G Michael Felker

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Troponin I in acute decompensated heart failure: insights from the ASCEND-HF study
    G Michael Felker
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur J Heart Fail 14:1257-64. 2012
  2. doi request reprint Diuretics and ultrafiltration in acute decompensated heart failure
    G Michael Felker
    Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    J Am Coll Cardiol 59:2145-53. 2012
  3. doi request reprint Loop diuretics in heart failure
    G Michael Felker
    Division of Cardiology, Duke Clinical Research Institute, Duke University School of Medicine, 2400 Pratt St, Room 0311 Terrace Level, Durham, NC 27705, USA
    Heart Fail Rev 17:305-11. 2012
  4. pmc Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study
    G Michael Felker
    Duke University Medical Center, Durham, NC 27710, USA
    Circ Heart Fail 5:72-8. 2012
  5. ncbi request reprint The Valsalva maneuver: a bedside "biomarker" for heart failure
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am J Med 119:117-22. 2006
  6. ncbi request reprint Outcomes with an alternate list strategy for heart transplantation
    G Michael Felker
    Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    J Heart Lung Transplant 24:1781-6. 2005
  7. ncbi request reprint Same bridge, new destinations rethinking paradigms for mechanical cardiac support in heart failure
    G Michael Felker
    Duke University School of Medicine, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 47:930-2. 2006
  8. ncbi request reprint Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 50:40-7. 2007
  9. doi request reprint Biomarkers as surrogate end points in heart failure trials
    G Michael Felker
    Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA
    Heart Fail Clin 7:501-7. 2011
  10. pmc Diuretic strategies in patients with acute decompensated heart failure
    G Michael Felker
    Duke University School of Medicine and Duke Heart Center, Durham, NC, USA
    N Engl J Med 364:797-805. 2011

Research Grants

Detail Information

Publications84

  1. doi request reprint Troponin I in acute decompensated heart failure: insights from the ASCEND-HF study
    G Michael Felker
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur J Heart Fail 14:1257-64. 2012
    ..Circulating troponins are a prognostic marker in patients with ADHF. Contemporary assays with greater sensitivity require reassessment of the significance of troponin elevation in HF...
  2. doi request reprint Diuretics and ultrafiltration in acute decompensated heart failure
    G Michael Felker
    Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    J Am Coll Cardiol 59:2145-53. 2012
    ..This review summarizes available data on the use of both diuretics and UF in ADHF patients and identifies challenges and unresolved questions for each approach...
  3. doi request reprint Loop diuretics in heart failure
    G Michael Felker
    Division of Cardiology, Duke Clinical Research Institute, Duke University School of Medicine, 2400 Pratt St, Room 0311 Terrace Level, Durham, NC 27705, USA
    Heart Fail Rev 17:305-11. 2012
    ..Data from other ongoing trials will continue to inform our understanding of the optimal role for loop diuretics in the treatment of heart failure...
  4. pmc Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study
    G Michael Felker
    Duke University Medical Center, Durham, NC 27710, USA
    Circ Heart Fail 5:72-8. 2012
    ..We evaluated the association between galectin-3 and long-term clinical outcomes in ambulatory heart failure patients enrolled in the HF-ACTION study...
  5. ncbi request reprint The Valsalva maneuver: a bedside "biomarker" for heart failure
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am J Med 119:117-22. 2006
    ..Although often overlooked in clinical training and practice, the cardiovascular response to the Valsalva maneuver is a potentially useful, noninvasive means of evaluating filling pressures in patients with heart failure...
  6. ncbi request reprint Outcomes with an alternate list strategy for heart transplantation
    G Michael Felker
    Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    J Heart Lung Transplant 24:1781-6. 2005
    ..The creation of an alternate list to match recipients with contraindications to traditional HT with sub-optimal donor organs has been implemented at some centers, but outcomes using this approach are uncertain...
  7. ncbi request reprint Same bridge, new destinations rethinking paradigms for mechanical cardiac support in heart failure
    G Michael Felker
    Duke University School of Medicine, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 47:930-2. 2006
    ....
  8. ncbi request reprint Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 50:40-7. 2007
    ..The goal of this study was to identify potentially novel laboratory markers of risk in chronic heart failure patients...
  9. doi request reprint Biomarkers as surrogate end points in heart failure trials
    G Michael Felker
    Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA
    Heart Fail Clin 7:501-7. 2011
    ..Ongoing research into the role of biomarkers as surrogates may lead to better clinical trial design and more efficient development of new therapies for heart failure...
