LAURA HALE

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Iron supplementation decreases severity of allergic inflammation in murine lung
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    PLoS ONE 7:e45667. 2012
  2. pmc A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e41797. 2012
  3. ncbi request reprint Hypoxia in the thymus: role of oxygen tension in thymocyte survival
    Laura P Hale
    Departments of Pathology, Duke University, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 282:H1467-77. 2002
  4. ncbi request reprint Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus
    Laura P Hale
    Department of Pathology, Duke University Medical Center, DUMC 3712, Durham, NC 27710, USA
    J Immunol 172:617-24. 2004
  5. ncbi request reprint Age-related thymic atrophy in the guinea pig
    L P Hale
    Department of Pathology, Duke University Medical Center, 27710, Durham, NC, USA
    Dev Comp Immunol 25:509-18. 2001
  6. ncbi request reprint Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer
    L P Hale
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 7:846-53. 2001
  7. ncbi request reprint Abnormal development of thymic dendritic and epithelial cells in human X-linked severe combined immunodeficiency
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 110:63-70. 2004
  8. ncbi request reprint Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice
    Laura P Hale
    Department of Pathology, Duke University Medical Center, 213 A Davison Bldg, Box 3712, Durham, NC 27710, USA
    Int Immunopharmacol 4:255-64. 2004
  9. ncbi request reprint Proteinase activity and stability of natural bromelain preparations
    Laura P Hale
    Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA
    Int Immunopharmacol 5:783-93. 2005
  10. ncbi request reprint Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease
    Laura P Hale
    Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 116:135-42. 2005

Research Grants

  1. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
  2. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
  3. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
  4. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
  5. Chemoprevention of IBD-Associated Colon Cancer
    LAURA HALE; Fiscal Year: 2007
  6. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010

