Hilary P Grocott

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 104:378-83. 2007
  2. ncbi request reprint Genetic influences on cerebral outcome after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 10:291-6. 2006
  3. ncbi request reprint The influence of xenon, nitrous oxide and nitrogen on gas bubble expansion during cardiopulmonary bypass
    H P Grocott
    Duke University Medical Center, Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Durham, NC 27710, USA
    Eur J Anaesthesiol 22:353-8. 2005
  4. ncbi request reprint Cognitive dysfunction after cardiac surgery: revisiting etiology
    Hilary P Grocott
    Department of Anesthesiology, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 9:123-9. 2005
  5. ncbi request reprint Lung isolation during port-access cardiac surgery: double-lumen endotracheal tube versus single-lumen endotracheal tube with a bronchial blocker
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 17:725-7. 2003
  6. ncbi request reprint Neuroprotection in cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Room 3435, Duke North Hospital, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Anesthesiol Clin North America 21:487-509, viii. 2003
  7. ncbi request reprint Genetic polymorphisms and the risk of stroke after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:1854-8. 2005
  8. ncbi request reprint Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 33:537-41. 2002
  9. ncbi request reprint Invited commentary
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Ann Thorac Surg 81:1406-7. 2006
  10. ncbi request reprint Neurological injury during cardiopulmonary bypass in the rat
    H P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Perfusion 16:75-81. 2001

Detail Information

Publications84

  1. ncbi request reprint A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 104:378-83. 2007
    ..In this study we assessed the safety of eritoran administration in patients undergoing cardiac surgery and obtained preliminary efficacy data for the prophylaxis of endotoxin-mediated surgical complications...
  2. ncbi request reprint Genetic influences on cerebral outcome after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 10:291-6. 2006
    ..Our work has established key links between post-cardiac surgery stroke and C-reactive protein (3'UTR 1846C/T) and interleukin-6 (-174 G/C) single nucleotide polymorphisms...
  3. ncbi request reprint The influence of xenon, nitrous oxide and nitrogen on gas bubble expansion during cardiopulmonary bypass
    H P Grocott
    Duke University Medical Center, Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Durham, NC 27710, USA
    Eur J Anaesthesiol 22:353-8. 2005
    ..The purpose of this study was to compare the effects of xenon (Xe), nitrous oxide (N2O) and nitrogen (N2) on gas bubble size during cardiopulmonary bypass (CPB)...
  4. ncbi request reprint Cognitive dysfunction after cardiac surgery: revisiting etiology
    Hilary P Grocott
    Department of Anesthesiology, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 9:123-9. 2005
    ..This review expands on these potential etiologies in detailing the evidence for their existence...
  5. ncbi request reprint Lung isolation during port-access cardiac surgery: double-lumen endotracheal tube versus single-lumen endotracheal tube with a bronchial blocker
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 17:725-7. 2003
    ..The purpose of this study was to compare the use of a double-lumen endotracheal tube to a single-lumen tube combined with a bronchial blocker for lung isolation during Port-Access cardiac surgery...
  6. ncbi request reprint Neuroprotection in cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Room 3435, Duke North Hospital, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Anesthesiol Clin North America 21:487-509, viii. 2003
    ..This article reviews past and present neuroprotective efforts and outlines a framework for the future development of techniques for neuroprotection during cardiac surgery...
  7. ncbi request reprint Genetic polymorphisms and the risk of stroke after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:1854-8. 2005
    ..Therefore, we tested the hypothesis that specific genetic polymorphisms are associated with an increased risk of stroke after cardiac surgery...
  8. ncbi request reprint Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 33:537-41. 2002
    ..Temperature is a well-known modulator of experimental cerebral injury. We hypothesized that hyperthermia would be associated with a worsened cognitive outcome after coronary artery bypass graft surgery (CABG)...
