Mark W Dewhirst

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Thresholds for thermal damage to normal tissues: an update
    Pavel S Yarmolenko
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
    Int J Hyperthermia 27:320-43. 2011
  2. ncbi Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes
    Mark W Dewhirst
    Radiation Oncology Department, Duke University Medical Center, Durham, NC 27710, USA Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA Biomedical Engineering Department, Duke University, Durham, NC 27708, USA Electronic address
    Surg Oncol Clin N Am 22:545-61. 2013
  3. ncbi Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Hyperthermia 26:283-93. 2010
  4. ncbi Chemodosimetry of in vivo tumor liposomal drug concentration using MRI
    Benjamin L Viglianti
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
    Magn Reson Med 56:1011-8. 2006
  5. ncbi Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    BMC Cancer 5:59. 2005
  6. ncbi Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer
    Lee W Jones
    Duke Univ Medical Center, Durham, NC 27710, USA
    J Appl Physiol 108:343-8. 2010
  7. ncbi DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study
    Oana I Craciunescu
    Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 25:405-15. 2009
  8. ncbi Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA
    Free Radic Biol Med 47:992-1004. 2009
  9. ncbi A comparison of antiangiogenic therapies for the prevention of liver metastases
    Jing Mi
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 131:97-104. 2006
  10. ncbi The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 165:192-201. 2006

Collaborators

Detail Information

Publications95

  1. ncbi Thresholds for thermal damage to normal tissues: an update
    Pavel S Yarmolenko
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
    Int J Hyperthermia 27:320-43. 2011
    ..For purposes of regulatory guidelines, both acute and lasting effects of thermal damage should be considered...
  2. ncbi Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes
    Mark W Dewhirst
    Radiation Oncology Department, Duke University Medical Center, Durham, NC 27710, USA Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA Biomedical Engineering Department, Duke University, Durham, NC 27708, USA Electronic address
    Surg Oncol Clin N Am 22:545-61. 2013
    ..A history of the development of thermosensitive liposomes is presented. Clinical trials have shown that the combination of radiofrequency ablation and doxorubicin-loaded thermosensitive liposomes is a promising treatment...
  3. ncbi Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Hyperthermia 26:283-93. 2010
    ..The review is organised by traditional outcome parameters: local response, local control and progression-free or overall survival. Included in the review is a discussion of future directions for this type of translational work...
  4. ncbi Chemodosimetry of in vivo tumor liposomal drug concentration using MRI
    Benjamin L Viglianti
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
    Magn Reson Med 56:1011-8. 2006
    ..This method of imaging exhibits potential for real-time evaluation of chemotherapeutic protocols and prediction of tumor response on an individual patient basis...
  5. ncbi Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    BMC Cancer 5:59. 2005
    ....
  6. ncbi Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer
    Lee W Jones
    Duke Univ Medical Center, Durham, NC 27710, USA
    J Appl Physiol 108:343-8. 2010
    ..Such findings may have important implications for inhibiting tumor metastasis and improving the efficacy of conventional cancer therapies...
  7. ncbi DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study
    Oana I Craciunescu
    Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 25:405-15. 2009
    ..The MPTS was extracted from pre-treatment MRI parameters, so independent of the combined therapy used...
  8. ncbi Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA
    Free Radic Biol Med 47:992-1004. 2009
    ..Mn porphyrins may be advantageous compared to other anti-cancer drugs, owing to their radioprotection of normal tissue and the ability to afford pain management in cancer patients via prevention of chronic morphine tolerance...
  9. ncbi A comparison of antiangiogenic therapies for the prevention of liver metastases
    Jing Mi
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 131:97-104. 2006
    ..These findings indicate that multiple antiangiogenic pathways are necessary for the growth of hepatic metastases, and each of these pathways is a potential clinically relevant antiangiogenic target for the treatment of this disease...
  10. ncbi The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 165:192-201. 2006
    ..In this nonanemic animal model of mammary adenocarcinoma, darbepoetin alfa does not significantly alter tumor growth or radioresponsiveness, even though it improves oxygenation when administered at high doses...
