R R Gainetdinov

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Mesolimbic dopamine in obesity and diabetes
    Raul R Gainetdinov
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Regul Integr Comp Physiol 293:R601-2. 2007
  2. ncbi request reprint Monoamine transporter pharmacology and mutant mice
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Dept of Cell Biology, Box 3287, Duke University Medical Center, Durham, NC 27710, USA
    Trends Pharmacol Sci 23:367-73. 2002
  3. ncbi request reprint Desensitization of G protein-coupled receptors and neuronal functions
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Neurosci 27:107-44. 2004
  4. ncbi request reprint Dopamine transporter mutant mice in experimental neuropharmacology
    Raul R Gainetdinov
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Naunyn Schmiedebergs Arch Pharmacol 377:301-13. 2008
  5. ncbi request reprint Monoamine transporters: from genes to behavior
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Pharmacol Toxicol 43:261-84. 2003
  6. ncbi request reprint Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
    F Xu
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 3:465-71. 2000
  7. ncbi request reprint Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice
    F Fumagalli
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 19:2424-31. 1999
  8. ncbi request reprint Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
    R R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:397-401. 1999
  9. ncbi request reprint Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter
    F Fumagalli
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 18:4861-9. 1998
  10. ncbi request reprint Loss of autoreceptor functions in mice lacking the dopamine transporter
    S R Jones
    Howard Hughes Medical Institute, Department of Cell Biology, North Carolina, USA
    Nat Neurosci 2:649-55. 1999

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Mesolimbic dopamine in obesity and diabetes
    Raul R Gainetdinov
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Regul Integr Comp Physiol 293:R601-2. 2007
  2. ncbi request reprint Monoamine transporter pharmacology and mutant mice
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Dept of Cell Biology, Box 3287, Duke University Medical Center, Durham, NC 27710, USA
    Trends Pharmacol Sci 23:367-73. 2002
    ..In this review, we summarize recent insights into the pharmacology of psychotropic drugs using mice in which the genes encoding these transporters have been deleted...
  3. ncbi request reprint Desensitization of G protein-coupled receptors and neuronal functions
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Neurosci 27:107-44. 2004
    ..Furthermore, the utility of a pharmacological strategy aimed at targeting this GPCR desensitization machinery to regulate brain functions can be envisaged...
  4. ncbi request reprint Dopamine transporter mutant mice in experimental neuropharmacology
    Raul R Gainetdinov
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Naunyn Schmiedebergs Arch Pharmacol 377:301-13. 2008
    ....
  5. ncbi request reprint Monoamine transporters: from genes to behavior
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Pharmacol Toxicol 43:261-84. 2003
    ..In the present review, we summarize recent advances in understanding the physiology and pharmacology of monoamine transporters gained in mice with targeted genetic deletion of DAT, SERT, and NET...
  6. ncbi request reprint Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
    F Xu
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 3:465-71. 2000
    ..Thus altering NET expression significantly modulates midbrain dopaminergic function, an effect that may be an important component of the actions of antidepressants and psychostimulants...
  7. ncbi request reprint Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice
    F Fumagalli
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 19:2424-31. 1999
    ....
  8. ncbi request reprint Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
    R R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:397-401. 1999
    ..The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants...
  9. ncbi request reprint Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter
    F Fumagalli
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 18:4861-9. 1998
    ..These observations demonstrate that DAT is required for, and DA is an essential mediator of, METH-induced striatal dopaminergic neurotoxicity, whereas serotonergic deficits are only partially dependent on DAT...
  10. ncbi request reprint Loss of autoreceptor functions in mice lacking the dopamine transporter
    S R Jones
    Howard Hughes Medical Institute, Department of Cell Biology, North Carolina, USA
    Nat Neurosci 2:649-55. 1999
    ..Direct assessment of impulse-, synthesis- and release-regulating autoreceptors in these mice reveals a nearly complete loss of function. These findings may provide insight into the neurochemical consequences of hyperdopaminergia...
  11. ncbi request reprint Mice lacking the dopamine transporter display altered regulation of distal colonic motility
    J K Walker
    Howard Hughes Medical Institute, Departments of Cell Biology and Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 279:G311-8. 2000
    ..The fact that spontaneous phasic and EFS-induced contractile activity were altered by the lack of the DA transporter suggests an important role for endogenous DA in modulating motility of mouse distal colon...