Collaborators

Detail Information

Publications52

  1. pmc Iron supplementation decreases severity of allergic inflammation in murine lung
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    PLoS ONE 7:e45667. 2012
    ..Further studies are indicated to determine the potential of iron supplementation to modulate the clinical severity of allergic diseases in humans...
  2. pmc A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e41797. 2012
    ..The T/I mouse model will be useful for developing new rationally-based therapies to prevent and/or treat IBD and inflammation-associated colon cancer and may further provide important insights into the pathogenesis of UC in humans...
  3. ncbi request reprint Hypoxia in the thymus: role of oxygen tension in thymocyte survival
    Laura P Hale
    Departments of Pathology, Duke University, Durham, North Carolina 27710, USA
    Am J Physiol Heart Circ Physiol 282:H1467-77. 2002
    ..Taken together, these data suggest that regulatory mechanisms exist to maintain thymic cellular hypoxia in vivo and that oxygen tension may regulate thymocyte survival both in vitro and in vivo...
  4. ncbi request reprint Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus
    Laura P Hale
    Department of Pathology, Duke University Medical Center, DUMC 3712, Durham, NC 27710, USA
    J Immunol 172:617-24. 2004
    ....
  5. ncbi request reprint Age-related thymic atrophy in the guinea pig
    L P Hale
    Department of Pathology, Duke University Medical Center, 27710, Durham, NC, USA
    Dev Comp Immunol 25:509-18. 2001
    ..Thus long-term supplementation with up to 130 mg/kg/day Vitamin C is insufficient to influence the time course and extent of age-related thymic atrophy in guinea pigs...
  6. ncbi request reprint Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer
    L P Hale
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 7:846-53. 2001
    ..The effects of elevated systemic ZAG on cachexia-associated complications in patients with advanced prostate cancer deserves additional investigation...
  7. ncbi request reprint Abnormal development of thymic dendritic and epithelial cells in human X-linked severe combined immunodeficiency
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 110:63-70. 2004
    ..These histopathologic findings indicate that in addition to T cells, thymic DC development and differentiation of TE cells are also abnormal in X-SCID...
  8. ncbi request reprint Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice
    Laura P Hale
    Department of Pathology, Duke University Medical Center, 213 A Davison Bldg, Box 3712, Durham, NC 27710, USA
    Int Immunopharmacol 4:255-64. 2004
    ..They provide further support for the hypothesis that oral bromelain may potentially modify inflammation within the gastrointestinal tract via local proteolytic activity within the colonic microenvironment...
  9. ncbi request reprint Proteinase activity and stability of natural bromelain preparations
    Laura P Hale
    Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA
    Int Immunopharmacol 5:783-93. 2005
    ....
  10. ncbi request reprint Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease
    Laura P Hale
    Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 116:135-42. 2005
    ..Although the exact mechanisms by which exogenous proteinases affect bowel inflammation have not yet been determined, the results justify additional studies of this complementary biologically based approach to treatment of IBD...
  11. ncbi request reprint Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Inflamm Bowel Dis 11:1060-9. 2005
    ..These studies support the hypothesis that increased exposure of mucosal cells to intestinal bacteria may lead to development of intestinal inflammation in IL-10 or other genetically susceptible individuals...
  12. ncbi request reprint Oral immunogenicity of the plant proteinase bromelain
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Int Immunopharmacol 6:2038-46. 2006
    ....
  13. ncbi request reprint Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Helicobacter 12:598-604. 2007
    ..However, the long lead time required before development of inflammation-associated colon neoplasia in commonly used murine models of IBD slows the development of effective chemopreventative therapies...
  14. pmc Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    J Inflamm (Lond) 5:4. 2008
    ..LMP-420 is a boronic acid-containing purine nucleoside analogue that transcriptionally inhibits TNF production but is non-cytotoxic to TNF-producing cells...
  15. pmc Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Inflamm Bowel Dis 16:2012-21. 2010
    ....
  16. ncbi request reprint Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes
    Laura P Hale
    Department of Pathology and the Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Invest Dermatol 119:464-70. 2002
    ....
  17. ncbi request reprint Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    AIDS Res Hum Retroviruses 17:1635-43. 2001
    ..Thymopoiesis in adult AIDS patients may contribute to immune reconstitution even after prolonged CD4+ T lymphopenia...
  18. ncbi request reprint Transplantation of thymus tissue in complete DiGeorge syndrome
    M L Markert
    Department of Pediatrics, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 341:1180-9. 1999
    ..The DiGeorge syndrome is a congenital disorder that affects the heart, parathyroid glands, and thymus. In complete DiGeorge syndrome, patients have severely reduced T-cell function...
  19. ncbi request reprint Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    AIDS Res Hum Retroviruses 16:403-13. 2000
