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origin recognition complex
Genomes and Genes
Duke University Medical Center
Ehlers M. Synapse structure: glutamate receptors connected by the shanks. Curr Biol. 1999;9:R848-50
..A family of proteins has been identified whose members, the Shanks, physically link two major receptor complexes at excitatory synapses - NMDA receptors and metabotropic glutamate receptors. ..
Ehlers M. Dendrite development: a surprising origin. J Cell Biol. 2005;170:517-9
..Neurons extend elaborate dendrites studded with spines. Unexpectedly, this cellular sculpting is regulated by the origin recognition complex -- the core machinery for initiating DNA replication. ..
Ehlers M, Heine M, Groc L, Lee M, Choquet D. Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity. Neuron. 2007;54:447-60
..Thus, local activity restricts GluR1 mobility on a submicron scale, defining an input-specific mechanism for regulating AMPA receptor composition and abundance. ..
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