MICHAEL S FREEMARK

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin
    Michael Freemark
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina 27710, USA
    Acta Paediatr 96:1326-32. 2007
  2. pmc Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development
    M Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 99:1107-17. 1997
  3. ncbi request reprint Pharmacotherapy of childhood obesity: an evidence-based, conceptual approach
    Michael Freemark
    Box 3080, Duke University Medical Center, Durham, NC 27710, USA
    Diabetes Care 30:395-402. 2007
  4. ncbi request reprint Regulation of maternal metabolism by pituitary and placental hormones: roles in fetal development and metabolic programming
    M Freemark
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, NC 27710, USA
    Horm Res 65:41-9. 2006
  5. ncbi request reprint Anti-obesity medication use in adolescents: risks and benefits
    Michael Freemark
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham NC 27710, USA, and Department of Pediatrics, Childrens Hospital, University of Leipzig, Oststr 21 25, Leipzig, D 04317, Germany
    Pediatr Endocrinol Rev 2:168-70. 2004
  6. ncbi request reprint Screening for celiac disease in children with type 1 diabetes: two views of the controversy
    Michael Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Diabetes Care 26:1932-9. 2003
  7. ncbi request reprint Pharmacologic approaches to the prevention of type 2 diabetes in high risk pediatric patients
    Michael Freemark
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Endocrinol Metab 88:3-13. 2003
  8. ncbi request reprint Body weight and fat deposition in prolactin receptor-deficient mice
    M Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 142:532-7. 2001
  9. ncbi request reprint Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance
    Michael Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 143:1378-85. 2002
  10. ncbi request reprint Ontogenesis of prolactin receptors in the human fetus: roles in fetal development
    M Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, U S A
    Biochem Soc Trans 29:38-41. 2001

