Larry Goldstein

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint 10 questions about statins and stroke
    Larry B Goldstein
    Department of Medicine Neurology, Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University and Durham VA Medical Center, Durham, NC 27710, USA
    Neurologist 14:262-4. 2008
  2. pmc Neurotransmitters and motor activity: effects on functional recovery after brain injury
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Duke University, Durham, NC 27710, USA
    NeuroRx 3:451-7. 2006
  3. ncbi request reprint Blood pressure management in patients with acute ischemic stroke
    Larry B Goldstein
    Department of Medicine, Duke Center for Cerebrovascular Disease, Duke University, Durham, NC 27710, USA
    Hypertension 43:137-41. 2004
  4. ncbi request reprint Extracranial carotid artery stenosis
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, and Stroke Policy Program, Duke University and Veterans Affairs Medical Center, Durham, NC 27710, USA
    Stroke 34:2767-73. 2003
  5. ncbi request reprint VA Stroke Study: neurologist care is associated with increased testing but improved outcomes
    L B Goldstein
    Durham VA Medical Center, Durham, NC, USA
    Neurology 61:792-6. 2003
  6. ncbi request reprint Neuropharmacology of TBI-induced plasticity
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Stroke Policy Program, Center for Clinical Health Policy Research, Duke University, Durham, NC 27710, USA
    Brain Inj 17:685-94. 2003
  7. doi request reprint How much can be gained by more systematic prevention of stroke?
    Larry B Goldstein
    Department of Medicine Neurology, Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University and Durham VA Medical Center, Durham, NC 27710, USA
    Int J Stroke 3:266-71. 2008
  8. doi request reprint Amphetamine trials and tribulations
    Larry B Goldstein
    Department of Medicine Neurology, Duke Stroke Center, Center for Clinical Health Policy Research, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:S133-5. 2009
  9. doi request reprint Stroke-related knowledge among uninsured Latino immigrants in Durham County, North Carolina
    Larry B Goldstein
    Department of Medicine Neurology, Duke University, Durham, NC 27710, USA
    J Stroke Cerebrovasc Dis 18:229-31. 2009
  10. ncbi request reprint Veterans Administration Acute Stroke (VASt) Study: lack of race/ethnic-based differences in utilization of stroke-related procedures or services
    Larry B Goldstein
    Durham Veterans Affairs Medical Center, Durham, NC, USA
    Stroke 34:999-1004. 2003

Research Grants

Detail Information

Publications97

  1. doi request reprint 10 questions about statins and stroke
    Larry B Goldstein
    Department of Medicine Neurology, Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University and Durham VA Medical Center, Durham, NC 27710, USA
    Neurologist 14:262-4. 2008
  2. pmc Neurotransmitters and motor activity: effects on functional recovery after brain injury
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Duke University, Durham, NC 27710, USA
    NeuroRx 3:451-7. 2006
    ..Understanding the neurobiological processes underlying recovery, and how they might be manipulated, may lead to novel strategies for improving recovery from stroke-related gait impairment in humans...
  3. ncbi request reprint Blood pressure management in patients with acute ischemic stroke
    Larry B Goldstein
    Department of Medicine, Duke Center for Cerebrovascular Disease, Duke University, Durham, NC 27710, USA
    Hypertension 43:137-41. 2004
  4. ncbi request reprint Extracranial carotid artery stenosis
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, and Stroke Policy Program, Duke University and Veterans Affairs Medical Center, Durham, NC 27710, USA
    Stroke 34:2767-73. 2003
    ..Carotid angioplasty with stenting is also being performed, and clinical trials comparing this procedure with carotid endarterectomy are in progress...
  5. ncbi request reprint VA Stroke Study: neurologist care is associated with increased testing but improved outcomes
    L B Goldstein
    Durham VA Medical Center, Durham, NC, USA
    Neurology 61:792-6. 2003
    ..VA Stroke Study (VASt) data were analyzed to determine whether neurologist management affected the process and outcome of care of patients with ischemic stroke...
  6. ncbi request reprint Neuropharmacology of TBI-induced plasticity
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Stroke Policy Program, Center for Clinical Health Policy Research, Duke University, Durham, NC 27710, USA
    Brain Inj 17:685-94. 2003
    ..The purpose of this report is to review both fundamental studies in laboratory animals and preliminary clinical data suggesting that certain drugs may affect behavioural recovery after brain injury...
