Research Topics
| Elizabeth DawsonSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Nicotine-alcohol interactions and cognitive function in ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Pharmacol Biochem Behav 72:865-72. 2002..This interaction may be an important consideration for nicotine and ethanol coabuse and the possible therapeutic use of nicotinic drugs for memory dysfunction...
Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in ratsAmir H Rezvani
Department of Psychiatry, Duke University Medical Center, Box 104790, Durham, NC 27710, USA
Psychopharmacology (Berl) 226:35-43. 2013..Acute administration of sazetidine-A has been shown to significantly improve attention by reversing impairments caused by the muscarinic cholinergic antagonist scopolamine and the NMDA glutamate antagonist dizocilpine...- Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USA
Psychopharmacology (Berl) 223:251-8. 2012.... - Novel medication targets for the treatment of alcoholism: preclinical studiesAmir H Rezvani
Dept of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Recent Pat CNS Drug Discov 7:151-62. 2012..The article presents some promising patents on novel medication targets for the treatment of alcoholism... - Alcohol and cognition - consideration of age of initiation, usage patterns and gender: a brief reviewPaige C Bartley
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Curr Drug Abuse Rev 5:87-97. 2012..The objective of this brief review is to examine the role of these factors on the effect of alcohol on cognition... - Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Eur J Pharmacol 682:110-7. 2012..Overall, our results show that pharmacological modulation of α4β2* nicotinic receptors elicits changes in body temperature that may involve desensitization of these receptors... 
Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administrationA H Rezvani
Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
Neuroscience 154:885-97. 2008..These results show that interfering with normal dopamine innervation of the frontal cortex during early postnatal development has persisting behavioral effects, which are sex-specific...- Attenuation of pharmacologically-induced attentional impairment by methylphenidate in ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Pharmacol Biochem Behav 92:141-6. 2009..These findings further validate the operant visual signal detection task for assessing attentional impairments and their reversal... - Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Prog Neuropsychopharmacol Biol Psychiatry 33:269-75. 2009.... - Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Alcohol Clin Exp Res 33:1366-73. 2009..The purpose of this project was to study the effect of the novel neuromodulator carisbamate, which is in development for epilepsy treatment, on alcohol intake in selectively bred alcohol-preferring rats... - Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcoholAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
Alcohol Alcohol 45:219-22. 2010..In this study, we tested the impact of pretreatment with alcohol on subsequent alcohol drinking in outbred Sprague-Dawley and selectively bred alcohol-preferring (P) rats... - Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USA
Psychopharmacology (Berl) 211:161-74. 2010..Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a novel compound that potently and selectively desensitizes alpha4beta2 nicotinic receptors with only modest receptor activation... - Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USA
Psychopharmacology (Berl) 215:621-30. 2011..This study was conducted to investigate the role of α4β2 nicotinic receptors in sustained attention using a novel selective α4β2 nicotinic receptor ligand, sazetidine-A... - Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:1030-40. 2008..In conclusion, the data suggest attentional impairments with clozapine alone and no modification of this effect with nicotine or dizocilpine. Moreover, cortical low affinity nicotinic receptors may have a role in attentional functions... - Further genetic characterization of the fawn-hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholismAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Psychiatr Genet 17:77-83. 2007..Recent comparisons of the parental strains with F1 and F2 intercrosses revealed that the alcohol and saccharin intakes were positively correlated with each other but not with immobility... - Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female ratsAmir H Rezvani
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Psychopharmacology (Berl) 164:369-75. 2002..In the current study, we explored the effects of nicotine and mecamylamine using an operant visual signal detection task designed to model sustained attention processes common to rats and humans... - Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female ratsAmir H Rezvani
Department of Psychiatry, Duke University Medical Center, 341 Bell Building, Box 3412, Durham, NC 27710, USA
Eur J Pharmacol 465:83-90. 2003..This study shows that dizocilpine reduces signal detection accuracy in a dose-dependent fashion. Nicotine can partially counteract an aspect of this reduction by reversing the dizocilpine-induced reduction of correct rejection... - Plant derivatives in the treatment of alcohol dependencyAmir H Rezvani
Department of Psychiatry, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
Pharmacol Biochem Behav 75:593-606. 2003..However, their role in the future of pharmacotherapy for alcoholism will depend upon the outcome of carefully conducted clinical trials... - Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female ratsAmir H Rezvani
Departments of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412, 341 Bell Building, Durham, NC 27710, USA
Pharmacol Biochem Behav 76:75-83. 2003..These results suggest that alcohol, when given alone, impairs sustained attention and blocks nicotine-induced attentional improvements even when it does not cause impairments on its own... - Nicotine-antipsychotic drug interactions and attentional performance in female ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
Eur J Pharmacol 486:175-82. 2004..Chronic nicotine diminished the adverse effects of haloperidol on performance. This study establishes a paradigm to reliably determine the attentional impairment caused by antipsychotic drugs... - Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperatureAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 341 Bell Building, Box 3412, Durham, NC 27710, USA
Int J Dev Neurosci 22:349-54. 2004..These preliminary results suggest that adolescent rats may have an increased sensitivity to nicotine and alcohol, which may consequently impact their initial addiction to these two drugs... - Nicotinic-serotonergic drug interactions and attentional performance in ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Psychopharmacology (Berl) 179:521-8. 2005..The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, on attentional function in rats and the interactions of ketanserin with nicotine administration... - Chronic nicotine interactions with clozapine and risperidone and attentional function in ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, 341 Bell Building, Box 3412 Duke University Medical Center, Durham, NC 27710, USA
Prog Neuropsychopharmacol Biol Psychiatry 30:190-7. 2006..Clozapine was more detrimental than risperidone but the adverse effects of both clozapine and risperidone on attentional performance were masked in rats chronically treated with nicotine... - Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female ratsAmir H Rezvani
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 3412, USA
Int J Neuropsychopharmacol 11:63-70. 2008.... - Specificity of cognitive impairment from Pfiesteria piscicida exposure in rats: attention and visual function versus behavioral plasticityA H Rezvani
Neurobehavioral Research Laboratory, Department of Psychiatry, Duke University Medical Center, 341 Bell Building, Box 3412 Durham, NC 27710, USA
Neurotoxicol Teratol 23:609-16. 2001..These findings suggest that Pfiesteria-induced deficits emerge during periods of behavioral transition and not during performance of previously learned tasks... - Problem-based learning outcomes: the glass half-fullLinda H Distlehorst
Department of Medical Education, Southern Illinois University School of Medicine, PO Box 19681, Springfield, IL 62794 9681, USA
Acad Med 80:294-9. 2005..To compare the characteristics and outcome data of students from a single institution with a two-track, problem based learning (PBL) and standard (STND) curriculum... - Development of Canadian screening tools for fetal alcohol spectrum disorderY Ingrid Goh
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario
Can J Clin Pharmacol 15:e344-66. 2008..Screening for FASD may facilitate diagnosis and hence management of these children. We present a variety of screening tools for the identification of children at risk for FASD...