  11. ncbi Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors
    Matthew E Hardee
    Department of Pathology, Duke University Medical Center, Durham, NC 22710, USA
    Cancer Chemother Pharmacol 63:219-28. 2009
    ..The growth factor receptor, Her2/neu, is overexpressed in 25-30% of breast tumors. Tumors that are Her2(+) may have an altered state of oxygenation, relative to Her2(-) tumors, due to differences in tumor growth rate and angiogenesis...
  12. ncbi Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression
    Matthew E Hardee
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 2:e549. 2007
    ..We investigated the role of the hematopoietic cytokine erythropoietin as an angiogenic factor that modulates tumor progression...
  13. ncbi Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours
    Pavel S Yarmolenko
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    Int J Hyperthermia 26:485-98. 2010
    ..Factors that may influence differences in HT-LTSL-DOX efficacy were also examined...
  14. ncbi Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth
    Yiting Cao
    Department of Radiation Oncology, Duke University Medical Center, Research Drive, DUMC 3455, Durham, NC 27710, USA
    Cancer Res 67:3835-44. 2007
    ..It also reveals that elevated Ang-2 levels have profound pleiotropic effects on tumor vessel structure, perfusion, oxygenation, and apoptosis...
  15. ncbi Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
    Seok Jin Kim
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Hospital, Durham, NC 27705, USA
    Lung Cancer 49:325-35. 2005
    ..Of the markers considered in this study, CA IX expression status was the most reliable hypoxia marker for predicting tumor aggressiveness...
  16. ncbi Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy
    Gregory M Palmer
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Control Release 142:457-64. 2010
    ....
  17. ncbi Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma
    Ellen Jones
    Department of Radiation Oncology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Hyperthermia 22:161-72. 2006
    ..These promising results suggest a role for the use of adjuvant whole abdomen hyperthermia as a means of augmenting chemosensitization...
  18. ncbi Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects
    Ana M Ponce
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    J Natl Cancer Inst 99:53-63. 2007
    ....
  19. ncbi Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy
    Benjamin L Viglianti
    Departments of Radiation Oncology, Biostatistics and Bioinformatics, and Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 15:4993-5001. 2009
    ..This study tests whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters obtained from canine patients with soft tissue sarcomas, treated with hyperthermia and radiotherapy, are predictive of therapeutic outcome...
  20. ncbi Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy
    Michael Lora-Michiels
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 12:5733-40. 2006
    ..The objective was to test whether tumor pH and (31)P magnetic resonance spectroscopic end points were related to treatment outcome in pet canine patients with spontaneous soft tissue sarcomas treated with thermoradiotherapy...
  21. ncbi Effect of pazopanib on tumor microenvironment and liposome delivery
    Tina D Tailor
    Duke University School of Medicine, Durham, North Carolina, USA
    Mol Cancer Ther 9:1798-808. 2010
    ....
  22. ncbi Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer
    Seok Jin Kim
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Hospital, Durham, NC, USA
    Med Oncol 27:91-7. 2010
    ..Considering the importance of EGFR activation after ligand binding, however, the expression of phosphorylated EGFR (p-EGFR) may have more significance in predicting tumor aggressiveness in NSCLC than either EGFR or COX-2 expression...
  23. ncbi Regulation of HIF-1alpha stability through S-nitrosylation
    Fang Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Mol Cell 26:63-74. 2007
    ..This interaction between NO and HIF-1 sheds new light on their involvement in tumor response to treatment as well as mammalian inflammation process in general...
  24. ncbi Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome
    Qing Chen
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Int J Hyperthermia 24:475-82. 2008
    ..Taken together, these data suggested that tumor microvascular permeability was more critical than the sensitivity of tumor cells to DOX in determining the antivascular efficacy of LTSL-DOX-HT treatment...
  25. ncbi Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
    Sith Sathornsumetee
    Department of Medicine, Duke University Medical Center, DUMC 2900, Durham, NC 27710, USA
    J Clin Oncol 26:271-8. 2008
    ....
  26. ncbi RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin
    Jing Mi
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Mol Ther 16:66-73. 2008
    ..These studies provide important insights into the mechanisms of Dox-induced chemoresistance, and they demonstrate a novel, effective, and clinically practical strategy for interfering with these processes...
  27. ncbi Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
    Benjamin J Moeller
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Cell 8:99-110. 2005
    ..These data provide a strong rationale for pursuing sequence-specific combinations of HIF-1 blockade and conventional therapeutics...
