Research Topics
| Lesley H CurtisSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Prostate specific antigen testing in men older than 75 years in the United StatesCharles D Scales
Duke Prostate Center, Division of Urology, Department of Surgery and Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Urol 176:511-4. 2006..Physician and practice characteristics are associated with prostate specific antigen PSA testing...- Costs of the metabolic syndrome in elderly individuals: findings from the Cardiovascular Health StudyLesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
Diabetes Care 30:2553-8. 2007..Little is known about how the metabolic syndrome and its individual components translate into long-term medical costs... - Sex and racial differences in the use of implantable cardioverter-defibrillators among patients hospitalized with heart failureAdrian F Hernandez
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
JAMA 298:1525-32. 2007..The influence of sex and race on ICD use among eligible patients is unknown... 
Clinical effectiveness of implantable cardioverter-defibrillators among medicare beneficiaries with heart failureAdrian F Hernandez
Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
Circ Heart Fail 3:7-13. 2010..The clinical effectiveness of implantable cardioverter-defibrillators (ICDs) in older patients with heart failure has not been established, and older patients have been underrepresented in previous studies...- Use of guideline-recommended therapies for heart failure in the Medicare populationLisa D DiMartino
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
Clin Cardiol 33:400-5. 2010..Most information about the use of guideline-recommended therapies for heart failure reflects what occurred at discharge after an inpatient stay... - Design and rationale of a retrospective clinical effectiveness study of aldosterone antagonist therapy in patients with heart failureLesley H Curtis
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Am Heart J 163:946-953.e1. 2012..Questions remain about its clinical effectiveness and safety for patients who are underrepresented in randomized trials and those at risk for hyperkalemia... - Treatment patterns for neovascular age-related macular degeneration: analysis of 284 380 medicare beneficiariesLesley H Curtis
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Am J Ophthalmol 153:1116-24.e1. 2012..To examine trends in the treatment of newly diagnosed neovascular age-related macular degeneration (AMD)... 
Toward estimating the impact of changes in immigrants' insurance eligibility on hospital expenditures for uncompensated careLiana D Castel
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27715 USA
BMC Health Serv Res 3:1. 2003..Our goal was to assess the effect of PRWORA on hospital uncompensated care in the United States...- Assessment of left ventricular function in older Medicare beneficiaries with newly diagnosed heart failureLesley H Curtis
Duke Clinical Research Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
Circ Cardiovasc Qual Outcomes 4:85-91. 2011..Little is known about the extent to which left ventricular function is assessed in real-world settings... - Geographic variation and trends in carotid imaging among medicare beneficiaries, 2001 to 2006Lesley H Curtis
Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
Circ Cardiovasc Qual Outcomes 3:599-606. 2010..We examined temporal trends and geographic variation in the use of carotid ultrasound, carotid magnetic resonance angiography (MRA), and carotid x-ray angiography... - Risks of mortality, myocardial infarction, bleeding, and stroke associated with therapies for age-related macular degenerationLesley H Curtis
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
Arch Ophthalmol 128:1273-9. 2010..To examine associations between therapies for age-related macular degeneration and risks of all-cause mortality, incident myocardial infarction, bleeding, and incident stroke... - Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databasesLesley H Curtis
Duke Clinical Research Institute, and Departments of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
Med Care 45:S103-7. 2007..Finally, we offer detailed guidance about how to implement the estimators in comparative effectiveness analyses... - Sex differences in the use of implantable cardioverter-defibrillators for primary and secondary prevention of sudden cardiac deathLesley H Curtis
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
