Donald Fox

Summary

Affiliation: Duke University Medical Center

Publications

  1. pmc Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component
    Steven H Myster
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 160:433-49. 2003
  2. doi Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation
    Vicki P Losick
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Dev Cell 21:159-71. 2011
  3. pmc Error-prone polyploid mitosis during normal Drosophila development
    Donald T Fox
    Howard Hughes Medical Institute Research Laboratories, Carnegie Institution for Science, Baltimore, Maryland 21218, USA
    Genes Dev 24:2294-302. 2010
  4. pmc The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage
    Donald T Fox
    Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution, Baltimore, MD 21218, USA
    Cell Stem Cell 5:290-7. 2009
  5. doi Stem cells and their niches: integrated units that maintain Drosophila tissues
    A C Spradling
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    Cold Spring Harb Symp Quant Biol 73:49-57. 2008
  6. pmc Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila
    Traci L Stevens
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 19:378-93. 2008
  7. ncbi Cell adhesion: separation of p120's powers?
    Donald T Fox
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, North Carolina 27599 3280, USA
    Curr Biol 17:R24-7. 2007
  8. ncbi Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila
    Donald T Fox
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 134:567-78. 2007
  9. ncbi Rho1 regulates Drosophila adherens junctions independently of p120ctn
    Donald T Fox
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Development 132:4819-31. 2005
  10. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003

Collaborators

  • Julie Gates
  • A C Spradling
  • Fei Wang
  • Mark Peifer
  • Vicki P Losick
  • Traci L Stevens
  • Elizabeth E Grevengoed
  • Steven H Myster
  • Lucy X Morris
  • Edward M Rogers
  • Nicholas B Artabazon
  • Stephanie H Nowotarski
  • Laura M Koontz
  • Catarina C F Homem
  • Robert Cavallo
  • Charles T Anderson

Detail Information

Publications12

  1. pmc Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component
    Steven H Myster
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 160:433-49. 2003
    ..Together, these data suggest that p120 is an important positive modulator of adhesion but that it is not an essential core component of adherens junctions...
  2. doi Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation
    Vicki P Losick
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Dev Cell 21:159-71. 2011
    ..We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice...
  3. pmc Error-prone polyploid mitosis during normal Drosophila development
    Donald T Fox
    Howard Hughes Medical Institute Research Laboratories, Carnegie Institution for Science, Baltimore, Maryland 21218, USA
    Genes Dev 24:2294-302. 2010
    ..Our results show that the switch to endocycles during development is not irreversible, but argue that the polyploid mitotic cycle is inherently error-prone, and that polyploid mitoses may help destabilize the cancer genome...
  4. pmc The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage
    Donald T Fox
    Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution, Baltimore, MD 21218, USA
    Cell Stem Cell 5:290-7. 2009
    ..Thus, the hindgut does not provide a model of tissue maintenance by constitutively active stem cells, but has great potential to illuminate mechanisms of stress-induced tissue repair...
  5. doi Stem cells and their niches: integrated units that maintain Drosophila tissues
    A C Spradling
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
    Cold Spring Harb Symp Quant Biol 73:49-57. 2008
    ..It is only when integrated into a system of multiple interacting cells (the niche) that stem cells achieve the capacity to serve as the fundamental units of tissue homeostasis and repair...
  6. pmc Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila
    Traci L Stevens
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 19:378-93. 2008
    ..These data provide new insight into how regulated Abl activity helps direct normal development and into possible biological functions of Bcr-Abl...
  7. ncbi Cell adhesion: separation of p120's powers?
    Donald T Fox
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, North Carolina 27599 3280, USA
    Curr Biol 17:R24-7. 2007
    ..The catenin p120 is involved in many processes, including cell-cell adhesion and cancer. Recent work explores whether p120 independently regulates two key binding partners, RhoGTPase and cadherin...
  8. ncbi Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila
    Donald T Fox
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 134:567-78. 2007
    ..These observations identify an important morphogenetic role for Abl and suggest a conserved mechanism for this kinase during apical cell constriction...
  9. ncbi Rho1 regulates Drosophila adherens junctions independently of p120ctn
    Donald T Fox
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Development 132:4819-31. 2005
    ..These data suggest Rho1 regulates AJs during morphogenesis, but this regulation is p120 independent...
  10. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003
    ..We also examined other actin regulators. Loss of Abl leads to changes in the localization of the Arp2/3 complex and the formin Diaphanous, and mutations in diaphanous or capping protein beta enhance abl phenotypes...
  11. pmc Endoreplication and polyploidy: insights into development and disease
    Donald T Fox
    Department of Pharmacology and Cancer Biology, and Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Development 140:3-12. 2013
    ..These studies demonstrate that cellular polyploidy plays important roles during normal development and also contributes to human disease, particularly cancer...