  28. ncbi Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation
    Yiting Cao
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 65:5498-505. 2005
    ..This is in contrast to the clear role of hypoxia in driving angiogenesis once initial tumor microvessel formation has occurred...
  29. ncbi Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer
    Shiva Sarraf-Yazdi
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 146:16-23. 2008
    ..We examined whether in vivo administration of an RNA aptamer that specifically blocks Ang 2 would inhibit tumor angiogenesis and growth...
  30. ncbi Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy
    Mitchell S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 62:255-9. 2005
    ..With the application of a better understanding of fundamental biology to clinical practice, new approaches to treating and preventing normal tissue injury can focus on correcting these disturbed molecular processes...
  31. ncbi Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors
    Ashley A Manzoor
    Medical Physics Program, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 72:5566-75. 2012
    ..These improvements in drug bioavailability establish a new paradigm in drug delivery: rapidly triggered drug release in the tumor bloodstream...
  32. ncbi Longitudinal optical imaging of tumor metabolism and hemodynamics
    Melissa C Skala
    Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708, USA
    J Biomed Opt 15:011112. 2010
    ....
  33. ncbi Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate
    Xiaodong Ye
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    Free Radic Res 45:1289-306. 2011
    ..The tumour oxidative stress was enhanced and its microvessel density reduced when mice were treated either with ascorbate or MnP/ascorbate; the trend towards tumour growth suppression was detected...
  34. ncbi Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation
    Bin Yan
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Cancer Res 66:11565-70. 2006
    ....
  35. ncbi A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer
    Zeljko Vujaskovic
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Int J Hyperthermia 26:514-21. 2010
    ..Therefore this phase I/II study was designed to evaluate the safety and efficacy of a novel neoadjuvant combination treatment of paclitaxel, liposomal doxorubicin, and hyperthermia...
  36. ncbi Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics
    Ines Batinic-Haberle
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 51:1035-53. 2011
    ....
  37. ncbi Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation
    Zahid N Rabbani
    Department of Radiation Oncology, Durham Regional Hospital Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Res 41:1273-82. 2007
    ..Administration of AEOL10150 at 5 mg/kg BID during and after RT results in a significant protective effect from long-term RT-induced lung injury. Low dose (2.5 mg/kg BID) delivery of AEOL10150 has no beneficial radioprotective effects...
  38. ncbi Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas
    Oana I Craciunescu
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 36:4848-58. 2009
    ..To establish accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas...
  39. ncbi Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics
    Jen Tsan Chi
    Institute for Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27708, USA
    Clin Cancer Res 17:2549-60. 2011
    ..While hyperthermia is an effective adjuvant treatment to radiotherapy, we do not completely understand the nature of the response heterogeneity...
  40. ncbi In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide
    Andrew J Simnick
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    J Control Release 155:144-51. 2011
    ....
  41. ncbi NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment
    Eui Jung Moon
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:20477-82. 2010
    ....
  42. ncbi The pervasive presence of fluctuating oxygenation in tumors
    Laura I Cárdenas-Navia
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
    Cancer Res 68:5812-9. 2008
    ..The widespread presence of fluctuations in tumor oxygenation has broad ranging implications for tumor progression, stress response, and signal transduction, which are altered by oxygenation/reoxygenation events...
  43. ncbi Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury
    Zahid N Rabbani
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 67:573-80. 2007
    ....
  44. ncbi Increased skin carcinogenesis in caspase-activated DNase knockout mice
    Bin Yan
    Department of Radiation Oncology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Carcinogenesis 30:1776-80. 2009
    ..The papillomas in CAD-null mice grew faster and reached larger sizes. These data indicate that loss of CAD function enhances tumorigenesis induced by a chemical carcinogen in the DMBA/TPA two-stage model of skin carcinogenesis in mice...
  45. ncbi Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity
    Matthew E Hardee
    Department of Pathology, Duke University Medical Center, Box 3893, Durham, NC 27710, USA
    Mol Cancer Ther 5:356-61. 2006
    ....
  46. ncbi Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury
    Song K Kang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 57:1056-66. 2003
    ..EC-SOD may be a potential therapeutic agent for radioprotection in the treatment of thoracic malignancies. Further investigation is needed to confirm and expand on the current results...
