V G Fowler

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients
    V G Fowler
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 30:1072-8. 1997
  2. ncbi request reprint Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up
    V G Fowler
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 28:106-14. 1999
  3. ncbi request reprint Enterococcal prosthetic valve infective endocarditis: report of 45 episodes from the International Collaboration on Endocarditis-merged database
    D J Anderson
    Duke University Medical Center and the Duke Clinical Research Institute, Box 3824, Durham, NC 27710, USA
    Eur J Clin Microbiol Infect Dis 24:665-70. 2005
  4. ncbi request reprint In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source
    V G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 182:1251-4. 2000
  5. doi request reprint Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study
    V H Chu
    Duke University Medical Center, Durham, NC 27710, USA
    Heart 95:570-6. 2009
  6. ncbi request reprint Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators
    A L Chamis
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 104:1029-33. 2001
  7. ncbi request reprint Prospective analysis of Staphylococcus aureus bacteremia in nonneutropenic adults with malignancy
    A K Gopal
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Clin Oncol 18:1110-5. 2000
  8. ncbi request reprint Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database
    T Lalani
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Clin Microbiol Infect Dis 25:365-8. 2006
  9. pmc Daptomycin use in infants: report of two cases with peak and trough drug concentrations
    M Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Perinatol 28:233-4. 2008
  10. ncbi request reprint Outcomes with daptomycin versus standard therapy for osteoarticular infections associated with Staphylococcus aureus bacteraemia
    T Lalani
    Division of Infectious Diseases, Duke Clinical Research Institute, Durham, NC, USA
    J Antimicrob Chemother 61:177-82. 2008

Detail Information

Publications79

  1. ncbi request reprint Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients
    V G Fowler
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 30:1072-8. 1997
    ..The purpose of this prospective study was to examine the role of echocardiography in patients with Staphylococcus aureus bacteremia (SAB)...
  2. ncbi request reprint Infective endocarditis due to Staphylococcus aureus: 59 prospectively identified cases with follow-up
    V G Fowler
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 28:106-14. 1999
    ..TEE established the diagnosis of S. aureus IE in many instances when TTE was nondiagnostic. Visualization of vegetations by TTE may provide prognostic information for patients with S. aureus IE...
  3. ncbi request reprint Enterococcal prosthetic valve infective endocarditis: report of 45 episodes from the International Collaboration on Endocarditis-merged database
    D J Anderson
    Duke University Medical Center and the Duke Clinical Research Institute, Box 3824, Durham, NC 27710, USA
    Eur J Clin Microbiol Infect Dis 24:665-70. 2005
    ..Importantly, the prevalence of enterococcal PVE was higher in the European centers in this study...
  4. ncbi request reprint In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source
    V G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 182:1251-4. 2000
    ..aureus strains and the severity of human IE. This work supports the concept that in vitro PMP resistance in clinical S. aureus strains is associated with important clinical characteristics of S. aureus endovascular infections in vivo...
  5. doi request reprint Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study
    V H Chu
    Duke University Medical Center, Durham, NC 27710, USA
    Heart 95:570-6. 2009
    ..To describe the contemporary features of coagulase-negative staphylococcal (CoNS) prosthetic valve endocarditis (PVE)...
  6. ncbi request reprint Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators
    A L Chamis
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 104:1029-33. 2001
    ..Conversely, in patients with late SAB, the cardiac device is rarely the initial source of bacteremia, and there is a paucity of local signs of device involvement. The cardiac device is involved, however, in >/=28% of these patients...
  7. ncbi request reprint Prospective analysis of Staphylococcus aureus bacteremia in nonneutropenic adults with malignancy
    A K Gopal
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Clin Oncol 18:1110-5. 2000
    ..To determine the primary sources and secondary complications of Staphylococcus aureus bacteremia (SAB) in cancer patients, as well as predictors of outcome in cancer patients with SAB...
  8. ncbi request reprint Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database
    T Lalani
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Clin Microbiol Infect Dis 25:365-8. 2006
    ..The results of this analysis demonstrate the aggressive nature of coagulase-negative staphylococcal PVE and the substantially greater morbidity and mortality associated with this infection compared to PVE caused by other pathogens...