  9. ncbi request reprint Invited commentary
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Ann Thorac Surg 81:1406-7. 2006
  10. ncbi request reprint Neurological injury during cardiopulmonary bypass in the rat
    H P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Perfusion 16:75-81. 2001
    ..016). This rat model of CPB may allow for the study of CPB-associated neurological injury...
  11. ncbi request reprint "Other" neurologic complications after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 8:213-26. 2004
    ..An overview of the current concepts of injury mechanisms/etiology, diagnosis, prognosis, and when possible, prevention of these injuries is presented...
  12. ncbi request reprint The effects of aprotinin on outcome from cerebral ischemia in the rat
    H P Grocott
    Neuroanesthesia Research Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 88:1-7. 1999
    ..99) or cerebral infarct volume (small-dose aprotinin: 136+/-80 mm3, n = 23; large-dose aprotinin: 132+/-101 mm3, n = 11; vehicle: 121+/-81 mm3, n = 21; P = 0.87)...
  13. ncbi request reprint Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat
    H P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27705, USA
    Stroke 29:1650-5. 1998
    ....
  14. pmc Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:880-7. 2009
    ..Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass...
  15. ncbi request reprint Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 78:1556-62. 2004
    ..Atherosclerotic disease of the aorta is a known risk factor for stroke after cardiac surgery, but its relationship to NCD is unclear. This study investigates the relationship between aortic atherosclerotic disease and NCD after CABG...
  16. pmc Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 70:953-9. 2008
    ..To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery...
  17. doi request reprint Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat
    H Mayumi Homi
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    J Thorac Cardiovasc Surg 140:660-6, 666.e1. 2010
    ..We hypothesized that cardiopulmonary bypass, through an enhanced systemic inflammatory response, might affect outcomes after focal cerebral ischemia...
  18. ncbi request reprint Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina
    J Am Coll Cardiol 49:1934-42. 2007
    ....
  19. ncbi request reprint Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG
    G Burkhard Mackensen
    Division of Cardiothoracic Anesthesia and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Ann Thorac Surg 78:520-6. 2004
    ..We hypothesized that patients with and without the epsilon4 allele (E4/non-E4) would have different associations between atheroma burden and postoperative renal dysfunction...
  20. doi request reprint Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass
    H Mayumi Homi
    Department of Anesthesiology, Division of Pediatric Anesthesia, Duke University, Durham, North Carolina, USA
    Anesth Analg 111:38-45. 2010
    ..We designed this study to determine whether an antiinflammatory dose of aprotinin could improve the histologic and functional neurologic outcome in a rat model of focal cerebral ischemia during CPB...
  21. ncbi request reprint Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 107:577-84. 2007
    ....
  22. ncbi request reprint Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events
    Madhav Swaminathan
    Duke University Medical Center, Department of Anesthesiology, Box 3094, Durham, North Carolina 27710, USA
    Anesthesiology 107:739-45. 2007
    ..Therefore, the authors hypothesized that deterioration in intraoperative left ventricular regional wall motion immediately after CABG surgery is associated with a higher risk of adverse cardiac events...
  23. doi request reprint Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome?
    Fellery de Lange
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    Anesth Analg 106:24-31, table of contents. 2008
    ..We designed this study to evaluate the effect of a 60% PFC emulsion (perfluoro-tert-butylcyclohexane; PTBCH) on the inflammatory response and neurocognitive outcome of rats after CPB...
  24. ncbi request reprint Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass
    Joseph P Mathew
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:294-9. 2005
    ....
  25. ncbi request reprint Intraoperative hyperglycemia and cognitive decline after CABG
    Ferenc Puskas
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 84:1467-73. 2007
    ..The factors influencing its incidence and severity are not completely known. We hypothesized that hyperglycemia, which is known to exacerbate other forms of cerebral injury, may exacerbate NCD after cardiac operations...
  26. ncbi request reprint The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery
    Alina M Grigore
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 94:4-10, table of contents. 2002
    ..Multivariable linear regression analysis, examining treatment group, diabetes, baseline cognitive function, and cross-clamp time revealed a significant association between change in cognitive function and rate of rewarming (P = 0.05)...