  7. doi request reprint How much can be gained by more systematic prevention of stroke?
    Larry B Goldstein
    Department of Medicine Neurology, Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University and Durham VA Medical Center, Durham, NC 27710, USA
    Int J Stroke 3:266-71. 2008
    ..Although specific estimates are difficult to calculate, the impact of improving the use of the wide array of effective stroke preventive interventions would be substantial...
  8. doi request reprint Amphetamine trials and tribulations
    Larry B Goldstein
    Department of Medicine Neurology, Duke Stroke Center, Center for Clinical Health Policy Research, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:S133-5. 2009
    ..Several small clinical trials evaluated the approach as a means of improving poststroke recovery...
  9. doi request reprint Stroke-related knowledge among uninsured Latino immigrants in Durham County, North Carolina
    Larry B Goldstein
    Department of Medicine Neurology, Duke University, Durham, NC 27710, USA
    J Stroke Cerebrovasc Dis 18:229-31. 2009
    ..Knowledge of stroke risk factors and symptoms is a necessary prerequisite for improving prevention and reducing treatment delays. Little is known about stroke-related knowledge among the US immigrant Latino population...
  10. ncbi request reprint Veterans Administration Acute Stroke (VASt) Study: lack of race/ethnic-based differences in utilization of stroke-related procedures or services
    Larry B Goldstein
    Durham Veterans Affairs Medical Center, Durham, NC, USA
    Stroke 34:999-1004. 2003
    ....
  11. ncbi request reprint Amphetamines and related drugs in motor recovery after stroke
    Larry B Goldstein
    Center for Cerebrovascular Disease, Department of Medicine Neurology, Center for Clinical Health Policy Research, Duke University, Durham, North Carolina 27710, USA
    Phys Med Rehabil Clin N Am 14:S125-34, x. 2003
    ..Combined with principles derived from the laboratory, these clinical studies provide important insights to guide the rational design of trials aimed at determining the clinical use of this approach to improving poststroke recovery...
  12. ncbi request reprint Prevention and health services delivery
    Larry B Goldstein
    Duke Center for Cerebrovascular Disease, Stroke Policy Program, Duke University and Durham VA Medical Center, Durham, North Carolina, USA
    Stroke 34:367-9. 2003
  13. doi request reprint Relative effects of statin therapy on stroke and cardiovascular events in men and women: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study
    Larry B Goldstein
    Duke University Medical Center, Durham, NC 27710, USA
    Stroke 39:2444-8. 2008
    ..9 years of follow-up. The purpose of this secondary analysis was to determine whether men and women similarly benefited from randomization to statin treatment...
  14. ncbi request reprint Prevention and health services delivery
    Larry B Goldstein
    Department of Medicine, Duke Center for Cerebrovascular Disease, Durham, NC 27710, USA
    Stroke 35:401-3. 2004
  15. ncbi request reprint Neuroprotective therapy for acute ischaemic stroke: down, but not out
    Larry B Goldstein
    Duke Center for Cerebrovascular Disease, Duke University Medical Center, Durham, NC 27710, USA
    Lancet 363:414-5. 2004
  16. ncbi request reprint Primary prevention and health services delivery
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University and Veterans Administration Medical Center, Durham, NC 27710, USA
    Stroke 38:222-4. 2007
  17. ncbi request reprint Stroke code chest radiographs are not useful
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University, NC, USA
    Cerebrovasc Dis 24:460-2. 2007
    ..The usefulness of the test in patients being evaluated by a stroke team for hyperacute stroke symptoms was assessed...
  18. ncbi request reprint Acute ischemic stroke treatment in 2007
    Larry B Goldstein
    Department of Medicine Neurology, Center for Cerebrovascular Disease, Duke University and Durham VA Medical Center, Durham, NC, USA
    Circulation 116:1504-14. 2007
  19. ncbi request reprint Advances in primary stroke prevention
    Larry B Goldstein
    Department of Medicine Neurology, Center for Cerebrovascular Disease, Duke University, Veterans Affairs Medical Center, Durham, NC, USA
    Stroke 37:317-9. 2006
  20. doi request reprint [Neurology and cardiology: points of contact]
    Larry B Goldstein
    Division of Neurology, Department of Medicine, Duke Stroke Center, Duke University Medical Center, Durham, North Carolina, Estados Unidos
    Rev Esp Cardiol 64:319-27. 2011
    ..Cardiologists and neurologists share responsibility for caring for patients with or at risk for cardiogenic strokes, and for screening and managing the heart disease associated with neuromuscular disorders...
