Anna Mae Diehl

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Underlying potential: cellular and molecular determinants of adult liver repair
    Anna Mae Diehl
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    J Clin Invest 123:1858-60. 2013
  2. pmc Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease
    Wing Kin Syn
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Gastroenterology 137:1478-1488.e8. 2009
  3. doi request reprint Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
    Rafal P Witek
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hepatology 50:1421-30. 2009
  4. ncbi request reprint Interleukin-15 increases hepatic regenerative activity
    Ayako Suzuki
    Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Hepatol 45:410-8. 2006
  5. pmc Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis
    Steve S Choi
    Duke University, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1093-106. 2009
  6. pmc Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
    Steve S Choi
    Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    J Biol Chem 285:36551-60. 2010
  7. pmc Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers
    Liu Yang
    Division of Gastroenterology, Snyderman Building GSRB 1, Suite 1073, 595 LaSalle Street, Duke University, Durham, North Carolina 27710, USA
    Stem Cells 26:2104-13. 2008
  8. ncbi request reprint Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis
    Kanji Yamaguchi
    Division of Gastroenterology, Duke University Medical Center, Durham, NC, USA
    Hepatology 47:625-35. 2008
  9. pmc Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma
    Isaac S Chan
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 72:6344-50. 2012
  10. ncbi request reprint Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice
    Steve S Choi
    Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hepatology 44:1267-77. 2006

Collaborators

Detail Information

Publications63

  1. pmc Underlying potential: cellular and molecular determinants of adult liver repair
    Anna Mae Diehl
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    J Clin Invest 123:1858-60. 2013
    ....
  2. pmc Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease
    Wing Kin Syn
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Gastroenterology 137:1478-1488.e8. 2009
    ....
  3. doi request reprint Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
    Rafal P Witek
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hepatology 50:1421-30. 2009
    ..05; 8 weeks, P < 0.005) and had reduced hepatic levels of collagen 1alpha1 messenger RNA (8 weeks, P < 0.05). Hydroxyproline content and Sirius red staining of VX-166-treated livers confirmed decreases in fibrosis...
  4. ncbi request reprint Interleukin-15 increases hepatic regenerative activity
    Ayako Suzuki
    Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Hepatol 45:410-8. 2006
    ..It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity...
  5. pmc Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis
    Steve S Choi
    Duke University, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1093-106. 2009
    ..We conclude that Hh signaling plays a key role in transition of Q-HSC into MF-HSC. Our findings suggest that Q-HSC are capable of transitioning between epithelial and mesenchymal fates...
  6. pmc Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway
    Steve S Choi
    Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    J Biol Chem 285:36551-60. 2010
    ....
  7. pmc Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers
    Liu Yang
    Division of Gastroenterology, Snyderman Building GSRB 1, Suite 1073, 595 LaSalle Street, Duke University, Durham, North Carolina 27710, USA
    Stem Cells 26:2104-13. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  8. ncbi request reprint Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis
    Kanji Yamaguchi
    Division of Gastroenterology, Duke University Medical Center, Durham, NC, USA
    Hepatology 47:625-35. 2008
    ..During culture, they retained more vitamin A, had repressed collagen a2 (I) transcriptional activity, and expressed less collagen a1 (I) and a2 (I) mRNA...
  9. pmc Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma
    Isaac S Chan
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 72:6344-50. 2012
    ..This discovery reveals new diagnostic and therapeutic targets that might be exploited to improve the outcomes of cirrhotic patients with HCCs...
  10. ncbi request reprint Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice
    Steve S Choi
    Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hepatology 44:1267-77. 2006
    ..In conclusion, sustained activation of Rac in HSCs perpetuates their activation and exacerbates toxin-induced liver injury and fibrosis, prompting speculation that Rac may be a therapeutic target in patients with cirrhosis...
  11. pmc Increased production of sonic hedgehog by ballooned hepatocytes
    Fatima Rangwala
    Division of Cellular Therapy, Hematology and Oncology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Pathol 224:401-10. 2011
    ..These results help to explain why fibrosis stage correlates with hepatocyte ballooning in NASH...