  27. ncbi request reprint Central nervous system injury associated with cardiac surgery
    Mark F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 277110, USA
    Lancet 368:694-703. 2006
    ..We describe these issues and the controversies that merit continued investigation...
  28. ncbi request reprint Xenon and the inflammatory response to cardiopulmonary bypass in the rat
    Jeffrey A Clark
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:488-93. 2005
    ..The purpose of this study was to investigate the effect of xenon on the inflammatory response to cardiopulmonary bypass...
  29. ncbi request reprint Cytokine secretion after cardiac surgery and its relationship to postoperative fever
    John D Mitchell
    Department of Anesthesiology and Critical Care Medicine, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Cytokine 38:37-42. 2007
    ..Of note is the previously undescribed bimodal pattern of cytokines' secretion after CABG. The association of fever with IL-6 levels suggests inflammatory mediation...
  30. ncbi request reprint Transcranial Doppler emboli count predicts rise in creatinine after coronary artery bypass graft surgery
    Gautam M Sreeram
    Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, NC, USA
    J Cardiothorac Vasc Anesth 18:548-51. 2004
    ..To examine the correlation between transcranial Doppler ultrasonography-detected emboli during coronary artery bypass graft surgery with cardiopulmonary bypass and renal dysfunction as determined by the postoperative change in creatinine...
  31. doi request reprint The effect of limited rewarming and postoperative hypothermia on cognitive function in a rat cardiopulmonary bypass model
    Fellery de Lange
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    Anesth Analg 106:739-45, table of contents. 2008
    ..In this study, we investigated the relative influence of CPB temperature, rewarming strategies, and postoperative temperature in a rat CPB model...
  32. ncbi request reprint Preoperative low molecular weight heparin reduces heparin responsiveness during cardiac surgery
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Can J Anaesth 54:107-13. 2007
    ..The current study examines the effect of preoperative LMWH therapy on subsequent heparin responsiveness during cardiac surgery...
  33. ncbi request reprint The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery
    Timothy O Stanley
    Departments of Anesthesiology, Psychiatry and Behavioral Sciences, Medicine Neurology, and Surgery, Duke University Medical Center, Durham, North Carolina
    Anesth Analg 94:290-5, table of contents. 2002
    ..Atrial fibrillation was associated with poorer cognitive function 6 wk after surgery. Although the mechanism of this association is yet to be determined, prevention of atrial fibrillation may result in improved neurocognitive function...
  34. ncbi request reprint Prevention of cerebral hyperthermia during cardiac surgery by limiting on-bypass rewarming in combination with post-bypass body surface warming: a feasibility study
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Anesth Analg 99:641-6, table of contents. 2004
    ..7 degrees C +/- 0.5 degrees C; P = 0.024). We conclude that limiting rewarming during CPB, when used in combination with surface warming, can prevent cerebral hyperthermia while minimizing the risk of postoperative hypothermia[corrected]...
  35. ncbi request reprint Neuroprotection during cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    J Anesth 21:367-77. 2007
    ..Although numerous studies have focused on a pharmacologic solution, more success has been found with nonpharmacologic strategies, including optimal temperature management and reducing emboli generation...
  36. ncbi request reprint Cardiopulmonary bypass reduces the minimum alveolar concentration for isoflurane
    Hong Yang
    Department of Anesthesiology Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC, USA
    J Cardiothorac Vasc Anesth 18:620-3. 2004
    ..The purpose of this investigation was to determine the influence of cardiopulmonary bypass (CPB) on the minimum alveolar concentration (MAC) of isoflurane in a rat model of CPB...
  37. ncbi request reprint A randomized controlled trial of the Arctic Sun Temperature Management System versus conventional methods for preventing hypothermia during off-pump cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology and Surgery, Duke University Medical Center, Durham, North Carolina
    Anesth Analg 98:298-302, table of contents. 2004
    ..Importantly, this was achieved in the absence of any other temperature modulating techniques, including the use of IV fluid warming or increases in the ambient operating room temperature...