JAMA 298:1517-24. 2007..Previous studies of sex differences in the use of implantable cardioverter-defibrillators (ICDs) predate recent expansions in Medicare coverage and did not provide patient follow-up over multiple years... - Pancreatic beta-cell function as a predictor of cardiovascular outcomes and costs: findings from the Cardiovascular Health StudyLesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Curr Med Res Opin 24:41-50. 2008..To explore relationships between beta-cell function and incident cardiovascular events, death, and medical costs among elderly individuals... - Incidence and prevalence of heart failure in elderly persons, 1994-2003Lesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
Arch Intern Med 168:418-24. 2008..We sought to estimate the annual incidence and prevalence of heart failure and associated survival in elderly persons from January 1, 1994, through December 31, 2003... - Early and long-term outcomes of heart failure in elderly persons, 2001-2005Lesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
Arch Intern Med 168:2481-8. 2008..The treatment of chronic heart failure has improved during the past 2 decades, but little is known about whether the improvements are reflected in trends in early and long-term mortality and hospital readmission... - The value of patient-reported health status in predicting short-term outcomes after coronary artery bypass graft surgeryLesley H Curtis
Department of Community and Preventive Medicine, University of Rochester School of Medicine, Rochester, New York, USA
Med Care 40:1090-100. 2002..Patient-reported health status may be an important independent predictor of short-term health outcomes... - Associations between aldosterone antagonist therapy and risks of mortality and readmission among patients with heart failure and reduced ejection fractionAdrian F Hernandez
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
JAMA 308:2097-107. 2012..Aldosterone antagonist therapy for heart failure and reduced ejection fraction has been highly efficacious in randomized trials. However, questions remain regarding the effectiveness and safety of the therapy in clinical practice... - Relationships between emerging measures of heart failure processes of care and clinical outcomesAdrian F Hernandez
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Am Heart J 159:406-13. 2010..Previous studies have not confirmed associations between some current performance measures for inpatient heart failure processes of care and postdischarge outcomes. It is unknown if alternative measures are associated with outcomes... - Pharmacologic prophylaxis for venous thromboembolism and 30-day outcomes among older patients hospitalized with heart failure: an analysis from the ADHERE national registry linked to Medicare claimsRobb D Kociol
Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
Clin Cardiol 34:682-8. 2011..Although pharmacologic prophylaxis regimens have reduced VTE risk in medically ill patients, associations with early postdischarge adverse clinical outcomes among patients with heart failure are unknown... - Outcomes of Medicare beneficiaries undergoing catheter ablation for atrial fibrillationJonathan P Piccini
Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
Circulation 126:2200-7. 2012..Atrial fibrillation is common among older persons. Catheter ablation is increasingly used in patients for whom medical therapy has failed... - Association between the Medicare Modernization Act of 2003 and patient wait times and travel distance for chemotherapyAlisa M Shea
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
JAMA 300:189-96. 2008..Anecdotal reports suggest that these adjustments may have negatively affected access to chemotherapy for Medicare beneficiaries... - Resource use in the last 6 months of life among medicare beneficiaries with heart failure, 2000-2007Kathleen T Unroe
Duke Clinical Research Institute, Durham, NC 27715, USA
Arch Intern Med 171:196-203. 2011..Heart failure is a common cause of death among Medicare beneficiaries, but little is known about health care resource use at the end of life... - Associations of patient demographic characteristics and regional physician density with early physician follow-up among medicare beneficiaries hospitalized with heart failureRobb D Kociol
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
Am J Cardiol 108:985-91. 2011..Strategies are needed to ensure access among vulnerable populations to this supply-sensitive resource... - Atypical antipsychotic drugs and diabetes mellitus in a large outpatient population: a retrospective cohort studyTruls Østbye
Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
Pharmacoepidemiol Drug Saf 14:407-15. 2005..We sought to compare the incidence of new onset diabetes among patients receiving atypical antipsychotics, traditional antipsychotics or antidepressants... - B-type natriuretic peptide level and postdischarge thrombotic events in older patients hospitalized with heart failure: insights from the Acute Decompensated Heart Failure National RegistryRobb D Kociol
