Michael Ehlers

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Synapse structure: glutamate receptors connected by the shanks
    M D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham, 27710, USA
    Curr Biol 9:R848-50. 1999
  2. pmc Dendrite development: a surprising origin
    Michael D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 170:517-9. 2005
  3. pmc Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes
    Mikyoung Park
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 52:817-30. 2006
  4. ncbi Secrets of the secretory pathway in dendrite growth
    Michael D Ehlers
    Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 55:686-9. 2007
  5. pmc Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
    Michael D Ehlers
    Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 54:447-60. 2007
  6. ncbi Synapse formation: astrocytes spout off
    Michael D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 15:R134-7. 2005
  7. ncbi Eppendorf 2003 prize-winning essay. Ubiquitin and the deconstruction of synapses
    Michael D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 302:800-1. 2003
  8. ncbi Deconstructing the axon: Wallerian degeneration and the ubiquitin-proteasome system
    Michael D Ehlers
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Trends Neurosci 27:3-6. 2004
  9. ncbi Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
    Michael D Ehlers
    Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 6:231-42. 2003
  10. ncbi Molecular morphogens for dendritic spines
    Michael D Ehlers
    Dept of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Trends Neurosci 25:64-7. 2002

Research Grants

  1. Molecular Targets of A-beta-Induced Synaptic Dysfunction
    Michael Ehlers; Fiscal Year: 2007
  2. The Endocytic Machinery of Dendritic Spines
    Michael Ehlers; Fiscal Year: 2007
  3. Synaptic Targeting of NMDA Receptors
    Michael Ehlers; Fiscal Year: 2009
  4. The Endocytic Machinery of Dendritic Spines
    Michael Ehlers; Fiscal Year: 2009
  5. The Endocytic Machinery of Dendritic Spines
    Michael D Ehlers; Fiscal Year: 2010
  6. Intracellular Trafficking of AMPA Receptors
    Michael Ehlers; Fiscal Year: 2006
  7. SYNAPTIC TARGETING AND CLUSTERING AND NMDA RECEPTORS
    Michael Ehlers; Fiscal Year: 2004
  8. Non-invasive Chemical Genetic Control of Neuronal Activity
    Michael D Ehlers; Fiscal Year: 2010

