Genomes and Genes
Affiliation: Duke University Medical Center
- Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction componentSteven H Myster
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Biol 160:433-49. 2003..Together, these data suggest that p120 is an important positive modulator of adhesion but that it is not an essential core component of adherens junctions...
- Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulationVicki P Losick
Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA
Dev Cell 21:159-71. 2011..We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice...
- Error-prone polyploid mitosis during normal Drosophila developmentDonald T Fox
Howard Hughes Medical Institute Research Laboratories, Carnegie Institution for Science, Baltimore, Maryland 21218, USA
Genes Dev 24:2294-302. 2010..Our results show that the switch to endocycles during development is not irreversible, but argue that the polyploid mitotic cycle is inherently error-prone, and that polyploid mitoses may help destabilize the cancer genome...
- The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damageDonald T Fox
Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution, Baltimore, MD 21218, USA
Cell Stem Cell 5:290-7. 2009..Thus, the hindgut does not provide a model of tissue maintenance by constitutively active stem cells, but has great potential to illuminate mechanisms of stress-induced tissue repair...
- Stem cells and their niches: integrated units that maintain Drosophila tissuesA C Spradling
Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
Cold Spring Harb Symp Quant Biol 73:49-57. 2008..It is only when integrated into a system of multiple interacting cells (the niche) that stem cells achieve the capacity to serve as the fundamental units of tissue homeostasis and repair...
- Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in DrosophilaTraci L Stevens
Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Mol Biol Cell 19:378-93. 2008..These data provide new insight into how regulated Abl activity helps direct normal development and into possible biological functions of Bcr-Abl...
- Cell adhesion: separation of p120's powers?Donald T Fox
Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, North Carolina 27599 3280, USA
Curr Biol 17:R24-7. 2007..The catenin p120 is involved in many processes, including cell-cell adhesion and cancer. Recent work explores whether p120 independently regulates two key binding partners, RhoGTPase and cadherin...
- Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in DrosophilaDonald T Fox
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Development 134:567-78. 2007..These observations identify an important morphogenetic role for Abl and suggest a conserved mechanism for this kinase during apical cell constriction...
- Rho1 regulates Drosophila adherens junctions independently of p120ctnDonald T Fox
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Development 132:4819-31. 2005..These data suggest Rho1 regulates AJs during morphogenesis, but this regulation is p120 independent...
- Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and EnabledElizabeth E Grevengoed
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
J Cell Biol 163:1267-79. 2003..We also examined other actin regulators. Loss of Abl leads to changes in the localization of the Arp2/3 complex and the formin Diaphanous, and mutations in diaphanous or capping protein beta enhance abl phenotypes...
- Endoreplication and polyploidy: insights into development and diseaseDonald T Fox
Department of Pharmacology and Cancer Biology, and Department of Cell Biology, Duke University, Durham, NC 27710, USA
Development 140:3-12. 2013..These studies demonstrate that cellular polyploidy plays important roles during normal development and also contributes to human disease, particularly cancer...