Timothy M Griffin

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Metabolic cost of generating muscular force in human walking: insights from load-carrying and speed experiments
    Timothy M Griffin
    Department of Integrative Biology, University of California, Berkley, California 94720, USA
    J Appl Physiol 95:172-83. 2003
  2. ncbi request reprint Biomechanics of quadrupedal walking: how do four-legged animals achieve inverted pendulum-like movements?
    Timothy M Griffin
    Orthopaedic Bioengineering Laboratory, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Biol 207:3545-58. 2004
  3. ncbi request reprint Biomechanical and energetic determinants of the walk-trot transition in horses
    Timothy M Griffin
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    J Exp Biol 207:4215-23. 2004
  4. pmc Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 12:R130. 2010
  5. pmc Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 64:443-53. 2012
  6. pmc Locomotor activity and gait in aged mice deficient for type IX collagen
    Kerry E Costello
    Department of Surgery, Duke University Medical Center, Durham, Durham, NC 27710, USA
    J Appl Physiol 109:211-8. 2010
  7. doi request reprint The energetic cost of climbing in primates
    Jandy B Hanna
    Biological Anthropology and Anatomy, Duke University, Durham, NC 27710, USA
    Science 320:898. 2008
  8. pmc Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 60:2935-44. 2009
  9. pmc Why is obesity associated with osteoarthritis? Insights from mouse models of obesity
    Timothy M Griffin
    Department of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
    Biorheology 45:387-98. 2008
  10. pmc Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
    Christopher J O'Conor
    Department of Orthopaedic Surgery, Duke University Medical Center, 375 MSRB, Box 3093, Durham, NC 27710, USA
    Ann Rheum Dis 72:300-4. 2013

Research Grants

Detail Information

Publications14

  1. ncbi request reprint Metabolic cost of generating muscular force in human walking: insights from load-carrying and speed experiments
    Timothy M Griffin
    Department of Integrative Biology, University of California, Berkley, California 94720, USA
    J Appl Physiol 95:172-83. 2003
    ..11 +/- 0.03 (SD) J/cm3]. These data indicate that, regardless of the work muscles do, the metabolic cost of walking can be largely explained by the cost of generating muscular force during the stance phase...
  2. ncbi request reprint Biomechanics of quadrupedal walking: how do four-legged animals achieve inverted pendulum-like movements?
    Timothy M Griffin
    Orthopaedic Bioengineering Laboratory, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Biol 207:3545-58. 2004
    ....
  3. ncbi request reprint Biomechanical and energetic determinants of the walk-trot transition in horses
    Timothy M Griffin
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    J Exp Biol 207:4215-23. 2004
    ..These results support the hypotheses that the walk-trot transition is triggered by inverted-pendulum dynamics and occurs at the speed that maximizes metabolic economy...
  4. pmc Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 12:R130. 2010
    ..In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet...
  5. pmc Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 64:443-53. 2012
    ....
  6. pmc Locomotor activity and gait in aged mice deficient for type IX collagen
    Kerry E Costello
    Department of Surgery, Duke University Medical Center, Durham, Durham, NC 27710, USA
    J Appl Physiol 109:211-8. 2010
    ..These results support the concept that current disease status, rather than age of disease onset, is the primary determinant of impaired locomotor activity with aging...
  7. doi request reprint The energetic cost of climbing in primates
    Jandy B Hanna
    Biological Anthropology and Anatomy, Duke University, Durham, NC 27710, USA
    Science 320:898. 2008
    ..These results have important implications for understanding the origins of primates, suggesting that small early primates may have been able to move into a novel arboreal niche without increasing metabolic costs...
  8. pmc Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 60:2935-44. 2009
    ..To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology...
  9. pmc Why is obesity associated with osteoarthritis? Insights from mouse models of obesity
    Timothy M Griffin
    Department of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
    Biorheology 45:387-98. 2008
    ..The ability to control these factors, together with the development of methods to conduct more intricate measures of local biomechanical factors, make mouse models an excellent system to study obesity and osteoarthritis...
  10. pmc Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
    Christopher J O'Conor
    Department of Orthopaedic Surgery, Duke University Medical Center, 375 MSRB, Box 3093, Durham, NC 27710, USA
    Ann Rheum Dis 72:300-4. 2013
    ....
  11. pmc Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen
    Kyle D Allen
    Duke University Medical Center and Duke University, Durham, NC 27710, USA
    Arthritis Rheum 60:2684-93. 2009
    ..The aim of this study was to investigate Col9a1(-/-) mice for functional and symptomatic changes that may be associated with these pathologies...
  12. ncbi request reprint Adaptive value of ambling gaits in primates and other mammals
    Daniel Schmitt
    Department of Biological Anthropology and Anatomy, Duke University, Durham, NC 27710, USA
    J Exp Biol 209:2042-9. 2006
    ..These findings allow us to better understand the mechanics of these unusual running gaits and shed new light on primate locomotor evolution...
  13. ncbi request reprint The role of mechanical loading in the onset and progression of osteoarthritis
    Timothy M Griffin
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Exerc Sport Sci Rev 33:195-200. 2005
    ..Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint...
  14. ncbi request reprint Powering locomotion? It's a loaded question
    Timothy M Griffin
    J Appl Physiol 101:1273-4. 2006

Research Grants1

  1. An Integrative Approach to Osteoarthritis and Obesity
    Timothy Griffin; Fiscal Year: 2006
    ..These studies will significantly improve our understanding of different mechanisms involved in the pathogenesis of OA and the efficacy of "biomechanical" therapies such as weight-loss and exercise in decreasing disease progression. ..