Research Topics
Genomes and Genes | Wendy Demark-WahnefriedSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapyW Demark-Wahnefried
Stedman Center for Nutritional Studies, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Am J Clin Nutr 65:1495-501. 1997..Additional research in this area will provide valuable insight into creating optimal interventions to curb weight gain in women with breast cancer...
Lifestyle intervention development study to improve physical function in older adults with cancer: outcomes from Project LEADWendy Demark-Wahnefried
School of Nursing, Department of Surgery, Older Americans Independence Center, Duke University Medical Center, Durham, NC 27710, USA
J Clin Oncol 24:3465-73. 2006..Declines in physical functioning (PF) among elderly cancer patients threaten quality of life and the ability to maintain independence. Adherence to healthy lifestyle behaviors may prevent functional decline...- Dietary intervention in the management of prostate cancerWendy Demark-Wahnefried
School of Nursing and Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Urol 17:168-74. 2007..This review integrates recent reports related to the dietary management of prostate cancer with the existing body of science in an effort to best inform practicing clinicians... - Leading the Way in Exercise and Diet (Project LEAD): intervening to improve function among older breast and prostate cancer survivorsWendy Demark-Wahnefried
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Control Clin Trials 24:206-23. 2003..In reporting our methods, we hope to give others "a leg up," so that they can hurdle with greater ease the barriers we experienced, and thus advance the field more rapidly... - Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivorsWendy Demark-Wahnefried
Duke School of Nursing, Duke Comprehensive Cancer Center, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Clin Oncol 25:2709-18. 2007..The FRESH START trial tested the efficacy of sequentially tailored versus standardized mailed materials on improving cancer survivors' diet and exercise behaviors... - Design of FRESH START: a randomized trial of exercise and diet among cancer survivorsWendy Demark-Wahnefried
Duke University Medical Center DUMC, Durham, NC 27710, USA
Med Sci Sports Exerc 35:415-24. 2003.... - Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancerWendy Demark-Wahnefried
Program of Cancer Preventive, Detection and Control Research, Duke Comprehensive Cancer Center, Durham, NC, USA
J Clin Oncol 23:5814-30. 2005.... - Early onset baldness and prostate cancer riskW Denmark-Wahnefried
Division of Urology Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer Epidemiol Biomarkers Prev 9:325-8. 2000.... - Promoting health and physical function among cancer survivors: potential for prevention and questions that remainWendy Demark-Wahnefried
Duke University Medical Center, School of Nursing and Department of Surgery, Durham, NC 27710, USA
J Clin Oncol 24:5125-31. 2006.... - Partnering with African American churches to achieve better health: lessons learned during the Black Churches United for Better Health 5 a day projectW Demark-Wahnefried
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Cancer Educ 15:164-7. 2000.... - Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axisStephen J Freedland
Department of Surgery, Durham VA Medical Center, Durham, North Carolina 27710, USA
Prostate 68:11-9. 2008..Recent evidence suggests carbohydrate intake may influence prostate cancer biology. We tested whether a no-carbohydrate ketogenic diet (NCKD) would delay prostate cancer growth relative to Western and low-fat diets in a xenograft model... - The Diet Quality Index-Revised: a tool to promote and evaluate dietary change among older cancer survivors enrolled in a home-based intervention trialDenise Clutter Snyder
School of Nursing, Duke University, Box 3322 Duke University Medical Center, Durham, NC 27710, USA
J Am Diet Assoc 107:1519-29. 2007..To utilize the Diet Quality Index-Revised (DQI-R) as a framework for delivering and evaluating an intervention to improve overall diet quality among older cancer survivors... 
