Genomes and Genes
Affiliation: Duke University Medical Center
- The role of astrocyte-secreted matricellular proteins in central nervous system development and functionCagla Eroglu
Cell Biology, Duke University Medical Center, 333A Nanaline Duke Bldg, Box 3709, Durham, NC 27710 USA
J Cell Commun Signal 3:167-76. 2009..We will discuss a newly described function for thrombospondins in synapse formation in the CNS in detail, and speculate whether other matricellular proteins could play similar roles in nervous system development and function...
- Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesisCagla Eroglu
Duke University Medical Center, Cell Biology Department, Durham, NC 27710, USA
Cell 139:380-92. 2009..These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation...
- Regulation of synaptic connectivity by gliaCagla Eroglu
Cell Biology Department, Box 3709, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 468:223-31. 2010..Understanding how signalling between glia and neurons regulates synaptic development will offer new insight into how the nervous system works and provide new targets for the treatment of neurological diseases...
- Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4Eric J Benner
George and Jean Brumley Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27710, USA
Nature 497:369-73. 2013..Taken together, these findings have important implications for post-injury applications of endogenous and transplanted NSCs in the therapeutic setting, as well as disease states where Thbs family members have important roles...
- Thrombospondins as key regulators of synaptogenesis in the central nervous systemW Christopher Risher
Cell Biology Department, Duke University Medical Center, Durham, NC 27710, United States
Matrix Biol 31:170-7. 2012....
- Huntingtin is required for normal excitatory synapse development in cortical and striatal circuitsSpencer U McKinstry
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710
J Neurosci 34:9455-72. 2014..Together, our findings reveal that cortical Htt is required for the correct establishment of cortical and striatal excitatory circuits, and this function of Htt is lost when the mutant Htt is present. ..
- Rapid Golgi analysis method for efficient and unbiased classification of dendritic spinesW Christopher Risher
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 9:e107591. 2014..This approach, built upon freely available software, can be utilized by researchers studying a broad range of synaptic connectivity phenotypes in both development and disease. ..
- Neuroligins provide molecular links between syndromic and nonsyndromic autismSandeep K Singh
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Sci Signal 6:re4. 2013..This understanding might bring us closer to development of therapeutic approaches for autism. ..
- Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARCHakan Kucukdereli
Cell Biology Department, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 108:E440-9. 2011....
- Look who is weaving the neural web: glial control of synapse formationM McLean Bolton
Department of Cell Biology, Duke University Medical Center, 333A Nanaline Duke Bldg, Box 3709, Durham, NC 27710, United States
Curr Opin Neurobiol 19:491-7. 2009....
- Astrocytes refine cortical connectivity at dendritic spinesW Christopher Risher
Department of Cell Biology, Duke University Medical Center, Durham, United States
elife 4:. 2015..These findings reveal that, through secretion of hevin, astrocytes control an important developmental synaptic refinement process at dendritic spines. ..
- Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthoodMary Louise Risher
Durham VA Medical Center, Duke University Medical Center, Durham, North Carolina
Alcohol Clin Exp Res 39:989-97. 2015..e., intermittent EtOH exposure during adolescence [AIE]) in rats to determine whether adolescent exposure to alcohol leads to long-term structural and functional changes that are manifested in adult neuronal circuitry...