Brian Czito

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 68:472-8. 2007
  2. doi request reprint Radiation therapy in anal and rectal cancer
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Surg Oncol Clin N Am 22:525-43. 2013
  3. pmc Preoperative chemoradiotherapy for locally advanced gastric cancer
    Joseph M Pepek
    Department of Radiation Oncology, Duke University School of Medicine, Box 3085, Durham, NC 27710, USA
    Radiat Oncol 8:6. 2013
  4. ncbi request reprint Current management of anal canal cancer
    Brian G Czito
    Department of Radiation Oncology, Box 3085, Duke University Medical Center, Durham, NC 27710, USA
    Curr Oncol Rep 11:186-92. 2009
  5. ncbi request reprint Commentary: rectal cancer an evolution of treatment
    Brian G Czito
    Radiation Oncology Clinical Support, Box 3085 Med Ctr, Durham, North Carolina 27710, USA
    Oncologist 12:1319-20. 2007
  6. ncbi request reprint Radiation therapy advances for treatment of anal cancer
    Joseph M Pepek
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Natl Compr Canc Netw 8:123-9. 2010
  7. ncbi request reprint Intensity-modulated radiation therapy for anal cancer
    Brian G Czito
    Department of Radiation Oncology, Duke University, School of Medicine, Durham, North Carolina, USA
    Oncology (Williston Park) 23:1082-9. 2009
  8. ncbi request reprint A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Invest 24:9-17. 2006
  9. ncbi request reprint Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 24:656-62. 2006
  10. ncbi request reprint Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Box 3085, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 62:1030-4. 2005

Detail Information

Publications34

  1. ncbi request reprint Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 68:472-8. 2007
    ..A Phase I trial was undertaken to evaluate the combination of bevacizumab, capecitabine, oxaliplatin, and radiation therapy in patients with rectal cancer...
  2. doi request reprint Radiation therapy in anal and rectal cancer
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Surg Oncol Clin N Am 22:525-43. 2013
    ..Chemotherapy and targeted agents are under study in both anal and rectal cancers to improve on the standard combinations of chemotherapy and radiation...
  3. pmc Preoperative chemoradiotherapy for locally advanced gastric cancer
    Joseph M Pepek
    Department of Radiation Oncology, Duke University School of Medicine, Box 3085, Durham, NC 27710, USA
    Radiat Oncol 8:6. 2013
    ..To examine toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer...
  4. ncbi request reprint Current management of anal canal cancer
    Brian G Czito
    Department of Radiation Oncology, Box 3085, Duke University Medical Center, Durham, NC 27710, USA
    Curr Oncol Rep 11:186-92. 2009
    ..Other studies are evaluating the use of capecitabine, oxaliplatin, and the anti-epidermal growth factor receptor agent cetuximab with RT in this malignancy...
  5. ncbi request reprint Commentary: rectal cancer an evolution of treatment
    Brian G Czito
    Radiation Oncology Clinical Support, Box 3085 Med Ctr, Durham, North Carolina 27710, USA
    Oncologist 12:1319-20. 2007
  6. ncbi request reprint Radiation therapy advances for treatment of anal cancer
    Joseph M Pepek
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Natl Compr Canc Netw 8:123-9. 2010
    ..This article reviews the basic principles of IMRT and highlights current literature on these recent advances and the application of new RT techniques...
  7. ncbi request reprint Intensity-modulated radiation therapy for anal cancer
    Brian G Czito
    Department of Radiation Oncology, Duke University, School of Medicine, Durham, North Carolina, USA
    Oncology (Williston Park) 23:1082-9. 2009
    ....
  8. ncbi request reprint A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Invest 24:9-17. 2006
    ..We addressed the safety of oral eniluracil/5-FU combined with radiation therapy and determined the profile of dose-limiting toxicities and recommended Phase II dose (RPTD) in patients with pancreatic and hepatobiliary cancers...
  9. ncbi request reprint Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 24:656-62. 2006
    ..We initiated two phase I trials assessing the combination of gefitinib, capecitabine, and radiation in patients with localized pancreatic and rectal cancer...
