Vance Fowler

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: evaluation from the CANVAS studies
    Amy Tong
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e37212. 2012
  2. pmc Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses
    Sun Hee Ahn
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Pathog 6:e1001088. 2010
  3. doi request reprint Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial
    Vance G Fowler
    Duke University Medical Center, Hanes Bldg, Room 153, Trent Drive, PO Box 102359, Durham, NC 27710, USA
    JAMA 309:1368-78. 2013
  4. pmc Presence of genes encoding panton-valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus
    Batu K Sharma-Kuinkel
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Clin Microbiol 50:848-56. 2012
  5. ncbi request reprint Clinical predictors of major infections after cardiac surgery
    Vance G Fowler
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 112:I358-65. 2005
  6. ncbi request reprint Clinical identifiers of complicated Staphylococcus aureus bacteremia
    Vance G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 163:2066-72. 2003
  7. ncbi request reprint Staphylococcus aureus bacteremia after median sternotomy: clinical utility of blood culture results in the identification of postoperative mediastinitis
    Vance G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 108:73-8. 2003
  8. ncbi request reprint In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source
    V G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 182:1251-4. 2000
  9. ncbi request reprint The intercellular adhesin locus ica is present in clinical isolates of Staphylococcus aureus from bacteremic patients with infected and uninfected prosthetic joints
    V G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27706, USA
    Med Microbiol Immunol 189:127-31. 2001
  10. pmc Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections
    Steven J Campbell
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Microbiol 46:678-84. 2008

Research Grants

  1. UNDERSTANDING THE PATHOGENESIS OF STAPHYLOCOCCUS AUREUS
    Vance Fowler; Fiscal Year: 2003
  2. Virulence determinants in S. aureus bacteremia
    Vance Fowler; Fiscal Year: 2004
  3. Virulence determinants in S. aureus bacteremia
    Vance Fowler; Fiscal Year: 2005
  4. Virulence determinants in S. aureus bacteremia
    Vance Fowler; Fiscal Year: 2006
  5. Host Susceptibility S. aureus
    Vance Fowler; Fiscal Year: 2007
  6. Host Susceptibility S. aureus
    Vance Fowler; Fiscal Year: 2009
  7. Host Susceptibility S. aureus
    Vance G Fowler; Fiscal Year: 2010

Detail Information

Publications89

  1. pmc Panton-Valentine leukocidin is not the primary determinant of outcome for Staphylococcus aureus skin infections: evaluation from the CANVAS studies
    Amy Tong
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e37212. 2012
    ..The results of this contemporary, international study suggest that pvl presence was not the primary determinant of outcome in patients with cSSSI due to either MRSA or MSSA...
  2. pmc Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses
    Sun Hee Ahn
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Pathog 6:e1001088. 2010
    ..These findings suggest that two genes, Tnfaip8 and Seh1l, may contribute to susceptibility to S. aureus in A/J mice, and represent promising candidates for human genetic susceptibility studies...
  3. doi request reprint Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial
    Vance G Fowler
    Duke University Medical Center, Hanes Bldg, Room 153, Trent Drive, PO Box 102359, Durham, NC 27710, USA
    JAMA 309:1368-78. 2013
    ..A novel vaccine candidate (V710) containing the highly conserved S. aureus iron surface determinant B is immunogenic and generally well tolerated in volunteers...
  4. pmc Presence of genes encoding panton-valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus
    Batu K Sharma-Kuinkel
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Clin Microbiol 50:848-56. 2012
    ..This study suggests that neither pvl presence nor in vitro level of alpha-hemolysin production is the primary determinant of outcome among patients with HAP caused by S. aureus...
  5. ncbi request reprint Clinical predictors of major infections after cardiac surgery
    Vance G Fowler
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 112:I358-65. 2005
    ....
