Research Topics
Species | LAURA HALESummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Iron supplementation decreases severity of allergic inflammation in murine lungLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC, USA
PLoS ONE 7:e45667. 2012..Further studies are indicated to determine the potential of iron supplementation to modulate the clinical severity of allergic diseases in humans...- A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like featuresLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 7:e41797. 2012..The T/I mouse model will be useful for developing new rationally-based therapies to prevent and/or treat IBD and inflammation-associated colon cancer and may further provide important insights into the pathogenesis of UC in humans... 
Hypoxia in the thymus: role of oxygen tension in thymocyte survivalLaura P Hale
Departments of Pathology, Duke University, Durham, North Carolina 27710, USA
Am J Physiol Heart Circ Physiol 282:H1467-77. 2002..Taken together, these data suggest that regulatory mechanisms exist to maintain thymic cellular hypoxia in vivo and that oxygen tension may regulate thymocyte survival both in vitro and in vivo...- Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymusLaura P Hale
Department of Pathology, Duke University Medical Center, DUMC 3712, Durham, NC 27710, USA
J Immunol 172:617-24. 2004.... - Age-related thymic atrophy in the guinea pigL P Hale
Department of Pathology, Duke University Medical Center, 27710, Durham, NC, USA
Dev Comp Immunol 25:509-18. 2001..Thus long-term supplementation with up to 130 mg/kg/day Vitamin C is insufficient to influence the time course and extent of age-related thymic atrophy in guinea pigs... - Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancerL P Hale
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Cancer Res 7:846-53. 2001..The effects of elevated systemic ZAG on cachexia-associated complications in patients with advanced prostate cancer deserves additional investigation... - Abnormal development of thymic dendritic and epithelial cells in human X-linked severe combined immunodeficiencyLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Clin Immunol 110:63-70. 2004..These histopathologic findings indicate that in addition to T cells, thymic DC development and differentiation of TE cells are also abnormal in X-SCID... - Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of miceLaura P Hale
Department of Pathology, Duke University Medical Center, 213 A Davison Bldg, Box 3712, Durham, NC 27710, USA
Int Immunopharmacol 4:255-64. 2004..They provide further support for the hypothesis that oral bromelain may potentially modify inflammation within the gastrointestinal tract via local proteolytic activity within the colonic microenvironment... - Proteinase activity and stability of natural bromelain preparationsLaura P Hale
Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA
Int Immunopharmacol 5:783-93. 2005.... - Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel diseaseLaura P Hale
Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA
Clin Immunol 116:135-42. 2005..Although the exact mechanisms by which exogenous proteinases affect bowel inflammation have not yet been determined, the results justify additional studies of this complementary biologically based approach to treatment of IBD... - Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteriaLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Inflamm Bowel Dis 11:1060-9. 2005..These studies support the hypothesis that increased exposure of mucosal cells to intestinal bacteria may lead to development of intestinal inflammation in IL-10 or other genetically susceptible individuals... - Oral immunogenicity of the plant proteinase bromelainLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Int Immunopharmacol 6:2038-46. 2006.... - Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) miceLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Helicobacter 12:598-604. 2007..However, the long lead time required before development of inflammation-associated colon neoplasia in commonly used murine models of IBD slows the development of effective chemopreventative therapies... - Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcriptionLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC, USA
J Inflamm (Lond) 5:4. 2008..LMP-420 is a boronic acid-containing purine nucleoside analogue that transcriptionally inhibits TNF production but is non-cytotoxic to TNF-producing cells... - Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitisLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
Inflamm Bowel Dis 16:2012-21. 2010.... - Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytesLaura P Hale
Department of Pathology and the Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710, USA
J Invest Dermatol 119:464-70. 2002.... - Thymopoiesis in HIV-infected adults after highly active antiretroviral therapyM L Markert
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
AIDS Res Hum Retroviruses 17:1635-43. 2001..Thymopoiesis in adult AIDS patients may contribute to immune reconstitution even after prolonged CD4+ T lymphopenia... - Transplantation of thymus tissue in complete DiGeorge syndromeM L Markert
Department of Pediatrics, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 341:1180-9. 1999..The DiGeorge syndrome is a congenital disorder that affects the heart, parathyroid glands, and thymus. In complete DiGeorge syndrome, patients have severely reduced T-cell function... - Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infectionM L Markert
