Simon G Gregory

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Genetic and functional association of FAM5C with myocardial infarction
    Jessica J Connelly
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Med Genet 9:33. 2008
  2. pmc SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach
    Jacob L McCauley
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Genomics 8:266. 2007
  3. pmc Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
    Simon G Gregory
    Duke Center for Human Genetics, DUMC, Durham, NC, USA
    BMC Med 7:62. 2009
  4. ncbi request reprint Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    Simon G Gregory
    Center for Human Genetics, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Genet 39:1083-91. 2007
  5. pmc SNPselector: a web tool for selecting SNPs for genetic association studies
    Hong Xu
    The Duke Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Bioinformatics 21:4181-6. 2005
  6. pmc Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis
    David R Crosslin
    Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, Durham, NC 27710, USA
    Hum Genet 125:217-29. 2009
  7. pmc Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy
    Yi Ju Li
    Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e18044. 2011
  8. pmc Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets
    Beth S Sutton
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:1318-28. 2008
  9. pmc Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease
    Liyong Wang
    Center for Human Genetics, Department of Medicine, Duke Univeristy Medical Center, Durham, NC, USA
    Am J Hum Genet 80:650-63. 2007
  10. pmc Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies
    Lisheng Zhang
    Department of Medicine Cardiology, Duke University Medical Center, Durham, NC, USA
    Hum Mol Genet 19:2754-66. 2010

Collaborators

Detail Information

Publications14

  1. pmc Genetic and functional association of FAM5C with myocardial infarction
    Jessica J Connelly
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Med Genet 9:33. 2008
    ..59, D1S1589/D1S518). The overlap of genetic screens in independent data sets provides evidence for the existence of a gene or genes for CAD in this region...
  2. pmc SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach
    Jacob L McCauley
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Genomics 8:266. 2007
    ..We chose annotated SNPs in the region based on location within MCSs (termed MCS-SNPs). We then obtained genotypes for 478 MCS-SNPs in 989 individuals from MS families...
  3. pmc Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
    Simon G Gregory
    Duke Center for Human Genetics, DUMC, Durham, NC, USA
    BMC Med 7:62. 2009
    ..Although numerous approaches have been used to identify genes implicated in the development of autism, less than 10% of autism cases have been attributed to single gene disorders...
  4. ncbi request reprint Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    Simon G Gregory
    Center for Human Genetics, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Genet 39:1083-91. 2007
    ..The SNP influences the amount of soluble and membrane-bound isoforms of the protein by putatively disrupting an exonic splicing silencer...
  5. pmc SNPselector: a web tool for selecting SNPs for genetic association studies
    Hong Xu
    The Duke Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Bioinformatics 21:4181-6. 2005
    ..SNPselector outputs result in compressed Excel spreadsheet files for review by the user...
  6. pmc Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis
    David R Crosslin
    Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, Durham, NC 27710, USA
    Hum Genet 125:217-29. 2009
    ....
  7. pmc Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy
    Yi Ju Li
    Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e18044. 2011
    ..5 Mb proximal to rs613872. In summary, our study presents evidence to support the role of the intronic TCF4 single nucleotide polymorphism rs613872 in late-onset FECD through both association and linkage studies...
  8. pmc Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets
    Beth S Sutton
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:1318-28. 2008
    ..Further functional studies involving a combination of risk alleles are warranted...
  9. pmc Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease
    Liyong Wang
    Center for Human Genetics, Department of Medicine, Duke Univeristy Medical Center, Durham, NC, USA
    Am J Hum Genet 80:650-63. 2007
    ..KALRN and two other associated genes identified in this study (CDGAP and MYLK) belong to the Rho GTPase-signaling pathway. Our data suggest the importance of the KALRN gene and the Rho GTPase-signaling pathway in the pathogenesis of CAD...
  10. pmc Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies
    Lisheng Zhang
    Department of Medicine Cardiology, Duke University Medical Center, Durham, NC, USA
    Hum Mol Genet 19:2754-66. 2010
    ..We conclude that TNFR1 polymorphisms associate with aging-related CAD in humans, and TNFR1 contributes to aging-dependent atherosclerosis in mice...
  11. pmc HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea
    Genglin Jin
    Department of Pathology, Pediatric Brain Tumor Foundation Institute and Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuro Oncol 12:956-66. 2010
    ..In summary, HDMX exhibits bona fide oncogenic properties and offers a promising molecular target for GBM therapeutic intervention...
  12. doi request reprint Refinement of 2q and 7p loci in a large multiplex NTD family
    Demetra S Stamm
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Birth Defects Res A Clin Mol Teratol 82:441-52. 2008
    ..Previous linkage analysis using a genome-wide SNP screen in family 8776 with multipoint nonparametric mapping methods identified maximum LOD* scores of approximately 3.0 mapping to 2q33.1-q35 and 7p21.1-pter...
  13. pmc Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family
    Hsiang Cheng Chen
    Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Rheum 62:781-90. 2010
    ..The goal of the current study was to use OA-related biomarkers of severity and disease burden as quantitative traits to identify genetic susceptibility loci for OA...
  14. pmc A general integrative genomic feature transcription factor binding site prediction method applied to analysis of USF1 binding in cardiovascular disease
    Tianyuan Wang
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genomics 3:221-35. 2009
    ..This method can be extended to other transcription factors identified in human disease studies to help further our understanding of the biology of complex disease...