  21. ncbi request reprint Is this patient having a stroke?
    Larry B Goldstein
    Department of Medicine, Duke Center for Cerebrovascular Disease, Durham, NC 27710, USA
    JAMA 293:2391-402. 2005
    ..Patients suspected of having a stroke or transient ischemic attack require accurate assessment for appropriate acute treatment and use of secondary preventive interventions...
  22. ncbi request reprint Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study
    L B Goldstein
    Duke University Medical Center, Durham, NC 27710, USA
    Neurology 70:2364-70. 2008
    ..Post hoc analysis found this overall benefit included an increase in the numbers of treated patients having hemorrhagic stroke (n = 55 for active treatment vs n = 33 for placebo)...
  23. ncbi request reprint Statins for stroke prevention
    Larry B Goldstein
    Duke Center for Cerebrovascular Disease, Stroke Policy Program, Center for Clinical Health Policy Research, Box 3651, Duke University Medical Center, Durham, NC 27710, USA
    Curr Atheroscler Rep 9:305-11. 2007
    ..Whether the benefit of statins in reducing the risk of stroke is due to their potent lipid-lowering effects, pleiotropic effects, or a combination of the two cannot be determined based on data available from clinical trials...
  24. ncbi request reprint Prevention and health services delivery
    Larry B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Stroke Policy Program, Center for Clinical Health Policy Research, Duke University and Veterans Affairs Medical Center, Durham, NC 27710, USA
    Stroke 36:222-4. 2005
  25. doi request reprint Advances in prevention and health services delivery 2007
    Larry B Goldstein
    Department of Medicine, Duke Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University, Durham, NC 27710, USA
    Stroke 39:258-60. 2008
  26. ncbi request reprint Charlson Index comorbidity adjustment for ischemic stroke outcome studies
    Larry B Goldstein
    Durham VA Medical Center, Durham, NC, USA
    Stroke 35:1941-5. 2004
    ..The purpose of the present study was to determine whether outcomes of ischemic stroke patients varied on the basis of the Charlson Index...
  27. ncbi request reprint New data about stenting versus endarterectomy for symptomatic carotid artery stenosis
    Larry B Goldstein
    Larry B Goldstein, MD Duke Stroke Center, Box 3651, Duke University Medical Center, Durham, NC 27710, USA
    Curr Treat Options Cardiovasc Med 11:232-40. 2009
    ..Whether carotid angioplasty/stenting is as efficacious as endarterectomy in patients with average periprocedural risk remains uncertain and is under investigation...
  28. ncbi request reprint Statins and ischemic stroke severity: cytoprotection
    Larry B Goldstein
    Department of Medicine Neurology, Duke Stroke Center, Duke University Medical Center, Durham, NC 27710, USA
    Curr Atheroscler Rep 11:296-300. 2009
    ....
  29. ncbi request reprint Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats
    Larry B Goldstein
    Neurorehabil Neural Repair 16:321-5. 2002
    ..A variety of drugs impair motor recovery after sensorimotor cortex (SMCTX) injury in laboratory animals and may have similar effects in humans...
  30. ncbi request reprint Should antihypertensive therapies be given to patients with acute ischemic stroke?
    L B Goldstein
    Duke Center for Cerebrovascular Disease, Stroke Policy Program, Duke University, North Carolina 27710, USA
    Drug Saf 22:13-8. 2000
    ..g. alpha2-adrenergic receptor agonists and alpha1-adrenergic receptor antagonists) to impair the recovery process should be considered when choosing an antihypertensive for treatment of these patients...
