PUDUGRAMAM DORAISWAMY

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Quality of life in geriatric depression: a comparison of remitters, partial responders, and nonresponders
    P M Doraiswamy
    Department of Psychiatry, Box 3018, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 9:423-8. 2001
  2. ncbi request reprint Pharmacological strategies for the prevention of Alzheimer's disease
    P Murali Doraiswamy
    Psychiatry Clinical Trials, Department of Psychiatry, Duke University Medical Center, DUMC Box 3018, Durham, NC 27710, USA
    Expert Opin Pharmacother 7:1-10. 2006
  3. ncbi request reprint Atypical antipsychotics and pituitary neoplasms in the WHO database
    P Murali Doraiswamy
    Department of Psychiatry and the Department of Medicine at Duke University Medical Center, DUMC 3018, Durham, NC 27514, USA
    Psychopharmacol Bull 40:74-6. 2007
  4. ncbi request reprint Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial
    P Murali Doraiswamy
    Department of Psychiatry, Center for the Study of Aging, and Duke Heart Center, Duke University Medical Center, Durham, North Carolina, USA
    Psychopharmacol Bull 40:54-62. 2007
  5. ncbi request reprint Metals in our minds: therapeutic implications for neurodegenerative disorders
    P Murali Doraiswamy
    Department of Psychiatry, Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    Lancet Neurol 3:431-4. 2004
  6. ncbi request reprint Alzheimer's disease and the glutamate NMDA receptor
    P Murali Doraiswamy
    Division of Biological Psychiatry, Duke University Medical Center, Durham, NC, USA
    Psychopharmacol Bull 37:41-9. 2003
  7. ncbi request reprint The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential
    P Murali Doraiswamy
    Departments of Psychiatry and Medicine, and the Center for the Study of Aging, Duke University Medical Center, Box 3018, Durham, NC 27710, USA
    Curr Neurol Neurosci Rep 3:373-8. 2003
  8. ncbi request reprint Long-term effects of rivastigmine in moderately severe Alzheimer's disease: does early initiation of therapy offer sustained benefits?
    P Murali Doraiswamy
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:705-12. 2002
  9. doi request reprint Diagnostic utility of the Quick Inventory of Depressive Symptomatology (QIDS-C16 and QIDS-SR16) in the elderly
    P Murali Doraiswamy
    Department of Psychiatry, and the Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA
    Acta Psychiatr Scand 122:226-34. 2010
  10. ncbi request reprint Prevalence and impact of medical comorbidity in Alzheimer's disease
    P Murali Doraiswamy
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gerontol A Biol Sci Med Sci 57:M173-7. 2002

Research Grants

  1. Treatment Outcomes of Vascular Depression
    PUDUGRAMAM DORAISWAMY; Fiscal Year: 2005
  2. Development of Inventory of Depressive Symptomatology
    PUDUGRAMAM DORAISWAMY; Fiscal Year: 2005

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Quality of life in geriatric depression: a comparison of remitters, partial responders, and nonresponders
    P M Doraiswamy
    Department of Psychiatry, Box 3018, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 9:423-8. 2001
    ..Findings support the importance of treating elderly depressed patients to full remission to maximize impact on both emotional and physical QOL domains...
  2. ncbi request reprint Pharmacological strategies for the prevention of Alzheimer's disease
    P Murali Doraiswamy
    Psychiatry Clinical Trials, Department of Psychiatry, Duke University Medical Center, DUMC Box 3018, Durham, NC 27710, USA
    Expert Opin Pharmacother 7:1-10. 2006
    ..Reducing the complexity of prevention trials and gaining regulatory consensus of design is a high priority for the field...
  3. ncbi request reprint Atypical antipsychotics and pituitary neoplasms in the WHO database
    P Murali Doraiswamy
    Department of Psychiatry and the Department of Medicine at Duke University Medical Center, DUMC 3018, Durham, NC 27514, USA
    Psychopharmacol Bull 40:74-6. 2007
    ..studies to confirm causality and suggest that clinicians, until then, would consider a pituitary adenoma in patients experiencing severe hyperprolactinemia or associated symptoms when receiving potent D2 antagonists [corrected]..