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Am Heart J 163:994-1001. 2012..Associations between BNP level and thromboembolic events in patients with HF without atrial fibrillation (AF) are not well studied... - Associations between published quality ratings of skilled nursing facilities and outcomes of medicare beneficiaries with heart failureKathleen T Unroe
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
J Am Med Dir Assoc 13:188.e1-6. 2012..Our study examined associations between ratings and readmission and mortality among Medicare beneficiaries admitted to a skilled nursing facility with a primary diagnosis of heart failure... - Long-term outcomes of medicare beneficiaries with worsening renal function during hospitalization for heart failureRobb D Kociol
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Am J Cardiol 105:1786-93. 2010..12, 95% confidence interval 1.04 to 1.20) but not readmission or total inpatient costs. In conclusion, worsening RF in patients hospitalized with HF was independently associated with long-term mortality... - Survival of patients receiving a primary prevention implantable cardioverter-defibrillator in clinical practice vs clinical trialsSana M Al-Khatib
Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
JAMA 309:55-62. 2013..Whether the survival of patients who received an ICD in primary prevention clinical trials differs from that of trial-eligible patients receiving a primary prevention ICD in clinical practice is unknown... - Frequency of high-risk use of QT-prolonging medicationsNancy M Allen LaPointe
Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Pharmacoepidemiol Drug Saf 15:361-8. 2006..Concurrent use of more than one QT-prolonging drug or a QT-prolonging drug with a drug that alters its pharmacokinetic profile is an important risk factor for adverse outcomes... - Representativeness of a national heart failure quality-of-care registry: comparison of OPTIMIZE-HF and non-OPTIMIZE-HF Medicare patientsLesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Circ Cardiovasc Qual Outcomes 2:377-84. 2009..Participation in clinical registries is nonrandom, so participants may differ in important ways from nonparticipants. The extent to which findings from clinical registries can be generalized to broader populations is unclear... - Follow-up of patients with new cardiovascular implantable electronic devices: are experts' recommendations implemented in routine clinical practice?Sana M Al-Khatib
Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
Circ Arrhythm Electrophysiol 6:108-16. 2013..A 2008 expert consensus statement outlined the minimum frequency of follow-up of patients with cardiovascular implantable electronic devices (CIEDs)... - National survey of hospital strategies to reduce heart failure readmissions: findings from the Get With the Guidelines-Heart Failure registryRobb D Kociol
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Circ Heart Fail 5:680-7. 2012..Reducing 30-day heart failure readmission rates is a national priority. Yet, little is known about how hospitals address the problem and whether hospital-based processes of care are associated with reductions in readmission rates... - Relationship between early physician follow-up and 30-day readmission among Medicare beneficiaries hospitalized for heart failureAdrian F Hernandez
Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
JAMA 303:1716-22. 2010..However, there are limited data describing patterns of follow-up after heart failure hospitalization and its association with readmission rates... - Resource use and costs associated with diabetic macular edema in elderly personsAlisa M Shea
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
Arch Ophthalmol 126:1748-54. 2008..To examine trends in resource use and the effect of incident diabetic macular edema (DME) on 1- and 3-year total direct medical costs in elderly patients... - Predicting costs among medicare beneficiaries with heart failureMelissa A Greiner
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
Am J Cardiol 109:705-11. 2012..In conclusion, a model based on variables from clinical registries can identify a group of patients with heart failure who on average will incur higher costs in the first year after hospitalization... - Clopidogrel use and clinical events after drug-eluting stent implantation: findings from the HealthCore Integrated Research DatabaseJohn L Petersen
