S J Freedland

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Androgenetic alopecia at various ages and prostate cancer risk in an equal-access multiethnic case-control series of veterans
    Jean Alfred Thomas
    Division of Urology, Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Cancer Causes Control 24:1045-52. 2013
  2. ncbi Treatment patterns in patients with prostate cancer and bone metastasis among US community-based urology group practices
    Stephen J Freedland
    Department of Surgery, Durham, VA Medical Center, Durham, NC, USA
    Urology 80:293-8. 2012
  3. ncbi Prostate cancer risk in men with baseline history of coronary artery disease: results from the REDUCE Study
    Jean Alfred Thomas
    Srgery Section, Durham VA Medical Center, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 21:576-81. 2012
  4. ncbi 5-α reductase inhibitors and prostate cancer prevention: where do we turn now?
    Robert J Hamilton
    Division of Urology, Department of Surgery, University of Toronto, Toronto, ON M4N 3M5, Canada
    BMC Med 9:105. 2011
  5. ncbi Update on outcomes research databases in prostate cancer 2006
    Stephen J Freedland
    Department of Surgery, Division of Urology, Duke University School of Medicine, Durham, NC 27710, USA
    Curr Opin Urol 16:168-72. 2006
  6. ncbi Obese men have higher-grade and larger tumors: an analysis of the duke prostate center database
    S J Freedland
    Department of Surgery, Duke University School of Medicine, Veterans Affairs Medical Center, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 12:259-63. 2009
  7. ncbi Death in patients with recurrent prostate cancer after radical prostatectomy: prostate-specific antigen doubling time subgroups and their associated contributions to all-cause mortality
    Stephen J Freedland
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, MD, USA
    J Clin Oncol 25:1765-71. 2007
  8. ncbi Invited commentary: Lower urinary tract symptoms and inflammation--weighing the evidence
    Stephen J Freedland
    Department of Surgery, Durham VA Medical Center, Durham, North Carolina, USA
    Am J Epidemiol 169:1291-3; discussion 1294-5. 2009
  9. ncbi Dietary intervention strategies to modulate prostate cancer risk and prognosis
    Stephen J Freedland
    Department of Surgery, Durham VA Medical Center, Durham, North Carolina, USA
    Curr Opin Urol 19:263-7. 2009
  10. ncbi Obesity and prostate cancer: making sense out of apparently conflicting data
    Stephen J Freedland
    Department of Surgery, Veterans Affairs Medical Center, Durham, NC 27710, USA
    Epidemiol Rev 29:88-97. 2007

Research Grants

  1. Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression
    Stephen Freedland; Fiscal Year: 2009
  2. Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression
    Salvatore V Pizzo; Fiscal Year: 2010

Detail Information

Publications103 found, 100 shown here

  1. ncbi Androgenetic alopecia at various ages and prostate cancer risk in an equal-access multiethnic case-control series of veterans
    Jean Alfred Thomas
    Division of Urology, Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Cancer Causes Control 24:1045-52. 2013
    ..Epidemiological data are conflicting regarding the association between androgenetic alopecia (AA) and prostate cancer (CaP). We examined the relationship between these two conditions...
  2. ncbi Treatment patterns in patients with prostate cancer and bone metastasis among US community-based urology group practices
    Stephen J Freedland
    Department of Surgery, Durham, VA Medical Center, Durham, NC, USA
    Urology 80:293-8. 2012
    ..To evaluate a cohort of United States-based urology practices for patterns related to screening, diagnosis, and treatment of bone metastases in men with castration-resistant prostate cancer...
  3. ncbi Prostate cancer risk in men with baseline history of coronary artery disease: results from the REDUCE Study
    Jean Alfred Thomas
    Srgery Section, Durham VA Medical Center, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 21:576-81. 2012
    ..Coronary artery disease (CAD) and prostate cancer (PCa) are not only common diseases, but share many risk factors. To date, only a few studies have explored the relationship between CAD and PCa risk, with conflicting results...
  4. ncbi 5-α reductase inhibitors and prostate cancer prevention: where do we turn now?
    Robert J Hamilton
    Division of Urology, Department of Surgery, University of Toronto, Toronto, ON M4N 3M5, Canada
    BMC Med 9:105. 2011
    ..Finally, we discuss future directions for 5-ARI research...
  5. ncbi Update on outcomes research databases in prostate cancer 2006
    Stephen J Freedland
    Department of Surgery, Division of Urology, Duke University School of Medicine, Durham, NC 27710, USA
    Curr Opin Urol 16:168-72. 2006
    ....