Differences in baseline characteristics and outcomes at 1- and 2-year follow-up of cancer survivors accrued via self-referral versus cancer registry in the FRESH START Diet and exercise trialDenise Clutter Snyder
School of Nursing, Duke University Medical Center, Box 3322, Room 1057, 311 Trent Drive, Durham, NC 27710
Cancer Epidemiol Biomarkers Prev 17:1288-94. 2008..05). Several differences exist between self-referred and registry-ascertained participants, including motivation to respond to standardized educational materials, which appears significantly greater in self-referred populations...- Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white menCathrine Hoyo
Department of Community and Family Medicine, Duke University Medical Center, Box 2914, Durham, NC 27710, USA
J Natl Med Assoc 101:711-6. 2009..Factors associated with variation in circulating levels of these peptide hormones remain unclear... - IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White menJoellen M Schildkraut
Program of Cancer Prevention, Detection and Control Research, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
Cancer Epidemiol Biomarkers Prev 14:403-8. 2005..Further research is needed to confirm these findings... - Effects of home-based diet and exercise on functional outcomes among older, overweight long-term cancer survivors: RENEW: a randomized controlled trialMiriam C Morey
Duke University Older Americans Independence Center, and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27705, USA
JAMA 301:1883-91. 2009..Lifestyle interventions may provide benefit, but it is unknown whether long-term cancer survivors can modify their lifestyle behaviors sufficiently to improve functional status... - Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID miceW Cooper Buschemeyer
Division of Urology, and the Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Prostate 70:1037-43. 2010..We hypothesized intermittent fasting (i.e., intermittent extreme CR), may be better tolerated and prolong survival of prostate cancer (CaP) bearing mice... - Agreement between a brief mailed screener and an in-depth telephone survey: observations from the Fresh Start studyDenise Clutter Snyder
Department of Surgery, Center for the Study of Aging and Human Development, Duke University Medical Center, Box 3003, Durham, NC 27710, USA
J Am Diet Assoc 104:1593-6. 2004..Decisions to use brief screening instruments should be based on available resources and tolerance for misclassification... - Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW): design, methods and recruitment challenges of a home-based exercise and diet intervention to improve physical function among long-term survivors of breast, prostate, and colorectal cancerDenise Clutter Snyder
Duke University School of Nursing, Durham, NC 27710, USA
Psychooncology 18:429-39. 2009..Lifestyle interventions may hold promise in reorienting functional decline in older cancer survivors, but few studies have been conducted... - Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in childrenEllen Perkins
Department of Community and Family Medicine, Duke University, Durham, NC 27710, USA
J Pediatr 161:31-9. 2012..To determine whether aberrant DNA methylation at differentially methylated regions (DMRs) regulating insulin-like growth factor 2 (IGF2) expression in umbilical cord blood is associated with overweight or obesity in a multiethnic cohort... - Childhood cancer survivors' perceived barriers to improving exercise and dietary behaviorsWhitney D Arroyave
School of Nursing, Duke University, Durham, NC, USA
Oncol Nurs Forum 35:121-30. 2008..To determine childhood cancer survivors' barriers to increasing exercise and consuming less fat and more fruits and vegetables, whole grains, and calcium-rich foods... - Response rates to a mailed survey targeting childhood cancer survivors: a comparison of conditional versus unconditional incentivesPhilip M Rosoff
Division of Hematology Oncology, Department of Pediatrics, Duke University Medical Center, 222 Bell Building, Trent Drive, Durham, NC 27710, USA
Cancer Epidemiol Biomarkers Prev 14:1330-2. 2005..A study was undertaken among childhood cancer survivors and their parents to determine if response rate to a mailed survey differed with provision of immediate versus delayed incentives... - Effect of physical activity guidelines on physical function in older adultsMiriam C Morey
Durham Veterans Affairs Medical Center Geriatric Research, Durham, North Carolina 27705, USA
J Am Geriatr Soc 56:1873-8. 2008.... - Survivors of childhood cancer and their guardiansWendy Demark-Wahnefried
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. demar001mc.duke.edu
Cancer 103:2171-80. 2005..Health promotion interventions aimed at areas of interest and delivered through acceptable channels have the potential to improve long-term health and function of this vulnerable population... - Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weightCathrine Hoyo
Department of Community and Family Medicine, Duke University Medical Center, 2200 West Main Street, Ste 600, Durham, NC 27705, USA
Cancer Causes Control 23:635-45. 2012..We examined associations among DNA methylation at IGF2 differentially methylated regions (DMRs), circulating IGF2 protein concentrations in umbilical cord blood (UCB) and birth weight in newborns... - No difference in response rate to a mailed survey among prostate cancer survivors using conditional versus unconditional incentivesBrian R Evans
Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer Epidemiol Biomarkers Prev 13:277-8. 2004..Other means, however, appear necessary to achieve acceptable response rates among minority group cancer survivors... - Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancyCathrine Hoyo
Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
Epigenetics 6:928-36. 2011.... - Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)Cathrine Hoyo
Department of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University, PO Box 104006, Durham, NC 27710, USA
BMC Public Health 11:46. 2011..The primary objective is to estimate the proportion of women taking folic acid (FA) doses exceeding the TUL before and during pregnancy, and to identify correlates of high FA use... - Diet, exercise, and complementary therapies after primary treatment for cancerLee W Jones
Department of Surgery, Duke University Medical Center, Durham, NC, USA
Lancet Oncol 7:1017-26. 2006..Overall, this review provides important information to oncology care providers who counsel their patients on preventive lifestyle practices to maximise health and longevity after a diagnosis of cancer... - Nutrition and the cancer survivor: evidence to guide oncology nursing practiceMark Toles
Duke University School of Nursing, Durham, NC, USA
Semin Oncol Nurs 24:171-9. 2008.... - Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whitesCathrine Hoyo
Department of Community and Family Medicine, Hanes House Room 347, Trent Drive, Box 2914, Medical Center, Duke University Medical Center, Durham, NC 27710, USA
J Natl Med Assoc 99:718-22. 2007..If confirmed in larger studies, these findings support the hypothesis that the association between IGFBP3 C allele and prostate cancer is grade specific in both ethnic groups... - Nutrition-related issues for the breast cancer survivorWendy Demark-Wahnefried
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Semin Oncol 30:789-98. 2003..Furthermore, diets high in vegetables, fruit, whole grains, and low-fat dairy foods, and low in saturated fat, may help to lower overall disease risk in this population... - Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exerciseRichard Sloane
The Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
Med Sci Sports Exerc 41:1334-40. 2009.... - Supplement use among men with prostate cancerJeremy B Wiygul
Division of Urology, Duke University Medical Center, Durham, North Carolina 27710, USA
Urology 66:161-6. 2005..To characterize supplement use within a sample population of men diagnosed with prostate cancer... - Erythropoietin and erythropoietin receptor expression in human prostate cancerMurat O Arcasoy
Department of Medicine, Duke University Medical Center, Durham, NC27710, USA
Mod Pathol 18:421-30. 2005..The coexpression of erythropoietin receptor and its ligand erythropoietin in human prostate cancer cells suggests the potential for growth regulation by erythropoietin-erythropoietin receptor in an autocrine or paracrine manner... - A simple, flexible and scalable approach for generating tailored questionnaires and health education messagesJennifer M Macri
Division of Clinical Informatics, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
Comput Inform Nurs 23:316-21. 2005..One project has provided patient-tailored decision support for physicians for over 82,000 patient encounters and the other generates tailored health questions and messages for patients through a tool developed in less than 4 months... - The older cancer survivorArati V Rao
Division of Geriatrics, Division of Medical Oncology, Duke University Medical Center and Durham VA Medical Center DUMC, Box 3003, Durham 27710, North Carolina, USA
Crit Rev Oncol Hematol 60:131-43. 2006..This paper also suggests some surveillance guidelines for following elderly cancer survivors and identifies areas that require further research... - Lifestyle interventions in cancer survivors: designing programs that meet the needs of this vulnerable and growing populationValeda B Stull
School of Nursing and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Nutr 137:243S-248S. 2007..More research is necessary to develop interventions that can reach and effectively promote long-term behavior change in this ever-increasing population... - Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigenWendy Demark-Wahnefried
Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Urology 63:900-4. 2004..A randomized controlled trial is needed to determine whether flaxseed supplementation, a low-fat diet, or a combination of the two regimens may be of use in controlling overall prostatic growth... - Interest in healthy diet and physical activity interventions peripartum among female partners of active duty militaryTruls Ostbye
Department of Community and Family Medicine, Duke University Medical Center. Box 2914, Durham, NC 27710, USA
Mil Med 168:320-5. 2003..Interest was high for interventions that promote physical activity and facilitate social interaction. Based on these results, a postpartum exercise intervention is being designed for female partners of active duty soldiers... - Overweight and obese perimenopausal and postmenopausal women exhibit increased abnormal mammary epithelial cytologyVictoria L Seewaldt
Department of Medicine, Duke University Medical Center, Box 2628, Durham, NC 27710, USA
Cancer Epidemiol Biomarkers Prev 16:613-6. 2007..Further research is needed to confirm these findings and to determine if this potential biomarker is responsive to changes in body weight resulting from diet and/or exercise interventions... - The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft modelJohn C Mavropoulos