  12. pmc Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice
    Wing Kin Syn
    Department of Medicine, Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    Liver Int 29:1262-72. 2009
    ..Design/Intervention: Beginning in adolescence, male C57BL6 (BL6) and 129/SVJ mice were fed control (n=15/group) or high-fat (HF) diets (n=30/group) for 6 months. Main..
  13. pmc Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells
    Rafal P Witek
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Gastroenterology 136:320-330.e2. 2009
    ..We studied whether adult liver cell-derived microparticles contain Hh ligands that alter hepatic sinusoidal endothelial cells (SEC)...
  14. pmc Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells
    Steve S Choi
    Division of Gastroenterology, Duke University, Durham, NC, USA
    Hepatology 52:278-90. 2010
    ....
  15. pmc Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans
    Youngmi Jung
    Department of Medicine, Duke University, Durham, North Carolina
    Gastroenterology 134:1532-43. 2008
    ..Hedgehog (Hh) pathway activation promotes expansion of progenitor populations in other tissues. We evaluated the hypothesis that chronic EtOH exposure activates Hh signaling in liver...
  16. pmc Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni
    Thiago A Pereira
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Liver Int 33:149-61. 2013
    ..Schistosomiasis mansoni is a major cause of portal fibrosis and portal hypertension. The Hedgehog pathway regulates fibrogenic repair in some types of liver injury...
  17. pmc Hedgehog controls hepatic stellate cell fate by regulating metabolism
    Yuping Chen
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Gastroenterology 143:1319-29.e1-11. 2012
    ..We investigated whether the Hedgehog (Hh) pathway controls the fate of HSCs by regulating metabolism...
  18. pmc Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease
    Kristin D Kistler
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, California 92103, USA
    Am J Gastroenterol 106:460-8; quiz 469. 2011
    ..Factors that determine disease severity in nonalcoholic fatty liver disease (NAFLD) are unclear, but exercise is a recommended treatment. We evaluated the association between physical activity intensity and histological severity of NAFLD...
  19. pmc Smoothened is a master regulator of adult liver repair
    Gregory A Michelotti
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 123:2380-94. 2013
    ..The results identify SMO as a master regulator of hepatic epithelial regeneration based on its ability to promote mesenchymal-to-epithelial transitions in a subpopulation of HSC-derived MFs with features of multipotent progenitors...
  20. pmc Hedgehog pathway and pediatric nonalcoholic fatty liver disease
    Marzena Swiderska-Syn
    Division of Gastroenterology and Hepatology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hepatology 57:1814-25. 2013
    ..Male gender and prepuberty were also associated with ductular proliferation (P < 0.05), increased numbers of portal Gli2(+) cells (P < 0.017) and portal fibrosis...
  21. pmc Signals from dying hepatocytes trigger growth of liver progenitors
    Youngmi Jung
    Division of Gastroenterology, Duke University, Snyderman Building GSRB 1, 595 LaSalle Street, Durham, NC 27710, USA
    Gut 59:655-65. 2010
    ....
  22. pmc Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease
    Wing Kin Syn
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hepatology 51:1998-2007. 2010
    ..NKT cell-conditioned medium stimulated HSC to become myofibroblastic. Liver explants were 2-fold enriched with NKT cells in patients with non-NASH cirrhosis, and 4-fold enriched in patients with NASH cirrhosis...
  23. pmc Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation
    Guanhua Xie
    Division of Gastroenterology Duke University Medical Center, Durham, NC 27710, USA
    Gut 62:299-309. 2013
    ..Hedgehog (Hh) signalling regulates vascular development and increases during liver injury. This study therefore examined its role in capillarisation...
  24. ncbi request reprint Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    Kanji Yamaguchi
    Division of Gastroenterology, Duke University Medical Center, 595 LaSalle Street, Durham, NC 27710, USA
    Hepatology 45:1366-74. 2007
    ..Progression of liver damage occurred despite reduced hepatic expression of tumor necrosis factor alpha, increased serum adiponectin, and striking improvement in systemic insulin sensitivity...