  6. ncbi Obese men have higher-grade and larger tumors: an analysis of the duke prostate center database
    S J Freedland
    Department of Surgery, Duke University School of Medicine, Veterans Affairs Medical Center, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 12:259-63. 2009
    ..In this study, obese men undergoing radical prostatectomy had higher-grade and larger tumors, providing further evidence that obese men undergoing radical prostatectomy have more aggressive prostate cancers...
  7. ncbi Death in patients with recurrent prostate cancer after radical prostatectomy: prostate-specific antigen doubling time subgroups and their associated contributions to all-cause mortality
    Stephen J Freedland
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, MD, USA
    J Clin Oncol 25:1765-71. 2007
    ..However, given the small number of patients in the highest risk PSADT subgroup, it is unclear which PSADT subgroups contribute the greatest to prostate cancer-specific death and how this influences all-cause mortality...
  8. ncbi Invited commentary: Lower urinary tract symptoms and inflammation--weighing the evidence
    Stephen J Freedland
    Department of Surgery, Durham VA Medical Center, Durham, North Carolina, USA
    Am J Epidemiol 169:1291-3; discussion 1294-5. 2009
    ..Given that clinical trials of antiinflammatory drugs for LUTS have been largely unsuccessful, the role of inflammation as a contributor to LUTS remains an interesting hypothesis that requires further study...
  9. ncbi Dietary intervention strategies to modulate prostate cancer risk and prognosis
    Stephen J Freedland
    Department of Surgery, Durham VA Medical Center, Durham, North Carolina, USA
    Curr Opin Urol 19:263-7. 2009
    ..We sought to review the latest literature regarding dietary interventions for prostate cancer with a special emphasis on dietary fat and carbohydrate intake for modulating prognosis among men with prostate cancer...
  10. ncbi Obesity and prostate cancer: making sense out of apparently conflicting data
    Stephen J Freedland
    Department of Surgery, Veterans Affairs Medical Center, Durham, NC 27710, USA
    Epidemiol Rev 29:88-97. 2007
    ..Emerging data suggest a differential effect of obesity by disease aggressiveness: obesity may reduce the risk of nonaggressive disease while it may promote aggressive disease...
  11. ncbi Obesity is a significant risk factor for prostate cancer at the time of biopsy
    Stephen J Freedland
    Departments of Surgery and Pathology, School of Medicine, Duke University, Veteran s Affairs Medical Center, Durham, North Carolina 27710, USA
    Urology 72:1102-5. 2008
    ..We hypothesized obesity is biologically associated with increased risk, although this is obscured owing to hemodilution of prostate-specific antigen (PSA) and larger prostate size...
  12. ncbi Obesity and oncological outcome after radical prostatectomy: impact of prostate-specific antigen-based prostate cancer screening: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databases
    Stephen J Freedland
    Urology Section, Department of Surgery, Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    BJU Int 102:969-74. 2008
    ....
  13. ncbi Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis
    Stephen J Freedland
    Department of Surgery, Durham VA Medical Center, Durham, North Carolina 27710, USA
    Prostate 68:11-9. 2008
    ..Recent evidence suggests carbohydrate intake may influence prostate cancer biology. We tested whether a no-carbohydrate ketogenic diet (NCKD) would delay prostate cancer growth relative to Western and low-fat diets in a xenograft model...
  14. ncbi Androgen deprivation therapy and estrogen deficiency induced adverse effects in the treatment of prostate cancer
    S J Freedland
    Department of Surgery Urology, Durham VA Medical Center and Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 12:333-8. 2009
    ..By providing clinicians with a greater awareness of the estrogen deficiency induced adverse effects from ADT, they can proactively intervene on the physical and psychological impact these effects have on patients...
  15. ncbi Radical prostatectomy for clinical stage T3a disease
    Stephen J Freedland
    Departments of Urology and Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, Maryland, USA
    Cancer 109:1273-8. 2007
    ..The long-term outcomes among men treated with radical prostatectomy for clinical stage T3a disease were examined...
  16. ncbi Delay of radical prostatectomy and risk of biochemical progression in men with low risk prostate cancer
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Urol 175:1298-302; discussion 1302-3. 2006
    ..Whether delays and especially prolonged delays, eg greater than 180 days, before RP negatively impact the disease outcome is unclear...
  17. ncbi Screening, risk assessment, and the approach to therapy in patients with prostate cancer
    Stephen J Freedland
    Department of Surgery, Durham VA Medical Center, Duke Prostate Center, Durham, North Carolina 27710, USA
    Cancer 117:1123-35. 2011
    ..The use of newly developed risk-stratification models and markers of disease progression should assist in the earlier identification of disease progression, allowing the optimal treatment of such patients...