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Am Heart J 159:462-470.e1. 2010..Relationships between long-term use and level of dual antiplatelet therapy and outcomes after drug-eluting stent implantation are not well established... - Prevalence of atypical antipsychotic drug use among commercially insured youths in the United StatesLesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Arch Pediatr Adolesc Med 159:362-6. 2005..Understanding the long-term effects on the developing brain of early and prolonged exposure to atypical antipsychotics is crucial given their use in pediatric populations... - Long-term outcomes and costs of ventricular assist devices among Medicare beneficiariesAdrian F Hernandez
Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
JAMA 300:2398-406. 2008..In 2003, Medicare expanded coverage of ventricular assist devices as destination, or permanent, therapy for end-stage heart failure. Little is known about the long-term outcomes and costs associated with these devices... - Incremental value of clinical data beyond claims data in predicting 30-day outcomes after heart failure hospitalizationBradley G Hammill
Duke Clinical Research Institute and Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
Circ Cardiovasc Qual Outcomes 4:60-7. 2011..As clinical data become more readily available, the incremental value of adding clinical data to claims-based models of mortality and readmission is unclear... - Racial differences in hospice use and patterns of care after enrollment in hospice among Medicare beneficiaries with heart failureKathleen T Unroe
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Am Heart J 163:987-993.e3. 2012..We examined racial differences in patterns of care and resource use among Medicare beneficiaries with heart failure after enrollment in hospice... - Linking inpatient clinical registry data to Medicare claims data using indirect identifiersBradley G Hammill
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Am Heart J 157:995-1000. 2009..We present a method to link hospitalization records from registries with Medicare inpatient claims data, without using direct identifiers, to create a unique data source that pairs rich clinical data with long-term outcome data... - Inappropriate prescribing for elderly Americans in a large outpatient populationLesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
Arch Intern Med 164:1621-5. 2004..Pharmaceutical claims databases can be important tools for accomplishing this task, though clinical and laboratory data are needed to improve the sensitivity and specificity of patient-specific alerts... - Costs of inpatient care among Medicare beneficiaries with heart failure, 2001 to 2004David J Whellan
Center for Clinical and Genetic Economics, Duke University School of Medicine, Durham, NC, USA
Circ Cardiovasc Qual Outcomes 3:33-40. 2010..Inpatient care is the primary driver of costs for patients with heart failure. It is unclear whether recent advances in heart failure care have reduced the costs to Medicare for the care of inpatients with heart failure... - Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007Jonathan P Piccini
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
Circ Cardiovasc Qual Outcomes 5:85-93. 2012..The frequency of AF increases with age, but representative national data about incidence and prevalence are limited. We examined the annual incidence, prevalence, and mortality associated with AF among older persons... - Process of care performance measures and long-term outcomes in patients hospitalized with heart failureMark E Patterson
Center for Clinical and Genetic Economics, Duke University School of Medicine, Durham, NC, USA
Med Care 48:210-6. 2010..Recent efforts to improve care for patients hospitalized with heart failure have focused on process-based performance measures. Data supporting the link between current process measures and patient outcomes are sparse... - Geographic variation in carotid revascularization among Medicare beneficiaries, 2003-2006Manesh R Patel
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
Arch Intern Med 170:1218-25. 2010..We examined geographic variation in and predictors of carotid endarterectomy and carotid stenting... - Relationship between cardiac rehabilitation and long-term risks of death and myocardial infarction among elderly Medicare beneficiariesBradley G Hammill
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
Circulation 121:63-70. 2010..The relationship between the number of sessions attended and long-term outcomes is unknown... - Socioeconomic status and outcome following acute myocardial infarction in elderly patientsSunil V Rao
Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27715, USA
Arch Intern Med 164:1128-33. 2004..Whether these disparities account for increased mortality among elderly poor patients is not known... - External validity of the cardiovascular health study: a comparison with the Medicare populationLisa D DiMartino
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