  25. pmc Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
    Alessia Omenetti
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, and Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    J Clin Invest 118:3331-42. 2008
    ..Together, these data suggest that activation of Hh signaling promotes EMT and contributes to the evolution of biliary fibrosis during chronic cholestasis...
  26. pmc Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
    Wing Kin Syn
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 53:106-15. 2011
    ..005). Cholangiocyte-derived OPN and recombinant OPN promoted fibrogenic responses in HSCs (P < 0.05); neutralizing OPN with RNA aptamers attenuated this (P < 0.05)...
  27. ncbi request reprint Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice
    Susanne V Fleig
    Division of Gastroenterology, Department of Medicine, Duke University, Durham, NC, USA
    Lab Invest 87:1227-39. 2007
    ..Hence, fatty liver injury increases Hedgehog activity in liver progenitors, and this might promote epithelial-mesenchymal transitions that result in liver fibrosis...
  28. pmc Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis
    Heather M Patton
    Division of Gastroenterology, University of California, San Diego, San Diego, California 92103, USA
    Gastroenterology 135:1961-1971.e2. 2008
    ..Noninvasive means to discriminate between NAFLD and nonalcoholic steatohepatitis (NASH) might diminish the requirement for liver biopsy or predict those at increased risk for progression...
  29. pmc Association between puberty and features of nonalcoholic fatty liver disease
    Ayako Suzuki
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Clin Gastroenterol Hepatol 10:786-94. 2012
    ..Physiological changes that occur during puberty might affect pathologic features of nonalcoholic fatty liver disease (NAFLD). We investigated associations between pubertal development and clinical and histopathologic features of NAFLD...
  30. ncbi request reprint Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation
    Alessia Omenetti
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lab Invest 87:499-514. 2007
    ..Our findings reveal that adult livers resurrect developmental signaling systems, such as the Hh pathway, to guide remodeling of the biliary epithelia and stroma after cholestatic injury...
  31. pmc Role for hedgehog pathway in regulating growth and function of invariant NKT cells
    Wing Kin Syn
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Eur J Immunol 39:1879-92. 2009
    ..Therefore, Hh pathway activation may contribute to the local expansion of pro-fibrogenic iNKT cell populations during certain types of fibrosing liver damage...
  32. pmc Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
    Liu Yang
    Gastroenterology and Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Hepatol 48:98-106. 2008
    ..The hedgehog (Hh) pathway regulates remodeling of other injured tissues. This study evaluates the hypothesis that autocrine production of Sonic hedgehog (Shh) promotes MFB growth...
  33. pmc Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
    Cynthia D Guy
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Hepatology 55:1711-21. 2012
    ..005), body mass index (P < 0.002), waist circumference (P < 0.0007), homeostatic model assessment of insulin resistance (P < 0.0001), and hypertension (P < 0.02), correlated with hepatic HH activity...
  34. pmc Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease
    Amy G Shah
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 7:1104-12. 2009
    ..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD...
  35. pmc Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Hepatology 51:1961-71. 2010
    ..05 for each). In older adults (age > or = 48 years), daily fructose consumption was associated with increased hepatic inflammation (P < 0.05) and hepatocyte ballooning (P = 0.05)...
  36. pmc The role of Hedgehog signaling in fibrogenic liver repair
    Steve S Choi
    Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Biochem Cell Biol 43:238-44. 2011
    ....
  37. pmc Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease
    Mark L Palmeri
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    J Hepatol 55:666-72. 2011
    ....
  38. pmc NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease
    Wing Kin Syn
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Gut 61:1323-9. 2012
    ....
  39. pmc Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production
    Alessia Omenetti
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC
    Hepatology 50:518-27. 2009
    ..We found that MF-HSCs release soluble Hh ligands that stimulate cholangiocytes to produce Cxcl16 and recruit NKT cells. Hh pathway activation during cholestatic liver injury also induces cholangiocyte expression of Cxcl16...