  10. pmc Diuretic strategies in patients with acute decompensated heart failure
    G Michael Felker
    Duke University School of Medicine and Duke Heart Center, Durham, NC, USA
    N Engl J Med 364:797-805. 2011
    ..Loop diuretics are an essential component of therapy for patients with acute decompensated heart failure, but there are few prospective data to guide their use...
  11. ncbi request reprint Anemia in patients with heart failure and preserved systolic function
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 151:457-62. 2006
    ..Although heart failure in the setting of preserved systolic function (PSF) is an important clinical problem, the relationship between anemia and outcomes in patients with PSF has not been carefully evaluated...
  12. ncbi request reprint Anaemia and coronary artery disease severity in patients with heart failure
    G Michael Felker
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Eur J Heart Fail 8:54-7. 2006
    ..Exacerbation of myocardial ischemia in patients with heart failure, coronary disease, and anaemia patients has been suggested as a potential mechanism underlying this association...
  13. doi request reprint Diuretic management in heart failure
    G Michael Felker
    Division of Cardiology, Duke University Medical Center, Durham, NC 27705, USA
    Congest Heart Fail 16:S68-72. 2010
    ....
  14. doi request reprint Biomarker-guided therapy in chronic heart failure: a meta-analysis of randomized controlled trials
    G Michael Felker
    Duke Clinical Research Institute and the Division of Cardiology, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 158:422-30. 2009
    ..We performed a quantitative meta-analysis of available randomized controlled trials to determine whether titration of therapy based on natriuretic peptide measurements improves mortality in chronic heart failure...
  15. pmc N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 158:S37-44. 2009
    ..To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure...
  16. ncbi request reprint The African-American heart failure trial: a new look at old drugs
    G Michael Felker
    Duke Clinical Research Institute, 2400 Pratt St, Room 0311 Terrace Level, Durham, NC 27705, USA
    Future Cardiol 1:311-3. 2005
    ..Future research will be required to assess whether benefits of this drug combination seen in AHeFT can be extended to the wider population of patients with advanced heart failure...
  17. pmc Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure
    Robb D Kociol
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 6:240-5. 2013
    ....
  18. ncbi request reprint Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Am J Cardiol 92:625-8. 2003
    ..Lower baseline hemoglobin is associated with risk of short-term adverse clinical outcomes in this population, even after controlling for other baseline differences...
  19. ncbi request reprint Racial differences in the characteristics of patients admitted for acute decompensated heart failure and their relation to outcomes: results from the OPTIME-CHF trial
    Melvin R Echols
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Card Fail 12:684-8. 2006
    ..Recent data suggest that differences in response to therapy and survival exist between African Americans and Caucasians with heart failure. Whether these differences exist in acute decompensated heart failure (ADHF) is uncertain...
  20. ncbi request reprint Marginal cardiac allografts do not have increased primary graft dysfunction in alternate list transplantation
    Brian Lima
    DUMC Box 3043, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 114:I27-32. 2006
    ..2) The objective of this study was to determine the incidence of and predictors for PGD...
  21. pmc Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 15:456-64. 2013
    ..To examine the characteristics associated with early dyspnoea relief during acute heart failure (HF) hospitalization, and its association with 30-day outcomes...
  22. doi request reprint Soluble ST2 in ambulatory patients with heart failure: Association with functional capacity and long-term outcomes
    G Michael Felker
    Division of Cardiology, Duke University Medical Center, Durham, NC
    Circ Heart Fail 6:1172-9. 2013
    ....
  23. ncbi request reprint Risk stratification after hospitalization for decompensated heart failure
    G Michael Felker
    Duke Clinical Research Institute, 2400 Pratt Street, Room 0311, Terrace Level, Durham, NC 27705, USA
    J Card Fail 10:460-6. 2004
    ..We used data from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study to develop a model that would predict outcomes in patients with decompensated HF...
  24. doi request reprint Infectious complications in extended criteria heart transplantation
    Keshava Rajagopal
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Heart Lung Transplant 27:1217-21. 2008
    ..We hypothesized that other adverse outcomes, principally determined by recipient characteristics, occur at a higher rate in extended criteria recipients...
  25. doi request reprint Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure
    Larry A Allen
    Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    J Card Fail 16:230-8. 2010
    ..Our study sought to validate the prognostic value of RDW in heart failure and to explore the potential mechanisms underlying this association...
