Geoffrey S Ginsburg

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Unsupervised Bayesian linear unmixing of gene expression microarrays
    Cécile Bazot
    University of Toulouse, IRIT INP ENSEEIHT, 2 rue Camichel, BP 7122, 31071 Toulouse cedex 7, France
    BMC Bioinformatics 14:99. 2013
  2. pmc Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond
    Geoffrey S Ginsburg
    Duke University Medical Center, Duke Center for Personalized Medicine, Institute for Genome Sciences and Policy, Durham, NC 27708, USA
    J Clin Oncol 30:4233-42. 2012
  3. pmc Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients
    Michael R Elashoff
    CardioDx, Inc, 2500 Faber Place, Palo Alto, CA 94602, USA
    BMC Med Genomics 4:26. 2011
  4. doi request reprint Genomic and personalized medicine: foundations and applications
    Geoffrey S Ginsburg
    Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Transl Res 154:277-87. 2009
  5. ncbi request reprint Translating genomic biomarkers into clinically useful diagnostics
    Geoffrey S Ginsburg
    Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University, Box 3382, Durham, NC 27708, USA
    Expert Rev Mol Diagn 6:179-91. 2006
  6. ncbi request reprint Public health. Genomics and medicine at a crossroads in Chernobyl
    Geoffrey S Ginsburg
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Science 314:62-3. 2006
  7. ncbi request reprint Prospects for personalized cardiovascular medicine: the impact of genomics
    Geoffrey S Ginsburg
    Division of Cardiovascular Medicine, Department of Medicine, Institute for Genome Sciences and Policy, Center for Genomic Medicine, Duke University, Durham, North Carolina 27708, USA
    J Am Coll Cardiol 46:1615-27. 2005
  8. doi request reprint Academic medical centers: ripe for rapid-learning personalized health care
    Geoffrey S Ginsburg
    Center for Genomic Medicine, Duke Institute for Genome Science and Policy, Duke University Health System, Durham, NC 27708, USA
    Sci Transl Med 3:101cm27. 2011
  9. doi request reprint Centralized biorepositories for genetic and genomic research
    Geoffrey S Ginsburg
    Center for Genomic Medicine, Duke Institute for Genome Sciences and Policy, Durham, NC 27708, USA
    JAMA 299:1359-61. 2008
  10. ncbi request reprint Taking cardiovascular genetic association studies to the next level
    Geoffrey S Ginsburg
    Duke Institute for Genome Sciences and Policy, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 50:930-2. 2007

Detail Information

Publications77

  1. pmc Unsupervised Bayesian linear unmixing of gene expression microarrays
    Cécile Bazot
    University of Toulouse, IRIT INP ENSEEIHT, 2 rue Camichel, BP 7122, 31071 Toulouse cedex 7, France
    BMC Bioinformatics 14:99. 2013
    ..A Gibbs sampling strategy is adopted here to generate random samples according to the posterior distribution of the factors, factor scores, and number of factors. These samples are then used to estimate all the unknown parameters...
  2. pmc Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond
    Geoffrey S Ginsburg
    Duke University Medical Center, Duke Center for Personalized Medicine, Institute for Genome Sciences and Policy, Durham, NC 27708, USA
    J Clin Oncol 30:4233-42. 2012
    ..The integration of CER methodology and genomics linked to RLHC should enhance, expedite, and expand the evidence generation required for fully realizing personalized cancer care...
  3. pmc Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients
    Michael R Elashoff
    CardioDx, Inc, 2500 Faber Place, Palo Alto, CA 94602, USA
    BMC Med Genomics 4:26. 2011
    ..A non-invasive blood test that could reliably assess obstructive CAD likelihood would have diagnostic utility...
  4. doi request reprint Genomic and personalized medicine: foundations and applications
    Geoffrey S Ginsburg
    Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Transl Res 154:277-87. 2009
    ....
  5. ncbi request reprint Translating genomic biomarkers into clinically useful diagnostics
    Geoffrey S Ginsburg
    Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University, Box 3382, Durham, NC 27708, USA
    Expert Rev Mol Diagn 6:179-91. 2006
    ..In addition, efforts will be needed to educate health professionals and the public about genomics-based tools, revise regulatory oversight mechanisms, and ensure privacy safeguards of the information generated from these new tests...
