Research Topics
Genomes and Genes | Patrick T FuegerSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Glucose phosphorylation as a barrier to muscle glucose uptakePatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
Clin Exp Pharmacol Physiol 32:314-8. 2005..4. Exercise is an important tool for diagnosing deficits in glucose phosphorylation...- Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase IIPatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 56:2476-84. 2007..The aim of this study was to determine the role of limitations in glucose phosphorylation in the control of MGU during either physiological insulin stimulation (4 mU x kg(-1) x min(-1)) or exercise with chow or high-fat feeding... 
Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained micePatrick T Fueger
Duke University Medical Center, Department of Pharmacology and Cancer Biology, 4321 Medical Park Drive, Suite 200, Durham, NC 27704, USA
J Physiol 562:925-35. 2005..The control of MGU is distributed rather than confined to a single rate-limiting step such as glucose transport as glucose transport and phosphorylation can both become barriers to skeletal muscle glucose influx...- Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mousePatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 279:50956-61. 2004..However, when glucose phosphorylation capacity is increased by HK II overexpression, GLUT4 availability becomes a marked limitation to exercise-stimulated MGU... - Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporterPatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Physiol 582:801-12. 2007..Finally, studies in GLUT4(-/-)HK(Tg) show that HK II improves exercise tolerance, independent of its effects on MGU... - Regulation of insulin-stimulated muscle glucose uptake in the conscious mouse: role of glucose transport is dependent on glucose phosphorylation capacityPatrick T Fueger
Duke University Medical Center, Department of Pharmacology and Cancer Biology, 4321 Medical Park Drive, Suite 200, Durham, North Carolina 27704, USA
Endocrinology 145:4912-6. 2004..However, when the glucose phosphorylation barrier is lowered by HK overexpression, GLUT4 availability becomes a limitation to insulin-stimulated MGU... - Hexokinase II protein content is a determinant of exercise endurance capacity in the mousePatrick T Fueger
Department of Molecular Physiology ans Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
J Physiol 566:533-41. 2005..In conclusion, adaptations that increase HK protein content and/or functional activity such as regular exercise contribute to increased muscular endurance... - Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liverR Richard Pencek
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 53:3041-7. 2004.... - Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J micePatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 53:306-14. 2004..In conclusion, high-fat feeding impairs both insulin- and exercise-stimulated MGU, but only exercise-stimulated MGU was corrected by HK II overexpression... 
Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscleJane Shearer
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA
Biochim Biophys Acta 1782:586-92. 2008..In conclusion, cardiac insulin resistance and glucose uptake is largely corrected by a reduction in FABP3 in vivo without contemporaneous deleterious effects on cardiac function...- Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of micePatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Am J Physiol Endocrinol Metab 285:E958-63. 2003..This impairment is critically dependent on the tissue's glucose metabolic rate and correlates with tissue oxidative capacity... - Prior exercise enhances passive absorption of intraduodenal glucoseR Richard Pencek
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
J Appl Physiol 95:1132-8. 2003..that prior exercise enhances passive absorption of intraduodenal glucose into the portal vein and 2). that basal and the added passive gut glucose absorption after exercise is dependent on initial transport of glucose via SGLT-1... - 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivoR Richard Pencek
Department of Molecular Physiology and Biophysics, Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Diabetes 54:355-60. 2005..These findings have important implications for the targeting of AMP kinase for the treatment of insulin resistance, using AMP analogs... - AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivoJane Shearer
Dept. of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232-0615, USA
Am J Physiol Endocrinol Metab 287:E871-7. 2004..These results demonstrate that, in vivo, AMPK stimulation increases LCFA but not glucose clearance by a NOS-independent mechanism... - Interaction of insulin and prior exercise in control of hepatic metabolism of a glucose loadR Richard Pencek
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 52:1897-903. 2003..Although the increase in glucose extraction after exercise could be ascribed to increased insulin action, the increase in hepatic glycogen synthesis was independent of it... - Distributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylationPatrick T Fueger
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Am J Physiol Endocrinol Metab 286:E77-84. 2004..Glucose transport is not normally a significant barrier during exercise. However, when the phosphorylation barrier is lowered by HK II overexpression, glucose transport becomes a key site of control for regulating MGU during exercise... - AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxideJane Shearer