    ..There was no clear difference in restoration of T cell function in the transplant recipients compared with the controls. Increases in TRECs after initiation of HAART may correlate with improved immune function...
  20. pmc Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection
    B F Haynes
    Department of Medicine, Duke Center for AIDS Research, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 103:453-60. 1999
    ..Thymectomy before HIV-1 infection did not preclude either peripheral CD4(+) T-cell rises or clinical responses after antiretroviral therapy...
  21. ncbi request reprint The human thymus. A chimeric organ comprised of central and peripheral lymphoid components
    B F Haynes
    Department of Medicine, Duke University School of Medicine, Duke Medical Center, Durham, NC, USA
    Immunol Res 18:175-92. 1998
    ....
  22. ncbi request reprint The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection
    B F Haynes
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 18:529-60. 2000
    ....
  23. pmc Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors
    J H Sampson
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 97:7503-8. 2000
    ..These data indicate that an unarmed, tumor-specific mAb may be an effective immunotherapy against human tumors and potentially other pathologic processes in the "immunologically privileged" central nervous system...
  24. ncbi request reprint The human thymus during aging
    B F Haynes
    Department of Medicine, Duke University Arthritis Center, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA
    Immunol Res 22:253-61. 2000
    ..This paper reviews work on human thymic aging at Duke University School of Medicine and discusses the relevance of this work to devising new strategies for T cell immune reconstitution in man...
  25. ncbi request reprint The human thymus. A chimeric organ comprised of central and peripheral lymphoid components
    B F Haynes
    Department of Medicine, Duke University School of Medicine, Duke Medical Center, Durham, NC, USA
    Immunol Res 18:61-78. 1998
    ....
  26. ncbi request reprint Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:998-1005. 1997
    ....
  27. ncbi request reprint Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy
    G D Sempowski
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 164:2180-7. 2000
    ..p. to mice over 3 days induced thymic atrophy with loss of CD4+, CD8+ cortical thymocytes. Taken together, these data suggest a role for thymic cytokines in the process of thymic atrophy...
  28. ncbi request reprint B cells in epithelial and perivascular compartments of human adult thymus
    K G Flores
    Department of Pathology and the Cell and Molecular Biology Program, Duke University Medical Center, Durham, NC 27710, USA
    Hum Pathol 32:926-34. 2001
    ....
  29. ncbi request reprint L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:5191-9. 1997
    ..These findings delineate an important role for L-selectin in lymphocyte recruitment to cutaneous sites of inflammation...
  30. ncbi request reprint Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms
    K A Slentz-Kesler
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Genomics 47:327-40. 1998
    ....
  31. pmc Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:4539-47. 2007
    ..In summary, diagnosis of complete DiGeorge anomaly is challenging because of the variability of presentation. Thymus transplantation was well tolerated and resulted in stable immunoreconstitution in these infants...
  32. ncbi request reprint Use of allograft biopsies to assess thymopoiesis after thymus transplantation
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Research Park 4, Durham, NC 27710, USA
    J Immunol 180:6354-64. 2008
    ..In summary, combining biopsy and autopsy data, allogeneic thymus tissues showed thymopoiesis in 24 of 29 (86%) evaluable transplants. The results of these biopsies led to improved care of these complex patients...
  33. ncbi request reprint Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function
    Gregory D Sempowski
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Immunol 25:462-72. 2005
    ....
  34. pmc Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, 10098 Berlin, Germany
    J Clin Microbiol 43:3380-9. 2005
    ..A Bacteroides fragilis biofilm is the main feature of IBD. This was not previously recognized due to a lack of appropriate tissue fixation. Both 5-ASA and antibiotics suppress but do not eliminate the adherent biofilm...
  35. ncbi request reprint BRCA2 monoclonal antibodies react with differentiating epithelium
    Lisa K Gilliam
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Hybrid Hybridomics 21:261-9. 2002
    ..These data suggest that BRCA2 may play a role in processes associated with cellular differentiation, in addition to its previously suggested roles in proliferation and DNA repair...
  36. ncbi request reprint Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation
    Laura P Hale
    Department of Pathology, Duke University, Durham, NC 27710, USA
    Clin Immunol 104:183-90. 2002
    ..Thus bromelain could potentially exert an antiinflammatory effect by multiple mechanisms, including alterations in leukocyte migration and activation...
  37. pmc Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro
    Jane E Onken
    Department of Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 126:345-52. 2008
    ..Bromelain may be a novel therapy for IBD...
  38. ncbi request reprint An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus
    Lihua Pan
    Department of Immunology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 168:3923-32. 2002