Collaborators

Detail Information

Publications50

  1. ncbi Synapse structure: glutamate receptors connected by the shanks
    M D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham, 27710, USA
    Curr Biol 9:R848-50. 1999
    ..A family of proteins has been identified whose members, the Shanks, physically link two major receptor complexes at excitatory synapses - NMDA receptors and metabotropic glutamate receptors...
  2. pmc Dendrite development: a surprising origin
    Michael D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 170:517-9. 2005
    ..Neurons extend elaborate dendrites studded with spines. Unexpectedly, this cellular sculpting is regulated by the origin recognition complex -- the core machinery for initiating DNA replication...
  3. pmc Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes
    Mikyoung Park
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 52:817-30. 2006
    ....
  4. ncbi Secrets of the secretory pathway in dendrite growth
    Michael D Ehlers
    Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 55:686-9. 2007
    ..Dendrites and axons exhibit different morphologies and patterns of growth. This difference in neuronal structure is controlled by evolutionarily conserved directed trafficking through the secretory pathway...
  5. pmc Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
    Michael D Ehlers
    Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 54:447-60. 2007
    ..Thus, local activity restricts GluR1 mobility on a submicron scale, defining an input-specific mechanism for regulating AMPA receptor composition and abundance...
  6. ncbi Synapse formation: astrocytes spout off
    Michael D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 15:R134-7. 2005
    ..Trillions of synapses form as the brain develops. This intimate contact between two neurons has now been shown to be facilitated by thrombospondins - large extracellular matrix proteins secreted by astrocytes...
  7. ncbi Eppendorf 2003 prize-winning essay. Ubiquitin and the deconstruction of synapses
    Michael D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 302:800-1. 2003
  8. ncbi Deconstructing the axon: Wallerian degeneration and the ubiquitin-proteasome system
    Michael D Ehlers
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Trends Neurosci 27:3-6. 2004
  9. ncbi Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
    Michael D Ehlers
    Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 6:231-42. 2003
    ....
  10. ncbi Molecular morphogens for dendritic spines
    Michael D Ehlers
    Dept of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Trends Neurosci 25:64-7. 2002
    ..These new studies reveal linkages between receptor complexes, the actin cytoskeleton and signaling molecules that help shape spines...
  11. ncbi Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting
    M D Ehlers
    Department of Neurobiology, Duke University Medical Center, Durham 27710, USA
    Neuron 28:511-25. 2000
    ..These results demonstrate that activity regulates AMPAR endocytic sorting, providing a potential mechanistic link between rapid and chronic changes in synaptic strength...
  12. ncbi Ubiquitin and synaptic dysfunction: ataxic mice highlight new common themes in neurological disease
    Michael D Ehlers
    Departments of Neurobiology, Cell Biology and Pharmacology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Trends Neurosci 26:4-7. 2003
  13. ncbi Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors
    Yuanyue Mu
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Neuron 40:581-94. 2003
    ....
  14. pmc Metaplasticity at single glutamatergic synapses
    Ming Chia Lee
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 66:859-70. 2010
    ..Thus, spontaneous glutamate release adjusts plasticity threshold at single synapses by local regulation of NMDA receptors, providing a novel spatially delimited form of synaptic metaplasticity...
  15. pmc Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation
    Ryan T Terry-Lorenzo
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 16:2349-62. 2005
    ....
  16. pmc Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1
    Isabel Pérez-Otaño
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, North Carolina 27710, USA
    Nat Neurosci 9:611-21. 2006
    ....
  17. ncbi Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging
    April C Horton
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 23:6188-99. 2003
    ..This distributed dendritic Golgi represents an organization of the secretory pathway unique among mammalian cells...
  18. pmc Pruning and loss of excitatory synapses by the parkin ubiquitin ligase
    Thomas D Helton
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:19492-7. 2008
    ..Thus, parkin negatively regulates the number and strength of excitatory synapses. Increased excitatory drive produced by disruption of parkin may contribute to the pathophysiology of PD...
  19. ncbi Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines
    Thomas A Blanpied
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 36:435-49. 2002
    ..These results reveal the presence of a novel specialization dedicated to endocytosis near the postsynaptic membrane...
  20. ncbi Recycling endosomes supply AMPA receptors for LTP
    Mikyoung Park
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Science 305:1972-5. 2004
    ..Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification...
  21. ncbi Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis
    April C Horton
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 48:757-71. 2005
    ..These results define a novel polarized organization of neuronal secretory trafficking and demonstrate a mechanistic link between directed membrane trafficking and asymmetric dendrite growth...
  22. pmc Structural plasticity with preserved topology in the postsynaptic protein network
    Thomas A Blanpied
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:12587-92. 2008
    ..We propose a flexible matrix model of the PSD based on stable molecular positioning of PSD-95 scaffolds...
  23. ncbi Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease
    Thomas A Blanpied
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 55:1121-7. 2004
    ....
  24. ncbi Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals
    Derek B Scott
    Program in Cell and Molecular Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:7096-109. 2004
    ..These results define a novel conserved signature of NMDARs regulating internalization and postendocytic trafficking...
  25. ncbi Secretory trafficking in neuronal dendrites
    April C Horton
    Department of Neurobiology, Duke University Medical Center, Box 3209 Durham, NC 27710, USA
    Nat Cell Biol 6:585-91. 2004
    ....
  26. pmc Secretory outposts for the local processing of membrane cargo in neuronal dendrites
    Cyril Hanus
    Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Traffic 9:1437-45. 2008
    ..Here we review what is currently known about dendritic secretory organelles and their role in the development, maintenance and plasticity of postsynaptic compartments...
  27. pmc Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity
    Zhiping Wang
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Cell 135:535-48. 2008
    ..Thus, Ca2+-activated MyoVb captures and mobilizes REs for AMPA receptor insertion and spine growth, providing a mechanistic link between the induction and expression of postsynaptic plasticity...
  28. doi Parallel on-axis holographic phase microscopy of biological cells and unicellular microorganism dynamics