  4. ncbi request reprint Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial
    P Murali Doraiswamy
    Department of Psychiatry, Center for the Study of Aging, and Duke Heart Center, Duke University Medical Center, Durham, North Carolina, USA
    Psychopharmacol Bull 40:54-62. 2007
    ..To study the effect of donepezil in treating patients with cognitive decline following coronary artery bypass graft (CABG) surgery...
  5. ncbi request reprint Metals in our minds: therapeutic implications for neurodegenerative disorders
    P Murali Doraiswamy
    Department of Psychiatry, Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    Lancet Neurol 3:431-4. 2004
    ..The therapeutic significance of metal dysregulation in neurodegenerative disorders has remained difficult to test...
  6. ncbi request reprint Alzheimer's disease and the glutamate NMDA receptor
    P Murali Doraiswamy
    Division of Biological Psychiatry, Duke University Medical Center, Durham, NC, USA
    Psychopharmacol Bull 37:41-9. 2003
    ..Memantine was recently approved in Europe for the treatment of moderately severe to severe AD and is an investigational drug in the United States...
  7. ncbi request reprint The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential
    P Murali Doraiswamy
    Departments of Psychiatry and Medicine, and the Center for the Study of Aging, Duke University Medical Center, Box 3018, Durham, NC 27710, USA
    Curr Neurol Neurosci Rep 3:373-8. 2003
    ....
  8. ncbi request reprint Long-term effects of rivastigmine in moderately severe Alzheimer's disease: does early initiation of therapy offer sustained benefits?
    P Murali Doraiswamy
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:705-12. 2002
    ..The results support the value of early treatment of AD patients, particularly those with moderately severe AD...
  9. doi request reprint Diagnostic utility of the Quick Inventory of Depressive Symptomatology (QIDS-C16 and QIDS-SR16) in the elderly
    P Murali Doraiswamy
    Department of Psychiatry, and the Center for the Study of Aging, Duke University Medical Center, Durham, NC, USA
    Acta Psychiatr Scand 122:226-34. 2010
    ..the Quick Inventory of Depressive Symptomatology-Clinician-rated (QIDS-C(16)) and Self-report (QIDS-SR(16)) scales to detect a current major depressive episode in the elderly...
  10. ncbi request reprint Prevalence and impact of medical comorbidity in Alzheimer's disease
    P Murali Doraiswamy
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gerontol A Biol Sci Med Sci 57:M173-7. 2002
    ..We examined the prevalence of comorbid medical illnesses in Alzheimer's disease (AD) patients at different severity levels. We also examined the effect of cumulative medical comorbidity on cognition and function...
  11. ncbi request reprint The spectrum of quality-of-life impairments in recurrent geriatric depression
    P Murali Doraiswamy
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gerontol A Biol Sci Med Sci 57:M134-7. 2002
    ....
  12. pmc Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 67:277-85. 2010
    ..Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity...
  13. ncbi request reprint Non-cholinergic strategies for treating and preventing Alzheimer's disease
    P Murali Doraiswamy
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    CNS Drugs 16:811-24. 2002
    ..This article provides an update on the current status of selected agents, focusing primarily on those agents with the most extensive clinical evidence at present...
  14. ncbi request reprint Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 60:58-65. 2006
    ....
  15. ncbi request reprint Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not?
    Glen Xiong
    Duke University Medical Center, Durham, NC, USA
    Geriatrics 60:22-6. 2005
    ..This review highlights the urgent need to systematically test additional rational drug combinations and the need for future trials to enroll adequate sample sizes and utilize relevant and sensitive outcome measures...
  16. ncbi request reprint Effect of mirtazapine orally disintegrating tablets on health-related quality of life in elderly depressed patients with comorbid medical disorders: a pilot study
    Indira Varia
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacol Bull 40:47-56. 2007
    ..There is a need for additional studies on the quality of life (QOL) of elderly depressed subjects with medical comorbidity...
  17. ncbi request reprint Statin use and hippocampal volumes in elderly subjects at risk for Alzheimer's disease: a pilot observational study
    P Murali Doraiswamy
    Department of Psychiatry and Medicine Geriatrics, Duke University Medical Center, Durham, North Carolina, USA
    Am J Alzheimers Dis Other Demen 19:275-8. 2004
    ..Prospective studies in both nondemented and AD subjects may provide more conclusive answers...