  10. ncbi request reprint Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Box 3085, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 62:1030-4. 2005
    ..To better define the role of adjuvant radiation therapy and chemotherapy, a retrospective analysis of the outcome of patients undergoing surgery and adjuvant therapy was undertaken...
  11. ncbi request reprint Adjuvant radiotherapy with and without concurrent chemotherapy for locally advanced transitional cell carcinoma of the renal pelvis and ureter
    Brian Czito
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Urol 172:1271-5. 2004
    ....
  12. doi request reprint Update on treatment advances in combined-modality therapy for anal and rectal carcinomas
    Jeffrey Meyer
    Department of Radiation Oncology, UT Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75390 9183, USA
    Curr Oncol Rep 13:177-85. 2011
    ..This review will discuss established regimens as well as newer and novel treatment approaches to treatment of anal and rectal cancer...
  13. ncbi request reprint Role of radiation therapy in patients with resectable pancreatic cancer
    Manisha Palta
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 25:715-21, 727. 2011
    ..Further therapeutic advances and prospective trials are needed to better define the optimal role of adjuvant and neoadjuvant treatment in patients with resectable pancreatic cancer...
  14. ncbi request reprint Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy
    Manisha Palta
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 19:1535-40. 2012
    ..Despite radical resection, survival rates remain low with high rates of local failure. We performed a single-institution outcomes analysis to define the role of concurrent chemoradiotherapy (CRT) in addition to surgery...
  15. doi request reprint Current and emerging treatment strategies for anal cancer
    Jeffrey Meyer
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75390 9183, USA
    Curr Oncol Rep 12:168-74. 2010
    ..Early clinical results from studies incorporating intensity-modulated radiation therapy are also discussed...
  16. doi request reprint IMRT treatment of anal cancer with a scrotal shield
    Rodney C Hood
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Med Dosim 37:432-5. 2012
    ..The combination of these techniques resulted in a highly conformal plan that spares organs and risk and avoids the genitals as well as entrance of primary radiation onto the shielding device...
  17. doi request reprint The role of intraoperative radiation therapy in patients with pancreatic cancer
    Manisha Palta
    Department of Radiation Oncology, Duke University, Durham, NC
    Semin Radiat Oncol 24:126-31. 2014
    ..At present, no phase III data clearly supports the use of IORT in the management of pancreatic cancer. ..
  18. ncbi request reprint Advanced radiation therapy technologies in the treatment of rectal and anal cancer: intensity-modulated photon therapy and proton therapy
    Jeffrey Meyer
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Colorectal Cancer 6:348-56. 2007
    ..Finally, preliminary results of IMRT in the treatment of lower gastrointestinal tract cancers will be reviewed. The potential and rationale for proton therapy in treatment of these malignancies are also discussed...
  19. doi request reprint Emerging role of intensity-modulated radiation therapy in anorectal cancer
    Jeffrey J Meyer
    Department of Radiation Oncology, Duke University Medical Center, DUMC Box 3085, Durham, NC 27710, USA
    Expert Rev Anticancer Ther 8:585-93. 2008
    ..This article reviews the rationale for its use in treating anorectal tumors and discusses early clinical data supporting its continued investigation...
  20. ncbi request reprint Radiation therapy in stage II and III rectal cancer
    Christopher G Willett
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 13:6903s-8s. 2007
    ..Current phase III studies are evaluating novel combinations of chemotherapy and targeted agents with radiation therapy...
  21. ncbi request reprint Combined-modality therapy for rectal cancer: future prospects
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Colorectal Cancer 6:625-33. 2007
    ..These agents are now being studied with radiation therapy in the neoadjuvant therapy of rectal cancer...
  22. ncbi request reprint Significance of histological response to preoperative chemoradiotherapy for pancreatic cancer
    Rebekah R White
    Department of Surgery, Duke University Medical Center, Box 3118, Durham, North Carolina 27710, USA
    Ann Surg Oncol 12:214-21. 2005
    ..We hypothesized that histological responses to CRT would be significant prognostic factors in patients undergoing neoadjuvant CRT followed by resection...