Med Care 47:916-23. 2009..The Cardiovascular Health Study (CHS), a population-based prospective cohort study, has been used to identify major risk factors associated with cardiovascular disease and stroke in the elderly... - Non-evidence-based ICD implantations in the United StatesSana M Al-Khatib
Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
JAMA 305:43-9. 2011.... - The effect of dementia on outcomes and process of care for Medicare beneficiaries admitted with acute myocardial infarctionFrank A Sloan
Department of Economics and Clinical Research Institute, Duke University, Durham, North Carolina 27708, USA
J Am Geriatr Soc 52:173-81. 2004..To determine differences in mortality after admission for acute myocardial infarction (AMI) and in use of noninvasive and invasive treatments for AMI between patients with and without dementia... - Changes in initial treatment for prostate cancer among Medicare beneficiaries, 1999-2007Michaela A Dinan
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Int J Radiat Oncol Biol Phys 82:e781-6. 2012..We examined changes in the management of patients with prostate cancer in the Medicare population... - Generalizability and longitudinal outcomes of a national heart failure clinical registry: Comparison of Acute Decompensated Heart Failure National Registry (ADHERE) and non-ADHERE Medicare beneficiariesRobb D Kociol
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Am Heart J 160:885-92. 2010..Clinical registries are used increasingly to analyze quality and outcomes, but the generalizability of findings from registries is unclear... - Geographic variation in the prescription of schedule II opioid analgesics among outpatients in the United StatesLesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, P.O. Box 17969, Durham, NC 27715, USA
Health Serv Res 41:837-55. 2006..Future research should use individual-level data to assess whether these findings reflect a reduction in abuse and diversion or suboptimal treatment of pain... - Resource use and costs of branch and central retinal vein occlusion in the elderlySharon Fekrat
Duke University School of Medicine, Durham, NC, USA 27715
Curr Med Res Opin 26:223-30. 2010..To examine the incidence, prevalence, resource use, and costs associated with branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) in elderly patients... - Prostate cancer in the Baby Boomer generation: results from CaPSURECharles D Scales
Duke Prostate Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Urology 70:1162-7. 2007..We sought to characterize prostate cancer (CaP) presentation among this group, and determine whether treatment patterns differ between Baby Boomers and the preceding generation... - Prostate-specific antigen screening among young men in the United StatesCharles D Scales
Duke Prostate Center, Division of Urology, Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
Cancer 113:1315-23. 2008..Little is known about the use of PSA testing in these men. To understand policy implications of risk stratification, the authors sought to characterize PSA use among young men... - Clinical effectiveness of beta-blockers in heart failure: findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) RegistryAdrian F Hernandez
Duke Clinical Research Institute, Durham, NC 27715, USA
J Am Coll Cardiol 53:184-92. 2009..We sought to examine associations between initiation of beta-blocker therapy and outcomes among elderly patients hospitalized for heart failure... - Patient and implanting physician factors associated with mortality and complications after implantable cardioverter-defibrillator implantation, 2002-2005Sana M Al-Khatib
Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27715, USA
Circ Arrhythm Electrophysiol 1:240-9. 2008..We examined patient and implanting physician factors associated with outcomes of ICD therapy in Medicare beneficiaries from 2002 through 2005... - Outcomes Associated With Warfarin Use in Older Patients With Heart Failure and Atrial Fibrillation and a Cardiovascular Implantable Electronic Device: Findings From the ADHERE Registry Linked to Medicare ClaimsPaul L Hess
Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina
Clin Cardiol 35:649-57. 2012..Warfarin use and associated outcomes in patients with heart failure and atrial fibrillation and a cardiovascular implantable electronic device have not been described previously... - Changes in the use and costs of diagnostic imaging among Medicare beneficiaries with cancer, 1999-2006Michaela A Dinan
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
JAMA 303:1625-31. 2010..Imaging is the fastest growing expense for Medicare but has not been examined among beneficiaries with cancer... - Evidence-based therapies and mortality in patients hospitalized in December with acute myocardial infarctionTrip J Meine
