H N Dawson

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
    H N Dawson
    Division of Neurology, Department of Medicine, Duke University, Durham, NC 27710 and OSV, Inc, Research Triangle Park, NC 27709, USA
    J Cell Sci 114:1179-87. 2001
  2. ncbi request reprint The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model
    Hana N Dawson
    Division of Neurology, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 27:9155-68. 2007
  3. pmc Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
    H N Dawson
    Division of Neurology, Duke University, Durham, NC 27710, USA
    Neuroscience 169:516-31. 2010
  4. pmc Quantitative measurement of postural sway in mouse models of human neurodegenerative disease
    D Hutchinson
    Division of Neurology, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Neuroscience 148:825-32. 2007
  5. doi request reprint Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic
    Daniel T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurotrauma 27:1983-95. 2010
  6. pmc Tau is essential to beta -amyloid-induced neurotoxicity
    Mark Rapoport
    Institute for Neuroscience, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 99:6364-9. 2002
  7. pmc Role of MAP1B in axonal retrograde transport of mitochondria
    Eva Maria Jimenez-Mateos
    Centro de Biologia Molecular Severo Ochoa, Campus de Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Biochem J 397:53-9. 2006

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
    H N Dawson
    Division of Neurology, Department of Medicine, Duke University, Durham, NC 27710 and OSV, Inc, Research Triangle Park, NC 27709, USA
    J Cell Sci 114:1179-87. 2001
    ..The ability of human tau proteins to rescue tau-deficient mouse neurons confirms that tau expression affects the rate of neurite extension...
  2. ncbi request reprint The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model
    Hana N Dawson
    Division of Neurology, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 27:9155-68. 2007
    ..Additionally, activated caspase-3 immunoreactivity in both neurons and astrocytes implicates the involvement of the apoptotic pathway in the pathology of these mice...
  3. pmc Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
    H N Dawson
    Division of Neurology, Duke University, Durham, NC 27710, USA
    Neuroscience 169:516-31. 2010
    ..1993; Terry, 1996; Stokin et al., 2005), and our current data suggests that loss of tau function may lead to neurodegeneration...
  4. pmc Quantitative measurement of postural sway in mouse models of human neurodegenerative disease
    D Hutchinson
    Division of Neurology, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Neuroscience 148:825-32. 2007
    ..The CoP assay provides a simple, sensitive and quantitative tool to detect motor deficits resulting from postural abnormalities in mice and may be useful in understanding the underlying mechanisms of disease...
  5. doi request reprint Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic
    Daniel T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurotrauma 27:1983-95. 2010
    ..These results demonstrate that TBI accelerates the cardinal neuropathological features of neurodegenerative disease, and establishes the potential for apoE mimetic therapies in reducing pathology associated with neurodegeneration...
  6. pmc Tau is essential to beta -amyloid-induced neurotoxicity
    Mark Rapoport
    Institute for Neuroscience, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 99:6364-9. 2002
    ..In addition, the analysis of the composition of the cytoskeleton of tau-depleted neurons suggested that the formation of more dynamic microtubules might confer resistance to Abeta-mediated neurodegeneration...
  7. pmc Role of MAP1B in axonal retrograde transport of mitochondria
    Eva Maria Jimenez-Mateos
    Centro de Biologia Molecular Severo Ochoa, Campus de Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Biochem J 397:53-9. 2006
    ....