  9. pmc Daptomycin use in infants: report of two cases with peak and trough drug concentrations
    M Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Perinatol 28:233-4. 2008
    ..7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin...
  10. ncbi request reprint Outcomes with daptomycin versus standard therapy for osteoarticular infections associated with Staphylococcus aureus bacteraemia
    T Lalani
    Division of Infectious Diseases, Duke Clinical Research Institute, Durham, NC, USA
    J Antimicrob Chemother 61:177-82. 2008
    ..To evaluate the clinical characteristics, treatment and outcomes of patients with osteoarticular infections (OAIs) associated with Staphylococcus aureus bacteraemia (SAB)...
  11. ncbi request reprint Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis
    J S Li
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
    Clin Infect Dis 30:633-8. 2000
    ..aureus should be considered a major criterion, regardless of whether the infection is nosocomially acquired or whether a removable source of infection is present. Positive Q-fever serology should be changed to a major criterion...
  12. ncbi request reprint The intercellular adhesin locus ica is present in clinical isolates of Staphylococcus aureus from bacteremic patients with infected and uninfected prosthetic joints
    V G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27706, USA
    Med Microbiol Immunol 189:127-31. 2001
    ..epidermidis and S. aureus and that PIA may be expressed only under in vivo conditions. Future investigations should include animal models to approximate the complex milieu surrounding implanted prosthetic medical devices...
  13. ncbi request reprint Echocardiographic risk stratification for early surgery with endocarditis: a cost-effectiveness analysis
    L Liao
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Heart 94:e18. 2008
    ..Despite widespread acceptance of echocardiography for diagnosis of infective endocarditis, few investigators have evaluated its utility as a risk-stratification tool to aid therapeutic decision-making...
  14. ncbi request reprint Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus
    E S Dodds Ashley
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 38:1555-60. 2004
    ..Changes in perioperative antimicrobial prophylaxis, in addition to other interventions, should be considered for prevention of POM due to MRSA in targeted, high-risk populations...
  15. pmc Meningococcemia in a patient coinfected with hepatitis C virus and HIV
    C G Nelson
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Emerg Infect Dis 6:646-8. 2000
    ..We describe the first reported case of meningococcemia in a patient coinfected with hepatitis C virus and HIV. Hypocomplementemia secondary to hepatic dysfunction may have enhanced the patient's susceptibility to meningococcal infection...
  16. ncbi request reprint Enterococcal endocarditis: 107 cases from the international collaboration on endocarditis merged database
    J R McDonald
    Duke University Medical Center, Durham, North Carolin, USA
    Am J Med 118:759-66. 2005
    ..To describe clinical features and outcomes of enterococcal left-sided native valve endocarditis and to compare it to endocarditis caused by other pathogens...
  17. pmc Candida infective endocarditis
    J W Baddley
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Eur J Clin Microbiol Infect Dis 27:519-29. 2008
    ..Indications for surgical intervention are different and mortality is increased. Newer antifungal treatment options are increasingly used. Large, multi-center studies are needed to help better define Candida IE...
  18. doi request reprint Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis
    Vivian H Chu
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 46:232-42. 2008
    ..Coagulase-negative staphylococci (CoNS) are an infrequent cause of native valve endocarditis (NVE), and our understanding of NVE caused by CoNS is incomplete...
  19. ncbi request reprint Correlation between fundamental binding forces and clinical prognosis of Staphylococcus aureus infections of medical implants
    Ruchirej Yongsunthon
    Ohio State University, 125 S Oval Mall, Columbus, OH 43210, USA
    Langmuir 23:2289-92. 2007
    ..This observation suggests that a microorganism's "force taxonomy" may provide a fundamental and practical indicator of the pathogen-related risk that infections pose to patients with implanted medical devices...
  20. ncbi request reprint Early surgery in patients with infective endocarditis: a propensity score analysis
    Olcay Aksoy
    Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Clin Infect Dis 44:364-72. 2007
    ..Largely because of these limitations, the role of surgery in long-term survival has not been adequately studied...
  21. pmc Analysis of the genotype and virulence of Staphylococcus epidermidis isolates from patients with infective endocarditis
    Alastair B Monk
    Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Infect Immun 76:5127-32. 2008
    ..This study is the first analysis suggesting that S. epidermidis isolates from patients with NVE constitute a more virulent subset within this species...