  6. ncbi request reprint Clinical identifiers of complicated Staphylococcus aureus bacteremia
    Vance G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 163:2066-72. 2003
    ..This investigation sought to define readily available clinical characteristics that could help identify patients at risk for complicated SAB...
  7. ncbi request reprint Staphylococcus aureus bacteremia after median sternotomy: clinical utility of blood culture results in the identification of postoperative mediastinitis
    Vance G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 108:73-8. 2003
    ..Mediastinitis is a complication of coronary artery bypass graft surgery (CABG) that can be difficult to diagnose. This study evaluated the utility of blood culture results in identifying patients with mediastinitis...
  8. ncbi request reprint In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source
    V G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 182:1251-4. 2000
    ..aureus strains and the severity of human IE. This work supports the concept that in vitro PMP resistance in clinical S. aureus strains is associated with important clinical characteristics of S. aureus endovascular infections in vivo...
  9. ncbi request reprint The intercellular adhesin locus ica is present in clinical isolates of Staphylococcus aureus from bacteremic patients with infected and uninfected prosthetic joints
    V G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27706, USA
    Med Microbiol Immunol 189:127-31. 2001
    ..epidermidis and S. aureus and that PIA may be expressed only under in vivo conditions. Future investigations should include animal models to approximate the complex milieu surrounding implanted prosthetic medical devices...
  10. pmc Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections
    Steven J Campbell
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Microbiol 46:678-84. 2008
    ..01). S. aureus strains from different geographic regions have different distributions of virulence genes...
  11. pmc Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia
    Carlo McCalla
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 52:3441-3. 2008
    ..1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure...
  12. doi request reprint Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic
    Sara E Cosgrove
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Clin Infect Dis 48:713-21. 2009
    ..This study evaluated the association between this practice and nephrotoxicity...
  13. pmc Phenotypic and genotypic characteristics of persistent methicillin-resistant Staphylococcus aureus bacteremia in vitro and in an experimental endocarditis model
    Yan Q Xiong
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    J Infect Dis 199:201-8. 2009
    ..Persistent MRSA bacteremia (PB) represents an important subset of Staphylococcus aureus infections and correlates with poor clinical outcomes...
  14. pmc Heterogeneous vancomycin-intermediate susceptibility phenotype in bloodstream methicillin-resistant Staphylococcus aureus isolates from an international cohort of patients with infective endocarditis: prevalence, genotype, and clinical significance
    In Gyu Bae
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Infect Dis 200:1355-66. 2009
    ..Using a multinational collection of isolates from methicillin-resistant S. aureus (MRSA) infective endocarditis (IE), we characterized patients with IE with and without hVISA, and we genotyped the infecting strains...
  15. pmc Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients
    Yanhong Li
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
    Clin J Am Soc Nephrol 4:428-34. 2009
    ..Staphylococcus aureus is a leading cause of infection in patients with ESRD. Clinical and economic outcomes associated with S. aureus bacteremia and other S. aureus infections in patients with ESRD were examined...
  16. pmc Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective
    Cathy A Petti
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    J Clin Microbiol 46:1780-4. 2008
    ..In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance...
  17. doi request reprint Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study
    V H Chu
    Duke University Medical Center, Durham, NC 27710, USA
    Heart 95:570-6. 2009
    ..To describe the contemporary features of coagulase-negative staphylococcal (CoNS) prosthetic valve endocarditis (PVE)...
  18. ncbi request reprint Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria
    Martin E Stryjewski
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 40:1601-7. 2005
    ..Telavancin is highly active against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate, and vancomycin-resistant strains...
  19. ncbi request reprint Early surgery in patients with infective endocarditis: a propensity score analysis
    Olcay Aksoy
    Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Clin Infect Dis 44:364-72. 2007
    ..Largely because of these limitations, the role of surgery in long-term survival has not been adequately studied...