  40. doi request reprint Mechanisms of disease progression in nonalcoholic fatty liver disease
    Janice Jou
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Liver Dis 28:370-9. 2008
    ..As in other types of chronic liver injury, cirrhosis ensues in patients with NAFLD when repair is extreme and sustained, but ultimately unsuccessful, at reconstituting healthy hepatic epithelia...
  41. ncbi request reprint Hedgehog signaling maintains resident hepatic progenitors throughout life
    Jason K Sicklick
    Division of Gastroenterology, Duke University Medical Center, Snyderman GSRB I, Suite 1073, 595 LaSalle St, Box 3256, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 290:G859-70. 2006
    ..Therefore, Hedgehog signaling is conserved in hepatic progenitors from fetal development through adulthood and may be a new therapeutic target in patients with liver damage...
  42. pmc Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease
    Cynthia D Guy
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Pathol 43:790-800. 2012
    ..Keratin 8/18 plus ubiquitin double immunohistochemical stain improves detection of hepatocyte injury in nonalcoholic fatty liver disease. Thus, it may help differentiate nonalcoholic steatohepatitis from nonalcoholic fatty liver...
  43. doi request reprint Hepatic complications of obesity
    Anna Mae Diehl
    Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Gastroenterol Clin North Am 39:57-68. 2010
    ....
  44. doi request reprint Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression
    Youngmi Jung
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Dig Dis 28:225-8. 2010
    ..Therefore, we postulated that outcomes of NASH depended upon whether or not hepatic regenerative responses could keep pace with the increased rate of hepatocyte death...
  45. pmc Apoptosis and cytokines in non-alcoholic steatohepatitis
    Wing Kin Syn
    Department of Medicine, Division of Gastroenterology, GSRB1, Suite 1073, 595 LaSalle Street, Durham, NC 27710, USA
    Clin Liver Dis 13:565-80. 2009
    ..This article summarizes the process of apoptosis and roles of putative cytokines in progressive NAFLD...
  46. pmc Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes
    Manal F Abdelmalek
    Division of Gastroenterology and Hepatology, Duke University, Durham, NC 27710, USA
    Hepatology 56:952-60. 2012
    ..08 versus 0.03; P = 0.05) and γ-ATP /Pi ratio after an IV fructose challenge (0.03 versus 0.06; P = 0.06). Patients with high UA (≥ 5.5 mg/dL) showed a lower minimum liver ATP/Pi ratio postfructose challenge (4.5 versus 7.0; P = 0.04)...
  47. doi request reprint Mechanisms of disease progression in NASH: new paradigms
    Brittany N Bohinc
    Department of Endocrinology, Diabetes and Metabolism, Duke University Hospital, Durham, NC 27710, USA
    Clin Liver Dis 16:549-65. 2012
    ..When the process of tissue repair and regeneration is prolonged or when Hh ligand and related genes are aberrantly regulated and excessive, tissue repair goes awry and NASH progresses to cirrhosis and hepatocellular carcinoma...
  48. doi request reprint Serum aminotransferase changes with significant weight loss: sex and age effects
    Ayako Suzuki
    Division of Gastroenterology, Department of Medicine, Duke University, Durham, NC 27710, USA
    Metabolism 59:177-85. 2010
    ..The patterns that we detected may have pathophysiologic significance beyond the practical implications of our findings in clinical practice related to underlying changes in fat metabolism...
  49. ncbi request reprint Evidence for epithelial-mesenchymal transitions in adult liver cells
    Jason K Sicklick
    Duke Univ Medical Center, Division of Gastroenterology, Snyderman GSRB I Suite 1073, 595 LaSalle St, Box 3256, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 291:G575-83. 2006
    ..In conclusion, HSC and hepatic epithelial progenitors both coexpress epithelial and mesenchymal markers, providing evidence that EMT occurs in adult liver cells...