    ..In contrast to germline E2A knockout mice, conditional E2A knockout mice do not develop T cell lymphoma. This work establishes a new model for further investigating E2A function in T cell development and leukemiogenesis...
  39. ncbi request reprint Thymic model for examining BRCA2 expression and function
    Kristina G Flores
    Department of Pathology, Duke University, Durham, North Carolina 27710, USA
    Mol Carcinog 35:103-9. 2002
    ..These studies suggest that BRCA2 mRNA levels are modulated during DNA damage and may be important during apoptosis...
  40. ncbi request reprint Idiopathic hyperammonemia following an unrelated cord blood transplant for mucopolysaccharidosis I
    Matthew J Snyder
    Department of Pathology, Duke University Medical Center, Box 3712, Durham, NC 27710, USA
    Pediatr Dev Pathol 6:78-83. 2003
    ..Determining if certain subsets of children are at increased risk for IHA requires further study...
  41. ncbi request reprint Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Allergy Clin Immunol 113:734-41. 2004
    ..T-cell counts and function varied greatly in each patient. Initial laboratory testing did not suggest athymia in these patients...
  42. ncbi request reprint Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome
    M Louise Markert
    Department of Pediatrics, Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Blood 104:2574-81. 2004
    ....
  43. ncbi request reprint Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 102:1121-30. 2003
    ..Thymic transplantation is efficacious, well tolerated, and should be considered as treatment for infants with complete DiGeorge syndrome...
  44. pmc Bromelain treatment decreases neutrophil migration to sites of inflammation
    David J Fitzhugh
    Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 128:66-74. 2008
    ..Taken together, these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation and support the specific removal of the CD128 chemokine receptor as a potential mechanism of action...
  45. ncbi request reprint A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2
    Sudha Srinivasan
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 12:473-82. 2003
    ..In addition, studies utilizing this animal model can yield valuable information on the role of ALK1 in maintenance of adult vascular architecture including arteriovenous identity...
  46. ncbi request reprint Fatal disseminated adenovirus infections in immunocompromised patients
    Teresa Tram N Pham
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Am J Clin Pathol 120:575-83. 2003
    ..Both clinicians and pathologists must become aware of the pathogenicity of adenovirus in this patient population, including its potential for causing life-threatening hemorrhage...
  47. ncbi request reprint Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations
    Nicholas W Plummer
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mamm Genome 17:119-28. 2006
    ..These data suggest that cerebral cavernous malformations arise as a result of defects in the neural parenchyma surrounding the vascular endothelial cells in the brain...
  48. ncbi request reprint Bacteria associated with bacterial vaginosis
    Laura P Hale
    N Engl J Med 354:202-3; author reply 202-3. 2006
  49. ncbi request reprint Histologic and molecular assessment of human thymus
    Laura P Hale
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Ann Diagn Pathol 8:50-60. 2004
    ..Accurate assessment of thymic function is critical for the diagnosis and treatment of patients with complete DiGeorge syndrome and can complement the clinical care of patients with a variety of disorders that affect the immune system...
  50. ncbi request reprint Adherent biofilms in bacterial vaginosis
    Alexander Swidsinski
    Medizinische Klinik, Charite, CCM, Humboldt Universitat, 10098 Berlin, Germany
    Obstet Gynecol 106:1013-23. 2005
    ..Our aims were to study the bacterial community structure and the spatial organization of microbiota on the epithelial surfaces of vaginal biopsy specimens...
  51. ncbi request reprint Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes
    John F Madden
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Pathol 35:594-603. 2004
    ..Because this virus is capable of infecting tissues in the gastrointestinal and urinary systems as well as in the respiratory tract, body secretions and fluids from each of these locations should be considered potentially infectious...
  52. ncbi request reprint Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerations
    Henry E Rice
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Pediatr Surg 39:1607-15. 2004
    ..Our program supports the transplantation of allogeneic thymic tissue in infants with DiGeorge syndrome to reconstitute immune function. This study reviews the multidisciplinary care of these complex infants...

Research Grants9

  1. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
    ..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
  2. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
    ..abstract_text> ..
  3. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
    ..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
  4. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
    ..If indicated, follow-up studies will be aimed at determining the mechanisms underlying mast cell activity in IBD as well as more rigorous studies of the efficacy of mast cell inhibitors for therapy of established IBD. ..
  5. Chemoprevention of IBD-Associated Colon Cancer
    LAURA HALE; Fiscal Year: 2007
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  6. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..