  20. ncbi request reprint Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 26:1159-61. 2007
    ..Infants with methicillin-resistant S. aureus infection had a longer median duration of bacteremia (4.5 versus 1 day, P = 0.01), but no difference in length of hospital stay, mortality, or neurodevelopmental impairment...
  21. ncbi request reprint Infective endocarditis caused by daptomycin-resistant Enterococcus faecalis: a case report
    Zeina A Kanafani
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Scand J Infect Dis 39:75-7. 2007
    ..Daptomycin is a first-in-class antibiotic with efficacy against Gram-positive bacteria. We document the second report of daptomycin resistance in a clinical isolate of Enterococcus faecalis...
  22. ncbi request reprint Risk of endocarditis among patients with prosthetic valves and Staphylococcus aureus bacteremia
    Fadi El-Ahdab
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med 118:225-9. 2005
    ..However, the risk of endocarditis in patients with a prosthetic valve who develop S. aureus bacteremia is unclear. The aim of this study was to define the risk of prosthetic valve endocarditis in patients with S. aureus bacteremia...
  23. ncbi request reprint Non-HACEK gram-negative bacillus endocarditis
    Susan Morpeth
    Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27710, USA
    Ann Intern Med 147:829-35. 2007
    ....
  24. pmc Presence of genes encoding the panton-valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: results of a multinational tr
    In Gyu Bae
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Microbiol 47:3952-7. 2009
    ..05). This contemporary, international study demonstrates that pvl was not the primary determinant of outcome in patients with MRSA cSSSI...
  25. ncbi request reprint Staphylococcus aureus bacteremia and endocarditis
    Cathy A Petti
    Departments of Pathology and Medicine, Box 3879, Duke University Medical Center, Durham, NC 27710, USA
    Infect Dis Clin North Am 16:413-35, x-xi. 2002
    ..In this review, the authors summarize recent changes in the epidemiology of SAB and IE, discuss the challenges in distinguishing SAB from IE, and discuss current trends in the management of patients with SAB and IE...
  26. ncbi request reprint Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: a report from the International Collaboration on Endocarditis-Merged Database
    Wissam M Kourany
    Duke University Medical Center, Durham, NC, USA
    Scand J Infect Dis 38:613-9. 2006
    ..08-2.70), especially in male patients, as diabetic males had higher mortality than non-diabetic males (OR 2.18, CI 1.08-4.35). DM is an independent predictor of in-hospital mortality among patients hospitalized with IE...
  27. pmc Phase II, randomized, multicenter, double-blind, placebo-controlled trial of a polyclonal anti-Staphylococcus aureus capsular polysaccharide immune globulin in treatment of Staphylococcus aureus bacteremia
    Mark E Rupp
    Division of Infectious Diseases, University of Nebraska Medical Center, 984031 Nebraska Medical Center, Omaha, NE 68198 4031, USA
    Antimicrob Agents Chemother 51:4249-54. 2007
    ..gov number NCT00063089)...
  28. ncbi request reprint Relationship between clinical outcomes and vascular access type among hemodialysis patients with Staphylococcus aureus bacteremia
    Jula K Inrig
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27705, USA
    Clin J Am Soc Nephrol 1:518-24. 2006
    ..Twelve-week mortality and costs that are associated with an episode of SAB are high in hemodialysis patients, regardless of vascular access type. Efforts should focus on the prevention of SAB in this high-risk group...
  29. ncbi request reprint Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection
    Vance G Fowler
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 196:738-47. 2007
    ..The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear...
  30. ncbi request reprint Contemporary clinical profile and outcome of prosthetic valve endocarditis
    Andrew Wang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 297:1354-61. 2007
    ..Prosthetic valve endocarditis (PVE) is associated with significant mortality and morbidity. The contemporary clinical profile and outcome of PVE are not well defined...
  31. ncbi request reprint Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 44:190-6. 2007
    ..Clinical outcomes resulting from such a therapeutic strategy have not been well defined...
