Patrick T Fueger
Affiliation: Duke University Medical Center
Fueger P, Hess H, Posey K, Bracy D, Pencek R, Charron M, et al
. Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse. J Biol Chem. 2004;279:50956-61 pubmed
..However, when glucose phosphorylation capacity is increased by HK II overexpression, GLUT4 availability becomes a marked limitation to exercise-stimulated MGU. ..
Fueger P, Shearer J, Krueger T, Posey K, Bracy D, Heikkinen S, et al
. Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse. J Physiol. 2005;566:533-41 pubmed
..In conclusion, adaptations that increase HK protein content and/or functional activity such as regular exercise contribute to increased muscular endurance. ..
Fueger P, Li C, Ayala J, Shearer J, Bracy D, Charron M, et al
. Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter. J Physiol. 2007;582:801-12 pubmed
..Finally, studies in GLUT4(-/-)HK(Tg) show that HK II improves exercise tolerance, independent of its effects on MGU. ..
Fueger P, Lee Young R, Shearer J, Bracy D, Heikkinen S, Laakso M, et al
. Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II. Diabetes. 2007;56:2476-84 pubmed
..Together, these studies show that the high-fat-fed mouse is characterized by defects at multiple steps of the MGU system that are precipitated by different physiological conditions. ..
Fueger P, Hess H, Bracy D, Pencek R, Posey K, Charron M, et al
. Regulation of insulin-stimulated muscle glucose uptake in the conscious mouse: role of glucose transport is dependent on glucose phosphorylation capacity. Endocrinology. 2004;145:4912-6 pubmed
..However, when the glucose phosphorylation barrier is lowered by HK overexpression, GLUT4 availability becomes a limitation to insulin-stimulated MGU. ..