  22. ncbi request reprint Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 44:190-6. 2007
    ..Clinical outcomes resulting from such a therapeutic strategy have not been well defined...
  23. ncbi request reprint Periannular complications in infective endocarditis involving prosthetic aortic valves
    Ignasi Anguera
    Corporació Sanitària Parc Taulí Hospital de Sabadell, Sabadell, Spain
    Am J Cardiol 98:1261-8. 2006
    ..Despite the frequent complications, fistulous tract formation in the current era of infective endocarditis is not an independent risk factor for mortality...
  24. ncbi request reprint Periannular complications in infective endocarditis involving native aortic valves
    Ignasi Anguera
    Corporació Sanitària Parc Taulí Hospital de Sabadell, Sabadell, Spain
    Am J Cardiol 98:1254-60. 2006
    ..Despite these higher rates of complications, fistulous tract formation in the current era of IE is not an independent risk factor for mortality...
  25. ncbi request reprint Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus
    Vance G Fowler
    Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 355:653-65. 2006
    ..Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed...
  26. pmc Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia
    J John Weems
    Greenville Hospital Sytem University Medical Center, South Carolina, USA
    Antimicrob Agents Chemother 50:2751-5. 2006
    ..Tefibazumab was well tolerated, with a safety profile similar to those of other monoclonal antibodies. Additional trials are warranted to address the dosing range and efficacy of tefibazumab...
  27. ncbi request reprint Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: a report from the International Collaboration on Endocarditis-Merged Database
    Wissam M Kourany
    Duke University Medical Center, Durham, NC, USA
    Scand J Infect Dis 38:613-9. 2006
    ..08-2.70), especially in male patients, as diabetic males had higher mortality than non-diabetic males (OR 2.18, CI 1.08-4.35). DM is an independent predictor of in-hospital mortality among patients hospitalized with IE...
  28. ncbi request reprint Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection
    Vance G Fowler
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 196:738-47. 2007
    ..The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear...
  29. ncbi request reprint Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia
    Shelby D Reed
    Center for Clinical and Genetic Economics, USA
    Infect Control Hosp Epidemiol 26:175-83. 2005
    ..We compared costs and outcomes of methicillin resistance in patients with S. aureus bacteremia and a single chronic condition...
  30. ncbi request reprint [Staphylococcus aureus infections: new challenges from an old pathogen]
    Zeina A Kanafani
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Enferm Infecc Microbiol Clin 24:182-93. 2006
    ..aureus and their impact on the clinical manifestations and management of serious infections. We also discuss new treatment modalities for MRSA infections and emphasize the importance of preventive approaches...
  31. ncbi request reprint Infective endocarditis caused by daptomycin-resistant Enterococcus faecalis: a case report
    Zeina A Kanafani
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Scand J Infect Dis 39:75-7. 2007
    ..Daptomycin is a first-in-class antibiotic with efficacy against Gram-positive bacteria. We document the second report of daptomycin resistance in a clinical isolate of Enterococcus faecalis...
  32. pmc Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia
    Carlo McCalla
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 52:3441-3. 2008
    ..1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure...
  33. ncbi request reprint Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia
    Anna Lisa Crowley
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Crit Care Med 36:385-90. 2008
    ....
  34. ncbi request reprint Non-HACEK gram-negative bacillus endocarditis
    Susan Morpeth
    Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27710, USA
    Ann Intern Med 147:829-35. 2007
    ....
  35. pmc Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections
    Steven J Campbell
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Microbiol 46:678-84. 2008
    ..01). S. aureus strains from different geographic regions have different distributions of virulence genes...
  36. ncbi request reprint Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 26:1159-61. 2007
    ..Infants with methicillin-resistant S. aureus infection had a longer median duration of bacteremia (4.5 versus 1 day, P = 0.01), but no difference in length of hospital stay, mortality, or neurodevelopmental impairment...
  37. pmc Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective
    Cathy A Petti
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    J Clin Microbiol 46:1780-4. 2008
    ..In particular, rpoB sequence data demonstrated unique genetic signatures with the potential to serve as an important tool for global surveillance...
