Coleen K Cunningham
Affiliation: Duke University Medical Center
- The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316Coleen K Cunningham
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
J Acquir Immune Defic Syndr 36:800-7. 2004..Race/ethnicity is significant in predicting viral suppression at the time of delivery...
- Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 3Coleen K Cunningham
Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, Syracuse, NY 13210, USA
J Infect Dis 186:181-8. 2002..The risk of nevirapine resistance should be considered when determining the risks or benefits of intrapartum nevirapine in women receiving antepartum antiretroviral therapy...
- Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional studySusan D Emmett
Duke University Medical Center, Durham, North Carolina, USA
J Acquir Immune Defic Syndr 54:368-75. 2010....
- Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replicationKevin O Saunders
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, 27710, USA
Virology 405:234-42. 2010..These data provide a way to focus the search for the suppressive factors and to potentially modulate their expression...
- Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replicationStephanie A Freel
Department of Surgery, Duke University Human Vaccine Institute, Durham, North Carolina, USA
J Virol 86:6835-46. 2012....
- Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern TanzaniaJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Trop Med Int Health 16:830-7. 2011..To describe the contribution of paediatric HIV and of HIV co-infections to admissions to a hospital in Moshi, Tanzania, using contemporary laboratory methods...
- A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern TanzaniaElizabeth A Reddy
Duke University Medical Center, Durham, NC, USA
BMC Infect Dis 14:89. 2014..This study sought to determine the impact of providing mycobacterial culture results over standard of care [unconcentrated acid-fast (AFB) smears] on management of persons with suspected tuberculosis...
- Prevalence of mycobacteremia among HIV-infected infants and children in northern TanzaniaKatherine D Gray
Duke University Medical Center, Durham, NC, USA
Pediatr Infect Dis J 32:754-6. 2013..We found no cases of mycobacteremia among 93 ill, HIV-infected children in northern Tanzania, despite optimization of laboratory methods and selection of patients thought to be at highest risk for disseminated infection. ..
- Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trialAlejandro Dorenbaum
Department of Pediatrics, University of California, San Francisco, USA
JAMA 288:189-98. 2002..However, it is unknown whether the addition of the 2-dose nevirapine regimen to standard ART would further reduce perinatal HIV transmission...
- Utility of rapid antibody tests to exclude HIV-1 infection among infants and children aged <18 months in a low-resource settingAnn M Buchanan
Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
J Clin Virol 55:244-9. 2012..Excluding HIV infection among infants and young children in resource-poor settings where nucleic acid amplification tests (NAAT) are not routinely available remains a considerable challenge...
- Advances and failures in preventing perinatal human immunodeficiency virus infectionAnn M Buchanan
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Box T3499, Durham, NC 27710, USA
Clin Microbiol Rev 22:493-507. 2009..Further work is needed to determine the optimal strategy for reducing perinatal transmission among women in resource-poor settings, with a particular need for reduction of transmission via breast-feeding...
- Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccinationStephanie A Freel
Duke University Human Vaccine Institute, Departments of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Virol 84:4998-5006. 2010..Our data define attributes of an antiviral CD8(+) T-cell response that may be optimized in the search for an efficacious HIV-1 vaccine...
- Randomized trial to determine safety and immunogenicity of two strategies for hepatitis B vaccination in healthy urban adolescents in the United StatesColeen K Cunningham
Department of Pediatrics, Duke, Durham, NC, USA
Pediatr Infect Dis J 29:530-4. 2010..Multiple studies have shown excellent response rates after hepatitis B immunization in youth; however, one previous study conducted in urban youth demonstrated poor responses...
- Progress in the prevention of mother to child transmission of HIV in three regions of Tanzania: a retrospective analysisAnn M Buchanan
Kilimanjaro Christian Medical Centre, Moshi, Tanzania Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America
PLoS ONE 9:e88679. 2014..Early infant diagnosis of HIV-1 using dried blood spot (DBS) PCR among exposed infants provides an opportunity to assess current MTCT rates...
- Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoirDeborah Persaud
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
AIDS 25:2227-34. 2011..Alternatively, latently infected CD4 T cells maybe killed, while exiting the reservoir upon activation...
- Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern TanzaniaOpemipo O Johnson
Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Pediatr Infect Dis J 28:493-7. 2009....
- Growth as a part of the composite endpoint in paediatric antiretroviral clinical trialsDaniel K Benjamin
Department of Pediatrics, Duke University, Durham, NC, USA
J Antimicrob Chemother 54:701-3. 2004....
- Newer treatments for HIV in childrenRoss E McKinney
Departmentof Pedicatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Pediatr 16:76-9. 2004..Several new antiretroviral agents have been introduced into pediatric and adult use. This review will summarize information about these new agents and other recent advances in the care of HIV-infected children...
- Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usageKevin O Saunders
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
Cell Immunol 266:154-64. 2011..We define a multifactorial cytokine profile of CD8(+) T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication...
- Establishment of haematological and immunological reference values for healthy Tanzanian children in Kilimanjaro RegionAnn M Buchanan
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Trop Med Int Health 15:1011-21. 2010..To determine the normal haematological and immunological reference intervals for healthy Tanzanian children...
- Treatment of children with HIV infectionTerry C Dixon
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Curr HIV/AIDS Rep 4:93-9. 2007..New information on key vaccines that should be administered to children with HIV infection is also discussed...
- An Infection Control Program for a 2009 influenza A H1N1 outbreak in a university-based summer campEphraim L Tsalik
Department of Medicine, Duke University Medical Center, Durham, North Carolinam, USA
J Am Coll Health 59:419-26. 2011..Describe two 2009-H1N1 influenza outbreaks in university-based summer camps and the implementation of an infection control program...
- Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationshipsDolors Soy
Department of Biopharmaceutical Sciences, School of Pharmacy, University of California San Francisco, San Francisco, Calif, USA
Clin Pharmacol Ther 74:569-80. 2003..Our objective was to describe the population pharmacokinetics and pharmacodynamics of enfuvirtide acting on viral ribonucleic acid in children with human immunodeficiency virus 1...
- Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine doseMark Mirochnick
Boston University School of Medicine, Boston Medical Center, 91 Concord Street, 6th Floor, Boston, MA 02118, USA
J Acquir Immune Defic Syndr 33:153-6. 2003..To evaluate cord blood and predose nevirapine concentrations in infants exposed to the two-dose intrapartum neonatal nevirapine regimen...
- Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316D Heather Watts
National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Am J Obstet Gynecol 190:506-16. 2004..The purpose of this study was to evaluate rates of maternal toxicity, pregnancy complications, and peripartum morbidity by type and duration of antiretroviral therapy (ART) during pregnancy...
- Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected childrenJoseph A Church
Childrens Hospital Los Angeles, Division of Clinical Immunology and Allergy, CA 90027, USA
Pediatr Infect Dis J 23:713-8. 2004..The safety and antiretroviral activity of enfuvirtide treatment of 24 weeks in HIV-1-infected children has been previously documented. Here we present the long term tolerability and safety of enfuvirtide...
- Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infectionJennifer J Kiser
University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
Antimicrob Agents Chemother 52:631-7. 2008..Additional studies of the exposure-response relationships of this regimen in children, adolescents, and adults would advance our knowledge of its pharmacodynamic properties...
- Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USAMarie Louise Newell
Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
BMC Infect Dis 7:60. 2007....
- Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIVKristine L Witt
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Environ Mol Mutagen 48:322-9. 2007..These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants is recommended to ensure their continued health...
- Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroadsHeather B Jaspan
Desmond Tutu HIV Centre, University of Cape Town, South Africa
J Acquir Immune Defic Syndr 47:86-92. 2008..This article examines these issues and proposes specific next steps to facilitate the routine inclusion of this high-priority population in preventive HIV vaccine trials as early and seamlessly as possible...