  31. ncbi request reprint North Carolina stroke prevention and treatment facilities survey. Statewide availability of programs and services
    L B Goldstein
    Department of Medicine Duke Center for Cerebrovascular Disease, Center for Clinical Health Policy Research Effectiveness, Duke University, Durham, NC 27710, USA
    Stroke 31:66-70. 2000
    ..The aim of this study was to determine the statewide availability of facilities and programs for stroke prevention and treatment to identify underserved regions and target educational efforts...
  32. ncbi request reprint Carotid endarterectomy for stroke prevention in older people
    L B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Duke University, Durham, NC, USA
    Clin Geriatr Med 15:685-700. 1999
    ..A thorough understanding of the benefits and risks of the operation for the individual patient is necessary in determining whether to recommend the operation...
  33. ncbi request reprint Evidence-based medicine and stroke
    L B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Stroke Policy Program, Center for Clinical Health Policy Research, Duke University, and Durham VA Medical Center, Durham, NC 27710 USA
    Neuroepidemiology 18:120-4. 1999
    ..New strategies such as the use of computerized decision support systems are being developed, but their impact on process of care, costs, and patient outcomes must be rigorously evaluated...
  34. ncbi request reprint North Carolina stroke prevention and treatment facilities survey: rtPA therapy for acute stroke
    L B Goldstein
    Departments of Medicine Neurology, Duke Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University, Durham, NC 27710
    Stroke 29:2069-72. 1998
    ..BACKGROUND and..
  35. ncbi request reprint Accuracy of ICD-9-CM coding for the identification of patients with acute ischemic stroke: effect of modifier codes
    L B Goldstein
    Department of Medicine, The Duke Center for Cerebrovascular Disease, Duke University, Durham Department of Veterans Affairs Medical Center, NC, USA
    Stroke 29:1602-4. 1998
    ..The aim of this study was to determine if the accuracy of the primary ICD-9-CM codes for ischemic stroke is improved by modifier codes and how specific codes reflect stroke subtype diagnoses...
  36. ncbi request reprint Potential effects of common drugs on stroke recovery
    L B Goldstein
    Department of Medicine Neurology Veterans Affairs Medical Center and Center for Clinical Health Policy Research, Duke University, Durham, NC 27710, USA
    Arch Neurol 55:454-6. 1998
    ..Understanding these pharmacological effects is important because several of the classes of drugs that impair recovery in laboratory experiments are used to treat coincident medical problems in patients who have had a stroke...
  37. ncbi request reprint Multicenter review of preoperative risk factors for endarterectomy for asymptomatic carotid artery stenosis
    L B Goldstein
    Center for Clinical Health Policy Research, Division of Neurology, Duke University, Department of Veterans Affairs Medical Center, Durham, NC, USA
    Stroke 29:750-3. 1998
    ..The purpose of this study was to analyze the impact of potential preoperative risk factors on the frequency of postoperative complications in patients undergoing the operation for asymptomatic disease in academic medical centers...
  38. ncbi request reprint Retrospective assessment of initial stroke severity with the Canadian Neurological Scale
    L B Goldstein
    Division of Neurology, Durham Department of Veterans Affairs Medical Center, NC, USA
    Stroke 28:1181-4. 1997
    ..We evaluated the validity and reliability of measuring initial stroke severity retrospectively with the Canadian Neurological Scale (CNS)...
  39. ncbi request reprint Influence of common drugs and related factors on stroke outcome
    L B Goldstein
    Durham Veterans Affairs Medical Center, NC 27710, USA
    Curr Opin Neurol 10:52-7. 1997
    ..Pharmacotherapy to enhance recovery may be possible in the future...
  40. ncbi request reprint Primary care physician-reported secondary and tertiary stroke prevention practices. A comparison between the United States and the United Kingdom
    L B Goldstein
    Center for Health Policy Research and Education, Duke University, Durham, NC
    Stroke 28:746-51. 1997
    ..Little comparative data are available concerning how generalist physicians in the two countries approach the management of patients at high risk of stroke...
  41. ncbi request reprint Reliability of the National Institutes of Health Stroke Scale. Extension to non-neurologists in the context of a clinical trial
    L B Goldstein
    Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 28:307-10. 1997
    ..This reliability testing has primarily focused on the use of the scale by neurologists. We sought to determine the reliability of the NIHSS as used by non-neurologists in the context of a clinical trial...