  18. ncbi Prostate-specific antigen: update 2006
    Stephen J Freedland
    Division of Urology, Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Urology 67:458-60. 2006
  19. ncbi Prostate specific antigen recurrence after definitive therapy
    Stephen J Freedland
    Division of Surgery, Durham Veterans Affairs Medical Center, Durham, NC, USA
    J Urol 177:1985-91. 2007
    ..However, to do so the risks and benefits of the various options must be known. Therefore, we provide a comprehensive overview of the natural history and treatment options for men with prostate specific antigen-only recurrence...
  20. ncbi Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Urol 175:500-4; discussion 504. 2006
    ..We examined the association between BMI, and PSA and prostate weight in a cohort of men undergoing RP...
  21. ncbi PSA in the new millennium: a powerful predictor of prostate cancer prognosis and radical prostatectomy outcomes--results from the SEARCH database
    Stephen J Freedland
    Urology Section, Veterans Affairs Medical Center, Durham, NC, USA
    Eur Urol 53:758-64; discussion 765-6. 2008
    ..We examined the prognostic significance of preoperative PSA to predict pathologic stage and biochemical progression among men undergoing radical prostatectomy in the new millennium (2000-2006)...
  22. ncbi The effect of race on the discriminatory accuracy of models to predict biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databases
    D M Moreira
    Division of Urologic Surgery, Department of Surgery, and Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA
    Prostate Cancer Prostatic Dis 13:87-93. 2010
    ..This indicates that currently used predictive models have similar performances among CM and AAM. Therefore, nomograms represent a valid and accurate method to predict BCR regardless of race...
  23. ncbi Preoperative weight change and risk of adverse outcome following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database
    B M Whitley
    Duke Prostate Center, Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 14:361-6. 2011
    ..We examined the relationship between weight change in the year before radical prostatectomy (RP) and biochemical recurrence (BCR) and adverse pathology...
  24. ncbi The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model
    John C Mavropoulos
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Prev Res (Phila) 2:557-65. 2009
    ....
  25. ncbi Improved clinical staging system combining biopsy laterality and TNM stage for men with T1c and T2 prostate cancer: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California-Los Angeles School of Medicine and Department of Surgery, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
    J Urol 169:2129-35. 2003
    ..If confirmed at other centers and in men who undergo with other treatment modalities, consideration should be given to revising the current TNM staging system to reflect these findings...
  26. ncbi Obesity and risk of biochemical progression following radical prostatectomy at a tertiary care referral center
    Stephen J Freedland
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    J Urol 174:919-22. 2005
    ..We sought to validate or refute these findings using data on men treated by multiple other surgeons at our institution...
  27. ncbi Preoperative predictors of blood loss at the time of radical prostatectomy: results from the SEARCH database
    J C Lloyd
    Division of Urologic Surgery, Department of Surgery and Pathology, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 12:264-8. 2009
    ..Finally, significant differences in EBL were observed between centers. Patients with multiple risk factors should be forewarned they are at increased risk for higher EBL, which may translate into a greater need for blood transfusion...
  28. ncbi Impact of nerve sparing on surgical margins and biochemical recurrence: results from the SEARCH database
    J L Nelles
    Department of Urology, San Francisco School of Medicine, University of California, San Francisco, CA, USA
    Prostate Cancer Prostatic Dis 12:172-6. 2009
    ..The risk for biochemical recurrence was not affected by bilateral or unilateral nerve sparing. When used on appropriately selected patients, nerve sparing does not increase the probability of PSM or biochemical recurrence after RP...
  29. ncbi Do younger men have better biochemical outcomes after radical prostatectomy?
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 63:518-22. 2004
    ..Prior studies have suggested that younger men have lower prostate-specific antigen recurrence rates after RP, although none of the prior studies had controlled for the year of surgery...
  30. ncbi The influence of hepatic function on prostate cancer outcomes after radical prostatectomy
    L L Bañez
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Prostate Cancer Prostatic Dis 13:173-7. 2010
    ..The effect of moderate-to-severe liver disease on disease outcomes in CaP patients managed non-surgically remains to be investigated...
  31. ncbi What are the factors associated with short prostate specific antigen doubling time after radical prostatectomy? A report from the SEARCH database group
    Anna E Teeter
    Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Urol 180:1980-4; discussion 1985. 2008
    ..We determined which demographic and clinicopathological variables were predictive of a short prostate specific antigen doubling time in a cohort of men with clinically localized prostate cancer treated with radical prostatectomy...
  32. ncbi Should a positive surgical margin following radical prostatectomy be pathological stage T2 or T3? Results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles and Department of Surgery, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California 90095, USA
    J Urol 169:2142-6. 2003
    ..We examined the significance of the pathological features of positive surgical margin and extracapsular extension for predicting biochemical failure following radical prostatectomy...
  33. ncbi Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095-1738, USA
    Urology 61:742-7. 2003
    ....