  26. doi request reprint Patterns of leukocyte counts on admissions for acute heart failure--presentation and outcome--results from a community based registry
    Olga Milo-Cotter
    Momentum Research Inc, Durham, North Carolina 27707, USA
    Int J Cardiol 148:17-22. 2011
    ..To determine the correlation between differential white blood cell (WBC) count and characteristics and outcome of acute heart failure (AHF) syndromes...
  27. doi request reprint Early worsening heart failure in patients admitted with acute heart failure--a new outcome measure associated with long-term prognosis?
    Beth Davison Weatherley
    Momentum Research Inc, Durham, NC, USA
    Fundam Clin Pharmacol 23:633-9. 2009
    ..7-6.3). Early WHF is a common adverse event in patients admitted with AHF, and is associated with AHF severity and excessive 6-month mortality. WHF should be considered as a clinically important endpoint in AHF studies...
  28. pmc Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program
    Larry A Allen
    Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    Eur J Heart Fail 11:170-7. 2009
    ..The prevalence and importance of liver function test (LFT) abnormalities in a large contemporary cohort of heart failure patients have not been systematically evaluated...
  29. pmc Admission, discharge, or change in B-type natriuretic peptide and long-term outcomes: data from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) linked to Medicare claims
    Robb D Kociol
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 4:628-36. 2011
    ..It is unknown if admission, discharge, or change from admission to discharge BNP measure is the most important predictor of long-term outcomes...
  30. ncbi request reprint Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure
    Benjamin H Trichon
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Am J Cardiol 91:538-43. 2003
    ..MR is common in patients with LV systolic dysfunction and heart failure. After adjusting for other clinical variables, the presence of MR independently predicted worsened survival...
  31. doi request reprint Ten-year experience with extended criteria cardiac transplantation
    Marc D Samsky
    Duke University Medical Center, and the Duke Clinical Research Institute, Durham, NC
    Circ Heart Fail 6:1230-8. 2013
    ..There is a paucity of data examining long-term outcomes with this strategy...
  32. pmc Association between adrenergic receptor genotypes and beta-blocker dose in heart failure patients: analysis from the HF-ACTION DNA substudy
    Mona Fiuzat
    Duke University and the Duke Clinical Research Institute, Durham, NC, USA
    Eur J Heart Fail 15:258-66. 2013
    ..We examined whether the Arg389Gly polymorphism in ADRĪ²1 interacts with the dose requirements of beta-blockers in patients with systolic HF...
  33. ncbi request reprint Implantable left ventricular assist devices: new hope for patients with end-stage heart failure
    Carmelo A Milano
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    N C Med J 67:110-5. 2006
    ..Recently, the Food and Drug Administration approved implantable left ventricular assist devices (LVAD) as destination therapy (DT) for end-stage heart failure patients who are ineligible for cardiac transplantation...
  34. pmc A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 77:239-46. 2010
    ..These differential outcomes underscore the need for dedicated trials in these subpopulations...
  35. doi request reprint Troponin elevation in heart failure prevalence, mechanisms, and clinical implications
    Robb D Kociol
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 56:1071-8. 2010
    ..Ultimately, this information might allow physicians to guide therapy, choose appropriate therapeutics, and improve HF outcomes...
  36. pmc Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial
    Margaret M Redfield
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    JAMA 309:1268-77. 2013
    ..Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF)...
  37. doi request reprint Comparison of Clinical characteristics and long-term outcomes of patients with ischemic cardiomyopathy with versus without angina pectoris (from the Duke Databank for Cardiovascular Disease)
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 109:1272-7. 2012
    ..03) (5-year event rates 85% vs 87% and 77% vs 73%, respectively). In conclusion, AP is common in patients with iCM despite medical therapy and previous revascularization and is associated with increased CV death or CV rehospitalization...
  38. ncbi request reprint Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk
    Thomas P Cappola
    Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 105:1663-8. 2002
    ....
  39. ncbi request reprint The pathophysiology of acute heart failure--is it all about fluid accumulation?
    Gad Cotter
    Duke University Medical Center, The Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 155:9-18. 2008
    ....
  40. pmc Permutation criteria to evaluate multiple clinical endpoints in a proof-of-concept study: lessons from Pre-RELAX-AHF
    Beth A Davison
    Momentum Research, Inc, Durham, NC, USA
    Clin Res Cardiol 100:745-53. 2011
    ..Although observing an effect on one of many endpoints due to chance is likely, observing concurrent positive trends across several outcomes by chance is usually unlikely...
