AUGUSTUS GRANT

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation
    Augustus O Grant
    Duke University Medical Center, Box 3504, Durham, North Carolina 27710, USA
    J Clin Invest 110:1201-9. 2002
  2. ncbi Electrophysiological basis and genetics of Brugada syndrome
    Augustus O Grant
    Cardiology Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cardiovasc Electrophysiol 16:S3-7. 2005
  3. ncbi Cardiovascular disease in women: are there solutions?
    Augustus O Grant
    Duke University Medical Center, Box 3504, Durham, NC 27710, USA
    Circulation 109:561. 2004
  4. ncbi Recent advances in the treatment of arrhythmias
    Augustus O Grant
    Cardiology Division, Duke University, Durham 27710, NC, USA
    Circ J 67:651-5. 2003
  5. ncbi The influence of cardiograph design and automated algorithms on the incidence and detection of electrode cable reversals in an academic electrocardiogram laboratory
    Kent R Nilsson
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Electrocardiol 41:382-7. 2008
  6. ncbi Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease
    Zhu Shan Zhang
    Duke Univ Medical Center, Box 3504, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 292:H399-407. 2007
  7. ncbi Task Force 7: arrhythmias
    Douglas P Zipes
    J Am Coll Cardiol 45:1354-63. 2005
  8. ncbi Ethnicity and arrhythmia susceptibility
    Kevin Thomas
    J Cardiovasc Electrophysiol 19:427-9. 2008
  9. ncbi Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affe
    Stephan E Lehnart
    Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, P and S 9 401 box 22, 630 W 168 St, New York, NY 10032, USA
    Circulation 116:2325-45. 2007
  10. ncbi ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats: the clinical and public health implications for the prevention and control of cardiovascular diseases
    George A Mensah
    J Am Coll Cardiol 49:1376-9. 2007

Research Grants

  1. Inherited Ion Channel Defects in Arrhythmias
    AUGUSTUS GRANT; Fiscal Year: 2005

Detail Information

Publications19

  1. ncbi Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation
    Augustus O Grant
    Duke University Medical Center, Box 3504, Durham, North Carolina 27710, USA
    J Clin Invest 110:1201-9. 2002
    ..The late component of Na(+) current was increased in the DeltaK1500 mutant channel. These changes can account for the complex phenotype in this kindred and point to an important role of the III/IV linker in channel activation...
  2. ncbi Electrophysiological basis and genetics of Brugada syndrome
    Augustus O Grant
    Cardiology Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cardiovasc Electrophysiol 16:S3-7. 2005
    ..By its nonspecific potassium channel blocking action, quinidine may also reduce arrhythmia recurrence. We still do not know the basis for defect in the majority of patients with Brugada syndrome...
  3. ncbi Cardiovascular disease in women: are there solutions?
    Augustus O Grant
    Duke University Medical Center, Box 3504, Durham, NC 27710, USA
    Circulation 109:561. 2004
  4. ncbi Recent advances in the treatment of arrhythmias
    Augustus O Grant
    Cardiology Division, Duke University, Durham 27710, NC, USA
    Circ J 67:651-5. 2003
    ..Future advances in arrhythmia management will include improvements in catheter design and energy sources for ablation, and greater monitoring capacity of implantable devices...
  5. ncbi The influence of cardiograph design and automated algorithms on the incidence and detection of electrode cable reversals in an academic electrocardiogram laboratory
    Kent R Nilsson
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Electrocardiol 41:382-7. 2008
    ..Proper interpretation, however, is dependent on the quality and accuracy of the acquired ECG...
  6. ncbi Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease
    Zhu Shan Zhang
    Duke Univ Medical Center, Box 3504, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 292:H399-407. 2007
    ..The findings also suggest how Brugada syndrome and PCCD which both result from loss of sodium channel function are sometimes present alone and at other times in combination...
  7. ncbi Task Force 7: arrhythmias
    Douglas P Zipes
    J Am Coll Cardiol 45:1354-63. 2005
  8. ncbi Ethnicity and arrhythmia susceptibility
    Kevin Thomas
    J Cardiovasc Electrophysiol 19:427-9. 2008
  9. ncbi Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affe
    Stephan E Lehnart
    Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, P and S 9 401 box 22, 630 W 168 St, New York, NY 10032, USA
    Circulation 116:2325-45. 2007
    ....
  10. ncbi ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats: the clinical and public health implications for the prevention and control of cardiovascular diseases
    George A Mensah
    J Am Coll Cardiol 49:1376-9. 2007
  11. ncbi ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats: the clinical and public health implications for the prevention and control of cardiovascular diseases
    George A Mensah
    J Am Coll Cardiol 49:1373-412. 2007
  12. ncbi ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats: the clinical and public health implications for the prevention and control of cardiovascular diseases
    George A Mensah
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341-3717, USA
    Circulation 115:1656-95. 2007
  13. ncbi ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats: the clinical and public health implications for the prevention and control of cardiovascular diseases
    George A Mensah
    Circulation 115:1659-62. 2007
  14. ncbi The benefit of prevention: engaging the public through strategic collaborations
    Augustus O Grant
    Circulation 109:3062-6063. 2004
  15. ncbi Critical reviews in basic electrophysiology: realizing the synergy between the basic and clinical sciences
    Augustus O Grant
    J Cardiovasc Electrophysiol 17:219. 2006
  16. ncbi What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channels
    C Frank Starmer
    Department of Biometry, Medical University of South Carolina, Suite 200 I Administration Library, 171 Ashley Ave, Charleston, SC 29425, USA
    Cardiovasc Res 57:82-91. 2003
    ..We hypothesized that during the VP, the Na conductance at the stimulus site is graded and that NaLOF would favor reentry specifically by flattening this gradient, which would destabilize antegrade front formation...
  17. ncbi The cardiovascular state of the union: confronting healthcare disparities
    Robert O Bonow
    Circulation 111:1205-7. 2005
  18. ncbi ACCF/AHA consensus conference report on professionalism and ethics
    Richard J Popp
    Circulation 110:2506-49. 2004
  19. ncbi Task force 5: Expert testimony and opinions
    Robert O Bonow
    J Am Coll Cardiol 44:1747-9. 2004

Research Grants4

  1. Inherited Ion Channel Defects in Arrhythmias
    AUGUSTUS GRANT; Fiscal Year: 2005
    ..Isoform expression will be determined by in situ hydridization. The proposed studies will provide new insights into ion channel function, their regulation and possible basis for cardiac arrhythmias. ..