Rasheed Gbadegesin

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA
    Pediatr Nephrol 24:281-5. 2009
  2. pmc Pathogenesis and therapy of focal segmental glomerulosclerosis: an update
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Nephrol 26:1001-15. 2011
  3. ncbi request reprint Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2)
    Bernward G Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    Pediatrics 119:e907-19. 2007
  4. pmc TNXB mutations can cause vesicoureteral reflux
    Rasheed A Gbadegesin
    Divisions of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 24:1313-22. 2013
  5. pmc Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study
    Debbie S Gipson
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, 1500 E Medical Center Drive, SPC5297, Ann Arbor, MI 48109 5297, USA
    Health Qual Life Outcomes 11:30. 2013
  6. pmc A new locus for familial FSGS on chromosome 2p
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 21:1390-7. 2010
  7. pmc Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome
    Saskia F Heeringa
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 5646, USA
    Nephrol Dial Transplant 23:3527-33. 2008
  8. pmc Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Am Soc Nephrol 19:365-71. 2008
  9. pmc COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
    Saskia F Heeringa
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 121:2013-24. 2011
  10. doi request reprint Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome
    Gil Chernin
    Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
    Pediatr Nephrol 23:1455-60. 2008

Detail Information

Publications17

  1. pmc Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA
    Pediatr Nephrol 24:281-5. 2009
    ..Kindreds appropriate for genome-wide screening are currently being subjected to analysis with the aim of identifying other genetic causes of FSGS...
  2. pmc Pathogenesis and therapy of focal segmental glomerulosclerosis: an update
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Nephrol 26:1001-15. 2011
    ..This review focuses on recent advances in the molecular pathogenesis of FSGS and currently available therapeutic agents as well as potential novel therapies...
  3. ncbi request reprint Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2)
    Bernward G Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    Pediatrics 119:e907-19. 2007
    ..Therefore, we analyzed all 4 of the genes jointly in a large European cohort of 89 children from 80 families with nephrotic syndrome manifesting in the first year of life and characterized genotype/phenotype correlations...
  4. pmc TNXB mutations can cause vesicoureteral reflux
    Rasheed A Gbadegesin
    Divisions of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 24:1313-22. 2013
    ..Taken together, these results suggest that mutations in TNXB can cause hereditary VUR. ..
  5. pmc Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study
    Debbie S Gipson
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, 1500 E Medical Center Drive, SPC5297, Ann Arbor, MI 48109 5297, USA
    Health Qual Life Outcomes 11:30. 2013
    ..Successful measurement of patient reported outcomes will contribute to our understanding of the impact of NS on children and adolescents...
  6. pmc A new locus for familial FSGS on chromosome 2p
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 21:1390-7. 2010
    ..These data support a new gene locus for familial FSGS on chromosome 2p15. Identification of the mutated gene at this locus may provide further insight into the disease mechanisms of FSGS...
  7. pmc Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome
    Saskia F Heeringa
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 5646, USA
    Nephrol Dial Transplant 23:3527-33. 2008
    ..So far, more than 80 different mutations of NPHS1 causing CNF have been published...
  8. pmc Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Am Soc Nephrol 19:365-71. 2008
    ..Because the age of onset can vary by several years among those with identical mutations, additional factors may modify the phenotype...
  9. pmc COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
    Saskia F Heeringa
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 121:2013-24. 2011
    ..These data suggest that coenzyme Q10-related forms of SRNS and hearing loss can be molecularly identified and potentially treated...
  10. doi request reprint Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome
    Gil Chernin
    Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
    Pediatr Nephrol 23:1455-60. 2008
    ..Knowledge of mutation rate of NPHS2 in different populations of SRNS patients facilitates the physician in planning a suitable genetic screening strategy for patients...
  11. pmc TRPC6 enhances angiotensin II-induced albuminuria
    Jason Eckel
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 22:526-35. 2011
    ..Our findings suggest that TRPC6 promotes albuminuria, perhaps by promoting angiotensin II-dependent increases in Ca(2+), suggesting that TRPC6 blockade may be therapeutically beneficial in proteinuric kidney disease...
  12. doi request reprint Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium
    Caroline Straatmann
    Department of Pediatrics, Louisiana State University Health Sciences Center, 200 Henry Clay Avenue, New Orleans, LA 70118, USA
    Pediatr Nephrol 28:1235-41. 2013
    ..These patients with late steroid resistance (LSR) are often treated with immunosuppressant medications, but the effect of these additional drugs on the long-term prognosis of LSR is still unknown...
  13. ncbi request reprint Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 38:1397-405. 2006
    ..These findings, together with the zebrafish model of human nephrotic syndrome generated by plce1 knockdown, open new inroads into pathophysiology and treatment mechanisms of nephrotic syndrome...
  14. doi request reprint Significance of hemolysis on extracorporeal life support after cardiac surgery in children
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Nephrol 24:589-95. 2009
    ..In conclusion, elevated FHb levels were associated with renal dysfunction and death during ECLS in children undergoing cardiac surgery. Further studies are needed to elucidate the cause-effect relationship in our findings...
  15. ncbi request reprint Mutational analysis of NPHS2 and WT1 in frequently relapsing and steroid-dependent nephrotic syndrome
    Rasheed Gbadegesin
    Department of Pediatrics, Division of Nephrology, Ann Arbor, MI 48109, USA
    Pediatr Nephrol 22:509-13. 2007
    ..0 in SRNS patients; p < 0.001). No NPHS2 or WT1 mutations were found in patients with FRNS/SDNS and uncomplicated SSNS. The hypothesis that FRNS/SDNS may be associated with heterozygous mutations in NPHS2 or WT1 was not confirmed...
  16. doi request reprint Arterial compliance in adolescents and young adults receiving chronic hemodialysis
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27157, USA
    Ren Fail 30:591-6. 2008
    ..Longitudinal studies with a larger sample size are needed to confirm our observation and speculation...
  17. pmc Therapeutic targets in focal and segmental glomerulosclerosis
    Peter J Lavin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Nephrol Hypertens 17:386-92. 2008
    ....