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
AIDS Res Hum Retroviruses 16:403-13. 2000..There was no clear difference in restoration of T cell function in the transplant recipients compared with the controls. Increases in TRECs after initiation of HAART may correlate with improved immune function... - Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infectionB F Haynes
Department of Medicine, Duke Center for AIDS Research, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 103:453-60. 1999..Thymectomy before HIV-1 infection did not preclude either peripheral CD4(+) T-cell rises or clinical responses after antiretroviral therapy... - The human thymus. A chimeric organ comprised of central and peripheral lymphoid componentsB F Haynes
Department of Medicine, Duke University School of Medicine, Duke Medical Center, Durham, NC, USA
Immunol Res 18:175-92. 1998.... - The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infectionB F Haynes
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Annu Rev Immunol 18:529-60. 2000.... - Unarmed, tumor-specific monoclonal antibody effectively treats brain tumorsJ H Sampson
Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 97:7503-8. 2000..These data indicate that an unarmed, tumor-specific mAb may be an effective immunotherapy against human tumors and potentially other pathologic processes in the "immunologically privileged" central nervous system... - The human thymus during agingB F Haynes
Department of Medicine, Duke University Arthritis Center, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA
Immunol Res 22:253-61. 2000..This paper reviews work on human thymic aging at Duke University School of Medicine and discusses the relevance of this work to devising new strategies for T cell immune reconstitution in man... - The human thymus. A chimeric organ comprised of central and peripheral lymphoid componentsB F Haynes
Department of Medicine, Duke University School of Medicine, Duke Medical Center, Durham, NC, USA
Immunol Res 18:61-78. 1998.... - Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymusM L Markert
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 158:998-1005. 1997.... - Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophyG D Sempowski
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 164:2180-7. 2000..p. to mice over 3 days induced thymic atrophy with loss of CD4+, CD8+ cortical thymocytes. Taken together, these data suggest a role for thymic cytokines in the process of thymic atrophy... - B cells in epithelial and perivascular compartments of human adult thymusK G Flores
Department of Pathology and the Cell and Molecular Biology Program, Duke University Medical Center, Durham, NC 27710, USA
Hum Pathol 32:926-34. 2001.... - L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient miceM L Tang
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 158:5191-9. 1997..These findings delineate an important role for L-selectin in lymphocyte recruitment to cutaneous sites of inflammation... - Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoformsK A Slentz-Kesler
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, 27710, USA
Genomics 47:327-40. 1998.... - Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplantsM Louise Markert
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Blood 109:4539-47. 2007..In summary, diagnosis of complete DiGeorge anomaly is challenging because of the variability of presentation. Thymus transplantation was well tolerated and resulted in stable immunoreconstitution in these infants... - Use of allograft biopsies to assess thymopoiesis after thymus transplantationM Louise Markert
Department of Pediatrics, Duke University Medical Center, Research Park 4, Durham, NC 27710, USA
J Immunol 180:6354-64. 2008..In summary, combining biopsy and autopsy data, allogeneic thymus tissues showed thymopoiesis in 24 of 29 (86%) evaluable transplants. The results of these biopsies led to improved care of these complex patients... - Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus functionGregory D Sempowski
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Immunol 25:462-72. 2005.... - Spatial organization and composition of the mucosal flora in patients with inflammatory bowel diseaseAlexander Swidsinski
Innere Klinik, Gastroenterologie, Charité Humboldt Universität, 10098 Berlin, Germany
J Clin Microbiol 43:3380-9. 2005..A Bacteroides fragilis biofilm is the main feature of IBD. This was not previously recognized due to a lack of appropriate tissue fixation. Both 5-ASA and antibiotics suppress but do not eliminate the adherent biofilm... - BRCA2 monoclonal antibodies react with differentiating epitheliumLisa K Gilliam
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Hybrid Hybridomics 21:261-9. 2002..These data suggest that BRCA2 may play a role in processes associated with cellular differentiation, in addition to its previously suggested roles in proliferation and DNA repair... - Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activationLaura P Hale
Department of Pathology, Duke University, Durham, NC 27710, USA
Clin Immunol 104:183-90. 2002..Thus bromelain could potentially exert an antiinflammatory effect by multiple mechanisms, including alterations in leukocyte migration and activation... - Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitroJane E Onken
Department of Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