  34. ncbi Time trends in biochemical recurrence after radical prostatectomy: results of the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095-1738, USA
    Urology 61:736-41. 2003
    ..This may reflect lead-time bias in detecting PSA recurrence by the use of more sensitive PSA assays in recent years...
  35. ncbi Percent of prostate needle biopsy cores with cancer is significant independent predictor of prostate specific antigen recurrence following radical prostatectomy: results from SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles, Department of Surgery, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California 90095, USA
    J Urol 169:2136-41. 2003
    ....
  36. ncbi Prostate cancer risk in men with prostate and breast cancer family history: results from the REDUCE study (R1)
    J A Thomas
    Surgery Section, Durham VA Medical Center, Durham, NC, USA
    J Intern Med 272:85-92. 2012
    ..We examined these questions within the REDUCE study, where biopsies were largely independent of prostate specific antigen (PSA) minimizing screening biases...
  37. ncbi Preoperative PSA velocity and doubling time do not predict adverse pathologic features or biochemical recurrence after radical prostatectomy
    S J Freedland
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095-1738, USA
    Urology 57:476-80. 2001
    ..In addition, there was no difference in PSA velocity or doubling time between the races studied...
  38. ncbi Improved risk stratification for biochemical recurrence after radical prostatectomy using a novel risk group system based on prostate specific antigen density and biopsy Gleason score
    Stephen J Freedland
    Department of Urology, University of California Los Angeles School of Medicine and Veterans Administration Greater Los Angeles Healthcare System, 90095-1738, USA
    J Urol 168:110-5. 2002
    ....
  39. ncbi Predicting unilateral prostate cancer based on biopsy features: implications for focal ablative therapy--results from the SEARCH database
    Charles D Scales
    Department of Surgery Division of Urologic Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Urol 178:1249-52. 2007
    ..However, few studies have assessed the correlation between biopsy parameters and pathological outcome (unilateral vs bilateral disease)...
  40. ncbi Percent tumor involvement and risk of biochemical progression after radical prostatectomy
    Edward N Rampersaud
    Division of Urologic Surgery, Duke Prostate Center, Durham, North Carolina, USA
    J Urol 180:571-6; discussion 576. 2008
    ..We hypothesized percent tumor involvement may be a good correlate of outcome in all stages of prostate cancer...
  41. ncbi Race as an outcome predictor after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095-1738, USA
    Urology 60:670-4. 2002
    ..The Shared Equal Access Regional Cancer Hospital database is a valuable resource for studying patients treated with RP...
  42. ncbi Predictive value of digital rectal examination for prostate cancer detection is modified by obesity
    D I Chu
    Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 14:346-53. 2011
    ..081). In conclusion, the predictive value of DRE is dependent on obesity and is significantly higher among obese men than normal-weight men...
  43. ncbi Preoperative p27 status is an independent predictor of prostate specific antigen failure following radical prostatectomy
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, 90095-1738, USA
    J Urol 169:1325-30. 2003
    ..5-fold increased risk of biochemical recurrence. To our knowledge this study is the first to show that p27 status of the prostate needle biopsy specimen can be used before radical prostatectomy to predict biochemical failure...
  44. ncbi Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital database study group
    Stephen J Freedland
    Department of Urology, The Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 2101, USA
    J Clin Oncol 22:446-53. 2004
    ..Given the limited information regarding the impact of obesity on treatment outcomes for prostate cancer, we sought to examine the relationship between body mass index (BMI) and cancer control after radical prostatectomy (RP)...
  45. ncbi Obesity and capsular incision at the time of open retropubic radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1798-801; discussion 1801. 2005
    ..Therefore, we examined the association between body mass index (BMI) and capsular incision at RP as a surrogate of a poor technical operation in men treated for prostate cancer by several high volume surgeons at a center of excellence...
  46. ncbi Clinical utility of percent prostate needle biopsy tissue with cancer cutpoints to risk stratify patients before radical prostatectomy
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095-1738, USA
    Urology 60:84-8. 2002
    ..These cutpoints could further stratify patients preoperatively who were at intermediate or high risk of biochemical failure on the basis of PSA and biopsy Gleason score...
  47. ncbi Clinical and pathologic outcome after radical prostatectomy for prostate cancer patients with a preoperative Gleason sum of 8 to 10
    Patrick J Bastian
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer 107:1265-72. 2006
    ..Whereas multimodal therapy has often meant radiation plus hormonal therapy, newer possibilities for multimodal therapy exist such as surgery with neoadjuvant or adjuvant chemohormonal therapy or surgery with adjuvant radiation...
  48. ncbi Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men
    H S Kim
    Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA
    Prostate Cancer Prostatic Dis 14:262-5. 2011
    ..001), Ki67 (P=0.007) and Ki67/lum (P=0.022) reaching significance. These data support the hypothesis that PCa may be biologically more aggressive among black men...