Duke University Medical Center, Durham, North Carolina, USA
Ann Intern Med 143:481-5. 2005..CONCLUSIONS: Thirty-day mortality rates were higher for Medicare patients hospitalized with acute MI in December than in other months, although the use of evidence-based therapies was not significantly lower... - Changing gender prevalence of stone diseaseCharles D Scales
Comprehensive Kidney Stone Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Urol 177:979-82. 2007..We examined changes in the prevalence by gender of inpatient hospital discharges for urinary stone disease... - Performance of propensity score methods when comparison groups originate from different data sourcesBradley G Hammill
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Pharmacoepidemiol Drug Saf 21:81-9. 2012..To examine the performance of propensity score-based methods for estimating relative risks when exposed and comparison subjects are selected from different data sources... - Identification of patients with diabetic macular edema from claims data: a validation studySrilaxmi Bearelly
Duke University Eye Center, Durham, NC 27715, USA
Arch Ophthalmol 126:986-9. 2008.... - Assessment of temporal trends in mortality with implementation of a statewide ST-segment elevation myocardial infarction (STEMI) regionalization programSeth W Glickman
Duke Clinical Research Institute, Duke University, Durham, NC, USA
Ann Emerg Med 59:243-252.e1. 2012..Our objective is to explore temporal trends in STEMI mortality with the implementation of a statewide STEMI regionalization program (Reperfusion of Acute Myocardial Infarction in North Carolina Emergency Departments [RACE])... - Sensitivity of International Classification of Diseases codes for hyponatremia among commercially insured outpatients in the United StatesAlisa M Shea
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina, USA
BMC Nephrol 9:5. 2008.... - Associations between worsening renal function and 30-day outcomes among Medicare beneficiaries hospitalized with heart failureUptal D Patel
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Am Heart J 160:132-138.e1. 2010..We examined associations between WRF and 30-day readmission, mortality, and costs among Medicare beneficiaries hospitalized with heart failure... - Variations in coronary procedure utilization depending on body mass indexWilliam S Yancy
Center for Health Services Research in Primary Care, Veterans Affairs Medical Center, Durham, NC 27705, USA
Arch Intern Med 165:1381-7. 2005..The relationship between BMI and utilization of diagnostic or therapeutic procedures for coronary heart disease has not been examined... - Bladder augmentation versus urinary diversion in patients with spina bifida in the United StatesJohn S Wiener
Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA
J Urol 186:161-5. 2011..Therefore, we characterized the use of bladder augmentation and urinary diversion in patients with spina bifida in a nationally representative, all payer, all ages data set... - Do heart failure disease management programs make financial sense under a bundled payment system?Zubin J Eapen
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
Am Heart J 161:916-22. 2011..Whether a bundled payment approach can address the negative financial impact of DM programs is unknown... - Relationship between body mass index and prostate cancer screening in the United StatesCharles D Scales
Duke Prostate Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Urol 177:493-8. 2007..To our knowledge the relationship between obesity and prostate cancer screening behavior in men 40 or older is unknown. Thus, we examined associations between body mass index and prostate cancer screening behavior... - Prescription of QT-prolonging drugs in a cohort of about 5 million outpatientsLesley H Curtis
Center for Clinical and Genetic Economics, Duke University Medical Center, Durham, North Carolina 27510, USA
Am J Med 114:135-41. 2003..Large pharmaceutical claims databases are useful for detecting potentially harmful prescribing behaviors, but better clinical evidence on medication safety is needed before such a system can be implemented fully... - Impact of heart failure on patients undergoing major noncardiac surgeryBradley G Hammill
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, North Carolina, USA
Anesthesiology 108:559-67. 2008..The authors evaluated short-term outcomes among patients with heart failure, coronary artery disease (CAD), or neither who underwent major noncardiac surgery... - Characteristics of nontraumatic subarachnoid hemorrhage in the United States in 2003Alisa M Shea
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina 27715, USA