  38. doi request reprint Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 46:1683-93. 2008
    ..Telavancin is an investigational, rapidly bactericidal lipoglycopeptide with a multifunctional mechanism of action...
  39. ncbi request reprint Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, NC, USA
    J Infect Dis 196:1425-30. 2007
    ..Endogenous antimicrobial peptides participate in the innate defense of skin against a variety of pathogens. The systemic expression of these peptides in normal-appearing skin of patients with infective cellulitis is unknown...
  40. pmc Phase II, randomized, multicenter, double-blind, placebo-controlled trial of a polyclonal anti-Staphylococcus aureus capsular polysaccharide immune globulin in treatment of Staphylococcus aureus bacteremia
    Mark E Rupp
    Division of Infectious Diseases, University of Nebraska Medical Center, 984031 Nebraska Medical Center, Omaha, NE 68198 4031, USA
    Antimicrob Agents Chemother 51:4249-54. 2007
    ..gov number NCT00063089)...
  41. ncbi request reprint Relationship between clinical outcomes and vascular access type among hemodialysis patients with Staphylococcus aureus bacteremia
    Jula K Inrig
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27705, USA
    Clin J Am Soc Nephrol 1:518-24. 2006
    ..Twelve-week mortality and costs that are associated with an episode of SAB are high in hemodialysis patients, regardless of vascular access type. Efforts should focus on the prevention of SAB in this high-risk group...
  42. ncbi request reprint Optimizing therapy for methicillin-resistant Staphylococcus aureus bacteremia
    Sara E Cosgrove
    Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Semin Respir Crit Care Med 28:624-31. 2007
    ..aureus endocarditis is life threatening. Selection of an appropriate antibiotic regimen is also an essential factor for optimal management...
  43. doi request reprint Management of methicillin-resistant Staphylococcus aureus bacteremia
    Sara E Cosgrove
    Johns Hopkins University School of Medicine, Baltimore, Maryland and 2Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 46:S386-93. 2008
    ..The increasing prevalence of methicillin-resistant S. aureus (MRSA) infections has created a tremendous demand for effective and safe antimicrobial agents other than the historic anti-MRSA agent vancomycin...
  44. ncbi request reprint Contemporary clinical profile and outcome of prosthetic valve endocarditis
    Andrew Wang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 297:1354-61. 2007
    ..Prosthetic valve endocarditis (PVE) is associated with significant mortality and morbidity. The contemporary clinical profile and outcome of PVE are not well defined...
  45. pmc Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study
    Martin E Stryjewski
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Antimicrob Agents Chemother 50:862-7. 2006
    ..These data support the ongoing studies assessing the efficacy and safety of telavancin in the treatment of serious gram-positive infections, particularly involving MRSA...
  46. ncbi request reprint Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Med 118:1416. 2005
    ..aureus bacteremia on patients with prosthetic devices. This investigation sought to define the clinical outcome, health care resource use, and infection-associated costs of S. aureus bacteremia in patients with prostheses...
  47. ncbi request reprint Use of surgery in patients with native valve infective endocarditis: results from the International Collaboration on Endocarditis Merged Database
    Christopher H Cabell
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 150:1092-8. 2005
    ..The aim of the study was to characterize patients with native valve IE relative to surgery and to determine if patients who benefit from an early surgical intervention can be identified...
  48. ncbi request reprint Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD)
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, NC, USA
    Scand J Infect Dis 36:453-5. 2004
    ..We evaluated 16 patients with Candida IE nested within a cohort of 2,022 patients with IE. Prosthetic valve IE was more common in patients with Candida (50% vs 17%); mortality was 37% for patients with Candida...
  49. ncbi request reprint Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin
    Christopher W Woods
    Clinical Microbiology, Durham Veterans Administration Medical Center, Durham, NC 27705, USA
    Clin Infect Dis 38:1188-91. 2004
    ..We report the strain characterization and treatment of a patient with SARV IE...
  50. ncbi request reprint Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999
    Christopher H Cabell
    Divisions of Division of Cardiology, Duke University Medical Center, and Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 147:582-6. 2004
    ....
  51. ncbi request reprint Early predictors of in-hospital death in infective endocarditis
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 109:1745-9. 2004
    ..Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE...
