Coleen K Cunningham
Affiliation: Duke University Medical Center
- The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316Coleen K Cunningham
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
J Acquir Immune Defic Syndr 36:800-7. 2004..Race/ethnicity is significant in predicting viral suppression at the time of delivery...
- Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional studySusan D Emmett
Duke University Medical Center, Durham, North Carolina, USA
J Acquir Immune Defic Syndr 54:368-75. 2010....
- Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 3Coleen K Cunningham
Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, Syracuse, NY 13210, USA
J Infect Dis 186:181-8. 2002..The risk of nevirapine resistance should be considered when determining the risks or benefits of intrapartum nevirapine in women receiving antepartum antiretroviral therapy...
- Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replicationKevin O Saunders
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, 27710, USA
Virology 405:234-42. 2010..These data provide a way to focus the search for the suppressive factors and to potentially modulate their expression...
- Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replicationStephanie A Freel
Department of Surgery, Duke University Human Vaccine Institute, Durham, North Carolina, USA
J Virol 86:6835-46. 2012....
- Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern TanzaniaJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Trop Med Int Health 16:830-7. 2011..To describe the contribution of paediatric HIV and of HIV co-infections to admissions to a hospital in Moshi, Tanzania, using contemporary laboratory methods...
- Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trialAlejandro Dorenbaum
Department of Pediatrics, University of California, San Francisco, USA
JAMA 288:189-98. 2002..CONCLUSION: Risk of perinatal HIV transmission was low and no benefit from additional intrapartum/newborn nevirapine was demonstrated when women received prenatal care and antenatal ART, and elective cesarean section was made available...
- Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccinationStephanie A Freel
Duke University Human Vaccine Institute, Departments of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Virol 84:4998-5006. 2010..Our data define attributes of an antiviral CD8(+) T-cell response that may be optimized in the search for an efficacious HIV-1 vaccine...
- Advances and failures in preventing perinatal human immunodeficiency virus infectionAnn M Buchanan
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Box T3499, Durham, NC 27710, USA
Clin Microbiol Rev 22:493-507. 2009..Further work is needed to determine the optimal strategy for reducing perinatal transmission among women in resource-poor settings, with a particular need for reduction of transmission via breast-feeding...
- Randomized trial to determine safety and immunogenicity of two strategies for hepatitis B vaccination in healthy urban adolescents in the United StatesColeen K Cunningham
Department of Pediatrics, Duke, Durham, NC, USA
Pediatr Infect Dis J 29:530-4. 2010..Multiple studies have shown excellent response rates after hepatitis B immunization in youth; however, one previous study conducted in urban youth demonstrated poor responses...
- Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoirDeborah Persaud
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
AIDS 25:2227-34. 2011..Alternatively, latently infected CD4 T cells maybe killed, while exiting the reservoir upon activation...
- Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usageKevin O Saunders
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
Cell Immunol 266:154-64. 2011..We define a multifactorial cytokine profile of CD8(+) T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication...
- Newer treatments for HIV in childrenRoss E McKinney
Departmentof Pedicatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Pediatr 16:76-9. 2004..Several new antiretroviral agents have been introduced into pediatric and adult use. This review will summarize information about these new agents and other recent advances in the care of HIV-infected children...
- Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern TanzaniaOpemipo O Johnson
Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Pediatr Infect Dis J 28:493-7. 2009....
- Growth as a part of the composite endpoint in paediatric antiretroviral clinical trialsDaniel K Benjamin
Department of Pediatrics, Duke University, Durham, NC, USA
J Antimicrob Chemother 54:701-3. 2004....
- Establishment of haematological and immunological reference values for healthy Tanzanian children in Kilimanjaro RegionAnn M Buchanan
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Trop Med Int Health 15:1011-21. 2010..To determine the normal haematological and immunological reference intervals for healthy Tanzanian children...
- Utility of rapid antibody tests to exclude HIV-1 infection among infants and children aged <18 months in a low-resource settingAnn M Buchanan
Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
J Clin Virol 55:244-9. 2012..Excluding HIV infection among infants and young children in resource-poor settings where nucleic acid amplification tests (NAAT) are not routinely available remains a considerable challenge...
- Treatment of children with HIV infectionTerry C Dixon
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Curr HIV/AIDS Rep 4:93-9. 2007..New information on key vaccines that should be administered to children with HIV infection is also discussed...
- An Infection Control Program for a 2009 influenza A H1N1 outbreak in a university-based summer campEphraim L Tsalik
Department of Medicine, Duke University Medical Center, Durham, North Carolinam, USA
J Am Coll Health 59:419-26. 2011..Describe two 2009-H1N1 influenza outbreaks in university-based summer camps and the implementation of an infection control program...
- Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine doseMark Mirochnick
Boston University School of Medicine, Boston Medical Center, 91 Concord Street, 6th Floor, Boston, MA 02118, USA
J Acquir Immune Defic Syndr 33:153-6. 2003..To evaluate cord blood and predose nevirapine concentrations in infants exposed to the two-dose intrapartum neonatal nevirapine regimen...
- Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationshipsDolors Soy
Department of Biopharmaceutical Sciences, School of Pharmacy, University of California-San Francisco, San Francisco, Calif, USA
Clin Pharmacol Ther 74:569-80. 2003..CONCLUSIONS: Regarding pharmacokinetics and pharmacodynamics, no statistically significant correlation between exposure measures and viral clearance was observed...
- Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316D Heather Watts
National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Am J Obstet Gynecol 190:506-16. 2004..The purpose of this study was to evaluate rates of maternal toxicity, pregnancy complications, and peripartum morbidity by type and duration of antiretroviral therapy (ART) during pregnancy...
- Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected childrenJoseph A Church
Childrens Hospital Los Angeles, Division of Clinical Immunology and Allergy, CA 90027, USA
Pediatr Infect Dis J 23:713-8. 2004..The safety and antiretroviral activity of enfuvirtide treatment of 24 weeks in HIV-1-infected children has been previously documented. Here we present the long term tolerability and safety of enfuvirtide...
- Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIVKristine L Witt
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Environ Mol Mutagen 48:322-9. 2007..These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants is recommended to ensure their continued health...
- Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USAMarie Louise Newell
Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
BMC Infect Dis 7:60. 2007....
- Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infectionJennifer J Kiser
University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
Antimicrob Agents Chemother 52:631-7. 2008..Additional studies of the exposure-response relationships of this regimen in children, adolescents, and adults would advance our knowledge of its pharmacodynamic properties...
- Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroadsHeather B Jaspan
Desmond Tutu HIV Centre, University of Cape Town, South Africa
J Acquir Immune Defic Syndr 47:86-92. 2008..This article examines these issues and proposes specific next steps to facilitate the routine inclusion of this high-priority population in preventive HIV vaccine trials as early and seamlessly as possible...