  32. ncbi request reprint Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus
    Vance G Fowler
    Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 355:653-65. 2006
    ..Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed...
  33. ncbi request reprint Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, NC, USA
    J Infect Dis 196:1425-30. 2007
    ..Endogenous antimicrobial peptides participate in the innate defense of skin against a variety of pathogens. The systemic expression of these peptides in normal-appearing skin of patients with infective cellulitis is unknown...
  34. ncbi request reprint Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia
    Anna Lisa Crowley
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Crit Care Med 36:385-90. 2008
    ....
  35. doi request reprint Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis
    Vivian H Chu
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 46:232-42. 2008
    ..Coagulase-negative staphylococci (CoNS) are an infrequent cause of native valve endocarditis (NVE), and our understanding of NVE caused by CoNS is incomplete...
  36. doi request reprint Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 46:1683-93. 2008
    ..Telavancin is an investigational, rapidly bactericidal lipoglycopeptide with a multifunctional mechanism of action...
  37. doi request reprint Management of methicillin-resistant Staphylococcus aureus bacteremia
    Sara E Cosgrove
    Johns Hopkins University School of Medicine, Baltimore, Maryland and 2Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 46:S386-93. 2008
    ..The increasing prevalence of methicillin-resistant S. aureus (MRSA) infections has created a tremendous demand for effective and safe antimicrobial agents other than the historic anti-MRSA agent vancomycin...
  38. pmc Associations between the genotypes of Staphylococcus aureus bloodstream isolates and clinical characteristics and outcomes of bacteremic patients
    Tahaniyat Lalani
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Microbiol 46:2890-6. 2008
    ..In this study of bloodstream isolates collected as part of a multinational randomized clinical trial, USA 300 and pvl-constitutive MRSA strains were associated with better clinical outcomes...
  39. doi request reprint Clinical outcomes and costs among patients with Staphylococcus aureus bacteremia and orthopedic device infections
    Tahaniyat Lalani
    Duke Clinical Research Institute, 2400 Pratt Street, Cube 7545, Durham, NC 27710, USA
    Scand J Infect Dis 40:973-7. 2008
    ..Patients with ODI had higher relapse of S. aureus infection, compared to bacteremic patients without ODI. Costs and outcomes were similar among ODI patients undergoing device removal and those treated with debridement and retention...
  40. doi request reprint Staphylococcus aureus bacteremia among patients with health care-associated fever
    Martin E Stryjewski
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Med 122:281-289.e2. 2009
    ..aureus bacteremia...
  41. pmc Using decision analysis to improve malaria control policy making
    Randall A Kramer
    Nicholas School of the Environment, Box 90328, Duke University, Durham, NC 27708, USA
    Health Policy 92:133-40. 2009
    ..Developing and applying such a framework can promote stronger and more effective linkages between research and policy, ultimately helping to reduce the burden of malaria and other vector-borne diseases...
  42. ncbi request reprint Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure
    Deverick J Anderson
    Division of Infectious Disease, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 31:701-9. 2010
    ..To determine the epidemiological characteristics of postoperative invasive Staphylococcus aureus infection following 4 types of major surgical procedures.design. Retrospective cohort study...
  43. ncbi request reprint The use and effect of surgical therapy for prosthetic valve infective endocarditis: a propensity analysis of a multicenter, international cohort
    Andrew Wang
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 150:1086-91. 2005
    ....
  44. ncbi request reprint A meta-analysis of medical versus surgical therapy for Candida endocarditis
    William J Steinbach
    Division of Infectious Diseases, Department of Pediatrics, Duke University, Durham, NC 27710, USA
    J Infect 51:230-47. 2005
    ..The optimal management of Candida infective endocarditis (IE) is unknown...
  45. ncbi request reprint Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999
    Christopher H Cabell
    Divisions of Division of Cardiology, Duke University Medical Center, and Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 147:582-6. 2004
    ....