  6. ncbi request reprint Public health. Genomics and medicine at a crossroads in Chernobyl
    Geoffrey S Ginsburg
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Science 314:62-3. 2006
  7. ncbi request reprint Prospects for personalized cardiovascular medicine: the impact of genomics
    Geoffrey S Ginsburg
    Division of Cardiovascular Medicine, Department of Medicine, Institute for Genome Sciences and Policy, Center for Genomic Medicine, Duke University, Durham, North Carolina 27708, USA
    J Am Coll Cardiol 46:1615-27. 2005
    ....
  8. doi request reprint Academic medical centers: ripe for rapid-learning personalized health care
    Geoffrey S Ginsburg
    Center for Genomic Medicine, Duke Institute for Genome Science and Policy, Duke University Health System, Durham, NC 27708, USA
    Sci Transl Med 3:101cm27. 2011
    ..Academic medical centers can play a central role in this transformation through the development of rapid learning environments, evidence generation, implementation research, and education of health professionals and the public...
  9. doi request reprint Centralized biorepositories for genetic and genomic research
    Geoffrey S Ginsburg
    Center for Genomic Medicine, Duke Institute for Genome Sciences and Policy, Durham, NC 27708, USA
    JAMA 299:1359-61. 2008
  10. ncbi request reprint Taking cardiovascular genetic association studies to the next level
    Geoffrey S Ginsburg
    Duke Institute for Genome Sciences and Policy, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 50:930-2. 2007
    ..Consideration of these principles should provide insight into disease biology based on genetic findings and encourage their meaningful adoption into clinical practice...
  11. pmc Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events
    Deepak Voora
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina Department of Medicine, Duke University, Durham, North Carolina Electronic address
    J Am Coll Cardiol 62:1267-76. 2013
    ..The aim of this study was to develop ribonucleic acid (RNA) profiles that could serve as novel biomarkers for the response to aspirin...
  12. pmc Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response
    Deepak Voora
    Division of Cardiovascular Medicine, the Institute for Genome and Science Policy, and the Center for Human Genetics, Duke University, Durham, NC 27708, USA
    Circ Cardiovasc Genet 1:100-6. 2008
    ..There is interindividual variation in low-density lipoprotein cholesterol (LDLc) lowering by statins and limited study into the genetic associations of the dose dependant LDLc lowering by statins...
  13. doi request reprint Detection of viruses via statistical gene expression analysis
    Minhua Chen
    Department of Electrical and Computer Engineering, Duke University, Durham, NC 90291 USA
    IEEE Trans Biomed Eng 58:468-79. 2011
    ..g., bacteria). In addition to analyzing these new datasets, we provide a detailed analysis of the bayesian ENet and compare it to related models...
  14. doi request reprint Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events
    Svati H Shah
    Department of Medicine, Duke University, Durham, NC, USA
    Circ Cardiovasc Genet 3:207-14. 2010
    ..Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events...
  15. pmc Gene expression signatures of radiation response are specific, durable and accurate in mice and humans
    Sarah K Meadows
    Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 3:e1912. 2008
    ..Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures...
  16. pmc A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities
    Katherine S Garman
    Institute for Genome Sciences and Policy and Department of Medicine, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 105:19432-7. 2008
    ..An ability to move beyond current staging by refining the estimation of prognosis in early stage colon cancer also has implications for individualized therapy...
  17. pmc Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome
    William T Barry
    Department of Biostatistics, Duke University Medical Center, Medical Center Box 3712, Durham, NC 27710, USA
    J Clin Oncol 28:2198-206. 2010
    ..Here, we investigate the additional impact of intratumor heterogeneity, a largely unstudied component of variance, on the performance of several microarray-based assays in breast cancer...
  18. pmc Gene expression signatures that predict radiation exposure in mice and humans
    Holly K Dressman
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Med 4:e106. 2007
    ..The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure to ionizing radiation...
  19. pmc Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study
    Sunil Suchindran
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 6:e1000928. 2010
    ..3 near the PLA2G7 gene. Our analyses demonstrate that genetic polymorphisms may contribute to inter-individual variation in Lp-PLA(2) activity and mass...