  12. ncbi request reprint Potentiated opioid analgesia in norepinephrine transporter knock-out mice
    L M Bohn
    Howard Hughes Medical Institute, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 20:9040-5. 2000
    ..In summary, these results demonstrate in a genetic model that both endogenous and exogenous opiate-mediated analgesia can be enhanced by elimination of the NET, indicating that the interaction of TCAs with NET mediates these effects...
  13. ncbi request reprint Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter
    S R Jones
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 18:1979-86. 1998
    ..Furthermore, these findings suggest that in the absence of pharmacological manipulation, such as the use of amphetamine, endogenous cytoplasmic DA normally does not reach sufficient concentrations to reverse the DAT...
  14. pmc Profound neuronal plasticity in response to inactivation of the dopamine transporter
    S R Jones
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:4029-34. 1998
    ....
  15. pmc Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
    R R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 98:11047-54. 2001
    ....
  16. ncbi request reprint Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice
    R R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurochem 70:1973-8. 1998
    ....
  17. ncbi request reprint Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
    L M Bohn
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 408:720-3. 2000
    ..However, the deletion of beta-arrestin-2 does not prevent the chronic morphine-induced up-regulation of adenylyl cyclase activity, a cellular marker of dependence, and the mutant mice still become physically dependent on the drug...
  18. ncbi request reprint Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice
    R R Gainetdinov
    Department of Cell Biology, Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 24:1029-36. 1999
    ....
  19. ncbi request reprint G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation
    J K L Walker
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 286:L312-9. 2004
    ..GRK5 regulation of airway responses may have implications in obstructive airway diseases such as asthma or chronic obstructive pulmonary disease...
  20. ncbi request reprint Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene
    Y M Wang
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Biol Psychiatry 46:1124-30. 1999
    ..Careful use of such an animal model can hopefully provide valuable insight into the multiple roles norepinephrine plays in normal and pathological physiology...
  21. ncbi request reprint Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine
    Y M Wang
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 19:1285-96. 1997
    ....
  22. ncbi request reprint Enhanced morphine analgesia in mice lacking beta-arrestin 2
    L M Bohn
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 286:2495-8. 1999
    ..Moreover, they suggest that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence...
  23. pmc A functional alternative splicing mutation in human tryptophan hydroxylase-2
    X Zhang
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 16:1169-76. 2011
    ..However, in combination with other gene variants linked to 5-HT homeostasis, this variant may exhibit important epistatic influences...
  24. ncbi request reprint Dopamine levels modulate the updating of tastant values
    R M Costa
    Department of Neurobiology and Center of Neuroengineering, Duke University Medical Center, Durham, NC, USA
    Genes Brain Behav 6:314-20. 2007
    ..These data suggest that dopamine levels can modulate the updating of tastant values, a finding with implications for understanding sensory-specific motivation and reward seeking...
  25. ncbi request reprint Genetic animal models: focus on schizophrenia
    R R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Dept of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Neurosci 24:527-33. 2001
    ..In this review we discuss how such animal models might be relevant for understanding the neurochemical underpinnings of certain manifestations of schizophrenia...
  26. ncbi request reprint Effects of a psychostimulant drug sydnocarb on rat brain dopaminergic transmission in vivo
    R R Gainetdinov
    Laboratory of Neurochemical Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow
    Eur J Pharmacol 340:53-8. 1997
    ..These data suggest that the stimulant action of sydnocarb is accompanied by a facilitation of central dopaminergic transmission involving an increase in Ca2+-dependent vesicular dopamine efflux...
  27. pmc Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2
    X Zhang
    Department of Cell Biology, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Box 3287, Durham, North Carolina 27710, USA
    Cell Mol Life Sci 63:6-11. 2006
    ..In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2...
  28. ncbi request reprint Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter
    R Bosse
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 19:127-38. 1997
    ..These results reveal an unexpected and important role or DA in the control of developmental events in the pituitary gland and assign a critical role for hypothalamic DA reuptake in regulating these events...