Research Grants

  1. PLACENTAL LACTOGEN AND FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 2001
  2. THE ROLE OF PLACENTAL LACTOGEN IN FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 1993
  3. THE ROLE OF PLACENTAL LACTOGEN IN FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 1990
  4. THE ROLE OF PLACENTAL LACTOGEN IN FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin
    Michael Freemark
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina 27710, USA
    Acta Paediatr 96:1326-32. 2007
    ....
  2. pmc Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development
    M Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 99:1107-17. 1997
    ..5 and e18.5 in the fetal rat. In addition to playing important roles in reproduction, lactation, and immune function, the lactogenic hormones likely play roles in tissue differentiation and organ development early in gestation...
  3. ncbi request reprint Pharmacotherapy of childhood obesity: an evidence-based, conceptual approach
    Michael Freemark
    Box 3080, Duke University Medical Center, Durham, NC 27710, USA
    Diabetes Care 30:395-402. 2007
  4. ncbi request reprint Regulation of maternal metabolism by pituitary and placental hormones: roles in fetal development and metabolic programming
    M Freemark
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, NC 27710, USA
    Horm Res 65:41-9. 2006
    ....
  5. ncbi request reprint Anti-obesity medication use in adolescents: risks and benefits
    Michael Freemark
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham NC 27710, USA, and Department of Pediatrics, Childrens Hospital, University of Leipzig, Oststr 21 25, Leipzig, D 04317, Germany
    Pediatr Endocrinol Rev 2:168-70. 2004
    ..This paper summarizes the indications for pharmacotherapy and the potential benefits and risks of anti-obesity medications...
  6. ncbi request reprint Screening for celiac disease in children with type 1 diabetes: two views of the controversy
    Michael Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Diabetes Care 26:1932-9. 2003
  7. ncbi request reprint Pharmacologic approaches to the prevention of type 2 diabetes in high risk pediatric patients
    Michael Freemark
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Endocrinol Metab 88:3-13. 2003
  8. ncbi request reprint Body weight and fat deposition in prolactin receptor-deficient mice
    M Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 142:532-7. 2001
    ..Our observations suggest roles for the lactogens in adipose tissue growth and metabolism in pregnancy and postnatal life...
  9. ncbi request reprint Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance
    Michael Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 143:1378-85. 2002
    ..02) than those in wild-type mice. On the other hand, the glucose response to ip insulin was normal. Our observations establish a physiologic role for lactogens in islet development and function...
  10. ncbi request reprint Ontogenesis of prolactin receptors in the human fetus: roles in fetal development
    M Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, U S A
    Biochem Soc Trans 29:38-41. 2001
    ..These observations suggest roles for the lactogens in pancreatic development and function during pregnancy and postnatal life...
  11. ncbi request reprint The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes
    M Freemark
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Pediatrics 107:E55. 2001
    ....
  12. ncbi request reprint Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency
    Donald Fleenor
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 146:103-12. 2005
    ..The combination of perinatal growth failure and late-onset obesity and insulin resistance suggests that the lactogen-resistant/GH-deficient mouse may serve as a model for the development of the metabolic syndrome...
  13. ncbi request reprint Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids
    Ramamani Arumugam
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 148:258-67. 2007
    ..We speculate that the lactogens facilitate food intake in response to fasting or nutrient deprivation, when glucose levels decline and cortisol levels rise...
  14. doi request reprint Seropositivity to celiac antigens in asymptomatic children with type 1 diabetes mellitus: association with weight, height, and bone mineralization
    Evelyn Artz
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Diabetes 9:277-84. 2008
    ..Screening for celiac disease (CD) in children with diabetes is controversial because no studies have demonstrated metabolic complications in asymptomatic, seropositive subjects or beneficial effects of dietary intervention...
  15. ncbi request reprint Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors
    Ramamani Arumugam
    Department of Pediatrics, Duke University Medical Center, Box 3080, Durham, NC 27710, USA
    Endocrine 32:182-91. 2007
    ..Phenotypic differences between double-mutant and GHD males suggest that lactogens and GH exert differential but overlapping effects on fat deposition and adipocytokine secretion and action...
  16. pmc The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy
    Ramamani Arumugam
    Departments of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 149:5401-14. 2008
    ..These observations suggest new mechanisms by which lactogens may preserve beta-cell mass and function and maternal glucose tolerance despite the doubling of maternal cortisol concentrations in late gestation...
  17. ncbi request reprint Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I
    Don Fleenor
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Horm Res 66:101-10. 2006
    ..These observations suggest that somatogens and lactogens regulate adipocyte development and fat metabolism through distinct but overlapping cellular mechanisms...
  18. pmc Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development
    Andrea M Haqq
    Department of Pediatrics, Division of Pediatric Endocrinology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Endocrinol (Oxf) 69:911-20. 2008
    ..This progressive weight gain is associated with hyperghrelinaemia and increased insulin sensitivity. The role of ghrelin excess in the pathogenesis of obesity is unclear...
  19. ncbi request reprint Acanthosis nigricans: a practical approach to evaluation and management
    Steven P Higgins
    Division of Dermatology, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Dermatol Online J 14:2. 2008
    ..In this review, we discuss the pathogenesis of acanthosis nigricans and its clinical implications and management...
  20. pmc Regulation of islet beta-cell pyruvate metabolism: interactions of prolactin, glucose, and dexamethasone
    Ramamani Arumugam
    Pediatric Endocrinology, Duke University Medical Center, Box 102820, Duke University Medical Center, Durham, NC 27710, USA
    Endocrinology 151:3074-83. 2010
    ..PRL counteracts the effects of DEX on PDH and PDK expression, suggesting novel roles for the lactogens in the defense against diabetes...
  21. pmc Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia
    Elizabeth Drake Brooks
    Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Mol Genet Metab 109:161-70. 2013
    ..In sum, these findings suggest that growth failure in GSD-Ia results, at least in part, from hepatic GH resistance. In addition, gene therapy improved growth in addition to promoting long-term survival in dogs and mice with GSD-Ia...
  22. ncbi request reprint Insulin pump therapy in toddlers and preschool children with type 1 diabetes mellitus
    Jean Litton
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Pediatr 141:490-5. 2002
    ..To test whether glycemic control in young children could be achieved more effectively and safely by using continuous insulin infusions administered by insulin pumps...
  23. ncbi request reprint The pathogenesis of insulin resistance in children: metabolic complications and the roles of diet, exercise and pharmacotherapy in the prevention of type 2 diabetes
    Evelyn Artz
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Endocrinol Rev 1:296-309. 2004
    ..We then review critically the benefits of diet, exercise and pharmacotherapy in preventing type 2 diabetes and vascular complications in high risk children and young adults...
  24. ncbi request reprint Leptin in the newborn mouse. Plasma concentrations, characterization of the circulating hormone, and tissue source
    Jon Oden
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Biol Neonate 82:109-16. 2002
    ..Factors regulating the expression of leptin by newborn WAT remain to be elucidated...
  25. pmc Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones
    Andrea M Haqq
    Department of Pediatrics, Division of Pediatric Endocrinology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Endocrinol (Oxf) 67:944-51. 2007
    ..We hypothesized that this increased insulin sensitivity is mediated by increased levels of total and high molecular weight adiponectin and associated with changes in levels of satiety hormones...
  26. pmc Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression
    Ramamani Arumugam
    Duke University Medical Center, Department of Pediatrics, Durham, North Carolina 27710, USA
    Endocrinology 152:856-68. 2011
    ..These findings suggest novel targets for prevention of neonatal glucose intolerance and gestational diabetes and may provide new insight into the pathogenesis of β-cell hyperplasia in obese subjects with insulin resistance...
  27. ncbi request reprint Hormonal and metabolic consequences of childhood obesity
    Evelyn Artz
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Box 3080, Durham, NC 27710, USA
    Endocrinol Metab Clin North Am 34:643-58, ix. 2005
    ..Obesity in childhood and adolescence hastens their development, enhances their rates of progression, increases the risks of severe complications, and if persistent, reduces life expectancy...

Research Grants17

  1. PLACENTAL LACTOGEN AND FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 2001
    ..The results of these studies should clarify the roles of lactogens in the control of perinatal and postnatal insulin production and may provide new insight into the pathogenesis of fetal macrosomia in the infant of the diabetic mother. ..
  2. THE ROLE OF PLACENTAL LACTOGEN IN FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 1993
    ..Since PL exerts metabolic and growth-promoting effects in fetal tissues, these studies may provide new insight into the regulation of fetal metabolism and the control of fetal growth...
  3. THE ROLE OF PLACENTAL LACTOGEN IN FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 1990
    ....
  4. THE ROLE OF PLACENTAL LACTOGEN IN FETAL DEVELOPMENT
    Michael Freemark; Fiscal Year: 2007
    ..The results of our studies should provide new insist into the roles of pituitary and placental hormones in adipose development and function. ..