  18. ncbi request reprint Learning and recall in subjects at genetic risk for Alzheimer's disease
    J Gene Chen
    Department of Psychiatry and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neuropsychiatry Clin Neurosci 14:58-63. 2002
    ..Memory impairments associated with genetic or family history risk may not manifest until the person is much closer to the onset age of AD...
  19. pmc Modulation of a human memory circuit by subsyndromal depression in late life: a functional magnetic resonance imaging study
    Shoshana L Woo
    Department of Psychiatry, Center for Study of Aging and School of Medicine, Duke University Medical Center, Duke University, Durham, NC 27710 3808, USA
    Am J Geriatr Psychiatry 17:24-9. 2009
    ..Functional deactivation of the posteromedial cortex (PMC) seems to be a physiologic process underlying normal memory. The authors examined whether older subjects with subsyndromal depressive symptoms show impaired PMC deactivation...
  20. ncbi request reprint Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging
    Jeffrey R Petrella
    Department of Radiology, Duke University Medical Center, 1527 Hosp North, Box 3808, Durham, NC 27710, USA
    Radiology 245:224-35. 2007
    ....
  21. ncbi request reprint Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve
    Larry A Tupler
    Department of Psychiatry and Behavioral Sciences, Box 3018, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 28:1644-56. 2007
    ..Age and sex did not enter into the model. We conclude that APOE-epsilon4 predicts longitudinal memory decline in healthy controls and that MRI morphometry of hippocampus adds slightly to predictive value...
  22. ncbi request reprint Coenzyme Q10: a review of its promise as a neuroprotectant
    A Joyce Young
    Duke University Medical Center, Durham, NC 27703, USA
    CNS Spectr 12:62-8. 2007
    ..Randomized controlled trials are warranted to confirm CoQ10's safety and promise as a clinically effective neuroprotectant...
  23. pmc Intima-media thickness and age of first depressive episode
    Patrick J Smith
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC 27710, USA
    Biol Psychol 80:361-4. 2009
    ..We therefore investigated the relationship between IMT and age of first depressive episode in a sample of 202 adults (age range 40-81 years) with major depression (MDD)...
  24. pmc Frontal white matter anisotropy and antidepressant remission in late-life depression
    Warren D Taylor
    The Department of Psychiatry, Durham, North Carolina, USA
    PLoS ONE 3:e3267. 2008
    ..We hypothesized that remission would be associated with higher frontal anisotropy measures, and failure to remit with lower anisotropy...
  25. pmc Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study
    Benson M Hoffman
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3119, Durham, NC 27710, USA
    Psychosom Med 73:127-33. 2011
    ..To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD)...
  26. ncbi request reprint Imaging genetics of brain longevity and mental wellness: the next frontier?
    Jeffrey R Petrella
    Alzheimer Imaging Research Laboratory, Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 246:20-32. 2008
    ..Selected examples will be used to illustrate how neuroimaging is being employed to study the effects of genes and how neurogenetics may affect future radiology research and practice...
  27. pmc Prognostic value of posteromedial cortex deactivation in mild cognitive impairment
    Jeffrey R Petrella
    Alzheimer Imaging Research Laboratory and Brain Imaging and Analysis Center, Department of Radiology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 2:e1104. 2007
    ..The goal of this study was to prospectively determine the prognostic significance of PMC deactivation in mild cognitive impairment (MCI)...
  28. pmc Understanding prognostic benefits of exercise and antidepressant therapy for persons with depression and heart disease: the UPBEAT study--rationale, design, and methodological issues
    James A Blumenthal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Clin Trials 4:548-59. 2007
    ..However, methodological limitations of previous studies have raised questions about the value of exercise, and no study has compared the effects of exercise with standard anti-depressant medication in depressed cardiac patients...
  29. pmc Cerebrovascular risk factors and cerebral hyperintensities among middle-aged and older adults with major depression
    Patrick J Smith
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 18:848-52. 2010
    ..To examine the association between cerebral hyperintensities and cerebrovascular risk factors (CVRF) among middle-aged and older adults with major depressive disorder (MDD)...