Clin Immunol 126:345-52. 2008..Bromelain may be a novel therapy for IBD... - An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymusLihua Pan
Department of Immunology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 168:3923-32. 2002..In contrast to germline E2A knockout mice, conditional E2A knockout mice do not develop T cell lymphoma. This work establishes a new model for further investigating E2A function in T cell development and leukemiogenesis... - Thymic model for examining BRCA2 expression and functionKristina G Flores
Department of Pathology, Duke University, Durham, North Carolina 27710, USA
Mol Carcinog 35:103-9. 2002..These studies suggest that BRCA2 mRNA levels are modulated during DNA damage and may be important during apoptosis... - Idiopathic hyperammonemia following an unrelated cord blood transplant for mucopolysaccharidosis IMatthew J Snyder
Department of Pathology, Duke University Medical Center, Box 3712, Durham, NC 27710, USA
Pediatr Dev Pathol 6:78-83. 2003..Determining if certain subsets of children are at increased risk for IHA requires further study... - Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 casesM Louise Markert
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
J Allergy Clin Immunol 113:734-41. 2004..Prompt diagnosis is necessary for appropriate management... - Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndromeM Louise Markert
Department of Pediatrics, Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
Blood 104:2574-81. 2004.... - Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patientsM Louise Markert
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Blood 102:1121-30. 2003..Thymic transplantation is efficacious, well tolerated, and should be considered as treatment for infants with complete DiGeorge syndrome... - Bromelain treatment decreases neutrophil migration to sites of inflammationDavid J Fitzhugh
Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA
Clin Immunol 128:66-74. 2008..Taken together, these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation and support the specific removal of the CD128 chemokine receptor as a potential mechanism of action... - A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2Sudha Srinivasan
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Hum Mol Genet 12:473-82. 2003..In addition, studies utilizing this animal model can yield valuable information on the role of ALK1 in maintenance of adult vascular architecture including arteriovenous identity... - Fatal disseminated adenovirus infections in immunocompromised patientsTeresa Tram N Pham
Department of Pathology, Duke University Medical Center, Durham, NC, USA
Am J Clin Pathol 120:575-83. 2003..Both clinicians and pathologists must become aware of the pathogenicity of adenovirus in this patient population, including its potential for causing life-threatening hemorrhage... - Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformationsNicholas W Plummer
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mamm Genome 17:119-28. 2006..These data suggest that cerebral cavernous malformations arise as a result of defects in the neural parenchyma surrounding the vascular endothelial cells in the brain... - Bacteria associated with bacterial vaginosisLaura P Hale
N Engl J Med 354:202-3; author reply 202-3. 2006 - Histologic and molecular assessment of human thymusLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Ann Diagn Pathol 8:50-60. 2004..Accurate assessment of thymic function is critical for the diagnosis and treatment of patients with complete DiGeorge syndrome and can complement the clinical care of patients with a variety of disorders that affect the immune system... - Adherent biofilms in bacterial vaginosisAlexander Swidsinski
Medizinische Klinik, Charite, CCM, Humboldt Universitat, 10098 Berlin, Germany
Obstet Gynecol 106:1013-23. 2005..Our aims were to study the bacterial community structure and the spatial organization of microbiota on the epithelial surfaces of vaginal biopsy specimens... - Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromesJohn F Madden
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Hum Pathol 35:594-603. 2004..Because this virus is capable of infecting tissues in the gastrointestinal and urinary systems as well as in the respiratory tract, body secretions and fluids from each of these locations should be considered potentially infectious... - Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerationsHenry E Rice
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Pediatr Surg 39:1607-15. 2004..Care of these children requires coordinated multidisciplinary support...
Research Grants
- Bromelain as a Biologically-Based Therapy for IBDLAURA HALE; Fiscal Year: 2005..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
- Novel Oral Adjuvant for Dental VaccinesLAURA HALE; Fiscal Year: 2005..abstract_text> ..
- Bromelain Proteinase Activity in IBDLAURA HALE; Fiscal Year: 2006..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
- Mast Cells and IBD PathogenesisLAURA HALE; Fiscal Year: 2007..If indicated, follow-up studies will be aimed at determining the mechanisms underlying mast cell activity in IBD as well as more rigorous studies of the efficacy of mast cell inhibitors for therapy of established IBD. ..
- Chemoprevention of IBD-Associated Colon CancerLAURA HALE; Fiscal Year: 2007..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
- Chemoprevention of IBD-Associated Colon CancerLaura P Hale; Fiscal Year: 2010..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..