  41. pmc Natriuretic peptides in the diagnosis and management of heart failure
    G Michael Felker
    Outcomes Research Group, Duke Clinical Research Institute, and the Division of Cardiology and Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    CMAJ 175:611-7. 2006
    ....
  42. ncbi request reprint Survival after coronary revascularization, with and without mitral valve surgery, in patients with ischemic mitral regurgitation
    Benjamin H Trichon
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Circulation 108:II103-10. 2003
    ....
  43. ncbi request reprint Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study
    G Michael Felker
    Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Cardiol 41:997-1003. 2003
    ..The goal of this study was to assess the interaction between heart failure (HF) etiology and response to milrinone in decompensated HF...
  44. doi request reprint End points for clinical trials in acute heart failure syndromes
    Larry A Allen
    Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Am Coll Cardiol 53:2248-58. 2009
    ....
  45. doi request reprint Rapid clinical assessment of patients with acute heart failure: first blood pressure and oxygen saturation--is that all we need?
    Olga Milo-Cotter
    Momentum Research Inc, 3100 Tower Blvd, Suite 802, Durham, NC 27707, USA
    Cardiology 114:75-82. 2009
    ..Low oxygen saturation (SaO2) and systolic blood pressure (SBP) are signs of impending respiratory and circulatory failure that can be obtained quickly in patients with AHF...
  46. doi request reprint The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure
    Tariq Ahmad
    Division of Cardiology, Duke University Medical Center, Durham, NC Duke Clinical Research Institute, Durham, NC
    Am Heart J 167:193-202.e1. 2014
    ..Whether exercise training leads to improvements in biomarkers and how such improvements relate to clinical outcomes are unclear...
  47. doi request reprint Reduction in body weight but worsening renal function with late ultrafiltration for treatment of acute decompensated heart failure
    Sandesh Dev
    Duke University Medical Center, Durham, NC, USA
    Cardiology 123:145-53. 2012
    ..The safety, effectiveness and indications for ultrafiltration (UF) are not well established. We hypothesized that UF would not worsen renal function in patients with heart failure (HF) who were not responding to medical therapy...
  48. doi request reprint Improvements in signs and symptoms during hospitalization for acute heart failure follow different patterns and depend on the measurement scales used: an international, prospective registry to evaluate the evolution of measures of disease severity in acut
    Larry A Allen
    Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA
    J Card Fail 14:777-84. 2008
    ..The natural evolution of signs and symptoms during acute heart failure (AHF) is poorly characterized...
  49. ncbi request reprint Mortality in primary and secondary myocarditis
    Todd C Pulerwitz
    Cardiology Division, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am Heart J 147:746-50. 2004
    ..Lymphocytic myocarditis presents as a primary disorder or in association with a systemic disease. Whether primary and secondary myocarditis have the same prognosis is unknown...
  50. doi request reprint Advances in the surgical treatment of heart failure
    Larry A Allen
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Curr Opin Cardiol 23:249-53. 2008
    ..The purpose of this review is to discuss emerging surgical therapies in heart failure, in particular, mechanical cardiac support and mitral valve repair...
  51. ncbi request reprint The problem of decompensated heart failure: nomenclature, classification, and risk stratification
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 145:S18-25. 2003
    ..It also defines the current understanding of strategies for risk stratification in the setting of decompensated heart failure...
  52. doi request reprint Impact of left ventricular assist device bridging on posttransplant outcomes
    Jay D Pal
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27705, USA
    Ann Thorac Surg 88:1457-61; discussion 1461. 2009
    ..However, referral for LVAD therapy may be limited secondary to reports of poor outcomes when mechanical circulatory support is required before transplantation...
  53. doi request reprint Thrombolytic therapy for thrombosis of continuous flow ventricular assist devices
    Kelly Schlendorf
    Division of Cardiology, Duke University Medical Center, Durham, North Carolina
    J Card Fail 20:91-7. 2014
    ..Limited data exist to guide management in these patients...
  54. doi request reprint Cardiohepatic interactions in heart failure: an overview and clinical implications
    Marc D Samsky
    Duke Clinical Research Institute and the Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 61:2397-405. 2013
    ..Finally, we provide recommendations regarding the management of both types of liver injury in HF patients...
  55. doi request reprint Dysphagia in the setting of left ventricular assist device hemolysis
    Robert J Mentz
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    ASAIO J 59:322-3. 2013
    ....