  29. ncbi request reprint Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin
    Michel Cyr
    Neuroscience Research Group, University of Quebec at Trois Rivieres, C P 500, Trois Rivieres, Quebec G9A 5H7, Canada
    FASEB J 20:2541-3. 2006
    ..These findings indicate that dopamine contributes to the deleterious effects of mutated huntingtin on striatal function, and this is accompanied by enhanced formation of huntingtin aggregates...
  30. ncbi request reprint Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction
    Rui M Costa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 52:359-69. 2006
    ..Thus, dopamine-related disorders like Parkinson's disease may not stem from changes in the overall levels of cortical activity, but from dysfunctional activity coordination in corticostriatal circuits...
  31. ncbi request reprint Dopaminergic control of sleep-wake states
    Kafui Dzirasa
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 26:10577-89. 2006
    ..We propose that psychosis and the sleep disturbances experienced by Parkinsonian patients result from dopamine-mediated disturbances of REM sleep...
  32. ncbi request reprint Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    J Biol Chem 281:32072-80. 2006
    ....
  33. ncbi request reprint Dopamine: from pharmacology to molecular biology and back
    Marc G Caron
    Duke University Medical Center, Durham, NC 27710, USA
    Wien Klin Wochenschr 118:565-8. 2006
  34. ncbi request reprint Physiological roles of G protein-coupled receptor kinases and arrestins
    Richard T Premont
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Physiol 69:511-34. 2007
    ....
  35. ncbi request reprint The Akt-GSK-3 signaling cascade in the actions of dopamine
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Pharmacol Sci 28:166-72. 2007
    ....
  36. ncbi request reprint G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice
    Laura M Bohn
    Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Neuromolecular Med 5:41-50. 2004
    ..Therefore, the regulation of GPCRs may have bearing on the neuronal adaptations that underlie the reinforcing properties of drugs of abuse...
  37. doi request reprint A beta-arrestin 2 signaling complex mediates lithium action on behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Cell 132:125-36. 2008
    ..These results point toward a pharmacological approach to modulating GPCR function that affects the formation of beta-arrestin-mediated signaling complexes...
  38. pmc Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency
    Jean Martin Beaulieu
    Department of Cell Biology, Mouse Behavioral and Neuroendocrine Analyses Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:1333-8. 2008
    ..Targeting GSK3beta and related signaling events may afford therapeutic advantages for the management of certain 5-HT-related psychiatric conditions...
  39. pmc Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter
    Ali Salahpour
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:4405-10. 2008
    ..2 and 0.5 mg/kg) than WT mice (2 mg/kg). These results suggest that overexpression of DAT leads to a marked increase in sensitivity to psychomotor and rewarding properties of amphetamine...
  40. doi request reprint Food reward in the absence of taste receptor signaling
    Ivan E de Araujo
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 57:930-41. 2008
    ..Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction...
  41. pmc Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor
    Larry S Barak
    Box 3287, Duke University, Durham, NC 27710
    Mol Pharmacol 74:585-94. 2008
    ....
  42. pmc Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics
    Bernard Masri
    Departments of Cell Biology, Medicine and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:13656-61. 2008
    ..Thus, selective targeting of D2(L)R/beta-arrestin 2 interaction and related signaling pathways may provide new opportunities for antipsychotic development...
  43. ncbi request reprint DDD mice, a novel acute mouse model of Parkinson's disease
    Tatyana D Sotnikova
    Department of Cell Biology and Center for Models of Human Disease, IGSP, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurology 67:S12-7. 2006
    ..This model is particularly promising as a tool for evaluating the efficacy of compounds that may induce movement independently of DA. The advantages and limitations of DDD mice in comparison to other rodent PD models are discussed...
  44. ncbi request reprint Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals
    Ali Salahpour
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 61:65-9. 2007
    ..This study sought to determine the efficiency of local small interfering RNA (siRNA) injections, comparing this approach with animals generated through classical gene targeting...
  45. pmc Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine
    Paul E M Phillips
    Department of Chemistry, Venable Hall CB3290, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Brain Res 961:63-72. 2003
    ..We conclude, therefore, that behavioral changes that have previously been observed in rats that were prenatally exposed to cocaine are not mediated through alteration of presynaptic dopaminergic mechanisms in these brain regions...