  49. ncbi Race and prostate weight as independent predictors for biochemical recurrence after radical prostatectomy
    F R Schroeck
    Division of Urology, Department of Surgery, Duke Prostate Center DPC, Duke University Medical Center, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 11:371-6. 2008
    ..75. Race and prostate weight were independent predictors for BCR after RP. By incorporating these variables, we developed a nomogram, which provides a highly accurate means for estimating risk of BCR after RP...
  50. ncbi Small transrectal ultrasound volume predicts clinically significant Gleason score upgrading after radical prostatectomy: results from the SEARCH database
    Ryan S Turley
    Division of Urological Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, North Carolina, USA
    J Urol 179:523-7; discussion 527-8. 2008
    ..We examined the likelihood of clinically relevant upgrading after radical prostatectomy as a function of transrectal ultrasound volume...
  51. ncbi Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy
    Bruce J Trock
    Brady Urological Institute, Johns Hopkins School of Medicine, 600 N Wolfe St, 546 Phipps Bldg, Baltimore, MD 21287, USA
    JAMA 299:2760-9. 2008
    ....
  52. ncbi Stronger association between obesity and biochemical progression after radical prostatectomy among men treated in the last 10 years
    Stephen J Freedland
    Departments of Urology, and Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:2883-8. 2005
    ..Whether the association between obesity and aggressive disease has changed as a result of these temporal changes is unclear...
  53. ncbi Validation of a nomogram to predict disease progression following salvage radiotherapy after radical prostatectomy: results from the SEARCH database
    Daniel M Moreira
    Division of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 104:1452-6. 2009
    ..termed the 'Stephenson nomogram') to predict disease progression after salvage radiotherapy (SRT) among patients with prostate cancer from the Shared Equal Access Regional Cancer Hospital (SEARCH) database...
  54. ncbi Predictors of prostate-specific antigen progression among men with seminal vesicle invasion at the time of radical prostatectomy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 100:1633-8. 2004
    ..The authors examined whether there was a subset of men with SV invasion who had long-term prostate-specific antigen (PSA) progression-free survival...
  55. ncbi Obesity and biochemical outcome following radical prostatectomy for organ confined disease with negative surgical margins
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287 2101, USA
    J Urol 172:520-4. 2004
    ....
  56. ncbi The percentage of prostate needle biopsy cores with carcinoma from the more involved side of the biopsy as a predictor of prostate specific antigen recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEAR
    Stephen J Freedland
    Department of Urology, University of California-Los Angeles, Los Angeles, California, USA
    Cancer 98:2344-50. 2003
    ..Using the percentage of cores from the dominant side along with the PSA level and the biopsy Gleason score provided significant risk stratification for PSA failure...
  57. ncbi Comparison of preoperative prostate specific antigen density and prostate specific antigen for predicting recurrence after radical prostatectomy: results from the search data base
    Stephen J Freedland
    Department of Urology, University of California-Los Angeles School of Medicine, USA
    J Urol 169:969-73. 2003
    ..The minimal and statistically insignificant improvement in preoperative risk assessment provided by PSA density does not justify the time and effort necessary to calculate this value...
  58. ncbi The prostatic specific antigen era is alive and well: prostatic specific antigen and biochemical progression following radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1276-81; discussion 1281; author reply 1281. 2005
    ..We examined the association between PSA and clinical progression in men undergoing RP...
  59. ncbi Racial differences in prognostic value of adult height for biochemical progression following radical prostatectomy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:7735-42. 2005
    ..However, hormonal activity and diets vary between races. We examined whether height was significantly associated with biochemical progression following radical prostatectomy and whether there was an interaction between height and race...
  60. ncbi Effect of intermittent fasting on prostate cancer tumor growth in a mouse model
    J A Thomas
    Division of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 13:350-5. 2010
    ..39). IF did not improve mouse survival nor did it delay prostate tumor growth. This may be secondary to metabolic adaptations to the 24 h fasting periods. Future studies are required to optimize CR for application in humans...
  61. ncbi Freedom from a detectable ultrasensitive prostate-specific antigen at two years after radical prostatectomy predicts a favorable clinical outcome: analysis of the SEARCH database
    Steven L Chang
    Department of Urology, Stanford University Medical Center, Stanford, California 94305, USA
    Urology 75:439-44. 2010
    ..Previous studies demonstrate that a PSADT < 9 months after radical prostatectomy is associated with prostate cancer-specific mortality. Conventionally, PSADT has been calculated after biochemical failure (PSA > or = 2 0.2 ng/mL)...
  62. ncbi Predicting biochemical recurrence after radical prostatectomy for patients with organ-confined disease using p27 expression
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095 1738, USA
    Urology 61:1187-92. 2003
    ..We sought to determine whether p27 staining in the PNBx specimen might serve as a molecular marker for PSA failure in the subset of patients who develop PSA recurrence despite organ-confined disease at RP...