  42. ncbi request reprint US National Survey of Physician Practices for the Secondary and Tertiary Prevention of Ischemic Stroke. Medical therapy in patients with carotid artery stenosis
    L B Goldstein
    Center for Health Policy Research and Education, Duke University, Durham, NC USA
    Stroke 27:1473-8. 1996
    ..The identification of variations in practice may help to both direct specific educational efforts and guide further research...
  43. ncbi request reprint US National Survey of Physician Practices for the Secondary and Tertiary Prevention of Ischemic Stroke. Carotid endarterectomy
    L B Goldstein
    Center for Health Policy Research and Education, Duke University, Durham, NC, USA
    Stroke 27:801-6. 1996
    ..Yet, there are few data concerning the patterns of use of CE by physicians for their patients at risk for stroke. These data are critical for the rational allocation of resources and targeting of educational efforts...
  44. ncbi request reprint Effects of amphetamines and small related molecules on recovery after stroke in animals and man
    L B Goldstein
    Box 3651, Duke University Medical Center, Durham, NC 27710, USA
    Neuropharmacology 39:852-9. 2000
    ..The impact of drugs affecting norepinephrine and gamma-aminobutyric acid have been among the most extensively studied in the laboratory, and preliminary clinical data suggest similar effects in humans...
  45. ncbi request reprint Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse
    L B Goldstein
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Box 3651, Duke University Medical Center, Durham, NC 27710, USA
    Neuroscience 99:705-10. 2000
    ..79, P=0.12). These data suggest that motor recovery after unilateral injury to the sensorimotor cortex does not vary with apolipoprotein E genotype...
  46. doi request reprint Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial
    Larry B Goldstein
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:3526-31. 2009
    ..We analyzed SPARCL trial data to determine whether treatment favorably shifts the distribution of severities of ischemic cerebrovascular outcomes...
  47. doi request reprint The 2009 Feinberg lecture: the continuum of stroke research and policy
    Larry B Goldstein
    Department of Medicine Neurology, Duke Stroke Center, Center for Clinical Health Policy Research, Duke University and Durham VA Medical Center, Durham, NC, USA
    Stroke 40:3879-82. 2009
    ..The discussion provides examples of how several of these approaches can be used to address various research questions. The importance for stroke investigators to contribute to related public policy issues is also reviewed...
  48. doi request reprint Reducing death and disability from stroke: the role of governmental advocacy
    Larry B Goldstein
    Department of Medicine, Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    Stroke 39:2898-901. 2008
    ..Although written from the perspective of the United States, the issues raised are relevant throughout the world...
  49. doi request reprint Statewide hospital-based stroke services in North Carolina: changes over 10 years
    Larry B Goldstein
    Department of Medicine Neurology, Duke Stroke Center, Center for Clinical Health Policy Research, Duke University, and the Durham Department of Veterans Affairs Medical Center, Durham, NC 27710, USA
    Stroke 41:778-83. 2010
    ..The 2003 survey found certain technologies, but not stroke-related programs, were more widely available. The survey was repeated in 2008 to determine whether there was an interval change in accessibility...
  50. ncbi request reprint Physical activity and the risk of stroke
    Larry B Goldstein
    Department of Medicine, Duke Stroke Center, Duke University Medical Center, Durham, NC 27710, USA
    Expert Rev Neurother 10:1263-5. 2010
    ..The results reinforce recommendations that both men and women participate in regular, leisure-time physical activity...
  51. ncbi request reprint Delay between stroke onset and emergency department evaluation
    L B Goldstein
    Department of Medicine Neurology, The Duke Center for Cerebrovascular Disease, and The Center for Clinical Health Policy Research, Duke University, Durham, NC 27710, USA
    Neuroepidemiology 20:196-200. 2001
    ..An increase in the proportion of patients presenting soon after stroke would reflect the effectiveness of these efforts...
  52. ncbi request reprint Medical therapy for acute ischemic stroke
    L B Goldstein
    Duke Center for Cerebrovascular Disease, Stroke Policy Program, Center for Clinical Health Policy Research, Duke University Medical Center, Box 3651, Durham, NC 27710, USA
    Curr Atheroscler Rep 3:299-306. 2001
    ..Medical management can have a large impact on stroke-related outcomes, even in patients who do not receive thrombolytic therapy...
