that contains it could bend or distort the central β-sheet, mediating free energy changes that lead to force production...
  5. pmc Ncd motor binding and transport in the spindle
    Mark A Hallen
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 121:3834-41. 2008
    ..Minus-end Ncd thus binds tightly to spindles and is transported in early metaphase towards microtubule plus-ends, the opposite direction to that in which the motor moves, to produce force in the spindle later in mitosis...
  6. pmc Two-state displacement by the kinesin-14 Ncd stalk
    Mark A Hallen
    Department of Cell Biology, Structural Biology and Biophysics Program, Duke University Medical Center, Durham, NC 27710, USA
    Biophys Chem 154:56-65. 2011
    ..We propose that the stalk rotation is initiated when the motor binds to microtubules and releases ADP, and is completed when ATP binds...
  7. pmc Dead-end elimination with perturbations (DEEPer): a provable protein design algorithm with continuous sidechain and backbone flexibility
    Mark A Hallen
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA
    Proteins 81:18-39. 2013
    ..These capabilities provide significant advantages for modeling protein mutations and protein-ligand interactions...
  8. pmc Fluorescence recovery kinetic analysis of gamma-tubulin binding to the mitotic spindle
    Mark A Hallen
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biophys J 95:3048-58. 2008
    ..gamma-Tubulin may interact transiently with the spindle, nucleating microtubules very rapidly, differing from centrosomes, where gamma-tubulin binds tightly to nucleate microtubules...
  9. doi request reprint Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions
    Ying Xu
    Department of Chemistry, Duke University, Durham, North Carolina 27708, United States
    Anal Chem 83:3555-62. 2011
    ....