  46. ncbi request reprint Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin
    Christopher W Woods
    Clinical Microbiology, Durham Veterans Administration Medical Center, Durham, NC 27705, USA
    Clin Infect Dis 38:1188-91. 2004
    ..We report the strain characterization and treatment of a patient with SARV IE...
  47. ncbi request reprint Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD)
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, NC, USA
    Scand J Infect Dis 36:453-5. 2004
    ..We evaluated 16 patients with Candida IE nested within a cohort of 2,022 patients with IE. Prosthetic valve IE was more common in patients with Candida (50% vs 17%); mortality was 37% for patients with Candida...
  48. ncbi request reprint Clinical outcomes and costs due to Staphylococcus aureus bacteremia among patients receiving long-term hemodialysis
    John J Engemann
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 26:534-9. 2005
    ..To examine the clinical outcomes and costs associated with Staphylococcus aureus bacteremia among hemodialysis-dependent patients...
  49. ncbi request reprint Repeat infective endocarditis: differentiating relapse from reinfection
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 41:406-9. 2005
    ..The agreement between clinical and molecular criteria was imperfect (agreement in 10 [77%] of 13 cases)...
  50. ncbi request reprint Native valve endocarditis due to coagulase-negative staphylococci: report of 99 episodes from the International Collaboration on Endocarditis Merged Database
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 39:1527-30. 2004
    ..These results emphasize the importance of CoNS as a cause of NVE and the potential for serious complications with this infection...
  51. ncbi request reprint Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia
    Anne Marie Valente
    Department of Pediatrics, Duke University, Box 3090, Durham, NC 27710, USA
    Pediatrics 115:e15-9. 2005
    ..The objective of this study was to determine prospectively the prevalence of IE among pediatric patients with SAB in a large tertiary care center...
  52. ncbi request reprint Staphylococcus aureus endocarditis: a consequence of medical progress
    Vance G Fowler
    Duke University Medical Center, Durham, NC 27710, USA
    JAMA 293:3012-21. 2005
    ..The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown...
  53. ncbi request reprint A returning traveler with fever and rash
    Deverick J Anderson
    Division of Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 41:1453-4, 1529-30. 2005
  54. ncbi request reprint Early predictors of in-hospital death in infective endocarditis
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 109:1745-9. 2004
    ..Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE...
  55. ncbi request reprint Changing patient characteristics and the effect on mortality in endocarditis
    Christopher H Cabell
    Department of Medicine, Duke University Medical Center, Box 31020, Durham, NC 27710
    Arch Intern Med 162:90-4. 2002
    ..Limited data exist on recent demographic and microbiological changes in infective endocarditis (IE) and the impact of these changes on patient survival...
  56. pmc Patient detection of a drug dispensing error by use of physician-provided drug samples
    Elizabeth S Dodds Ashley
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacotherapy 22:1642-3. 2002
  57. ncbi request reprint Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection
    John J Engemann
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 36:592-8. 2003
    ..Methicillin resistance is independently associated with increased mortality and hospital charges among patients with S. aureus SSI...
  58. ncbi request reprint Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia
    Vance G Fowler
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 40:695-703. 2005
    ..The role of both host and pathogen characteristics in hematogenous seeding following Staphylococcus aureus bacteremia is incompletely understood...
  59. ncbi request reprint Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein
    Vance G Fowler
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 190:1140-9. 2004
    ..This investigation examined potential associations between PB with key clinical features and several in vitro bacterial genotypic and phenotypic characteristics, in isolates from 1 institution...
  60. pmc Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study
    Martin E Stryjewski
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Antimicrob Agents Chemother 50:862-7. 2006
    ..These data support the ongoing studies assessing the efficacy and safety of telavancin in the treatment of serious gram-positive infections, particularly involving MRSA...
  61. ncbi request reprint Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Med 118:1416. 2005
    ..aureus bacteremia on patients with prosthetic devices. This investigation sought to define the clinical outcome, health care resource use, and infection-associated costs of S. aureus bacteremia in patients with prostheses...