    Natan T Shaked
    1Department of Biomedical Engineering, Fitzpatrick Institute for Photonics, Duke University, Durham, North Carolina 27708, USA
    Appl Opt 49:2872-8. 2010
    ..The method is demonstrated experimentally through phase microscopy of neurons and unicellular microorganisms...
  29. ncbi Ubiquitin and protein turnover in synapse function
    Jason J Yi
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, North Carolina 27710, USA
    Neuron 47:629-32. 2005
    ..These recent findings raise intriguing questions as to how enduring changes at synapses are accomplished in the face of robust, ongoing molecular turnover...
  30. pmc Organelles and trafficking machinery for postsynaptic plasticity
    Matthew J Kennedy
    Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Neurosci 29:325-62. 2006
    ....
  31. ncbi Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses
    Isabel Pérez-Otaño
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, N C 27710, USA
    Neurosignals 13:175-89. 2004
    ..Here, we review recent evidence that challenges this view, focusing on the role that activity plays in altering NMDAR trafficking and how such dynamic regulation of NMDARs may impact on the plasticity of neural circuits...
  32. doi Spine microdomains for postsynaptic signaling and plasticity
    Thomas M Newpher
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Cell Biol 19:218-27. 2009
    ..We discuss the emerging functions of glutamate receptors residing within sub-spine microdomains and propose a model for distinct signaling platforms with specialized functions in synaptic plasticity...
  33. ncbi Neuronal polarity and trafficking
    April C Horton
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Neuron 40:277-95. 2003
    ....
  34. ncbi Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons
    Dhanrajan M Tiruchinapalli
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    RNA Biol 5:157-68. 2008
    ..We propose that post-transcriptional regulation of neuronal mRNAs by HuD RBPs mediates protein synthesis-dependent changes in synaptic plasticity...
  35. ncbi Age-related regulation of dendritic endocytosis associated with altered clathrin dynamics
    Thomas A Blanpied
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 24:1095-104. 2003
    ..Thus, endocytic function in dendrites is altered in older neurons, suggesting that as neurons age, protein trafficking mechanisms are controlled to complement maturational requirements...
  36. pmc Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer
    Jiuyi Lu
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 55:874-89. 2007
    ..Thus, a physical link between the PSD and the EZ ensures localized endocytosis and recycling by recapturing and maintaining a proximate pool of cycling AMPA receptors...
  37. ncbi Emerging roles for ubiquitin and protein degradation in neuronal function
    Jason J Yi
    Program in Cell and Molecular Biology, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Rev 59:14-39. 2007
    ..Here, we summarize existing knowledge about the role of the UPS in brain function, highlighting recent work delineating its importance in neuronal development, plasticity, and degeneration...
  38. ncbi Cell type-specific dendritic polarity in the absence of spatially organized external cues
    April C Horton
    Department of Neurobiology, Durham, NC, 27710, USA
    Brain Cell Biol 35:29-38. 2006
    ..Thus, pyramidal neurons have a cellular program for polarized dendrite growth independent of tissue microenvironment...
  39. pmc Genetic control of neuronal activity in mice conditionally expressing TRPV1
    Benjamin R Arenkiel
    Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, North Carolina 27710, USA
    Nat Methods 5:299-302. 2008
    ..Application of the TRPV1 ligand capsaicin induced strong inward currents, triggered action potentials and activated stereotyped behaviors, allowing cell type-specific chemical genetic control of neuronal activity in vitro and in vivo...
  40. pmc Ubiquitination in postsynaptic function and plasticity
    Angela M Mabb
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Cell Dev Biol 26:179-210. 2010
    ..We describe postsynaptic ubiquitination pathways and their role in brain development, neuronal physiology, and brain disorders...
  41. pmc TGF-beta signaling specifies axons during brain development
    Jason J Yi
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Cell 142:144-57. 2010
    ..These results define an extrinsic cue for neuronal polarity in vivo that patterns neural circuits in the developing brain...
  42. ncbi Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors
    Derek B Scott
    Program in Cell and Molecular Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropharmacology 45:755-67. 2003
    ....
  43. pmc Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines
    Matthew J Kennedy
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Cell 141:524-35. 2010
    ..Thus, Stx4 defines an exocytic zone that directs membrane fusion for postsynaptic plasticity, revealing a novel specialization for local membrane traffic in dendritic spines...
  44. pmc Molecular genetics and imaging technologies for circuit-based neuroanatomy
    Benjamin R Arenkiel
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, North Carolina 27710, USA
    Nature 461:900-7. 2009
    ..This sophisticated molecular and genetic 'toolbox', coupled with new methods in optical and electron microscopy, provides an expanding array of techniques for probing neural anatomy and function...
  45. pmc In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2
    Benjamin R Arenkiel
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 54:205-18. 2007
    ....
  46. pmc Glutamate receptor dynamics in dendritic microdomains
    Thomas M Newpher
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 58:472-97. 2008
    ..We also examine the cooperative relationship between intracellular trafficking and surface diffusion of glutamate receptors that underlies the expression of learning-related synaptic plasticity...
  47. ncbi Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor
    HYANG SOOK HOE
    Department of Neuroscience and Physiology, Georgetown University Medical Center, Washington, DC 20057 1464, USA
    J Biol Chem 281:3425-31. 2006
    ..These studies suggest that ApoEr2 can form a multiprotein complex with NMDA receptor subunits and PSD95...
  48. ncbi Lateral organization of endocytic machinery in dendritic spines
    Bence Racz
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nat Neurosci 7:917-8. 2004
    ..Thus, previously unrecognized lateral domains of the spine organize endocytic protein machinery at sites removed from the postsynaptic density...
  49. ncbi Homeostatic plasticity and NMDA receptor trafficking
    Isabel Pérez-Otaño
    Department of Neurosciences, CIMA, University of Navarra Medical School, Pamplona, 31008, Spain
    Trends Neurosci 28:229-38. 2005
    ..An emerging concept is that activity-dependent alterations in NMDA receptor trafficking contribute to homeostatic plasticity at central glutamatergic synapses...
  50. ncbi Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin
    Ioannis E Michailidis
    Department of Molecular Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 27:5523-32. 2007
    ..Thus, our results extend the influence of PIP2 to the NMDA ionotropic glutamate receptors and introduce a novel mechanism of "indirect" regulation of transmembrane protein activity by PIP2...