Neurosurgery 61:1131-7; discussion 1137-8. 2007..We examined the epidemiology and in-hospital outcomes of nontraumatic SAH in the United States... - The insurance effect on prescription drug expenditures among the elderly: findings from the 1997 Medical Expenditure Panel SurveyLesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
Med Care 42:439-46. 2004..By quantifying the insurance effect on expenditures among the elderly, the data reported here could reduce uncertainty in the budget estimation process... - Comparative effectiveness of beta-blockers in elderly patients with heart failureJudith M Kramer
Department of Medicine, Duke Clinical Research Institute, Durham, NC 27715, USA
Arch Intern Med 168:2422-8; discussion 2428-32. 2008..We compared the effectiveness of EBBBs vs non-EBBBs on survival... - Does the ownership of the admitting hospital make a difference? Outcomes and process of care of Medicare beneficiaries admitted with acute myocardial infarctionFrank A Sloan
Department of Economics, Duke University, Durham, North Carolina 27708, USA
Med Care 41:1193-205. 2003..Concerns have been expressed about quality of for-profit hospitals and their use of expensive technologies... - The Medicare Modernization Act and reimbursement for outpatient chemotherapy: do patients perceive changes in access to care?Joeëlle Y Friedman
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
Cancer 110:2304-12. 2007.... - Medical costs of abnormal serum sodium levelsAlisa M Shea
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
J Am Soc Nephrol 19:764-70. 2008..2%). Costs associated with hypernatremia were not significantly different from those incurred by patients with normal serum sodium. In conclusion, hyponatremia is a significant independent predictor of 6-mo and 1-yr direct medical costs... - Practice variation in the surgical management of urinary lithiasisCharles D Scales
Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina, USA
J Urol 186:146-50. 2011..We identified patient, provider and practice setting characteristics associated with the selection of ureteroscopy or shock wave lithotripsy... - Prescription of nonsteroidal anti-inflammatory drugs and muscle relaxants for back pain in the United StatesXuemei Luo
Center for Clinical Effectiveness, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Spine (Phila Pa 1976) 29:E531-7. 2004..OBJECTIVE.: To examine national prescription patterns of nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants among individuals with back pain in the United States... - Outpatient prescribing of antiarrhythmic drugs from 1995 to 2000Sana M Al-Khatib
Duke Center for Education and Research on Therapeutics (CERTs) at the Duke Clinical Research Institute, Durham, North Carolina 27715, USA
Am J Cardiol 91:91-4. 2003 - Geographic variations in the use of medical and surgical therapies for benign prostatic hyperplasiaJeffrey C Sung
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
J Urol 175:1023-7. 2006..Finasteride rates are inversely related to surgery rates, and tamsulosin rates are positively associated with surgery rates. Surgery rates are not significantly associated with urologists per capita... - Welfare reform and Latinas' use of perinatal health careDamon M Seils
Am J Public Health 92:699-700; author reply 700. 2002 - Trends in operator and hospital procedure volume and outcomes for percutaneous transluminal coronary angioplasty, 1996 to 2001Susan M Kansagra
Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 99:339-43. 2007..There were outcome differences within subpopulations of operators in classes 2 and 4, which suggest possibilities for alternative volume classification guidelines... - Insurance status and race represent independent predictors of undergoing laparoscopic surgery for appendicitis: secondary data analysis of 145,546 patientsUlrich Guller
Department of Surgery, Division of General Surgery, University of Basel/Switzerland
J Am Coll Surg 199:567-75; discussion 575-7. 2004..CONCLUSIONS: Even after adjusting for potential confounders, insurance status and race are marked independent predictors of having laparoscopic surgery in patients treated for appendicitis in this sample...
Research Grants
- Heart Failure: Epidemiology & Outcomes in the ElderlyLesley Curtis; Fiscal Year: 2007..At the conclusion of this study, we will have a comprehensive understanding of heart failure in elderly Americans and how investments in health care for patients with HF are directly linked to survival and health. ..
- Patterns of Health Care Use, Treatment & Outcomes in Atrial Fibrillation: PATH-AFSUSAN HECKBERT; Fiscal Year: 2010..Second, it will directly answer critical questions of how investments in health care for patients with atrial fibrillation are directly linked to survival and health. ..