  63. ncbi External validation of the SEARCH model for predicting aggressive recurrence after radical prostatectomy: results from the Duke Prostate Center Database
    Anna E Teeter
    Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    BJU Int 106:796-800. 2010
    ..79 using a cohort of men from the Duke Prostate Center (DPC)...
  64. ncbi Obesity as a predictor of adverse outcome across black and white race: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database
    Jayakrishnan Jayachandran
    Division of Urologic Surgery, Departments of Surgery and Pathology, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    Cancer 115:5263-71. 2009
    ..Whether these associations vary by race is unknown. In the current study, the authors examined the association between obesity and outcome after RP stratified by race...
  65. ncbi Defining the ideal cutpoint for determining PSA recurrence after radical prostatectomy. Prostate-specific antigen
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095-1738, USA
    Urology 61:365-9. 2003
    ..2 ng/mL are at very high risk of developing an additional rise in PSA. On the basis of this finding, a PSA value greater than 0.2 ng/mL is an appropriate cutpoint to define PSA recurrence after RP...
  66. ncbi Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer
    Lionel L Banez
    Division of Urologic Surgery and Duke Prostate Center, and Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Urol 184:149-56. 2010
    ..In the current study we validated PITX2 methylation status as a biochemical recurrence predictor after radical prostatectomy using a novel microarray based platform in a multi-institutional setting...
  67. ncbi Low-carbohydrate diets and prostate cancer: how low is "low enough"?
    Elizabeth M Masko
    Duke University Medical Center, Box 2626, Durham, NC 27710, USA
    Cancer Prev Res (Phila) 3:1124-31. 2010
    ..55, respectively). Insulin was significantly lower in the 20% carbohydrate arm (P = 0.03). LAPC-4 xenograft mice fed a low-carbohydrate diet (10-20% carbohydrate kcal) had similar survival as mice consuming NCKD (0% carbohydrate kcal)...
  68. ncbi Do nomograms predict aggressive recurrence after radical prostatectomy more accurately than biochemical recurrence alone?
    Florian R Schroeck
    Division of Urologic Surgery, Department of Surgery, and Duke Prostate Center, Duke University Medical Center, Durham, NC 27710, USA
    BJU Int 103:603-8. 2009
    ..To compare the predictive accuracy (PA) of existing models in estimating risk of biochemical recurrence (BCR) vs aggressive recurrence (BCR with a prostate-specific antigen, PSA, doubling time, DT, of <9 months)...
  69. ncbi Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    JAMA 294:433-9. 2005
    ....
  70. ncbi The association between prostate size and Gleason score upgrading depends on the number of biopsy cores obtained: results from the Shared Equal Access Regional Cancer Hospital Database
    Ryan S Turley
    Division of Urological Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 102:1074-9. 2008
    ..To test the hypothesis that the association between prostate size and risk of Gleason grade upgrading varies as a function of sampling...
  71. ncbi Biochemical outcome after radical prostatectomy among men with normal preoperative serum prostate-specific antigen levels
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Cancer 101:748-53. 2004
    ..Whether malignancies in such men are associated with better outcomes is unclear. The authors compared the risk of biochemical failure after radical prostatectomy (RP) between men with normal PSA levels and men with elevated PSA levels...
  72. ncbi Diabetes and prostate cancer risk in the REDUCE trial
    C Wu
    Duke University School of Medicine, Durham, NC, USA
    Prostate Cancer Prostatic Dis 14:326-31. 2011
    ..35 vs 1.38). In the REDUCE trial, when all men underwent biopsy, diabetes was not associated with lower PCa risk, but rather equal risk of PCa, low-grade PCa and high-grade PCa...
  73. ncbi Definition and preoperative predictors of persistently elevated prostate-specific antigen after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database
    Daniel M Moreira
    Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Durham, NC, USA
    BJU Int 105:1541-7. 2010
    ....
  74. ncbi Re-calibration and external validation of an existing nomogram to predict aggressive recurrences after radical prostatectomy
    Florian R Schroeck
    Division of Urologic Surgery, Department of Surgery, and Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 105:1654-9. 2010
    ..e. a BCR with a postoperative PSA doubling time (PSADT) of <9 months)...
  75. ncbi Multiinstitutional validation of the UCSF cancer of the prostate risk assessment for prediction of recurrence after radical prostatectomy
    Matthew R Cooperberg
    Department of Urology, Program in Urologic Oncology, Urologic Outcomes Research Group, UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Cancer 107:2384-91. 2006
    ..This study used a large external dataset to validate CAPRA...