  53. ncbi request reprint Improving the reliability of stroke subgroup classification using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria
    L B Goldstein
    Durham Veterans Affairs Medical Center, Department of Medicine, Duke University, Durham, NC 27710, USA
    Stroke 32:1091-8. 2001
    ..However, the investigators cautioned that disagreements in subtype assignment remain despite the use of these explicit criteria and that trials should include measures to ensure the most uniform diagnosis possible...
  54. ncbi request reprint Novel risk factors for stroke: homocysteine, inflammation, and infection
    L B Goldstein
    Duke Center for Cerebrovascular DiseaseHead, Stroke Policy Program, Center for Clinical Health Policy Research, Box 3651, Duke University Medical Center Durham, NC 27710, USA
    Curr Atheroscler Rep 2:110-4. 2000
    ..The therapeutic implications of these latter associations have not yet been explored...
  55. ncbi request reprint New transient ischemic attack and stroke: outpatient management by primary care physicians
    L B Goldstein
    Department of Medicine Neurology, Box 3651, Duke University Medical Center, Durham, NC 27710
    Arch Intern Med 160:2941-6. 2000
    ..The purpose of the present study was to identify a group of patients seen by primary care physicians in an office setting for a first-ever TIA or stroke and characterize their evaluation and management...
  56. ncbi request reprint Statewide assessment of hospital-based stroke prevention and treatment services in North Carolina: changes over the last 5 years
    Osvaldo Camilo
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Durham, NC 27710, USA
    Stroke 34:2945-50. 2003
    ..The purpose of the present study was to measure changes in these services that may have occurred over the last 5 years...
  57. ncbi request reprint Neurological deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats
    Ali Abdel-Rahman
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Toxicol Environ Health A 67:331-56. 2004
    ....
  58. ncbi request reprint Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Toxicol Environ Health A 71:119-30. 2008
    ..These changes may have long-term adverse health effects in the offspring...
  59. doi request reprint Dysnomia, ataxia, choreoathetosis, sensory impairment, and gait imbalance after lentiform nucleus stroke
    Andrew D Galbreath
    Department of Medicine, Division of Neurology, Center for Cerebrovascular Disease, Duke University and Durham Department of Veterans Affairs Medical Centers, Durham, North Carolina 27710, USA
    J Stroke Cerebrovasc Dis 18:494-6. 2009
    ..Accurate localization of the lesion to the anterior circulation has potential therapeutic implications...
  60. pmc Predicting aspiration in patients with ischemic stroke: comparison of clinical signs and aerodynamic measures of voluntary cough
    Carol A Smith Hammond
    Durham Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Chest 135:769-77. 2009
    ..We hypothesized that objective measure of voluntary cough would improve the accuracy of the clinical evaluation of swallow to predict those patients who are at risk...
  61. ncbi request reprint Advancing the study of stroke in women: summary and recommendations for future research from an NINDS-Sponsored Multidisciplinary Working Group
    Cheryl D Bushnell
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 37:2387-99. 2006
    ..Besides the role of estrogen there are many gaps of knowledge about issues specific to women and stroke...
  62. ncbi request reprint Statin use and sex-specific stroke outcomes in patients with vascular disease
    Cheryl D Bushnell
    Center for Cerebrovascular Disease, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 37:1427-31. 2006
    ..We investigated the relationships between statin use and sex-specific stroke incidence, severity, and mortality...
  63. ncbi request reprint Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Arch Toxicol 77:452-8. 2003
    ..These data suggest that exposure to either nicotine or chlorpyrifos or a combination of the two may impair neurobehavioral performance and affect the central nervous system cholinergic pathways...
  64. ncbi request reprint Risk of ischemic stroke with tamoxifen treatment for breast cancer: a meta-analysis
    Cheryl D Bushnell
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 63:1230-3. 2004
    ..To assess the overall risk of stroke, specifically ischemic stroke, associated with tamoxifen use by performing a meta-analysis of data reported in breast cancer trials...
  65. ncbi request reprint Cough and aspiration of food and liquids due to oral-pharyngeal dysphagia: ACCP evidence-based clinical practice guidelines
    Carol A Smith Hammond
    Durham VAMC, 508 Fulton St, No 126, Durham, NC 27705, USA
    Chest 129:154S-168S. 2006
    ..Cough may be an indicator of aspiration due to oral-pharyngeal dysphagia...