  20. pmc Effect of genetic testing for risk of type 2 diabetes mellitus on health behaviors and outcomes: study rationale, development and design
    Alex H Cho
    Center for Personalized Medicine, Duke University, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    BMC Health Serv Res 12:16. 2012
    ....
  21. doi request reprint Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections
    Micah T McClain
    Durham VA Medical Center, Durham, NC, United States Division of Infectious Diseases, Duke University Medical Center, Durham, NC, United States Electronic address
    J Clin Virol 58:689-95. 2013
    ..However, most published work is limited to a single timepoint at initial presentation to a medical provider, which may correspond to widely varying points in the course of disease...
  22. ncbi request reprint Genomic signatures to guide the use of chemotherapeutics
    Anil Potti
    Duke Institute for Genome Sciences and Policy, Duke University, Box 3382, Durham, North Carolina 27710, USA
    Nat Med 12:1294-300. 2006
    ..The development of gene expression profiles that can predict response to commonly used cytotoxic agents provides opportunities to better use these drugs, including using them in combination with existing targeted therapies...
  23. pmc Public knowledge of and attitudes toward genetics and genetic testing
    Susanne B Haga
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Genet Test Mol Biomarkers 17:327-35. 2013
    ..Variable health literacy and genetic knowledge may pose significant challenges to engaging the general public in personal genomics, specifically with respect to promoting risk comprehension and healthy behaviors...
  24. pmc A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2
    Christopher W Woods
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 8:e52198. 2013
    ..The host genomic response to Influenza infection is robust and may provide the means for detection before typical clinical symptoms are apparent...
  25. pmc Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study
    Ornit Chiba-Falek
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    BMC Med Genet 11:9. 2010
    ..However, the mechanism underlying this gene by sex interaction has not been explored...
  26. ncbi request reprint Gene expression analysis of cardiovascular diseases: novel insights into biology and clinical applications
    David Seo
    Division of Cardiology, Department of Medicine and Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710 0001, USA
    J Am Coll Cardiol 48:227-35. 2006
    ..This paper highlights the progress that has been made in using gene expression analysis cardiovascular genomic research and the potential for applying these findings in clinical medicine...
  27. pmc Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis
    Svati H Shah
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 5:e1000318. 2009
    ..We conclude that NPY contributes to atherosclerosis pathogenesis...
  28. doi request reprint A host-based RT-PCR gene expression signature to identify acute respiratory viral infection
    Aimee K Zaas
    Institute for Genome Sciences and Policy, Duke University School of Medicine, Durham, NC 27710, USA
    Sci Transl Med 5:203ra126. 2013
    ....
  29. pmc Examining the impact of genetic testing for type 2 diabetes on health behaviors: study protocol for a randomized controlled trial
    Corrine I Voils
    Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA
    Trials 13:121. 2012
    ....
  30. pmc Genomic medicine: genetic variation and its impact on the future of health care
    Huntington F Willard
    Institute for Genome Sciences and Policy, Duke University, CIEMAS 2376, 101 Science Drive, Durham, NC 27708, USA
    Philos Trans R Soc Lond B Biol Sci 360:1543-50. 2005
    ....
  31. pmc Time-dependent changes in non-COX-1-dependent platelet function with daily aspirin therapy
    Deepak Voora
    Institute for Genome Sciences and Policy, Duke University, 905 S Lasalle Dr, DUMC Box 3445, Durham, NC 27710, USA
    J Thromb Thrombolysis 33:246-57. 2012
    ..Despite suppression of COX-1 activity, NCDPF during aspirin therapy is predictably dynamic: those with heightened NCDPF continue to decline whereas those with low/normal NCDPF return to pre-aspirin levels over time...
  32. pmc Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling
    Susanne B Haga
    Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    J Gen Intern Med 26:834-40. 2011
    ..There is considerable controversy as to how, and even whether, to incorporate these tests into routine medical care...
  33. pmc A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine
    Kensaku Kawamoto
    Division of Clinical Informatics, Department of Community and Family Medicine, Box 104007, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Med Inform Decis Mak 9:17. 2009
    ..Genomic and personalized medicine could transform healthcare systems and catalyze significant reductions in morbidity, mortality, and overall healthcare costs...
