Coleen K Cunningham

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316
    Coleen K Cunningham
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Acquir Immune Defic Syndr 36:800-7. 2004
  2. ncbi request reprint Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 3
    Coleen K Cunningham
    Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, Syracuse, NY 13210, USA
    J Infect Dis 186:181-8. 2002
  3. doi request reprint Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional study
    Susan D Emmett
    Duke University Medical Center, Durham, North Carolina, USA
    J Acquir Immune Defic Syndr 54:368-75. 2010
  4. pmc Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication
    Kevin O Saunders
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, 27710, USA
    Virology 405:234-42. 2010
  5. pmc Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication
    Stephanie A Freel
    Department of Surgery, Duke University Human Vaccine Institute, Durham, North Carolina, USA
    J Virol 86:6835-46. 2012
  6. pmc Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern Tanzania
    John A Crump
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Trop Med Int Health 16:830-7. 2011
  7. pmc A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania
    Elizabeth A Reddy
    Duke University Medical Center, Durham, NC, USA
    BMC Infect Dis 14:89. 2014
  8. pmc Prevalence of mycobacteremia among HIV-infected infants and children in northern Tanzania
    Katherine D Gray
    Duke University Medical Center, Durham, NC, USA
    Pediatr Infect Dis J 32:754-6. 2013
  9. ncbi request reprint Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial
    Alejandro Dorenbaum
    Department of Pediatrics, University of California, San Francisco, USA
    JAMA 288:189-98. 2002
  10. pmc Utility of rapid antibody tests to exclude HIV-1 infection among infants and children aged <18 months in a low-resource setting
    Ann M Buchanan
    Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    J Clin Virol 55:244-9. 2012