  62. ncbi request reprint Use of surgery in patients with native valve infective endocarditis: results from the International Collaboration on Endocarditis Merged Database
    Christopher H Cabell
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 150:1092-8. 2005
    ..The aim of the study was to characterize patients with native valve IE relative to surgery and to determine if patients who benefit from an early surgical intervention can be identified...
  63. ncbi request reprint Novel approaches to clinical trials: device-related infections
    Robert M Califf
    Division of Cardiology, Duke University Medical Center and the Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 147:599-604. 2004
    ..The purpose of this manuscript is to discuss issues about the design of studies and their organization...
  64. ncbi request reprint Staphylococcus aureus bacteremia and endocarditis
    Cathy A Petti
    Departments of Pathology and Medicine, Box 3879, Duke University Medical Center, Durham, NC 27710, USA
    Cardiol Clin 21:219-33, vii. 2003
    ..In this review, the authors summarize recent changes in the epidemiology of SAB and IE, discuss the challenges in distinguishing SAB from IE, and discuss current trends in the management of patients with SAB and IE...
  65. doi request reprint A host-based RT-PCR gene expression signature to identify acute respiratory viral infection
    Aimee K Zaas
    Institute for Genome Sciences and Policy, Duke University School of Medicine, Durham, NC 27710, USA
    Sci Transl Med 5:203ra126. 2013
    ....
  66. ncbi request reprint Leptotrichia endocarditis: report of two cases from the International Collaboration on Endocarditis (ICE) database and review of previous cases
    L B Caram
    Division of Infectious Diseases, Duke University Medical Center, Box 3824, Durham, NC 27710, USA
    Eur J Clin Microbiol Infect Dis 27:139-43. 2008
    ..goodfellowii sp. nov. Both cases were identified using 16S rRNA gene sequencing. Review of the English literature revealed only two other cases of Leptotrichia sp. endocarditis...
  67. pmc Candida infective endocarditis
    J W Baddley
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Eur J Clin Microbiol Infect Dis 27:519-29. 2008
    ..Indications for surgical intervention are different and mortality is increased. Newer antifungal treatment options are increasingly used. Large, multi-center studies are needed to help better define Candida IE...
  68. ncbi request reprint [Staphylococcus aureus infections: new challenges from an old pathogen]
    Zeina A Kanafani
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Enferm Infecc Microbiol Clin 24:182-93. 2006
    ..aureus and their impact on the clinical manifestations and management of serious infections. We also discuss new treatment modalities for MRSA infections and emphasize the importance of preventive approaches...
  69. ncbi request reprint The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: an analysis from the ICE Prospective Cohort Study (ICE-PCS)
    Stuart A Dickerman
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    Am Heart J 154:1086-94. 2007
    ....
  70. ncbi request reprint Update on infective endocarditis
    Thomas M Bashore
    Duke University Medical Center, USA
    Curr Probl Cardiol 31:274-352. 2006
    ....
  71. pmc Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis
    Ephraim L Tsalik
    Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
    J Clin Microbiol 48:26-33. 2010
    ..Real-time multiplex PCR has the potential to serve as an adjunct to conventional blood culture, adding diagnostic yield and shortening the time to pathogen identification...
  72. pmc Bonds between fibronectin and fibronectin-binding proteins on Staphylococcus aureus and Lactococcus lactis
    Andrew W Buck
    Duke University Medical Center, Durham, North Carolina, USA
    Langmuir 26:10764-70. 2010
    ..aureus. These measurements demonstrate that fibronectin-binding adhesins FnBPA and FnBPB are necessary and sufficient for the binding of S. aureus to prosthetic devices that are coated with host fibronectin...
