Research Topics
Species | Timothy M GriffinSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Metabolic cost of generating muscular force in human walking: insights from load-carrying and speed experimentsTimothy M Griffin
Department of Integrative Biology, University of California, Berkley, California 94720, USA
J Appl Physiol 95:172-83. 2003..11 +/- 0.03 (SD) J/cm3]. These data indicate that, regardless of the work muscles do, the metabolic cost of walking can be largely explained by the cost of generating muscular force during the stance phase...- Biomechanics of quadrupedal walking: how do four-legged animals achieve inverted pendulum-like movements?Timothy M Griffin
Orthopaedic Bioengineering Laboratory, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Exp Biol 207:3545-58. 2004.... - Biomechanical and energetic determinants of the walk-trot transition in horsesTimothy M Griffin
Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
J Exp Biol 207:4215-23. 2004..These results support the hypotheses that the walk-trot transition is triggered by inverted-pendulum dynamics and occurs at the speed that maximizes metabolic economy... 
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in miceTimothy M Griffin
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Arthritis Res Ther 12:R130. 2010..In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet...- Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exerciseTimothy M Griffin
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 64:443-53. 2012.... - Locomotor activity and gait in aged mice deficient for type IX collagenKerry E Costello
Department of Surgery, Duke University Medical Center, Durham, Durham, NC 27710, USA
J Appl Physiol 109:211-8. 2010..These results support the concept that current disease status, rather than age of disease onset, is the primary determinant of impaired locomotor activity with aging... 
The energetic cost of climbing in primatesJandy B Hanna
Biological Anthropology and Anatomy, Duke University, Durham, NC 27710, USA
Science 320:898. 2008..These results have important implications for understanding the origins of primates, suggesting that small early primates may have been able to move into a novel arboreal niche without increasing metabolic costs...- Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritisTimothy M Griffin
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 60:2935-44. 2009..To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology... - Why is obesity associated with osteoarthritis? Insights from mouse models of obesityTimothy M Griffin
Department of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
Biorheology 45:387-98. 2008..The ability to control these factors, together with the development of methods to conduct more intricate measures of local biomechanical factors, make mouse models an excellent system to study obesity and osteoarthritis... - Decreased physical function and increased pain sensitivity in mice deficient for type IX collagenKyle D Allen
Duke University Medical Center and Duke University, Durham, NC 27710, USA
Arthritis Rheum 60:2684-93. 2009..The aim of this study was to investigate Col9a1(-/-) mice for functional and symptomatic changes that may be associated with these pathologies... - Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat dietChristopher J O'Conor
Correspondence to Dr Farshid Guilak, Department of Orthopaedic Surgery, Duke University Medical Center, 375 MSRB, Box 3093, Durham, NC 27710, USA
Ann Rheum Dis 72:300-4. 2013.... - Adaptive value of ambling gaits in primates and other mammalsDaniel Schmitt
Department of Biological Anthropology and Anatomy, Duke University, Durham, NC 27710, USA
J Exp Biol 209:2042-9. 2006..These findings allow us to better understand the mechanics of these unusual running gaits and shed new light on primate locomotor evolution... - The role of mechanical loading in the onset and progression of osteoarthritisTimothy M Griffin
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Exerc Sport Sci Rev 33:195-200. 2005..Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint... - Powering locomotion? It's a loaded questionTimothy M Griffin
J Appl Physiol 101:1273-4. 2006
Research Grants
- An Integrative Approach to Osteoarthritis and ObesityTimothy Griffin; Fiscal Year: 2006..These studies will significantly improve our understanding of different mechanisms involved in the pathogenesis of OA and the efficacy of "biomechanical" therapies such as weight-loss and exercise in decreasing disease progression. ..