  38. ncbi request reprint Novel diagnostic test for acute stroke
    John R Lynch
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 35:57-63. 2004
    ..The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of cerebral ischemia...
  39. ncbi request reprint Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Box 3094, DUMC, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 68:369-75. 2006
    ..We sought to determine the impact of this postoperative cognitive dysfunction on quality of life (QOL) and to characterize the dysfunction from the patient's perspective...
  40. ncbi request reprint Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emulsion, AF0144
    Steven E Hill
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 80:1401-7. 2005
    ....
  41. ncbi request reprint The "sandblasting" effect of aortic cannula on arch atheroma during cardiopulmonary bypass
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 104:1350-1. 2007
  42. pmc A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper
    Fellery de Lange
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    J Cardiothorac Surg 3:51. 2008
    ..We developed a new in vivo survival model that combines administration of antegrade cardioplegia with endoaortic crossclamping during cardiopulmonary bypass (CPB) in the rat...
  43. ncbi request reprint Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice
    H Mayumi Homi
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 99:1145-51. 2003
    ..To date, all models evaluated have included profound systemic arterial hypotension as a component of the ischemic insult. This study was designed to determine if isoflurane protection persists in a global insult devoid of hypotension...
  44. ncbi request reprint Preliminary evaluation of the Arctic Sun temperature-controlling system during off-pump coronary artery bypass surgery
    Timothy O Stanley
    Department of Anesthesiology, Division of Cardiac Anesthesiology and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 75:1140-4. 2003
    ..The purpose of this study was to determine the efficacy of a new thermoregulatory device, the Arctic Sun temperature-controlling circulating fluid adhesive pad system, in preventing hypothermia during OPCAB surgery...
  45. ncbi request reprint Postoperative hyperthermia following off-pump versus on-pump coronary artery bypass surgery
    Jeffrey A Clark
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:426-9. 2005
    ..The purpose of this study was to describe the postoperative temperature pattern following OPCAB and to compare it with that following on-pump cardiac surgery...
  46. ncbi request reprint Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes
    Mihai V Podgoreanu
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 130:330-9. 2005
    ..By using microarray technology, this study examines myocardial gene expression responses to cardiopulmonary bypass in the absence of cardioplegic arrest and ischemia-reperfusion injury...
  47. ncbi request reprint Change in plasma glutamate concentration during cardiac surgery is a poor predictor of cognitive outcome
    James D Reynolds
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 16:431-6. 2002
    ....
  48. ncbi request reprint Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats
    H Mayumi Homi
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 99:974-81, table of contents. 2004
    ..043). In this experimental model of CPB with reversible MCAO-induced focal cerebral ischemia, hemodilution worsened neurological function and increased cerebral infarct volume...
  49. ncbi request reprint Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, NC 27710, USA
    Anesthesiology 106:295-301. 2007
    ....
  50. doi request reprint The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass
    Ma Qing
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 142:424-9. 2011
    ..This study was designed to investigate the influence of mean arterial pressures on cerebral functional and histologic outcome after cerebral air embolism during cardiopulmonary bypass in an established rat model...
  51. doi request reprint Neuroprotection during cardiac surgery
    Niamh Conlon
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Expert Rev Cardiovasc Ther 6:503-20. 2008
    ..Past, present and future directions in the field of neuroprotection in cardiac surgery will be discussed...
  52. doi request reprint Longitudinal assessment of neurocognitive function in rats after cardiopulmonary bypass: evidence for long-term deficits
    H Mayumi Homi
    Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    J Cardiothorac Vasc Anesth 24:293-9. 2010
    ..The objective of this study was to evaluate the effects of CPB on long-term neurocognitive function in the rat...