Department of Molecular Physiology and Biophysics, 702 Light Hall, Vanderbilt University, Nashville, TN, 37232 0615, USA
Diabetes 53:1429-35. 2004..In addition, AICAR-induced increases in K(g) but not K(f) were abolished by l-NAME in the majority of muscles examined. This shows that the mechanisms by which AMPK stimulates glucose and LCFA uptake are distinct... - Glucose metabolism in vivo in four commonly used inbred mouse strainsEric D Berglund
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 57:1790-9. 2008..To characterize differences in whole-body glucose metabolism between commonly used inbred mouse strains... - Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exerciseJane Shearer
Dept of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, Nashville, TN 37232 0615, USA
Am J Physiol Endocrinol Metab 288:E292-7. 2005..These results show that, in vivo, H-FABP has reciprocal effects on glucose and LCFA utilization and whole body fuel homeostasis when metabolic demands are elevated by exercise... - Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistanceJane Shearer
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 54:3133-9. 2005..In conclusion, a partial reduction in H-FABP protein normalizes fasting glucose levels and improves whole-body insulin sensitivity in HFD-fed mice despite obesity... - Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious miceJulio E Ayala
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 2200 Pierce Ave, 702 Light Hall, Nashville, TN 37232, USA
Diabetes 56:1025-33. 2007..These results show that phosphodiesterase-5 is a potential target for therapies aimed at preventing diet-induced energy imbalance and insulin resistance... - The physiological regulation of glucose flux into muscle in vivoDavid H Wasserman
Department of Molecular Physiology and Biophysics and the Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Exp Biol 214:254-62. 2011..More recent research definitively shows that the distributed control paradigm more accurately defines the regulation of muscle glucose uptake as each of the three steps that define this process are important sites of flux control... - Mobilization of glucose from the liver during exercise and replenishment afterwardR Richard Pencek
Dept. of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA
Can J Appl Physiol 30:292-303. 2005..The fate of glucose taken up by the liver is critically dependent on hepatic glycogen stores, however, as glycogen deposition is greatly facilitated by prior glycogen depletion... - Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1Jonathan C Schisler
Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Duke Independence Park Facility, 4321 Medical Park Drive, Suite 200, Durham, NC 27704, USA
Mol Cell Biol 28:3465-76. 2008..1 is among the very rare factors capable of stimulating beta-cell replication with retention or enhancement of function, properties that may be exploitable for expansion of beta-cell mass in treatment of both major forms of diabetes... - Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferationPatrick Kelly
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 285:15777-85. 2010..This newly defined signaling pathway may yield unique targets for the treatment of beta-cell dysfunction in diabetes... - Fiber type-specific determinants of Vmax for insulin-stimulated muscle glucose uptake in vivoHilary Ann Petersen
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Am J Physiol Endocrinol Metab 284:E541-8. 2003.... - Point-Counterpoint: Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscleDavid H Wasserman
Department of Molecular Physiology and Biophysics and Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Appl Physiol 101:1803-5. 2006 - Galphaz negatively regulates insulin secretion and glucose clearanceMichelle E Kimple
Department of Pharmacology, and the Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710 3813, USA
J Biol Chem 283:4560-7. 2008..These findings indicate that Galphaz may be a potential new target for therapeutics aimed at ameliorating beta-cell dysfunction in Type 2 diabetes... - Transporter-mediated absorption is the primary route of entry and is required for passive absorption of intestinal glucose into the blood of conscious dogsR Richard Pencek
Department of Molecular Physiology and Biophysics, Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
J Nutr 132:1929-34. 2002..The method described here is applicable to investigation of the mechanisms of gut glucose absorption under a variety of nutritional, physiologic and pathophysiologic conditions... - Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of functionPatrick T Fueger
Sarah W Stedman Nutrition and Metabolism Center, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27704, USA
Mol Endocrinol 22:1251-9. 2008..In summary, our findings reveal a novel TFF3-mediated pathway for stimulation of beta-cell replication that could ultimately be exploited for expansion or preservation of islet beta-cell mass...
Research Grants
- Mechanisms to Induce Islet ProliferationPATRICK FUEGER; Fiscal Year: 2007..This award will be an instrumental component towards my ultimate goal of pursuing a career in diabetes research. ..