  73. pmc Critical role of NOD2 in regulating the immune response to Staphylococcus aureus
    Hitesh S Deshmukh
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Infect Immun 77:1376-82. 2009
    ..Thus, mice deficient in NOD2 are more susceptible to S. aureus. Increased susceptibility is due in part to defective neutrophil phagocytosis, elevated serum levels of Th1 cytokines, and a higher bacterial tissue burden...
  74. ncbi request reprint Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?
    Harmony P Garges
    Pediatrics, Duke University, Durham, North Carolina, USA
    Pediatrics 117:1094-100. 2006
    ..Abnormal cerebrospinal fluid (CSF) parameters are often used to predict neonatal meningitis and determine length and type of antibiotic therapy in neonates with a positive blood culture and negative CSF culture...
  75. ncbi request reprint Periannular complications in infective endocarditis involving native aortic valves
    Ignasi Anguera
    Corporació Sanitària Parc Taulí Hospital de Sabadell, Sabadell, Spain
    Am J Cardiol 98:1254-60. 2006
    ..Despite these higher rates of complications, fistulous tract formation in the current era of IE is not an independent risk factor for mortality...
  76. pmc Antimicrobial activity of prosthetic heart valve sewing cuffs coated with minocycline and rifampin
    Rabih O Darouiche
    Center for Prostheses Infection, Baylor College of Medicine and Veterans Affairs Medical Center, St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 46:543-5. 2002
    ..An in vitro elution study of these coated sewing cuffs demonstrated residual zones of inhibition against Staphylococcus epidermidis for at least 4 weeks...
  77. ncbi request reprint Surgical treatment of pacemaker and defibrillator lead endocarditis: the impact of electrode lead extraction on outcome
    Ana del Rio
    Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Chest 124:1451-9. 2003
    ..Medical treatment has been suggested for the treatment of CD endocarditis, but there is increasing evidence that surgical treatment is to be preferred as the best approach to achieve eradication of the infection and reduce mortality...
  78. pmc Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia
    J John Weems
    Greenville Hospital Sytem University Medical Center, South Carolina, USA
    Antimicrob Agents Chemother 50:2751-5. 2006
    ..Tefibazumab was well tolerated, with a safety profile similar to those of other monoclonal antibodies. Additional trials are warranted to address the dosing range and efficacy of tefibazumab...
  79. ncbi request reprint Fatal outcome of bacteraemic patients caused by infection with staphylokinase-deficient Staphylococcus aureus strains
    Tao Jin
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Med Microbiol 52:919-23. 2003
    ..aureus bacteraemia. The high frequency of SAK production in nasal isolates and in cases with uncomplicated bacteraemia suggests that SAK may be one of the adaptive mechanisms of S. aureus symbiosis with the host...
  80. ncbi request reprint Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia
    Shelby D Reed
    Center for Clinical and Genetic Economics, USA
    Infect Control Hosp Epidemiol 26:175-83. 2005
    ..We compared costs and outcomes of methicillin resistance in patients with S. aureus bacteremia and a single chronic condition...
  81. ncbi request reprint Periannular complications in infective endocarditis involving prosthetic aortic valves
    Ignasi Anguera
    Corporació Sanitària Parc Taulí Hospital de Sabadell, Sabadell, Spain
    Am J Cardiol 98:1261-8. 2006
    ..Despite the frequent complications, fistulous tract formation in the current era of infective endocarditis is not an independent risk factor for mortality...
  82. ncbi request reprint Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants
    Ruchirej Yongsunthon
    Ohio State University, 125 S Oval Mall, Columbus, OH 43210, USA
    Langmuir 23:2289-92. 2007
    ..This observation suggests that a microorganism's "force taxonomy" may provide a fundamental and practical indicator of the pathogen-related risk that infections pose to patients with implanted medical devices...