  34. doi request reprint Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer
    Chaitanya R Acharya
    Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    JAMA 299:1574-87. 2008
    ..Gene expression profiling may be useful for prognostic and therapeutic strategies in breast carcinoma...
  35. doi request reprint Genomic medicine: a decade of successes, challenges, and opportunities
    Jeanette J McCarthy
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Sci Transl Med 5:189sr4. 2013
    ....
  36. pmc Patient and primary care provider experience using a family health history collection, risk stratification, and clinical decision support tool: a type 2 hybrid controlled implementation-effectiveness trial
    R Ryanne Wu
    Health Services Research and Development, VA Health System, Durham, NC, USA
    BMC Fam Pract 14:111. 2013
    ..Here we present data on the experience of patients and providers after integration of MeTree into 2 primary care practices...
  37. ncbi request reprint Development and validation of a primary care-based family health history and decision support program (MeTree)
    Lori A Orlando
    Department of Medicine, Duke University, Durham, North Carolina 27705, USA
    N C Med J 74:287-96. 2013
    ..MeTree is designed for integration into primary care practices as part of the genomic medicine model for primary care...
  38. pmc Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans
    Sun Hee Ahn
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, North Carolina, USA
    PLoS ONE 8:e48979. 2013
    ..Furthermore, this study advances our understanding of S. aureus infection; the host response to it; and identifies new diagnostic and therapeutic avenues...
  39. pmc Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease
    Peter R Sinnaeve
    Duke University Medical Center and Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 4:e7037. 2009
    ..In conclusion, the simultaneous expression pattern of 160 genes in whole blood correlates with the severity of coronary artery disease and mirrors expression changes in the atherosclerotic vascular wall...
  40. pmc Evaluation of the PharmGKB knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays
    Kensaku Kawamoto
    Division of Clinical Informatics, Department of Community and Family Medicine, Duke University, Durham, NC, USA
    AMIA Annu Symp Proc 2009:307-11. 2009
    ..Thus, we conclude that PharmGKB can facilitate the systematic assessment of pharmacogenetic assays through the efficient identification of relevant peer-reviewed manuscripts...
  41. doi request reprint High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients
    Keyur Patel
    Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    Hepatology 53:1809-18. 2011
    ..A model averaging approach for identified peptides resulted in an AUROC of 0.86 in the validation cohort, and correctly identified virologic response in 71% of patients without the favorable IL28B "responder" genotype...
  42. ncbi request reprint Genetic profiling and tailored therapy in asthma: are we there yet?
    Njira L Lugogo
    Duke University Medical Center, Division of Pulmonary, Allergy and Critical Care Medicine, PO Box 2629, Durham, NC 27710, USA
    Curr Opin Mol Ther 9:528-37. 2007
    ....
  43. pmc Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies
    Bo Chen
    Electrical and Computer Engineering Department, Duke University, Durham, NC, USA
    BMC Bioinformatics 11:552. 2010
    ..The posterior density function on the model parameters is computed using Gibbs sampling and variational Bayesian (VB) analysis...
  44. pmc The Biomedical Resource Ontology (BRO) to enable resource discovery in clinical and translational research
    Jessica D Tenenbaum
    Duke Translational Medicine Institute, Duke University School of Medicine, Durham, NC, USA
    J Biomed Inform 44:137-45. 2011
    ....
  45. doi request reprint Blood gene expression signatures predict invasive candidiasis
    Aimee K Zaas
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Sci Transl Med 2:21ra17. 2010
    ..Our results demonstrate a temporal pattern of host molecular responses that distinguish candidemia from S. aureus-induced bacteremia and establish a novel paradigm for infectious disease diagnosis...
  46. doi request reprint Clinical application of cardiovascular pharmacogenetics
    Deepak Voora
    Duke Institute for Genome Science and Policy, Duke University, Durham, NC 27708, USA
    J Am Coll Cardiol 60:9-20. 2012
    ..Until the evidentiary gaps are filled, however, clinicians may choose to target therapeutics to individual patients whose genetic background indicates that they stand to benefit the most from pharmacogenetic testing...