  52. ncbi request reprint Importance of aggressive evaluation in patients with Staphylococcus aureus bacteremia
    Chris H Cabell
    Am Heart J 147:379-80. 2004
  53. ncbi request reprint Surgical treatment of pacemaker and defibrillator lead endocarditis: the impact of electrode lead extraction on outcome
    Ana del Rio
    Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Chest 124:1451-9. 2003
    ..Medical treatment has been suggested for the treatment of CD endocarditis, but there is increasing evidence that surgical treatment is to be preferred as the best approach to achieve eradication of the infection and reduce mortality...
  54. ncbi request reprint Clinical identifiers of complicated Staphylococcus aureus bacteremia
    Vance G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 163:2066-72. 2003
    ..This investigation sought to define readily available clinical characteristics that could help identify patients at risk for complicated SAB...
  55. ncbi request reprint Fatal outcome of bacteraemic patients caused by infection with staphylokinase-deficient Staphylococcus aureus strains
    Tao Jin
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Med Microbiol 52:919-23. 2003
    ..aureus bacteraemia. The high frequency of SAK production in nasal isolates and in cases with uncomplicated bacteraemia suggests that SAK may be one of the adaptive mechanisms of S. aureus symbiosis with the host...
  56. ncbi request reprint Staphylococcus aureus bacteremia and endocarditis
    Cathy A Petti
    Departments of Pathology and Medicine, Box 3879, Duke University Medical Center, Durham, NC 27710, USA
    Cardiol Clin 21:219-33, vii. 2003
    ..In this review, the authors summarize recent changes in the epidemiology of SAB and IE, discuss the challenges in distinguishing SAB from IE, and discuss current trends in the management of patients with SAB and IE...
  57. ncbi request reprint Staphylococcus aureus bacteremia after median sternotomy: clinical utility of blood culture results in the identification of postoperative mediastinitis
    Vance G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 108:73-8. 2003
    ..Mediastinitis is a complication of coronary artery bypass graft surgery (CABG) that can be difficult to diagnose. This study evaluated the utility of blood culture results in identifying patients with mediastinitis...
  58. ncbi request reprint Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection
    John J Engemann
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 36:592-8. 2003
    ..Methicillin resistance is independently associated with increased mortality and hospital charges among patients with S. aureus SSI...
  59. pmc Patient detection of a drug dispensing error by use of physician-provided drug samples
    Elizabeth S Dodds Ashley
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacotherapy 22:1642-3. 2002
  60. ncbi request reprint Staphylococcus aureus bacteremia and endocarditis
    Cathy A Petti
    Departments of Pathology and Medicine, Box 3879, Duke University Medical Center, Durham, NC 27710, USA
    Infect Dis Clin North Am 16:413-35, x-xi. 2002
    ..In this review, the authors summarize recent changes in the epidemiology of SAB and IE, discuss the challenges in distinguishing SAB from IE, and discuss current trends in the management of patients with SAB and IE...
  61. pmc Antimicrobial activity of prosthetic heart valve sewing cuffs coated with minocycline and rifampin
    Rabih O Darouiche
    Center for Prostheses Infection, Baylor College of Medicine and Veterans Affairs Medical Center, St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 46:543-5. 2002
    ..An in vitro elution study of these coated sewing cuffs demonstrated residual zones of inhibition against Staphylococcus epidermidis for at least 4 weeks...
  62. ncbi request reprint Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein
    Vance G Fowler
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 190:1140-9. 2004
    ..This investigation examined potential associations between PB with key clinical features and several in vitro bacterial genotypic and phenotypic characteristics, in isolates from 1 institution...
  63. ncbi request reprint Native valve endocarditis due to coagulase-negative staphylococci: report of 99 episodes from the International Collaboration on Endocarditis Merged Database
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 39:1527-30. 2004
    ..These results emphasize the importance of CoNS as a cause of NVE and the potential for serious complications with this infection...
  64. ncbi request reprint Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia
    Anne Marie Valente
    Department of Pediatrics, Duke University, Box 3090, Durham, NC 27710, USA
    Pediatrics 115:e15-9. 2005
    ..The objective of this study was to determine prospectively the prevalence of IE among pediatric patients with SAB in a large tertiary care center...
  65. ncbi request reprint The use and effect of surgical therapy for prosthetic valve infective endocarditis: a propensity analysis of a multicenter, international cohort
    Andrew Wang
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 150:1086-91. 2005
    ....