  47. ncbi Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer
    Howard S Kim
    Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 110:1062-9. 2012
    ..Moreover, lactate inhibition resulted in changes in the tumour microenvironment that may have implications for future metabolic targeting of prostate cancer growth...
  48. ncbi Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury
    Mitchell S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 66:477-82. 2006
    ..The purpose of this study was to determine the maximal tolerated dose of thalidomide when used in combination with vinorelbine plus thoracic radiotherapy...
  49. ncbi In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy
    Ronald J Viola
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    AJR Am J Roentgenol 191:1779-84. 2008
    ..Active HIF-1 consists of alpha and beta subunits that bind to promoter sequences in many genes, including those that protect endothelial cells, promote angiogenesis, and alter metastasis and tumor cell metabolism...
  50. ncbi Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer
    Ellen L Jones
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Clin Cancer Res 10:4287-93. 2004
    ..Hyperthermia may offer a strategy for improving tumor reoxygenation with consequent treatment response. However, the effect of hyperthermia on tumor reoxygenation appears to depend on thermal dose and requires additional investigation...
  51. ncbi Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors
    Matthew R Dreher
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Cancer Res 67:4418-24. 2007
    ..More broadly, this study shows a new approach--tumor thermal cycling--to exploit stimuli-responsive polymers in vivo to target the tumor vasculature or extravascular compartment with high specificity...
  52. ncbi Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma
    Ryan S Turley
    Department of Surgery, Duke University, and Durham VA Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 18:3328-39. 2012
    ....
  53. ncbi ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells
    Katherine M Aird
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Breast Cancer Res Treat 132:109-19. 2012
    ..Taken together, these data demonstrate a novel mechanism of lapatinib-analog-induced apoptosis and indicate that resistant cells have increased antioxidant potential, which can be overcome by treatment with SOD modulators...
  54. ncbi In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters
    Gregory M Palmer
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Nat Protoc 6:1355-66. 2011
    ..The procedure takes ∼2 h to complete, plus up to several weeks for tumor growth and treatment procedures...
  55. ncbi Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B
    Hyoungsu Kim
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    Org Lett 11:89-92. 2009
    ..In addition, the hydroxyl group at C-7 and C-7''' can be replaced with a carbonyl group without loss of activity...
  56. ncbi Hyperthermia for locally advanced breast cancer
    Timothy M Zagar
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Hyperthermia 26:618-24. 2010
    ..The goal of this review is to highlight important research utilising HT in patients with LABC as well as to suggest future directions for its use...
  57. ncbi Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity
    Siqing Shan
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Chemother Pharmacol 58:245-55. 2006
    ..The preferential extravasation of DiI-LV from tumor vasculature as well as its differential retention in tumor tissue provides the basis for the enhancement in antitumor activity of LV over VCR...
  58. ncbi Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development
    Brian S Sorg
    Duke University Medical Center, Department of Radiation Oncology, Durham, North Carolina, USA
    J Biomed Opt 10:44004. 2005
    ..In this work, in vivo calibration of the imaging system is described and in vivo results are shown...
  59. ncbi A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness
    Benjamin J Moeller
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 63:545-52. 2005
    ....
  60. ncbi Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone)
    Hong Yuan
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    J Nucl Med 47:989-98. 2006
    ..Further studies are needed to define retention mechanisms for this PET marker...
  61. ncbi HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors
    Kimberly L Blackwell
    Duke University Comprehensive Cancer Center, Durham, North Carolina, USA
    Clin Cancer Res 10:4083-8. 2004
    ..Plasma from 36 patients with primary tumor samples had VEGF (R&D Systems, MN) and d-dimer (American Diagnostica, Greenwich, CT) levels determined...
  62. ncbi Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat
    Thies Schroeder
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 65:5163-71. 2005
    ..This explains the repeatedly observed correlation between tumor blood flow and 18F-deoxyglucose uptake...
  63. ncbi Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts
    Karthik Vishwanath
    Duke University, Department of Biomedical Engineering, 136 Hudson Hall, Box 90281, Durham, North Carolina 27708, USA
    J Biomed Opt 14:054051. 2009
    ....
  64. ncbi Randomized trial of hyperthermia and radiation for superficial tumors
    Ellen L Jones
    Radiation Oncology, Duke University Medical Center, DUMC Box 3085, Durham, NC 27710, USA
    J Clin Oncol 23:3079-85. 2005
    ....