  23. ncbi request reprint Locally advanced pancreatic cancer
    Christopher G Willett
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 23:4538-44. 2005
    ..These treatments include external-beam irradiation with and without fluorouracil-based chemotherapy, intraoperative irradiation, and, more recently, external-beam irradiation with new systemic targeted agents...
  24. ncbi request reprint A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 67:1002-7. 2007
    ..The optimal combination of chemotherapeutic agents with RT is undefined. We evaluated a combination of capecitabine, carboplatin, and paclitaxel with RT in a phase I study...
  25. ncbi request reprint Intraoperative radiation therapy
    Christopher G Willett
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:971-7. 2007
    ..Optimally, phase III randomized trials will be carried out to prove its efficacy in these disease sites...
  26. pmc Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer
    Christopher G Willett
    Duke University Medical Center, Durham, NC 27710, USA
    Nat Clin Pract Oncol 4:316-21. 2007
    ..The case presented here is a complete pathological response seen in a patient with extensive and locally invasive carcinoma after receiving this combined treatment...
  27. ncbi request reprint Adjuvant therapy of pancreatic cancer
    Christopher G Willett
    Department of Radiation Oncology and Division of Medical Oncology and Transplantation, Duke University Medical Center, Durham, NC 27705, USA
    Cancer J 13:185-91. 2007
    ..Phase III trials evaluating these modalities have led to conflicting results, leading to controversy in the use and selection of therapy. Phase II studies are now being conducted to evaluate target agent therapy with chemoradiation...
  28. ncbi request reprint Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy
    Chris R Kelsey
    Department of Radiation Oncology, Division of Medical Oncology and Transplantation, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:1436-41. 2007
    ..To report patterns of disease recurrence after resection of adenocarcinoma of the duodenum and compare outcomes between patients undergoing surgery only vs. surgery with concurrent chemotherapy and radiation therapy (CT-RT)...
  29. ncbi request reprint A phase I study of UFT/leucovorin, carboplatin, and paclitaxel in combination with external beam radiation therapy for advanced esophageal carcinoma
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 70:1066-72. 2008
    ..We evaluated the safety and preliminary efficacy of a combination of UFT/leucovorin, carboplatin, and paclitaxel with RT in a Phase I study of patients with advanced esophageal cancer...
  30. ncbi request reprint Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:770-6. 2007
    ..To compare a neoadjuvant regimen of cisplatin/5-fluorouracil (5-FU) and concurrent radiation therapy (RT) with paclitaxel-based regimens and RT in the management of operable esophageal (EC)/gastroesophageal junction (GEJ) cancer...
  31. pmc Targeted therapy in rectal cancer
    Christopher G Willett
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27705, USA
    Oncology (Williston Park) 21:1055-65; discussion 1065, 1070, 1075 passim. 2007
    ..This review will address completed and ongoing trials that have established and continue to clarify the effects of these agents in rectal cancer...
  32. ncbi request reprint A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon
    Brian G Czito
    Department ofRadiation Oncology, Duke University Medical Center, Durham, NC, USA
    Int J Radiat Oncol Biol Phys 58:779-85. 2004
    ..We addressed the safety of oral eniluracil and 5-FU combined with preoperative radiotherapy and determined the recommended Phase II dose and dose-limiting toxicity in patients with locally advanced rectal and colon cancer...
  33. ncbi request reprint Radiation therapy in the treatment of cholangiocarcinoma
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 20:873-84; discussion 886-8, 893-5. 2006
    ..Although these new approaches hold promise, the prognosis in patients with biliary cancers remains poor, and the integration of novel therapeutic strategies is indicated...
  34. ncbi request reprint Radiation therapy for resectable colon cancer. Is there a role in the modern chemotherapy era?
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 20:179-87; discussion 187-8, 192. 2006
    ..Adjuvant radiation therapy should be considered in patients with colon cancer at high risk for local failure...