  30. pmc Cerebrovascular risk factors, vascular disease, and neuropsychological outcomes in adults with major depression
    Patrick J Smith
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:578-86. 2007
    ..Neuropsychological deficits are common among adults with MDD, particularly among those with CVRFs and potentially persons with subclinical vascular disease...
  31. ncbi request reprint Mild cognitive impairment: evaluation with 4-T functional MR imaging
    Jeffrey R Petrella
    Department of Radiology, Brain Imaging and Analysis Center, Duke University Medical Center, Box 3808, Durham, NC 27710 3808, USA
    Radiology 240:177-86. 2006
    ..To prospectively assess abnormalities in brain activation patterns during encoding and retrieval in subjects with mild cognitive impairment by using 4-T functional magnetic resonance (MR) imaging...
  32. ncbi request reprint Treatment of social anxiety disorder with citalopram
    Indu M Varia
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:205-8. 2002
    ..These cases are consistent with two other published reports with citalopram from outside the US. Randomized controlled studies are warranted...
  33. ncbi request reprint Mood disorders and chronic obstructive pulmonary disease: current research and future needs
    Greg L Clary
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, PO Box 3519 Medical Center, Durham, NC 27710, USA
    Curr Psychiatry Rep 4:213-21. 2002
    ..Also reviewed is the impact of pulmonary rehabilitation on psychologic status and quality of life issues in the daily functioning of the COPD patient...
  34. pmc Exercise and pharmacotherapy in the treatment of major depressive disorder
    James A Blumenthal
    Department of Psychiatry and Behavioral Sciences, Box 3119, Duke University Medical Center, Durham, NC, USA
    Psychosom Med 69:587-96. 2007
    ....
  35. pmc Donepezil for the treatment of language deficits in adults with Down syndrome: a preliminary 24-week open trial
    James H Heller
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet A 116:111-6. 2003
    ..The results support the need for large-scale controlled studies of the effects of donepezil treatment on language and on other cognitive domains in DS...
  36. ncbi request reprint Neuroimaging and early diagnosis of Alzheimer disease: a look to the future
    Jeffrey R Petrella
    Department of Radiology, Duke University Medical Center, Duke Hospital North, Rm 1513, Erwin Rd, Durham, NC 27710, USA
    Radiology 226:315-36. 2003
    ..PET ligands are in late-stage development for demonstration of amyloid plaques, and human studies have already begun. Functional MR-based memory challenge tests are in development as well...
  37. ncbi request reprint Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease
    K Ranga Rama Krishnan
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 160:2003-11. 2003
    ..The authors examined the effect of the acetylcholinesterase inhibitor donepezil on magnetic resonance markers of neurodegeneration in Alzheimer's disease...
  38. ncbi request reprint Does antidepressant therapy improve cognition in elderly depressed patients?
    P Murali Doraiswamy
    Departments of Psychiatry and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gerontol A Biol Sci Med Sci 58:M1137-44. 2003
    ..To analyze the effects of antidepressants on cognitive functioning in elderly depression...
  39. ncbi request reprint Marked increase in Alzheimer's disease identified in medicare claims records between 1991 and 1999
    Donald H Taylor
    Box 90253, Duke University, Durham, NC 27708, USA
    J Gerontol A Biol Sci Med Sci 59:762-6. 2004
    ..Examining longitudinal trends in the number of persons who are identified as having AD in administrative databases may provide insights into this phenomenon...
  40. ncbi request reprint Increasing memory load modulates regional brain activity in older adults as measured by fMRI
    Jeffrey R Petrella
    Department of Radiology, DUMC, Box 3808, Durham NC 27710 3808, USA
    J Neuropsychiatry Clin Neurosci 17:75-83. 2005
    ..It was concluded that the ability to modulate activity with increasing load is preserved in older adults despite reductions in neural volume...
  41. ncbi request reprint Statins and cognition: what can we learn from existing randomized trials?
    Glen L Xiong
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    CNS Spectr 10:867-74. 2005
    ..Additionally, results of observational nonrandomized studies may have been affected by treatment bias...