  65. ncbi Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 61:480-91. 2005
    ....
  66. ncbi Carbonic anhydrase IX in early-stage non-small cell lung cancer
    Seok Jin Kim
    Department of Medicine, Thoracic Oncology Program, Duke University Medical Center and Durham Veterans Affairs Hospital, Durham, North Carolina, USA
    Clin Cancer Res 10:7925-33. 2004
    ..We hypothesized that CA IX expression is related to tumor cell proliferation and poor disease-free survival in patients with early-stage non-small-cell lung cancer (NSCLC)...
  67. ncbi Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
    Benjamin J Moeller
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 5:429-41. 2004
    ..These data describe novel pathways contributing significantly to our understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance...
  68. ncbi Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome
    Qing Chen
    Department of Biomedical Engineering, Duke University, Box 90281, Durham, NC 27708, USA
    Mol Cancer Ther 3:1311-7. 2004
    ..In conclusion, the rapid release of DOX during hyperthermia could make the drug to shutdown tumor blood flow while have only minor effects on normal microcirculation in s.c. tissues...
  69. ncbi Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors
    Stephen T Keir
    Preston Robert Tisch Brain Tumor Center at Duke, Duke University, Durham, NC 27710, USA
    Anticancer Agents Med Chem 11:202-12. 2011
    ..Our findings suggest that the use of Mn porphyrin-based SOD mimics, and in particular lipophilic analogues such as MnTnHex-2-PyP(5+), is a promising approach for brain tumor therapy...
  70. ncbi Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
    Matthew R Dreher
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    J Natl Cancer Inst 98:335-44. 2006
    ..Dextrans of 40 and 70 kDa had the highest accumulation in solid tumors but were largely concentrated near the vascular surface...
  71. ncbi Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Cancer 8:425-37. 2008
    ..HIF1 can then promote endothelial and tumour cell survival. As discussed here, a constant theme emerges: inhibition of HIF1 activity will have therapeutic benefit...
  72. ncbi Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival
    Siqing Shan
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710-3455, USA
    FASEB J 18:326-8. 2004
    ..These subsequent signals from endothelial cells promote early survival and proliferation of disseminated tumor cells before onset of angiogenesis...
  73. ncbi A novel rodent mammary window of orthotopic breast cancer for intravital microscopy
    Siqing Shan
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Microvasc Res 65:109-17. 2003
    ..This model will allow for study of tumor microcirculatory function, angiogenesis, tumor cell-host interactions, and evaluation of effects of various treatments...
  74. ncbi In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery
    Benjamin L Viglianti
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27705, USA
    Magn Reson Med 51:1153-62. 2004
    ..Additionally, the drug-loading method used for this liposome is applicable to a wide range of drugs, thereby broadening its applicability. The method is also applicable to other liposomal formulations with triggered release mechanisms...
  75. ncbi Hyperthermia mediated liposomal drug delivery
    Ana M Ponce
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Int J Hyperthermia 22:205-13. 2006
    ..Significantly, recent studies show that this liposome, in combination with local hyperthermia, exhibits vascular shutdown as a mechanism of anti-tumour effect that is not observed with free doxorubicin...
  76. ncbi A unique role of the DNA fragmentation factor in maintaining genomic stability
    Bin Yan
    Departments of Radiation Oncology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:1504-9. 2006
    ....
  77. ncbi Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase
    Xiuwu Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 9:1155-60. 2003
    ..The overexpression of ILK was also shown to induce a more rapid tumor growth in a murine prostate cancer cell line CONCLUSION: ILK plays an important role in tumor growth and tumor response to hyperthermia treatment...
  78. ncbi Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation
    Kristian Erickson
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 63:4705-12. 2003
    ..Therefore, the tumor surface is refractory to improvement in pO(2) with this method. Additional refinements may be needed to improve pO(2) of analogous regions in larger tumors; mechanism-driven suggestions are provided...
  79. ncbi Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide
    Pierre Sonveaux
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 96:1119-26. 2005
    ..Overall, these results indicate that the properties of SNO-Hb are attributable to allosteric control of NO release by oxygen in central as well as peripheral issues...