  83. ncbi request reprint Aorto-cavitary fistulous tract formation in infective endocarditis: clinical and echocardiographic features of 76 cases and risk factors for mortality
    Ignasi Anguera
    Corporació Sanitària Parc Taulí Hospital de Sabadell, Sabadell, Spain
    Eur Heart J 26:288-97. 2005
    ..Aorto-cavitary communications create intra-cardiac shunts, which may result in further clinical deterioration and haemodynamic instability...
  84. ncbi request reprint Clinical characteristics and outcome of aortic endocarditis with periannular abscess in the International Collaboration on Endocarditis Merged Database
    Ignasi Anguera
    The Corporació Sanitària Parc Taulí, Hospital de Sabadell, University of Barcelona, Barcelona, Spain
    Am J Cardiol 96:976-81. 2005
    ..S. aureus infection is an independent prognostic factor for mortality in patients who have abscess formation...
  85. ncbi request reprint Optimizing therapy for methicillin-resistant Staphylococcus aureus bacteremia
    Sara E Cosgrove
    Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Semin Respir Crit Care Med 28:624-31. 2007
    ..aureus endocarditis is life threatening. Selection of an appropriate antibiotic regimen is also an essential factor for optimal management...
  86. pmc Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function
    George Sakoulas
    Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 49:2687-92. 2005
    ..In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP. The precise mechanism(s) underlying these findings is the subject of current investigations...
  87. ncbi request reprint Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database
    Jose M Miro
    Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 41:507-14. 2005
    ..Staphylococcus aureus native valve infective endocarditis (SA-NVIE) is not completely understood. The objective of this investigation was to describe the characteristics of a large, international cohort of patients with SA-NVIE...
  88. pmc Analysis of the genotype and virulence of Staphylococcus epidermidis isolates from patients with infective endocarditis
    Alastair B Monk
    Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Infect Immun 76:5127-32. 2008
    ..This study is the first analysis suggesting that S. epidermidis isolates from patients with NVE constitute a more virulent subset within this species...
  89. ncbi request reprint Importance of aggressive evaluation in patients with Staphylococcus aureus bacteremia
    Chris H Cabell
    Am Heart J 147:379-80. 2004

Research Grants8

  1. UNDERSTANDING THE PATHOGENESIS OF STAPHYLOCOCCUS AUREUS
    Vance Fowler; Fiscal Year: 2003
    ..Accomplishing the aims of this proposal will contribute to improved clinical management of patients with S. aureus bacteremia, and will add to the understanding of S. aureus virulence factors. ..
  2. Virulence determinants in S. aureus bacteremia
    Vance Fowler; Fiscal Year: 2004
    ..aureus infections will advance our understanding of staphylococcal pathogenesis and will enable key advances in protecting the public health from this pathogen. ..
  3. Virulence determinants in S. aureus bacteremia
    Vance Fowler; Fiscal Year: 2005
    ..aureus infections will advance our understanding of staphylococcal pathogenesis and will enable key advances in protecting the public health from this pathogen. ..
  4. Virulence determinants in S. aureus bacteremia
    Vance Fowler; Fiscal Year: 2006
    ..aureus infections will advance our understanding of staphylococcal pathogenesis and will enable key advances in protecting the public health from this pathogen. ..
  5. Host Susceptibility S. aureus
    Vance Fowler; Fiscal Year: 2007
    ..Understanding the host genetic determinants of disease severity in S. aureus infections will advance our understanding of staphylococcal pathogenesis and will enable key advances in protecting the public health from this pathogen. ..
  6. Host Susceptibility S. aureus
    Vance Fowler; Fiscal Year: 2009
    ..Understanding the host genetic determinants of disease severity in S. aureus infections will advance our understanding of staphylococcal pathogenesis and will enable key advances in protecting the public health from this pathogen. ..
  7. Host Susceptibility S. aureus
    Vance G Fowler; Fiscal Year: 2010
    ..Understanding the host genetic determinants of disease severity in S. aureus infections will advance our understanding of staphylococcal pathogenesis and will enable key advances in protecting the public health from this pathogen. ..