  66. ncbi request reprint A returning traveler with fever and rash
    Deverick J Anderson
    Division of Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 41:1453-4, 1529-30. 2005
  67. ncbi request reprint A meta-analysis of medical versus surgical therapy for Candida endocarditis
    William J Steinbach
    Division of Infectious Diseases, Department of Pediatrics, Duke University, Durham, NC 27710, USA
    J Infect 51:230-47. 2005
    ..The optimal management of Candida infective endocarditis (IE) is unknown...
  68. ncbi request reprint Clinical characteristics and outcome of aortic endocarditis with periannular abscess in the International Collaboration on Endocarditis Merged Database
    Ignasi Anguera
    The Corporació Sanitària Parc Taulí, Hospital de Sabadell, University of Barcelona, Barcelona, Spain
    Am J Cardiol 96:976-81. 2005
    ..S. aureus infection is an independent prognostic factor for mortality in patients who have abscess formation...
  69. ncbi request reprint Clinical predictors of major infections after cardiac surgery
    Vance G Fowler
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 112:I358-65. 2005
    ....
  70. ncbi request reprint Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database
    Jose M Miro
    Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 41:507-14. 2005
    ..Staphylococcus aureus native valve infective endocarditis (SA-NVIE) is not completely understood. The objective of this investigation was to describe the characteristics of a large, international cohort of patients with SA-NVIE...
  71. ncbi request reprint Clinical outcomes and costs due to Staphylococcus aureus bacteremia among patients receiving long-term hemodialysis
    John J Engemann
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 26:534-9. 2005
    ..To examine the clinical outcomes and costs associated with Staphylococcus aureus bacteremia among hemodialysis-dependent patients...
  72. ncbi request reprint Repeat infective endocarditis: differentiating relapse from reinfection
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 41:406-9. 2005
    ..The agreement between clinical and molecular criteria was imperfect (agreement in 10 [77%] of 13 cases)...
  73. pmc Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function
    George Sakoulas
    Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Antimicrob Agents Chemother 49:2687-92. 2005
    ..In vitro, these events were associated with defective lysis and reduced susceptibility to tPMP. The precise mechanism(s) underlying these findings is the subject of current investigations...
  74. ncbi request reprint Staphylococcus aureus endocarditis: a consequence of medical progress
    Vance G Fowler
    Duke University Medical Center, Durham, NC 27710, USA
    JAMA 293:3012-21. 2005
    ..The global significance of infective endocarditis (IE) caused by Staphylococcus aureus is unknown...
  75. ncbi request reprint Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria
    Martin E Stryjewski
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 40:1601-7. 2005
    ..Telavancin is highly active against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate, and vancomycin-resistant strains...
  76. ncbi request reprint Risk of endocarditis among patients with prosthetic valves and Staphylococcus aureus bacteremia
    Fadi El-Ahdab
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med 118:225-9. 2005
    ..However, the risk of endocarditis in patients with a prosthetic valve who develop S. aureus bacteremia is unclear. The aim of this study was to define the risk of prosthetic valve endocarditis in patients with S. aureus bacteremia...
  77. ncbi request reprint Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia
    Vance G Fowler
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 40:695-703. 2005
    ..The role of both host and pathogen characteristics in hematogenous seeding following Staphylococcus aureus bacteremia is incompletely understood...
  78. ncbi request reprint Aorto-cavitary fistulous tract formation in infective endocarditis: clinical and echocardiographic features of 76 cases and risk factors for mortality
    Ignasi Anguera
    Corporació Sanitària Parc Taulí Hospital de Sabadell, Sabadell, Spain
    Eur Heart J 26:288-97. 2005
    ..Aorto-cavitary communications create intra-cardiac shunts, which may result in further clinical deterioration and haemodynamic instability...
  79. ncbi request reprint Changing patient characteristics and the effect on mortality in endocarditis
    Christopher H Cabell
    Department of Medicine, Duke University Medical Center, Box 31020, Durham, NC 27710
    Arch Intern Med 162:90-4. 2002
    ..Limited data exist on recent demographic and microbiological changes in infective endocarditis (IE) and the impact of these changes on patient survival...