  80. ncbi Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors
    Intae Lee
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 530:177-86. 2003
    ..3 mm Hg to 13.8 mm Hg. We hypothesized that combined treatment with glucose + MIBG significantly enhanced radiation-induced tumoricidal effects on R3230 Ac tumors, mainly due to reduction in QO2 and increase in tumor pO2...
  81. ncbi Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor
    Jennifer Lanzen
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Cancer Res 66:2219-23. 2006
    ..These results show that fluctuations in red cell flux, as opposed to vascular stasis, can cause temporal variations in pO2 that extend from perivascular regions to the maximum oxygen diffusion distance...
  82. ncbi A pilot Phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma
    Ellen L Jones
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 98:277-82. 2003
    ..The authors evaluated response and toxicity in patients with locally advanced cervical carcinoma (LACC) who were treated with concurrent weekly CDDP, HT, and RT (whole pelvis [n=7] and whole pelvis and paraaortic nodes [n=5])...
  83. ncbi Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Dis Markers 18:293-311. 2002
    ..Examples of some of these differences are provided in this review as a means to illustrate how they can be used...
  84. ncbi Predicting lung radiotherapy-induced pneumonitis using a model combining parametric Lyman probit with nonparametric decision trees
    Shiva K Das
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 68:1212-21. 2007
    ..To develop and test a model to predict for lung radiation-induced Grade 2+ pneumonitis...
  85. ncbi The relationship between the tumor physiologic microenvironment and angiogenesis
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Room 201, Medical Science Research Building, Research Drive, Box 3455, Durham, NC 27710, USA
    Hematol Oncol Clin North Am 18:973-90, vii. 2004
    ..This article examines the pathophysiology of tumors, with an emphasis on how these features influence angiogenesis in tumors...
  86. ncbi Individual responses to chemotherapy-induced oxidative stress
    Dora Il'yasova
    Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC, 27710, USA
    Breast Cancer Res Treat 125:583-9. 2011
    ....
  87. ncbi Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 169:350-4. 2008
    ..g., tissue with pO(2)<0.5-5 mmHg) when tumor oxygenation is modeled. The model also permits calculation of the limiting substrate concentration for cell viability when the reaction rate constant is known and vice versa...
  88. ncbi The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis
    Patrick Kelly
    Department Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:8173-8. 2006
    ....
  89. ncbi The potential role of intrinsic hypoxia markers as prognostic variables in cancer
    Eui Jung Moon
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antioxid Redox Signal 9:1237-94. 2007
    ..In conclusion, this review suggests the need for further studies with standardized methods to examine gene expression, as well as the use of multiple gene expressions...
  90. ncbi Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions
    L Isabel Cardenas-Navia
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    Int J Radiat Oncol Biol Phys 67:581-6. 2007
    ..To examine the effects of fluctuating oxygen levels on the hypoxic cytotoxin tirapazamine (TPZ) using theoretical predictions...
  91. ncbi Novel imaging provides new insights into mechanisms of oxygen transport in tumors
    Matthew E Hardee
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Mol Med 9:435-41. 2009
    ..In this paper, we document new insights into tumor oxygen transport enabled by spectral imaging of microvascular hemoglobin saturation...
  92. ncbi Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy
    Holly K Dressman
    Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
    Clin Cancer Res 12:819-26. 2006
    ..In addition, we defined molecular signatures that correlate with response to neoadjuvant chemotherapy...
  93. ncbi A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 159:336-44. 2003
    ..This model demonstrates that hypoxia is quite sensitive to metabolic rate and geometric factors. It also predicts quantitatively the effects of inhibited oxygen metabolism and enhanced mass transfer on tumor oxygenation...
  94. ncbi Predicting radiotherapy-induced cardiac perfusion defects
    Shiva K Das
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 32:19-27. 2005
    ..In conclusion, the nonparametric LDA model appears to be a more accurate predictor of radiotherapy-induced left ventricular perfusion defects than commonly used parametric models...
  95. ncbi Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
    Mark W Dewhirst
    Radiation Oncology Department, Duke University Medical Center, Durham, Durham, NC 27710, USA
    Radiat Res 172:653-65. 2009
    ..Cycling hypoxia can influence angiogenesis, treatment responses and metastatic behavior. It represents an important and relatively less well understood feature of tumor biology that requires additional research...