  66. ncbi request reprint Homocysteine testing in patients with acute ischemic stroke
    Cheryl D Bushnell
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 59:1541-6. 2002
    ....
  67. ncbi request reprint Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 72:881-90. 2002
    ..Ligand binding densities for the m2 muscarinic receptor did not show any change. These results show that low-dose, multiple exposure to uranyl acetate caused prolonged neurobehavioral deficits after the initial exposure has ceased...
  68. ncbi request reprint Physician knowledge and practices in the evaluation of coagulopathies in stroke patients
    Cheryl D Bushnell
    Duke Center for Cerebrovascular Disease, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 33:948-53. 2002
    ..We sought to determine neurologists' views regarding their use of specialized coagulation testing to better understand the possible reasons for these practices...
  69. ncbi request reprint In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Arch Toxicol 80:620-31. 2006
    ..Collectively, this study demonstrates that maternal exposure to environmental neurotoxic chemicals, i.e., nicotine and chlorpyrifos leads to developmental abnormalities in the offspring that persist latter into adulthood...
  70. ncbi request reprint Screening for hypercoagulable syndromes following stroke
    Cheryl Bushnell
    Duke Center for Cerebrovascular Disease, Department of Medicine Neurology, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Curr Atheroscler Rep 5:291-8. 2003
    ..Although the diagnosis of thrombophilia aids in the potential explanation of stroke etiology, the best regimen for secondary prevention treatment for the majority of thrombophilias is still unknown...
  71. ncbi request reprint Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, P O Box 3813, Durham, NC 27710, USA
    Pharmacol Biochem Behav 77:253-62. 2004
    ..These results suggest that exposure to various doses of PB, alone and in combination with DEET and permethrin, leads to sensorimotor deficits and differential alterations of the cholinergic system in the CNS...
  72. ncbi request reprint Sensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Toxicol Sci 66:148-58. 2002
    ..Furthermore, these results show that treatment with either sarin or PB alone resulted in sensorimotor impairments, while coexposure to high doses of sarin with PB caused an exacerbated deficit...
  73. ncbi request reprint Model of recovery of locomotor ability after sensorimotor cortex injury in rats
    Larry B Goldstein
    Duke Center for Cerebrovascular Disease, Department of Medicine Neurology, Duke University and Department of Veterans Affairs Medical Center, Durham, NC, USA
    ILAR J 44:125-9. 2003
    ..The model has proven particularly useful in predicting the effects of drugs on poststroke recovery in humans...
  74. doi request reprint Lack of impact of paramedic training and use of the cincinnati prehospital stroke scale on stroke patient identification and on-scene time
    Daniel M Frendl
    Duke University, Durham, NC, USA
    Stroke 40:754-6. 2009
    ..Data evaluating its performance in the field are limited. We assessed the impact of training and use of the CPSS on the accuracy of paramedics' stroke patient identification and on-scene time...
  75. ncbi request reprint Non-atherosclerotic vascular disease in the young
    Osvaldo Camilo
    Department of Medicine Neurology, Duke Center for Cerebrovascular Disease, Duke University, Durham, NC 27710, USA
    J Thromb Thrombolysis 20:93-103. 2005
    ..Moyamoya can be idiopathic (moyamoya disease) or the result of other conditions. An appreciation of the unusual causes of stroke in the young is important when considering secondary prevention measures...
  76. ncbi request reprint Lower stroke-related mortality in counties with stroke centers: North Carolina Stroke Facilities Survey
    Osvaldo Camilo
    Department of Medicine Neurology, Duke University, Durham, NC, USA
    Neurology 64:762-3. 2005
  77. doi request reprint Antithrombotic therapy for ischemic stroke: guidelines translated for the clinician
    Anandi Krishnan
    Duke Clinical Research Institute, Duke University Medical Center, Box 3850, 27710, Durham, NC, USA
    J Thromb Thrombolysis 29:368-77. 2010
    ..Future directions are also reviewed, with particular emphasis on improving therapeutic options early after stroke onset...