  76. ncbi Is a positive bladder neck margin truly a T4 lesion in the prostate specific antigen era? Results from the SEARCH Database
    W Cooper Buschemeyer
    Department of Surgery Division of Urologic Surgery, Duke University School of Medicine and Urology Section, Surgical Service, Veterans Affairs Medical Center Durham, Durham, North Carolina 27710, USA
    J Urol 179:124-9; discussion 129. 2008
    ..We examined the association between positive bladder neck margins and prostate specific antigen recurrence relative to other pathological findings...
  77. ncbi Outcomes after radical prostatectomy among men who are candidates for active surveillance: results from the SEARCH database
    Christopher J Kane
    Division of Urology, Department of Surgery, University of California San Diego, San Diego, CA 92103 8897, USA
    Urology 76:695-700. 2010
    ..We sought to evaluate outcomes after radical prostatectomy among men with low-risk prostate cancer who would be candidates for active surveillance...
  78. ncbi Association between serum adiponectin, and pathological stage and grade in men undergoing radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1266-70. 2005
    ..Obesity has been associated with advanced stage and a higher risk of biochemical progression following radical prostatectomy (RP) in several series. We examined whether serum adiponectin is associated with advanced disease stage at RP...
  79. ncbi Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice
    W Cooper Buschemeyer
    Division of Urology, and the Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Prostate 70:1037-43. 2010
    ..We hypothesized intermittent fasting (i.e., intermittent extreme CR), may be better tolerated and prolong survival of prostate cancer (CaP) bearing mice...
  80. ncbi The Shared Equal Access Regional Cancer Hospital (SEARCH) nomogram for risk stratification in intermediate risk group of men with prostate cancer: validation in the Duke Prostate Center database
    Jayakrishnan Jayachandran
    Division of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 105:180-4. 2010
    ....
  81. ncbi The influence of statin medications on prostate-specific antigen levels
    Robert J Hamilton
    Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    J Natl Cancer Inst 100:1511-8. 2008
    ..However, the influence of statins on prostate-specific antigen (PSA) levels and what effect this could potentially have on prostate cancer diagnosis are unknown...
  82. ncbi Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2
    Naoko Kobayashi
    Department of Urology, Division of Clinical Nutrition and Hematology-Oncology, University of California, Los Angeles School of Medicine, 90095-1738, USA
    Clin Cancer Res 12:4662-70. 2006
    ....
  83. ncbi Obesity and positive surgical margins by anatomic location after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database
    Jayakrishnan Jayachandran
    Urology Section, Veterans Affairs Medical Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 102:964-8. 2008
    ....
  84. ncbi Biochemical failure after radical prostatectomy in men with pathologic organ-confined disease: pT2a versus pT2b
    Stephen J Freedland
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Cancer 100:1646-9. 2004
    ..Whether this distinction provides prognostic significance is unclear. The authors evaluated biochemical outcomes between men with pT2aN0 and pT2bN0 disease...
  85. ncbi Race is associated with discontinuation of active surveillance of low-risk prostate cancer: results from the Duke Prostate Center
    M R Abern
    Division of Urology, Department of Surgery and the Duke Prostate Center, Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA
    Prostate Cancer Prostatic Dis 16:85-90. 2013
    ..Although black race has traditionally been associated with adverse PC characteristics, its prognostic value for patients managed with AS is unclear...
  86. ncbi Is there a difference in outcome after radical prostatectomy between patients with biopsy Gleason sums 4, 5, and 6? Results from the SEARCH database
    S J Freedland
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095 1738, USA
    Prostate Cancer Prostatic Dis 6:261-5. 2003
    ..We sought to examine the significance of biopsy Gleason sum for predicting biochemical failure following radical prostatectomy (RP) for men with biopsy Gleason sums of 4, 5, and 6...
  87. ncbi Exercise therapy across the prostate cancer continuum
    J Antonelli
    Division of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC 27710, USA
    Prostate Cancer Prostatic Dis 12:110-5. 2009
    ..Given the low-risk, high-reward nature of these studies, further investigations are needed to better define the function of exercise along the PC continuum...
  88. ncbi Immunotherapy of prostate cancer
    S J Freedland
    University of California, Los Angeles School of Medicine, Department of Urology, 10833 Le Conte Avenue, Room 66-118 CHS, Los Angeles, CA 90095-1738, USA
    Curr Urol Rep 2:242-7. 2001
    ..This review summarizes the latest findings from each of these approaches and gives results from the few completed human clinical trials...
  89. ncbi Optimal timing, cutoff, and method of calculation of preoperative prostate-specific antigen velocity to predict relapse after prostatectomy: a report from SEARCH
    Christopher R King
    Department of Radiation Oncology, Division of Urologic Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Urology 69:732-7. 2007
    ..We studied the timing, cutoff levels, and method of calculation to better define its usefulness...
