Mario Gonzalez-Gronow

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells
    M Gonzalez-Gronow
    Department of Pathology, Box 3712, Duke University Medical Center, Durham, NC 27710, USA
    Biochem J 355:397-407. 2001
  2. ncbi request reprint A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling
    Uma Kant Misra
    Department of Pathology, Duke University Medical Center, Box 3712, Durham, NC 27710, USA
    Cell Signal 16:929-38. 2004
  3. ncbi request reprint The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling
    Uma Kant Misra
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:2092-7. 2005
  4. pmc The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 288:498-509. 2013
  5. pmc Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neuroimmunol 227:153-61. 2010
  6. doi request reprint GRP78: a multifunctional receptor on the cell surface
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antioxid Redox Signal 11:2299-306. 2009
  7. ncbi request reprint Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Front Biosci 13:1610-8. 2008
  8. ncbi request reprint Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 282:32811-20. 2007
  9. ncbi request reprint Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 66:11424-31. 2006
  10. ncbi request reprint Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:27173-8. 2005

Collaborators

Detail Information

Publications20

  1. pmc Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells
    M Gonzalez-Gronow
    Department of Pathology, Box 3712, Duke University Medical Center, Durham, NC 27710, USA
    Biochem J 355:397-407. 2001
    ..This is the first demonstration of a direct association between the expression of MMP-9 and the Pg activation system...
  2. ncbi request reprint A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling
    Uma Kant Misra
    Department of Pathology, Duke University Medical Center, Box 3712, Durham, NC 27710, USA
    Cell Signal 16:929-38. 2004
    ..Suppressing Grp78 expression leads to the loss of these activation events in transfected macrophages. We thus conclude that Grp78 is the alpha2M* signalling receptor...
  3. ncbi request reprint The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling
    Uma Kant Misra
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:2092-7. 2005
    ....
  4. pmc The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 288:498-509. 2013
    ..This ternary complex is an efficient proteolytic complex that may facilitate removal of amyloid β peptide deposits from the normal brain and cell debris from injured brain tissue...
  5. pmc Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neuroimmunol 227:153-61. 2010
    ..Because VDAC and hexokinase-I are essential for brain protection from ischemic damage, the presence of these autoantibodies suggests a possible causal role in the neurologic pathogenesis of autism...
  6. doi request reprint GRP78: a multifunctional receptor on the cell surface
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antioxid Redox Signal 11:2299-306. 2009
    ..Here, we discuss the significance of these associations, and the possible mechanisms involved in the transportation of GRP78 from the cytosol to the cell surface...
  7. ncbi request reprint Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Front Biosci 13:1610-8. 2008
    ....
  8. ncbi request reprint Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 282:32811-20. 2007
    ..We show that kringle 5 inhibits 1-LN cell proliferation and promotes caspase-7 activity by a mechanism that requires binding to cell surface voltage-dependent anion channel and is inhibited by human hexokinase I...
  9. ncbi request reprint Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 66:11424-31. 2006
    ..Furthermore, increasing concentrations of human anti-GRP78 IgG show a dose-dependent protective effect on apoptosis induced by tumor necrosis factor alpha...
  10. ncbi request reprint Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:27173-8. 2005
    ..These associations suggest that Pg has the potential to simultaneously regulate calcium signaling pathways and Na+/H+ exchanges necessary for tumor cell proliferation and invasiveness...
  11. ncbi request reprint Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 99:4562-7. 2002
    ..The current studies suggest that Pg oligosaccharide chains regulate the binding of Pg 1 and Pg 2 to separate receptors on the cell surface...
  12. ncbi request reprint The voltage-dependent anion channel is a receptor for plasminogen kringle 5 on human endothelial cells
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:27312-8. 2003
    ..K5 binding to endothelial cells also induces a decrease in intracellular pH and hyperpolarization of the mitochondrial membrane. These studies suggest that VDAC is a receptor for K5...
  13. ncbi request reprint Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells
    Mario Gonzalez-Gronow
    Department of Pathology, Box 3712, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 279:20993-8. 2004
    ..Thus, ADA may be a factor regulating events in prostate cancer cells that occur when Pg binds to the cell surface and is activated...
  14. ncbi request reprint Angiostatin directly inhibits human prostate tumor cell invasion by blocking plasminogen binding to its cellular receptor, CD26
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Exp Cell Res 303:22-31. 2005
    ..These studies suggest that, in addition to its ability to inhibit tumor vascularization, angiostatin 2epsilon may also directly block tumor metastasis...
  15. ncbi request reprint The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction
    Uma K Misra
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:42082-7. 2002
    ....
  16. ncbi request reprint Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis
    John C Mavropoulos
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Rheumatol 32:2116-24. 2005
    ..IgG antibody titers against chaperone Bip (GRP78), phosphoglucose isomerase (PGI), lactate dehydrogenase (LDH), fibronectin (FN), and actin were also studied...
  17. doi request reprint Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival
    Maria A Selim
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
    Melanoma Res 21:323-34. 2011
    ..In conclusion, the anti-GRP78 IgG autoantibodies downregulate apoptosis and activate unfolded protein response mechanisms, which are essential to promote melanoma cell growth and survival...
  18. doi request reprint Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma
    John A Papalas
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Mod Pathol 23:134-43. 2010
    ....
  19. ncbi request reprint Angiostatin's molecular mechanism: aspects of specificity and regulation elucidated
    Miriam L Wahl
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biochem 96:242-61. 2005
    ....
  20. pmc Streptokinase promotes development of dipeptidyl peptidase IV (CD26) autoantibodies after fibrinolytic therapy in myocardial infarction patients
    Miguel Cuchacovich
    Rheumatology Section, University of Chile Clinical Hospital, Santiago, Chile
    Clin Diagn Lab Immunol 9:1253-9. 2002
    ....