  78. ncbi request reprint American Heart Association guide for improving cardiovascular health at the community level: a statement for public health practitioners, healthcare providers, and health policy makers from the American Heart Association Expert Panel on Population and Pre
    Thomas A Pearson
    Circulation 107:645-51. 2003
  79. ncbi request reprint Contrast-enhanced magnetic resonance angiography of carotid arteries: utility in routine clinical practice
    Dean C C Johnston
    Department of Medicine Neurology, University of British Columbia, Center for Health Evaluation and Outcome Sciences, St Paul s Hospital, Vancouver, British Columbia, Canada
    Stroke 33:2834-8. 2002
    ..Contrast-enhanced magnetic resonance angiography (CEMRA) is among the newer noninvasive tests used for the evaluation of patients with carotid artery disease. Evidence supporting its utility in routine clinical practice is lacking...
  80. ncbi request reprint Guidelines for the early management of patients with ischemic stroke: A scientific statement from the Stroke Council of the American Stroke Association
    Harold P Adams
    Stroke 34:1056-83. 2003
  81. ncbi request reprint Patient safety in trials of therapy for acute ischemic stroke
    Larry B Goldstein
    JAMA 287:987. 2002
  82. ncbi request reprint Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Counc
    Larry B Goldstein
    Stroke 37:1583-633. 2006
    ..This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk...
  83. ncbi request reprint Medicine. Stroke--tPA and the clinic
    John R Marler
    National Institute of Neurological Disorders and Stroke, Bethesda, MD 20817, USA
    Science 301:1677. 2003
    ..These barriers are not insurmountable but will require a concerted effort to overcome...
  84. ncbi request reprint Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Counc
    Larry B Goldstein
    Circulation 113:e873-923. 2006
    ..This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk...
  85. ncbi request reprint Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on C
    Ralph L Sacco
    Circulation 113:e409-49. 2006
    ....
  86. ncbi request reprint High-dose atorvastatin after stroke or transient ischemic attack
    Pierre Amarenco
    Denis Diderot University, Paris
    N Engl J Med 355:549-59. 2006
    ..Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established...
  87. ncbi request reprint Primum non nocere: antithombotics after intracerebral hemorrhage?
    Larry B Goldstein
    Neurology 66:162-3. 2006
  88. ncbi request reprint Efficacy of drug therapy in the secondary prevention of cardiovascular disease and stroke
    Gerald F Fletcher
    Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA
    Am J Cardiol 99:1E-35E. 2007
  89. ncbi request reprint Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on C
    Ralph L Sacco
    Stroke 37:577-617. 2006
    ....
  90. ncbi request reprint Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association
    Harold Adams
    Stroke 36:916-23. 2005
  91. ncbi request reprint Recommendations for the establishment of stroke systems of care: recommendations from the American Stroke Association's Task Force on the Development of Stroke Systems
    Lee H Schwamm
    Stroke 36:690-703. 2005
  92. doi request reprint Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack
    Robert J Adams
    Stroke 39:1647-52. 2008
  93. pmc Impact of comorbidities on ischemic stroke outcomes in women
    Cheryl D Bushnell
    Stroke 39:2138-40. 2008
    ..We assessed the association of prestroke comorbidities with long-term stroke outcomes among women with ischemic stroke...
  94. ncbi request reprint Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, 46, rue Henri Huchard, 75018, Paris, France
    Stroke 38:3198-204. 2007
    ..In this exploratory analysis, our aim was to evaluate the benefit and risks associated with achieving a >or=50% low-density lipoprotein cholesterol (LDL-C) reduction from baseline...
  95. ncbi request reprint Low LDL cholesterol, statins, and brain hemorrhage: should we worry?
    Larry B Goldstein
    Neurology 68:719-20. 2007
  96. ncbi request reprint Editorial comment--Prenatal influences on stroke mortality in England and Wales
    Larry B Goldstein
    Stroke 34:1602-3. 2003

Research Grants4

  1. AMPHETAMINE ENHANCED STROKE RECOVERY--BURKE SRCI GROUP
    Larry Goldstein; Fiscal Year: 2002
    ..However the treatment duration will be increased to a total of 10 sessions. ..
  2. MIDCAREER INVESTIGATOR AWARD IN CEREBROVASCULAR RESEARCH
    Larry Goldstein; Fiscal Year: 2004
    ....