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer Prev Res (Phila) 2:557-65. 2009.... - Management of terminal cancer in elderly patientsLinda M Sutton
Duke Oncology Network at Duke University Medical Center, Durham, NC 27701, USA
Lancet Oncol 4:149-57. 2003..We present a rational approach to nutritional issues along with a description of the psychosocial issues that must be included in the overall management of these patients... - Effect of flaxseed supplementation on prostatic carcinoma in transgenic miceXu Lin
Division of Urologic Surgery, Department of Surgery, and Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
Urology 60:919-24. 2002..45 +/- 0.14 versus 3.3 +/- 0.31 (P <0.0001). Similar differences were seen after 30 weeks of treatment. CONCLUSIONS: A diet supplemented with 5% flaxseed inhibits the growth and development of prostate cancer in the TRAMP model... - Using cognitive interviews to evaluate items for measuring sexual functioning across cancer populations: improvements and remaining challengesAlice K Fortune-Greeley
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
Qual Life Res 18:1085-93. 2009..We describe how cognitive interviews improved the quality of the items and discuss remaining challenges to assessing sexual functioning in research with cancer populations... - Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapyWendy Demark-Wahnefried
Department of Behavioral Sciences, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Breast Cancer 8:70-9. 2008..Exercise interventions can prevent these changes, but time and travel pose barriers to participation. The Survivor Training for Enhancing Total Health (STRENGTH) trial assessed the feasibility and impact of 2 home-based interventions... - Nutrition and survival after the diagnosis of breast cancer: a review of the evidenceCheryl L Rock
Department of Family and Preventive Medicine, Cancer Prevention and Control Program, Dept 901, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0901, USA
J Clin Oncol 20:3302-16. 2002..To review and summarize evidence from clinical and epidemiologic studies that have examined the relationship between nutritional factors, survival, and recurrence after the diagnosis of breast cancer... - Can lifestyle modification increase survival in women diagnosed with breast cancer?Cheryl L Rock
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0901, USA
J Nutr 132:3504S-3507S. 2002..The results of these studies will contribute to understanding the roles of diet and physical activity in the progression of breast cancer... - Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choicesJean K Brown
University at Buffalo School of Nursing, The State University of New York, Buffalo, NY, USA
CA Cancer J Clin 53:268-91. 2003.... - Nutrition and women's health: position of the American Dietetic Association and Dietitians of CanadaSandra Affenito
St. Joseph College, West Hartford, CT, USA
Can J Diet Pract Res 65:85-9. 2004.... - Cancer survival: time to get moving? Data accumulate suggesting a link between physical activity and cancer survivalWendy Demark-Wahnefried
J Clin Oncol 24:3517-8. 2006 - Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choicesColleen Doyle
American Cancer Society, Atlanta, GA, USA
CA Cancer J Clin 56:323-53. 2006.... - Health behaviours in survivors of childhood cancerMarina Reeves
Cancer Prevention Research Centre, University of Queensland, Australia
Aust Fam Physician 36:95-6. 2007..These survivors expressed strong interest in health promotion aimed at improving diet and physical activity... - Move onward, press forward, and take a deep breath: can lifestyle interventions improve the quality of life of women with breast cancer, and how can we be sure?Wendy Demark-Wahnefried
J Clin Oncol 25:4344-5. 2007 - Lifestyle interventions to reduce cancer risk and improve outcomesWendy Demark-Wahnefried
Department of Behavioral Science, University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
Am Fam Physician 77:1573-8. 2008.... - Promoting a healthy lifestyle among cancer survivorsWendy Demark-Wahnefried
Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, 1155 Herman P Pressler, CPPB3 3245, Houston, TX 77030, USA
Hematol Oncol Clin North Am 22:319-42, viii. 2008.... - Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancerWendy Demark-Wahnefried
Division of Cancer Prevention and Control Department of Behavioral Science, MD Anderson Cancer Center, Houston, TX, USA
Clin Trials 5:262-72. 2008..Despite the many strengths of presurgical models, there are practical issues and challenges that arise when using this approach... - Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathwayLi Hua Chen
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai, China
Mol Cancer Ther 6:2581-90. 2007..Mechanistic studies suggested roles for Akt, GSK-3beta, MDM2, and p53 in enterolactone-dependent apoptosis. Our findings encourage further studies of enterolactone as a promising chemopreventive agent against prostate cancer...
Research Grants
- Daughters And MothErS (DAMES) Against Breast CancerWendy Demark Wahnefried; Fiscal Year: 2007..This project will determine the feasibility of a home-based, diet and exercise intervention focused on weight loss in both mothers diagnosed with breast cancer and their overweight adult daughters. ..
- STRENGTH--Survivor TRaining for ENhancinG Total HealthWendy Demark Wahnefried; Fiscal Year: 2002..If data show promise, further and larger study will be pursued - study which will be focused on testing an optimal intervention and powered on known effect sizes. ..