  56. ncbi request reprint Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure
    Karen E Joynt
    Department of Medicine Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 93:783-5. 2004
    ..Baseline angiotensin-converting enzyme inhibitor plus beta-blocker use were associated with lower levels of CRP; no relation was found between CRP levels and aspirin or statin use...
  57. doi request reprint United States stock market performance and acute myocardial infarction rates in 2008-2009 (from the Duke Databank for Cardiovascular Disease)
    Mona Fiuzat
    Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 106:1545-9. 2010
    ..02). In conclusion, unadjusted and adjusted analyses of patients in the Duke Databank for Cardiovascular Disease indicated a significant correlation between a period of stock market decrease and increased AMI rates in our local cohort...
  58. doi request reprint Biomarker guided therapy for heart failure: focus on natriuretic peptides
    Kirkwood F Adams
    Department of Medicine, School of Medicine, UNC Heart Failure Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    Heart Fail Rev 15:351-70. 2010
    ..Although pilot work has provided encouraging results, appropriately designed, large-scale, prospective randomized trials are needed to confirm these preliminary findings and definitively establish this therapeutic approach...
  59. ncbi request reprint Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial
    Dianne H Leloudis
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
    J Heart Lung Transplant 25:1164-6. 2006
    ..A better understanding of the factors affecting pain during EMBx could improve the comfort level of this procedure...
  60. ncbi request reprint Anemia as a risk factor and therapeutic target in heart failure
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 44:959-66. 2004
    ..Multiple ongoing studies will provide definitive data on the balance of risks and benefits of anemia treatment in chronic HF...
  61. ncbi request reprint Recurrence of cardiac sarcoidosis in a heart transplant recipient
    Jonathan E E Yager
    Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    J Heart Lung Transplant 24:1988-90. 2005
    ..He subsequently underwent uncomplicated heart transplantation. Nineteen months later, a routine surveillance endomyocardial biopsy specimen demonstrated recurrence of sarcoidosis in the transplanted heart...
  62. pmc Obesity and the response to intensified diuretic treatment in decompensated heart failure: a DOSE trial substudy
    Achal Gupta
    Division of Cardiology, University of Utah, Salt Lake City, Utah, USA
    J Card Fail 18:837-44. 2012
    ..Obesity could attenuate diuretic effectiveness in treatment of acute decompensated heart failure (HF)...
  63. ncbi request reprint A standardized definition of ischemic cardiomyopathy for use in clinical research
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 39:210-8. 2002
    ....
  64. doi request reprint Relationship between anemia and health care costs in heart failure
    Larry A Allen
    Division of Cardiology, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Card Fail 15:843-9. 2009
    ..Anemia is associated with higher morbidity and mortality in patients with heart failure (HF), but its implications for heath care costs are not well described...
  65. pmc Discordance between patient-predicted and model-predicted life expectancy among ambulatory patients with heart failure
    Larry A Allen
    Duke Clinical Research Institute and Division of Cardiology, Durham, NC 27705, USA
    JAMA 299:2533-42. 2008
    ..Patients with chronic heart failure have impaired long-term survival, but their own expectations regarding prognosis have not been well studied...
  66. ncbi request reprint Clinical outcomes in patients on beta-blocker therapy admitted with worsening chronic heart failure
    Wendy A Gattis
    Duke University Medical Center Duke Clinical Research Institute, Division of Cardiology, Durham, North Carolina 27705, USA
    Am J Cardiol 91:169-74. 2003
    ..These results also suggest that caution should be taken when withdrawing beta blockade in this population...
  67. doi request reprint Hyponatraemia in acute heart failure is a marker of increased mortality but not when associated with hyperglycaemia
    Olga Milo-Cotter
    Momentum Research, Inc, Durham, NC 27707, USA
    Eur J Heart Fail 10:196-200. 2008
    ..Although diabetes is a common co-morbidity in heart failure, no prior study has considered the impact of serum glucose on this relationship...
  68. ncbi request reprint Natriuretic Peptide-guided therapy for heart failure
    Robert J Mentz
    Department of Cardiology, Duke Clinical Research Institute, Durham, NC, USA
    Circ J 75:2031-7. 2011
    ..This article reviews the rationale, accumulated data, and unanswered questions for BGT in chronic HF...
  69. doi request reprint Novel biomarkers in chronic heart failure
    Tariq Ahmad
    Division of Cardiology, Duke University School of Medicine, 2400 Pratt Street, Durham, NC 27705, USA
    Nat Rev Cardiol 9:347-59. 2012
    ..We will also discuss the potential role for these biomarkers within a multimarker-based strategy that could, in the future, lead to better care for these patients...