  90. ncbi Upgrading and downgrading of prostate needle biopsy specimens: risk factors and clinical implications
    Stephen J Freedland
    Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Urology 69:495-9. 2007
    ..Given the critical role that needle biopsy plays in treatment decisions, we sought to determine the risk factors for upgrading and downgrading the prostate biopsy specimen...
  91. ncbi Percent prostate needle biopsy tissue with cancer is more predictive of biochemical failure or adverse pathology after radical prostatectomy than prostate specific antigen or Gleason score
    Stephen J Freedland
    Departments of Urology and Biostatistics, UCLA School of Medicine, Los Angeles 90095-1738, USA
    J Urol 167:516-20. 2002
    ..Consideration should be given to reporting percent of total biopsy tissue with cancer in all prostate biopsy results...
  92. ncbi Pathological outcomes and biochemical progression in men with T1c prostate cancer undergoing radical prostatectomy with prostate specific antigen 2.6 to 4.0 vs 4.1 to 6.0 ng/ml
    Danil V Makarov
    James Buchanan Brady Urological Institute, and the Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 176:554-8. 2006
    ..5 ng/ml as opposed to the more traditional greater than 4.0 ng/ml. We compared outcomes between men with clinical stage T1c disease undergoing radical prostatectomy who had a low vs slightly increased prostate specific antigen...
  93. ncbi Impact of obesity on the utility of preoperative prostate-specific antigen velocity to predict for relapse after prostatectomy: a report from the SEARCH database
    Christopher R King
    Division of Urologic Oncology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Urology 69:921-6. 2007
    ....
  94. ncbi Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites
    Cathrine Hoyo
    Department of Community and Family Medicine, Hanes House Room 347, Trent Drive, Box 2914, Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    J Natl Med Assoc 99:718-22. 2007
    ..If confirmed in larger studies, these findings support the hypothesis that the association between IGFBP3 C allele and prostate cancer is grade specific in both ethnic groups...
  95. ncbi Preoperative model for predicting prostate specific antigen recurrence after radical prostatectomy using percent of biopsy tissue with cancer, biopsy Gleason grade and serum prostate specific antigen
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 171:2215-20. 2004
    ..We developed a preoperative model to risk stratify patients for prostate specific antigen (PSA) failure following radical prostatectomy (RP) and identify those at high risk who would be potential candidates for neoadjuvant clinical trials...
  96. ncbi Risk stratification for biochemical recurrence in men with positive surgical margins or extracapsular disease after radical prostatectomy: results from the SEARCH database
    Jayakrishnan Jayachandran
    Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Urol 179:1791-6; discussion 1796. 2008
    ..We further stratified these men into a low risk group in which watchful waiting after surgery may be preferred and a high risk cohort in which adjuvant therapy may be preferred...
  97. ncbi The effect of race/ethnicity on the accuracy of the 2001 Partin Tables for predicting pathologic stage of localized prostate cancer
    Elisabeth I Heath
    Barbara Ann Karmanos Cancer Institute, Department of Hematology and Oncology, Wayne State University, 4100 John R, 4 HWCRC, Detroit, MI 48201, USA
    Urology 71:151-5. 2008
    ..To test the accuracy of the 2001 Partin Tables in African American men who underwent radical prostatectomy at multiple centers throughout the United States...
  98. ncbi A single-institution comparison between radical perineal and radical retropubic prostatectomy on perioperative and pathological outcomes for obese men: an analysis of the Duke Prostate Center database
    Nicholas J Fitzsimons
    Division of Urologic Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Urology 70:1146-51. 2007
    ....
  99. ncbi Rising PSA in nonmetastatic prostate cancer
    Judd W Moul
    Division of Urologic Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC 27710, USA
    Oncology (Williston Park) 21:1436-45; discussion 1449, 1452, 1454. 2007
    ..In this article, we will explore these prostate cancer disease states with an emphasis on practical, clinically applicable approaches...
  100. ncbi Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer
    Lionel L Banez
    Division of Urologic Surgery and the Duke Prostate Center, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 298:2275-80. 2007
    ..Because men with higher body mass index (BMI) have greater circulating plasma volumes, lower PSA concentrations among obese men may be due to hemodilution...
  101. ncbi Black race does not independently predict adverse outcome following radical retropubic prostatectomy at a tertiary referral center
    Matthew E Nielsen
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 176:515-9. 2006
    ..However, on multivariate analysis black race was not an independent predictor of adverse pathological outcome or biochemical recurrence. Further efforts are needed to detect prostate cancer earlier among black men...

Research Grants2

  1. Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression
    Stephen Freedland; Fiscal Year: 2009
    ....
  2. Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression
    Salvatore V Pizzo; Fiscal Year: 2010
    ....