  42. ncbi request reprint A systematic review of antidepressant placebo-controlled trials for geriatric depression: limitations of current data and directions for the future
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:2285-99. 2004
    ..Large simple studies are urgently needed to address the unmet needs for data on safety and efficacy of antidepressants in this population...
  43. ncbi request reprint A review of 1H MR spectroscopy findings in Alzheimer's disease
    Brian J Soher
    Center for Advanced MR Development, Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimaging Clin N Am 15:847-52, xi. 2005
    ..Multiparametric data analyses show, however, that metabolite changes correlate with in-vitro, postmortem, and metabolic changes and to changes in or predictions of cognitive scores...
  44. ncbi request reprint Mifepristone (RU 486) for Alzheimer's disease
    Nunzio Pomara
    Department of Psychiatry, New York University School of Medicine, USA
    Neurology 58:1436. 2002
  45. ncbi request reprint Prolactin-related and metabolic adverse effects of atypical antipsychotic agents
    David C Henderson
    Department of Psychiatry, Harvard Medical School, and Schizophrenia, Diabetes, and Weight Reduction Research Program, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 69:32-44. 2008
    ....
  46. pmc Safety and efficacy of rivastigmine in adolescents with Down syndrome: a preliminary 20-week, open-label study
    James H Heller
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Child Adolesc Psychopharmacol 16:755-65. 2006
    ..These results underscore the need for larger, controlled studies employing a carefully constructed test battery capable of measuring the full scope of performance across multiple domains and a wide range of functional levels...
  47. ncbi request reprint Statin-associated memory loss: analysis of 60 case reports and review of the literature
    Leslie R Wagstaff
    Drug Information Service, Duke University Medical Center, Durham, North Carolina 27710, USA
    Pharmacotherapy 23:871-80. 2003
    ..To review case reports of statin-associated memory loss as well as the available published evidence for and against such a link...
  48. ncbi request reprint Current status of metals as therapeutic targets in Alzheimer's disease
    Anne E Finefrock
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Geriatr Soc 51:1143-8. 2003
    ..This article summarizes the role of transition metals in amyloidgenesis and reviews the potential promise of chelation therapy as a treatment for AD...
  49. ncbi request reprint A randomized controlled trial of paroxetine for noncardiac chest pain
    P Murali Doraiswamy
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacol Bull 39:15-24. 2006
    ..Some recommendations for future studies to definitively test this potential are presented...
  50. ncbi request reprint Health perception, pain, and disability as correlates of anxiety and depression symptoms in primary care patients
    Lawrence R Wu
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Am Board Fam Pract 15:183-90. 2002
    ..The purpose of this study was to analyze the relations among symptoms, diagnoses, and severity of illness as indicators of anxiety and depression in primary care...
  51. ncbi request reprint Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders
    Sriyesh Krishnan
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 31:560-71. 2006
    ..These findings suggest decreased normalization accuracy in memory-impaired subjects is a potentially important confounder of template-based fMRI analyses in the hippocampus and MTL...
  52. ncbi request reprint The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 347:143-6. 2003
    ..We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association...
  53. ncbi request reprint Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research
    Sriyesh Krishnan
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimaging Clin N Am 15:853-68, xi. 2005
    ..Assessment of the diagnostic efficacy of these technologies in detecting early Alzheimer's disease in its preclinical and prodromal stages is ongoing...
  54. ncbi request reprint Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis
    Ping I Lin
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Neurogenetics 7:157-65. 2006
    ..0026). These results suggest that subset and covariate analyses may be one approach to help identify novel susceptibility genes on chromosome 12q for LOAD...

Research Grants8

  1. Treatment Outcomes of Vascular Depression
    PUDUGRAMAM DORAISWAMY; Fiscal Year: 2005
    ..The proposed trial will provide information of value to the practitioner and also provide data to build a more comprehensive model of the prognostic impact of frontal-subcortical brain changes on the outcome of late-life depression. ..
  2. Development of Inventory of Depressive Symptomatology
    PUDUGRAMAM DORAISWAMY; Fiscal Year: 2005
    ..g., anxiety, irritability) (IDS-C and SR) that are in the public domain for use with patients across the age spans seen in practice and in research. ..