  70. doi request reprint Hyponatremia and long-term outcomes in chronic heart failure--an observational study from the Duke Databank for Cardiovascular Diseases
    Luca Bettari
    Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy
    J Card Fail 18:74-81. 2012
    ..Hyponatremia is a well known predictor of short-term outcomes in heart failure (HF); however, its impact on long-term survival in HF patients with systolic dysfunction is not well established...
  71. doi request reprint Clinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantation
    Valentino Piacentino
    Duke University Medical Center, Durham, NC, USA
    Ann Thorac Surg 92:1414-8; discussion 1418-9. 2011
    ..Preoperative TR is associated with negative outcomes but the clinical benefit of concomitant tricuspid valve procedures has not been extensively studied...
  72. ncbi request reprint Inflammatory biomarkers in heart failure
    John W Petersen
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, NC, USA
    Congest Heart Fail 12:324-8. 2006
    ..In this review, the authors analyze available data supporting the use of inflammatory markers both as biomarkers and as potential therapeutic targets...
  73. doi request reprint Inotropes in the management of acute heart failure
    John W Petersen
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, NC, USA
    Crit Care Med 36:S106-11. 2008
    ..Whether newer inotropes with differing mechanisms of action will realize the potential clinical benefits of inotropic therapy without the risk remains a subject of ongoing investigation...
  74. doi request reprint Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial
    Sunil V Rao
    Duke Clinical Research Institute, Durham, NC, USA
    Circulation 121:1713-21. 2010
    ..We performed a phase 2 randomized trial to evaluate the safety and feasibility of M118 in the setting of elective percutaneous coronary intervention...
  75. doi request reprint A global ranking approach to end points in trials of mechanical circulatory support devices
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    J Card Fail 14:368-72. 2008
    ..The ideal composite end point for studies of MCSDs is uncertain...
  76. doi request reprint Mechanisms of bleeding and approach to patients with axial-flow left ventricular assist devices
    Jorge Suarez
    Duke Clinical Research Institute and the Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    Circ Heart Fail 4:779-84. 2011
    ....
  77. ncbi request reprint Left ventricular assist devices as destination therapy for end-stage heart failure
    Jonathan E E Yager
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 148:252-3. 2004
  78. doi request reprint Low lymphocyte ratio as a novel prognostic factor in acute heart failure: results from the Pre-RELAX-AHF study
    Olga Milo-Cotter
    Momentum Research, Duke University, 3100 Tower Boulevard, Durham, NC 27707, USA
    Cardiology 117:190-6. 2010
    ..Previous studies have suggested that a lower lymphocyte ratio (Ly%) in the white blood cell (WBC) differential count is related to worse outcomes in patients with acute heart failure (AHF) and other cardiovascular disorders...
  79. ncbi request reprint Acute heart failure associated with high admission blood pressure--a distinct vascular disorder?
    Olga Milo-Cotter
    Duke University Medical Center and the Duke Clinical Research Institute, Durham NC, 27515, USA
    Eur J Heart Fail 9:178-83. 2007
    ..Although blood pressure (BP) is elevated in patients with acute heart failure (AHF), first admission BP has not been meticulously recorded before treatment in previous studies...
  80. ncbi request reprint The impact of arrhythmias in acute heart failure
    Raymond L Benza
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Card Fail 10:279-84. 2004
    ..Arrhythmias are common in chronic heart failure and affect outcomes. The incidence and significance of new arrhythmias in acute heart failure, however, are largely unknown...
  81. ncbi request reprint A bridge for the 21st century in heart transplantation?
    G Michael Felker
    Am Heart J 145:198-9. 2003
  82. ncbi request reprint Unraveling the pathophysiology of acute heart failure: an inflammatory proposal
    G Michael Felker
    Am Heart J 151:765-7. 2006
  83. ncbi request reprint Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) s
    Liviu Klein
    Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Circulation 111:2454-60. 2005
    ..The prognostic value of serum sodium in patients hospitalized for worsening heart failure has not been well defined...
  84. ncbi request reprint B-type natriuretic peptide - a biomarker for all seasons?
    Daniel B Mark
    N Engl J Med 350:718-20. 2004

Research Grants2

  1. Inflammation & Prognosis in Decompensated Heart Failure
    GARY FELKER; Fiscal Year: 2007
    ..Felker's development into an established independent clinical investigator with expertise in both complex clinical research methodology and the role of inflammation in the pathophysiology of heart failure. ..