  46. ncbi request reprint Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice
    Raul R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 38:291-303. 2003
    ..The present study indicates that postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity...
  47. pmc Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
    Tsuyoshi Miyakawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory and RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:8987-92. 2003
    ..Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis...
  48. pmc Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons
    Michel Cyr
    Howard Hughes Medical Institute Laboratory, Department of Cell Biology, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 100:11035-40. 2003
    ..These findings provide in vivo evidence that, in addition to its proposed role in the degeneration of dopamine neurons, dopamine can also contribute to the selective death of its target neurons via a previously unappreciated mechanism...
  49. pmc Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
    Jean Martin Beaulieu
    Howard Hughes Medical Institute, Department of Cell Biology and Center for Models of Human Disease, Institute of Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 101:5099-104. 2004
    ....
  50. ncbi request reprint Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice
    Laura M Bohn
    Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    J Neurosci 23:10265-73. 2003
    ..Thus, beta(arr2) appears to play a more important role in the dopaminergic effects mediated by morphine than those induced by cocaine...
  51. ncbi request reprint MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice
    Susan B Powell
    Department of Psychiatry 0804, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 173:310-7. 2004
    ..The hyperactivity of DAT (-/-) mice can be attenuated by psychostimulants and by serotonin uptake inhibitors, suggesting an important role for serotonin in the attenuation of locomotor hyperactivity in these mice...
  52. ncbi request reprint Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity
    Wei Dong Yao
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 41:625-38. 2004
    ..Our findings uncover a previously unappreciated role of PSD-95 in psychostimulant action and identify a molecular and cellular mechanism shared between drug-related plasticity and learning...
  53. ncbi request reprint Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    Eric K Richfield
    Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Exp Neurol 175:35-48. 2002
    ..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers...
  54. ncbi request reprint Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice
    Ivan O Medvedev
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 180:408-13. 2005
    ..The dopamine transporter (DAT) is thought to play a major role in the rewarding effects of cocaine. Therefore, it is surprising that cocaine reveals conditioned effects in DAT knockout (DAT-KO) mice...
  55. pmc Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine
    Evgeny A Budygin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 101:7781-6. 2004
    ..The 5-HT system may be involved in the rewarding effects of AMPH in these mice...
  56. ncbi request reprint Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine
    Tatyana D Sotnikova
    Howard Hughes Medical Institute, Department of Cell Biology and Medicine, and Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurochem 91:362-73. 2004
    ..The inhibitory action on hyperactivity and certain stereotypies induced by beta-PEA in DAT-KO mice indicate that targets other than the DAT are responsible for these effects...
  57. ncbi request reprint G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation
    Kyeong Man Kim
    Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang Ju, Korea
    J Biol Chem 280:12774-80. 2005
    ..These findings provide a novel GRK-based mechanism for regulating D3R signaling potential and provide insight for interpreting D3R autoreceptor behavior...
  58. ncbi request reprint An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    ....
  59. pmc Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease
    Tatyana D Sotnikova
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 3:e271. 2005
    ..Identification of dopamine transporter- and dopamine-independent locomotor actions of amphetamines suggests a novel paradigm in the search for prospective anti-Parkinsonian drugs...
  60. pmc Social context-dependent singing-regulated dopamine
    Aya Sasaki
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 26:9010-4. 2006
    ..Our findings implicate DA and molecules that control DA kinetics in singing behavior and social context-dependent brain function...
  61. ncbi request reprint Plasma membrane monoamine transporters: structure, regulation and function
    Gonzalo E Torres
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University, Durham, North Carolina 27710, USA
    Nat Rev Neurosci 4:13-25. 2003
  62. ncbi request reprint The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice
    Alasdair M Barr
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Neuropsychopharmacology 29:221-8. 2004
    ....
  63. ncbi request reprint Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo
    Jean Martin Beaulieu
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:881-5. 2007
    ....
  64. ncbi request reprint Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter
    Tatyana D Sotnikova
    Dept of Cell Biology, Center for Models of Human Disease, Duke University Medical Center, Durham, NC 27710, USA
    CNS Neurol Disord Drug Targets 5:45-56. 2006
    ..Significant new insights on these issues have been gained using mice with genetic deletion of DAT...