Detail Information

Publications30

  1. ncbi request reprint The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316
    Coleen K Cunningham
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Acquir Immune Defic Syndr 36:800-7. 2004
    ..Race/ethnicity is significant in predicting viral suppression at the time of delivery...
  2. ncbi request reprint Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 3
    Coleen K Cunningham
    Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, Syracuse, NY 13210, USA
    J Infect Dis 186:181-8. 2002
    ..The risk of nevirapine resistance should be considered when determining the risks or benefits of intrapartum nevirapine in women receiving antepartum antiretroviral therapy...
  3. doi request reprint Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional study
    Susan D Emmett
    Duke University Medical Center, Durham, North Carolina, USA
    J Acquir Immune Defic Syndr 54:368-75. 2010
    ....
  4. pmc Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication
    Kevin O Saunders
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, 27710, USA
    Virology 405:234-42. 2010
    ..These data provide a way to focus the search for the suppressive factors and to potentially modulate their expression...
  5. pmc Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication
    Stephanie A Freel
    Department of Surgery, Duke University Human Vaccine Institute, Durham, North Carolina, USA
    J Virol 86:6835-46. 2012
    ....
  6. pmc Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern Tanzania
    John A Crump
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Trop Med Int Health 16:830-7. 2011
    ..To describe the contribution of paediatric HIV and of HIV co-infections to admissions to a hospital in Moshi, Tanzania, using contemporary laboratory methods...
  7. pmc A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania
    Elizabeth A Reddy
    Duke University Medical Center, Durham, NC, USA
    BMC Infect Dis 14:89. 2014
    ..This study sought to determine the impact of providing mycobacterial culture results over standard of care [unconcentrated acid-fast (AFB) smears] on management of persons with suspected tuberculosis...
  8. pmc Prevalence of mycobacteremia among HIV-infected infants and children in northern Tanzania
    Katherine D Gray
    Duke University Medical Center, Durham, NC, USA
    Pediatr Infect Dis J 32:754-6. 2013
    ..We found no cases of mycobacteremia among 93 ill, HIV-infected children in northern Tanzania, despite optimization of laboratory methods and selection of patients thought to be at highest risk for disseminated infection. ..
  9. ncbi request reprint Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial
    Alejandro Dorenbaum
    Department of Pediatrics, University of California, San Francisco, USA
    JAMA 288:189-98. 2002
    ..However, it is unknown whether the addition of the 2-dose nevirapine regimen to standard ART would further reduce perinatal HIV transmission...
  10. pmc Utility of rapid antibody tests to exclude HIV-1 infection among infants and children aged <18 months in a low-resource setting
    Ann M Buchanan
    Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    J Clin Virol 55:244-9. 2012
    ..Excluding HIV infection among infants and young children in resource-poor settings where nucleic acid amplification tests (NAAT) are not routinely available remains a considerable challenge...
  11. pmc Advances and failures in preventing perinatal human immunodeficiency virus infection
    Ann M Buchanan
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Box T3499, Durham, NC 27710, USA
    Clin Microbiol Rev 22:493-507. 2009
    ..Further work is needed to determine the optimal strategy for reducing perinatal transmission among women in resource-poor settings, with a particular need for reduction of transmission via breast-feeding...
  12. pmc Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination
    Stephanie A Freel
    Duke University Human Vaccine Institute, Departments of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 84:4998-5006. 2010
    ..Our data define attributes of an antiviral CD8(+) T-cell response that may be optimized in the search for an efficacious HIV-1 vaccine...
  13. pmc Randomized trial to determine safety and immunogenicity of two strategies for hepatitis B vaccination in healthy urban adolescents in the United States
    Coleen K Cunningham
    Department of Pediatrics, Duke, Durham, NC, USA
    Pediatr Infect Dis J 29:530-4. 2010
    ..Multiple studies have shown excellent response rates after hepatitis B immunization in youth; however, one previous study conducted in urban youth demonstrated poor responses...
  14. pmc Progress in the prevention of mother to child transmission of HIV in three regions of Tanzania: a retrospective analysis
    Ann M Buchanan
    Kilimanjaro Christian Medical Centre, Moshi, Tanzania Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 9:e88679. 2014
    ..Early infant diagnosis of HIV-1 using dried blood spot (DBS) PCR among exposed infants provides an opportunity to assess current MTCT rates...
  15. pmc Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir
    Deborah Persaud
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    AIDS 25:2227-34. 2011
    ..Alternatively, latently infected CD4 T cells maybe killed, while exiting the reservoir upon activation...
  16. pmc Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern Tanzania
    Opemipo O Johnson
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Infect Dis J 28:493-7. 2009
    ....
  17. ncbi request reprint Growth as a part of the composite endpoint in paediatric antiretroviral clinical trials
    Daniel K Benjamin
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Antimicrob Chemother 54:701-3. 2004
    ....
  18. ncbi request reprint Newer treatments for HIV in children
    Ross E McKinney
    Departmentof Pedicatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Pediatr 16:76-9. 2004
    ..Several new antiretroviral agents have been introduced into pediatric and adult use. This review will summarize information about these new agents and other recent advances in the care of HIV-infected children...
  19. pmc Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage
    Kevin O Saunders
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Cell Immunol 266:154-64. 2011
    ..We define a multifactorial cytokine profile of CD8(+) T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication...
  20. pmc Establishment of haematological and immunological reference values for healthy Tanzanian children in Kilimanjaro Region
    Ann M Buchanan
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Trop Med Int Health 15:1011-21. 2010
    ..To determine the normal haematological and immunological reference intervals for healthy Tanzanian children...
  21. ncbi request reprint Treatment of children with HIV infection
    Terry C Dixon
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Curr HIV/AIDS Rep 4:93-9. 2007
    ..New information on key vaccines that should be administered to children with HIV infection is also discussed...
  22. doi request reprint An Infection Control Program for a 2009 influenza A H1N1 outbreak in a university-based summer camp
    Ephraim L Tsalik
    Department of Medicine, Duke University Medical Center, Durham, North Carolinam, USA
    J Am Coll Health 59:419-26. 2011
    ..Describe two 2009-H1N1 influenza outbreaks in university-based summer camps and the implementation of an infection control program...
  23. ncbi request reprint Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationships
    Dolors Soy
    Department of Biopharmaceutical Sciences, School of Pharmacy, University of California San Francisco, San Francisco, Calif, USA
    Clin Pharmacol Ther 74:569-80. 2003
    ..Our objective was to describe the population pharmacokinetics and pharmacodynamics of enfuvirtide acting on viral ribonucleic acid in children with human immunodeficiency virus 1...
  24. ncbi request reprint Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine dose
    Mark Mirochnick
    Boston University School of Medicine, Boston Medical Center, 91 Concord Street, 6th Floor, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 33:153-6. 2003
    ..To evaluate cord blood and predose nevirapine concentrations in infants exposed to the two-dose intrapartum neonatal nevirapine regimen...
  25. ncbi request reprint Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316
    D Heather Watts
    National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 190:506-16. 2004
    ..The purpose of this study was to evaluate rates of maternal toxicity, pregnancy complications, and peripartum morbidity by type and duration of antiretroviral therapy (ART) during pregnancy...
  26. ncbi request reprint Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children
    Joseph A Church
    Childrens Hospital Los Angeles, Division of Clinical Immunology and Allergy, CA 90027, USA
    Pediatr Infect Dis J 23:713-8. 2004
    ..The safety and antiretroviral activity of enfuvirtide treatment of 24 weeks in HIV-1-infected children has been previously documented. Here we present the long term tolerability and safety of enfuvirtide...
  27. pmc Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection
    Jennifer J Kiser
    University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    Antimicrob Agents Chemother 52:631-7. 2008
    ..Additional studies of the exposure-response relationships of this regimen in children, adolescents, and adults would advance our knowledge of its pharmacodynamic properties...
  28. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
    ....
  29. pmc Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV
    Kristine L Witt
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:322-9. 2007
    ..These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants is recommended to ensure their continued health...
  30. ncbi request reprint Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads
    Heather B Jaspan
    Desmond Tutu HIV Centre, University of Cape Town, South Africa
    J Acquir Immune Defic Syndr 47:86-92. 2008
    ..This article examines these issues and proposes specific next steps to facilitate the routine inclusion of this high-priority population in preventive HIV vaccine trials as early and seamlessly as possible...