  47. pmc Consideration of patient preferences and challenges in storage and access of pharmacogenetic test results
    Susanne B Haga
    Institute for Genome Sciences and Policy and Sanford School of Public Policy, Duke University, Durham, NC 27708, USA
    Genet Med 13:887-90. 2011
    ..We aimed to assess public interest and concerns regarding sharing and storage of pharmacogenetic test results that would facilitate the reuse of pharmacogenetic data across a lifetime of care...
  48. doi request reprint A hub for bench-to-bedside pharmacogenomic-based research
    Deepak Voora
    Institute for Genome Sciences and Policy, Center for Genomic Medicine, 101 Science Drive, Duke University, DUMC Box 3382, Durham, NC 27708, USA
    Pharmacogenomics 12:1095-8. 2011
    ..These new treatment paradigms can, potentially, ensure that the right dose of the right drug is prescribed to the right individual - an often stated goal of personalized medicine and pharmacogenomics...
  49. ncbi request reprint A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer
    Anil Potti
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    N Engl J Med 355:570-80. 2006
    ..Indeed, approximately 25 percent of patients with stage IA disease have a recurrence after surgery, suggesting the need to identify patients in this subgroup for more effective therapy...
  50. doi request reprint Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics
    Hsin Neng Wang
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Anal Chim Acta 786:153-8. 2013
    ....
  51. pmc Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism
    Deborah A Lewis
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Thromb Res 128:536-40. 2011
    ..Identification of patients at risk for recurrent venous thromboembolism would facilitate decisions concerning the duration of anticoagulant therapy...
  52. doi request reprint Personalized medicine: progress and promise
    Isaac S Chan
    Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Annu Rev Genomics Hum Genet 12:217-44. 2011
    ..This review focuses on providing a comprehensive understanding of personalized medicine, from scientific discovery at the laboratory bench to integration of these novel ways of understanding human biology at the bedside...
  53. ncbi request reprint Genomic medicine: bringing biomarkers to clinical medicine
    David Seo
    Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Chem Biol 9:381-6. 2005
    ..This review highlights both the opportunities and challenges in bringing biomarkers into clinical medicine...
  54. pmc The SLCO1B1*5 genetic variant is associated with statin-induced side effects
    Deepak Voora
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina 27708, USA
    J Am Coll Cardiol 54:1609-16. 2009
    ..We sought to identify single nucleotide polymorphisms associated with mild statin-induced side effects...
  55. pmc High heritability of metabolomic profiles in families burdened with premature cardiovascular disease
    Svati H Shah
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Mol Syst Biol 5:258. 2009
    ..27). We report a novel finding of high heritabilities of metabolites in premature CAD, establishing a possible genetic basis for these profiles. These results have implications for understanding CAD pathophysiology and genetics...
  56. ncbi request reprint Embracing the complexity of genomic data for personalized medicine
    Mike West
    Duke Institute for Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Durham, NC 27710, USA
    Genome Res 16:559-66. 2006
    ..All forms of potentially relevant data should be examined, with particular emphasis on understanding the interactions, complementarities, and possible conflicts among gene expression, genetic, and clinical markers of risk...
  57. ncbi request reprint Genomic analyses: a neonatology perspective
    C Michael Cotten
    From the Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Pediatr 148:720-6. 2006
  58. pmc Peripheral blood gene expression profiling for cardiovascular disease assessment
    Hamza Aziz
    School of Medicine, Duke University, Durham, USA
    Genomic Med 1:105-12. 2007
    ....
  59. doi request reprint A novel diagnostic approach may reduce inappropriate antibiotic use for acute respiratory infections
    Lori L Hudson
    Department of Medicine, Duke University School of Medicine, Duke University, Durham, NC 27710, USA
    Expert Rev Anti Infect Ther 12:279-82. 2014
    ....
  60. pmc H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25797. 2011
    ..In contrast, a history of recent seasonal trivalent vaccine in younger adults was not associated with protection...
  61. ncbi request reprint Prescribing BiDil: is it black and white?
    Susanne B Haga
    Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    J Am Coll Cardiol 48:12-4. 2006
    ..Until more accurate selection criteria are developed to identify patients who are most likely to benefit, both clinicians and the general public will need to consider the unique issues raised by BiDil...