Research Grants31

  1. Molecular Targets of A-beta-Induced Synaptic Dysfunction
    Michael Ehlers; Fiscal Year: 2007
    ..As such, the proposed research holds promise for the development of new therapeutic approaches for AD-associated memory loss and cognitive deficit. ..
  2. The Endocytic Machinery of Dendritic Spines
    Michael Ehlers; Fiscal Year: 2007
    ..abstract_text> ..
  3. Synaptic Targeting of NMDA Receptors
    Michael Ehlers; Fiscal Year: 2009
    ..Moreover, because NMDA receptors participate in the pathogenesis of a wide range of neurologic disorders, psychiatric disease, and states of addiction, these studies hold promise for the development of novel therapeutic strategies. ..
  4. The Endocytic Machinery of Dendritic Spines
    Michael Ehlers; Fiscal Year: 2009
    ....
  5. The Endocytic Machinery of Dendritic Spines
    Michael D Ehlers; Fiscal Year: 2010
    ....
  6. Intracellular Trafficking of AMPA Receptors
    Michael Ehlers; Fiscal Year: 2006
    ....
  7. SYNAPTIC TARGETING AND CLUSTERING AND NMDA RECEPTORS
    Michael Ehlers; Fiscal Year: 2004
    ..Together, the proposed experiments will elucidate basic molecular mechanisms underlying synaptic transmission and synaptic plasticity. ..
  8. Non-invasive Chemical Genetic Control of Neuronal Activity
    Michael D Ehlers; Fiscal Year: 2010
    ....