  53. ncbi request reprint Perioperative temperature and cardiac surgery
    Hilary P Grocott
    Duke University Medical Center, Durham, North Carolina, USA
    J Extra Corpor Technol 38:77-80. 2006
  54. ncbi request reprint Renal medullary hypoxia during experimental cardiopulmonary bypass: a pilot study
    Mark Stafford-Smith
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Perfusion 20:53-8. 2005
    ..To determine the effect of cardiopulmonary bypass (CPB) on renal medullary oxygenation...
  55. ncbi request reprint Brief report: The declining incidence of cerebral hyperthermia during cardiac surgery: a seven-year experience in 6,334 patients
    William B Corkey
    Department of Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Can J Anaesth 52:626-9. 2005
    ..As a result, we hypothesized that the maximum temperature reached during cardiac surgery has decreased at our institution over time...
  56. ncbi request reprint Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells
    Scott A Hagen
    Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 98:343-8. 2003
    ..This is important because GRKs regulate the function of G protein-coupled receptors involved in inflammation...
  57. ncbi request reprint Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients
    Lian K Ti
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 125:211-3. 2003
  58. ncbi request reprint Left ventricular endocardial irregularity: evaluation using epicardial echocardiography
    Christopher F Sulzer
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 21:305-6. 2007
  59. ncbi request reprint The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice
    H Mayumi Homi
    Department of Anesthesiology Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, North Carolina, USA
    Anesthesiology 99:876-81. 2003
    ..However, its putative neuroprotective properties have not been evaluated in focal cerebral ischemia. The purpose of this study was to determine if xenon offers neuroprotection in a mouse model of middle cerebral artery occlusion...
  60. ncbi request reprint Genetics and outcome after cardiac surgery
    Hilary P Grocott
    Duke University Medical Center, Durham, North Carolina, USA
    J Extra Corpor Technol 38:49-51. 2006
  61. ncbi request reprint Con: Methylprednisolone is not indicated for patients during cardiopulmonary bypass
    Christopher F Sulzer
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:255-8. 2005
  62. ncbi request reprint Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass
    L K Ti
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 32:1514-9. 2001
    ....
  63. ncbi request reprint Reduction in air bubble size using perfluorocarbons during cardiopulmonary bypass in the rat
    Kenji Yoshitani
    Department of Anesthesiology, Duke University Medical Center, DMUC Box 3094, Durham, NC 27710, USA
    Anesth Analg 103:1089-93. 2006
    ..We designed this study to test whether PFC emulsions could reduce the volume of bubbles within the CPB circuit...
  64. ncbi request reprint Asymmetric cerebral near-infrared oximetric measurements during cardiac surgery
    Shahar Bar-Yosef
    Department of Anesthesiology, Division of Veterans Affairs Anesthesia, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 17:773-4. 2003
  65. ncbi request reprint Cerebral emboli and serum S100beta during cardiac operations
    H P Grocott
    Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 65:1645-9; discussion 1649-50. 1998
    ..The purpose of this investigation was to determine the correlation between cerebral microemboli and S100beta levels during cardiac operations...
  66. ncbi request reprint Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery
    A M Grigore
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 95:1110-9. 2001
    ..CONCLUSIONS: Hypothermic CPB does not provide additional central nervous system protection in adult cardiac surgical patients who were maintained at either 30 or 35 degrees C during CPB...
  67. ncbi request reprint Apolipoprotein E polymorphisms and age at first coronary artery bypass graft
    M F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 92:824-9. 2001
    ..Identifying at-risk individuals may help prevent atherosclerosis. Further study is needed to define the mechanism of this association, and to define which coronary intervention is appropriate, based on long-term outcome...
  68. ncbi request reprint Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat
    G B Mackensen
    Department of Anesthesiology, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Brain Res 853:15-21. 2000
    ..The results also support the concept that neuroprotective strategies, which combine drugs with different mechanisms of action, may yield cumulative benefits...