  62. ncbi request reprint Implications of pharmacogenomics for drug development and clinical practice
    Geoffrey S Ginsburg
    Department of Medicine, School of Medicine, Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    Arch Intern Med 165:2331-6. 2005
    ..Although the potential of these technologies is driving change in the development of clinical sciences, it remains to be seen which health care systems level needs will be addressed...
  63. pmc Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans
    Aimee K Zaas
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Duke University, Durham, NC 27710, USA
    Cell Host Microbe 6:207-17. 2009
    ..These results demonstrate that ARIs induce changes in human peripheral blood gene expression that can be used to diagnose a viral etiology of respiratory infection and triage symptomatic individuals...
  64. pmc Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease
    Albert K Luo
    Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Med Genet 44:161-5. 2007
    ..In this paper, salient issues to facilitate research in this important field are reviewed...
  65. ncbi request reprint An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer
    Holly K Dressman
    Division of Gynecologic Surgical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Clin Oncol 25:517-25. 2007
    ..We have used gene expression profiles to identify patients likely to be resistant to primary platinum-based chemotherapy and also to identify alternate targeted therapeutic options for patients with de novo platinum-resistant disease...
  66. ncbi request reprint The path to personalized medicine
    Joanne M Meyer
    Millennium Pharmaceuticals, Inc, 45 Sidney Street, Cambridge, MA 02139, USA
    Curr Opin Chem Biol 6:434-8. 2002
    ..Successful personalized medicine research programs will not only require strategies for developing and validating biomarkers, but also coordinating these efforts with drug discovery and clinical development...
  67. ncbi request reprint Integration of molecular diagnostics with therapeutics: implications for drug discovery and patient care
    Jeffrey S Ross
    Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208, USA
    Expert Rev Mol Diagn 2:531-41. 2002
    ..For the diagnostics industry this represents an unprecedented opportunity for integration, increased value and commercial opportunities for molecularly-derived tests...
  68. ncbi request reprint The Personalized Medicine Coalition: goals and strategies
    Edward Abrahams
    Personalized Medicine Coalition, Washington, DC 20005, USA
    Am J Pharmacogenomics 5:345-55. 2005
    ....
  69. ncbi request reprint The integration of molecular diagnostics with therapeutics. Implications for drug development and pathology practice
    Jeffrey S Ross
    Dept of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208, USA
    Am J Clin Pathol 119:26-36. 2003
    ....
  70. pmc Genomic Medicine: 'grand challenges' in the translation of genomics to human health
    Geoffrey S Ginsburg
    Eur J Hum Genet 16:873-4. 2008
  71. ncbi request reprint Microarrays coming of age in cardiovascular medicine: standards, predictions, and biology
    Geoffrey S Ginsburg
    J Am Coll Cardiol 48:1618-20. 2006
  72. ncbi request reprint Task Force on Strategic Research Direction: Basic Science Subgroup key science topics report
    Joseph Loscalzo
    Circulation 106:e149-61. 2002
  73. ncbi request reprint Highlights of the Year in JACC 2006
    Anthony N Demaria
    Cardiology Division, University of California San Diego, 92103 9000, USA
    J Am Coll Cardiol 49:509-27. 2007
  74. doi request reprint Highlights of the year in JACC 2007
    Anthony N Demaria
    Cardiology Division, University of California San Diego, San Diego, California 92103 8411, USA
    J Am Coll Cardiol 51:490-512. 2008
  75. ncbi request reprint Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate
    Alex Parker
    Millennium Pharmaceuticals Inc, Cambridge, Massachusetts, USA
    J Rheumatol 34:1817-22. 2007
    ..We analyzed association of gene expression with disease activity, rheumatoid factor (RF), age, sex, disease duration, treatment modality, and clinical response...
  76. ncbi request reprint A framework to evaluate the economic impact of pharmacogenomics
    Sarah C Stallings
    Massachusetts Institute of Technology Program on the Pharmaceutical Industry MIT POPI and Department of Biology, USA
    Pharmacogenomics 7:853-62. 2006
    ..This paper describes a framework using health claims data for analyzing the potential value of pharmacogenomic testing in clinical practice...
  77. ncbi request reprint Targeted therapies for cancer 2004
    Jeffrey S Ross
    Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA
    Am J Clin Pathol 122:598-609. 2004
    ....