  50. pmc Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication
    Steve S Choi
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 54:1580-90. 2011
    ..These effects were observed with both viral infections and a subgenomic replicon. Finally, we demonstrated that GDC-0449 decreased HCV RNA levels in a dose-response manner...
  51. pmc Epithelial-to-mesenchymal transitions in the liver
    Steve S Choi
    Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 50:2007-13. 2009
    ..Conversely, predominance of MET favors more normal liver regeneration. In this review, we summarize evidence that certain resident liver cells are capable of EMTs in vitro and during chronic liver injury...
  52. pmc Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease
    Ayako Suzuki
    Duke University, Durham, North Carolina, USA
    Clin Gastroenterol Hepatol 8:1062-9. 2010
    ..We investigated whether peripheral and/or abdominal adipose depot size correlates with stage of hepatic fibrosis in patients with NAFLD in sex- and/or menopausal stage-specific manners...
  53. pmc Hepatic fat and adenosine triphosphate measurement in overweight and obese adults using 1H and 31P magnetic resonance spectroscopy
    Steven F Solga
    Department of Medicine, Division of Gastroenterology, Johns Hopkins University, Baltimore, MD 21205, USA
    Liver Int 28:675-81. 2008
    ..We aimed to evaluate the inter- and intrarater reliability and stability of hepatic fat and ATP measurements in a cohort of overweight and obese adults...
  54. pmc Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice
    Begoña Ochoa
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 51:1712-23. 2010
    ..These global inhibitory effects on liver regeneration dramatically reduced survival after PH...
  55. ncbi request reprint Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis
    Youngmi Jung
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 45:1091-6. 2007
    ..Such Hh-responsive cells accumulate during the fibroproliferative response to chronic cholestatic liver injury, suggesting a role for Hh signaling in this process...
  56. pmc Epithelial-mesenchymal transitions and hepatocarcinogenesis
    Janice Jou
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    J Clin Invest 120:1031-4. 2010
    ..In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcinomas initiates a molecular cascade that results in EMT...
  57. ncbi request reprint Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling
    Yin Xiong Li
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lab Invest 87:231-40. 2007
    ..This insight into FASD pathogenesis may suggest novel strategies for preventing these common congenital defects...
  58. pmc Domain 3 of hepatitis C virus core protein is sufficient for intracellular lipid accumulation
    Ravi Jhaveri
    Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    J Infect Dis 200:1781-8. 2009
    ..In this study, we investigated the sufficiency of d3 to promote lipid accumulation, the role of HCV genotype in d3 lipid accumulation, and the subcellular distribution of d3...
  59. pmc Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia
    Alessia Omenetti
    Division of Gastroenterology, Duke University Medical Center, Durham, NC, USA
    Hepatology 53:1246-58. 2011
    ..Treating immature ductular cells with Hh ligand-enriched medium induced mesenchymal genes; neutralizing Hh ligands inhibited this...
  60. pmc Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis
    Wing Kin Syn
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Liver Dis 29:200-10. 2009
    ..The purpose of this review is to summarize similarities and differences in the pathogenesis of steatohepatitis in alcoholic fatty liver disease and nonalcoholic fatty liver disease...
  61. ncbi request reprint Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers
    Liu Yang
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lab Invest 87:927-37. 2007
    ..In conclusion, ER stress-related decreases in hepatocyte CD1d contribute to NKT cell dysregulation in fatty livers...
  62. pmc In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force
    Michael H Wang
    Department of Biomedical Engineering, Duke University, Duke University Medical Center, Durham, NC 27708 0281, USA
    Ultrasound Med Biol 35:1709-21. 2009
    ..This suggests that stiffness measurement using acoustic radiation force can provide a quantitative assessment of the extent of fibrosis in the liver and can be potentially used for the diagnosis, management and study of liver fibrosis...
  63. pmc Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines
    Fatima Rangwala
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    BMC Cancer 12:402. 2012
    ..The aim was to compare the chemosensitization potential of arsenic trioxide (ATO) in combination with sorafenib or fluorouracil (5-FU), in both hepatic tumor cells and stromal cells...