  69. ncbi request reprint Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery
    M F Newman
    Department of Anesthesiology, Division of Neurology, Duke University Medical Center, Durham, NC, USA
    Stroke 32:2874-81. 2001
    ..The purpose of our investigation was to determine the association between cognitive dysfunction and long-term quality of life after cardiac surgery...
  70. ncbi request reprint Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat
    G B Mackensen
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 95:1485-91. 2001
    ..CONCLUSIONS: CPB caused both neurologic and neurocognitive impairment in a rodent recovery model. This model could potentially facilitate the investigation of CPB-related injury mechanisms and possible neuroprotective interventions...
  71. pmc Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery
    M V Podgoreanu
    Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 114:I275-81. 2006
    ..We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to risk of PMI after cardiac surgery...
  72. ncbi request reprint Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?
    Yukie Sato
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 94:1389-94, table of contents. 2002
    ....
  73. ncbi request reprint Glucose and outcome after cardiac surgery: what are the issues?
    Hilary P Grocott
    Duke University Medical Center, Durham, North Carolina, USA
    J Extra Corpor Technol 38:65-7. 2006
  74. ncbi request reprint Cerebral embolization during cardiac surgery: impact of aortic atheroma burden
    G B Mackensen
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Br J Anaesth 91:656-61. 2003
    ..In this study, we sought to determine the relationship between cerebral microemboli and aortic atheroma burden in patients undergoing cardiac surgery...
  75. ncbi request reprint Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat
    Jan M Dieleman
    Division of Perioperative Care and Emergency Medicine, University Medical Center Utrecht, PO Box 85500, mail stop Q04 2 313, 3508 GA Utrecht, The Netherlands
    Life Sci 79:551-8. 2006
    ..Similar cytokine patterns in both operated groups suggest that surgical trauma rather than exposure of blood to extra-corporeal circuit was probably responsible for the inflammatory response...
  76. ncbi request reprint False increase BIS values with forced-air head warming
    Hilary P Grocott
    Anesth Analg 96:1230. 2003
  77. ncbi request reprint Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology
    Stroke 34:508-13. 2003
    ..We therefore sought to determine the association of decreased EndoCAb and the incidence of postoperative cognitive decline...
  78. ncbi request reprint An evidence-based review of the practice of cardiopulmonary bypass in adults: a focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response
    Kenneth G Shann
    J Thorac Cardiovasc Surg 132:283-90. 2006
  79. doi request reprint Oxygen toxicity during one-lung ventilation: is it time to re-evaluate our practice?
    Hilary P Grocott
    I H Asper Clinical Research Institute, CR3008 369 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Anesthesiol Clin 26:273-80, v. 2008
    ..Continued efforts are needed to improve overall outcome in these patients, including a reevaluation of our management of oxygen therapy...
  80. ncbi request reprint High spinal anesthesia for cardiac surgery: effects on beta-adrenergic receptor function, stress response, and hemodynamics
    Trevor W R Lee
    Department of Anesthesia, Health Sciences Center, University of Manitoba, Canada
    Anesthesiology 98:499-510. 2003
    ....
  81. ncbi request reprint Pharmacologic neuroprotection: the search continues
    Hilary P Grocott
    University of Manitoba, Winnipeg, Canada
    J Extra Corpor Technol 39:296-301. 2007
    ..This review summarizes the past, present, and future of pharmacologic neuroprotection for cardiac surgery...
  82. ncbi request reprint Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat
    Daqing Ma
    Department of Anesthetics, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Anesthesiology 98:690-8. 2003
    ....
  83. ncbi request reprint S100beta and postcardiac surgery neurological dysfunction: reasons to disregard any link
    Hilary P Grocott
    Can J Anaesth 52:441-2; author reply 442-3. 2005
  84. ncbi request reprint Apolipoprotein E genotype and S100beta after cardiac surgery: is inflammation the link?
    Hilary P Grocott
    Anesth Analg 100:1869-70; author reply 1870. 2005