Research Topics
| John A CrumpSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Ethical considerations for short-term experiences by trainees in global healthJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Box 3867, Durham, NC 27710, USA
JAMA 300:1456-8. 2008- Evaluation of the Abbott m2000rt RealTime HIV-1 assay with manual sample preparation compared with the ROCHE COBAS AmpliPrep/AMPLICOR HIV-1 MONITOR v1.5 using specimens from East AfricaJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Box 102359, Durham, NC 27710, USA
J Virol Methods 162:218-22. 2009..5 assay and that the RealTime HIV-1 assay performs well on samples from East Africa... - Invasive disease caused by nontuberculous mycobacteria, TanzaniaJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Emerg Infect Dis 15:53-5. 2009..avium complex sequevar MAC-D. Invasive NTM disease is present in HIV-infected patients in sub-Saharan Africa... - Ethics and best practice guidelines for training experiences in global healthJohn A Crump
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Trop Med Hyg 83:1178-82. 2010..The Working Group on Ethics Guidelines for Global Health Training encourages efforts to develop and implement a means of assessing the potential benefits and harms of global health training programs... - Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected adults and adolescents in northern TanzaniaJohn A Crump
Division of Infectious Diseases and International Health, Department ofMedicine, Duke University Medical Center, Box 102359, Durham, NC 27710, USA
Clin Infect Dis 52:341-8. 2011..few studies describe patterns of human immunodeficiency virus (HIV) co-infections in African hospitals in the antiretroviral therapy (ART) era... 
Two decades of disseminated tuberculosis at a university medical center: the expanding role of mycobacterial blood cultureJohn A Crump
Clinical Microbiology Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Infect Dis 37:1037-43. 2003..Mycobacterial blood culture can play an increasing role in the diagnosis of disseminated tuberculosis when localized disease is not found...- Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern TanzaniaJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Trop Med Int Health 16:830-7. 2011..To describe the contribution of paediatric HIV and of HIV co-infections to admissions to a hospital in Moshi, Tanzania, using contemporary laboratory methods... - Characteristics of HIV voluntary counseling and testing clients before and during care and treatment scale-up in Moshi, TanzaniaMeghan M Shorter
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Acquir Immune Defic Syndr 52:648-54. 2009..We evaluated changes in characteristics of clients presenting for voluntary counseling and testing (VCT) before and during care and treatment center (CTC) scale-up activities in Moshi, Tanzania, between November 2003 and December 2007... - Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort studyJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Clin Infect Dis 55:242-50. 2012.... 
Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional studySusan D Emmett
Duke University Medical Center, Durham, North Carolina, USA
J Acquir Immune Defic Syndr 54:368-75. 2010....- Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern TanzaniaOpemipo O Johnson
Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Pediatr Infect Dis J 28:493-7. 2009.... - Brucellosis among hospitalized febrile patients in northern TanzaniaAndrew J Bouley
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Trop Med Hyg 87:1105-11. 2012..Brucellosis is an underdiagnosed and untreated cause of febrile disease among hospitalized adult and pediatric patients in northern Tanzania... - Histoplasmosis among hospitalized febrile patients in northern TanzaniaSarah M Lofgren
Division of Infectious Diseases and International Health, Department of Medicine, Box 102359, Duke University Medical Center, Durham, NC 27710, USA
Trans R Soc Trop Med Hyg 106:504-7. 2012..Histoplasmosis is an important cause of febrile illness in Tanzania but is rarely considered in the differential diagnosis. Increased clinician awareness and availability of reliable diagnostic tests may improve patient outcomes... - Changes in HIV risk behavior and seroincidence among clients presenting for repeat HIV counseling and testing in Moshi, TanzaniaSuzanne P Fiorillo
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, United States
AIDS Care 24:1264-71. 2012..Promoting behavior change through HCT should continue to be a focus of HIV prevention efforts in sub-Saharan Africa... - Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine designMattia Bonsignori
Duke Human Vaccine Institute, Durham, North Carolina, USA
J Virol 86:4688-92. 2012..These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities... - Performance of nucleic acid amplification following extraction of 5 milliliters of whole blood for diagnosis of Mycobacterium tuberculosis bacteremiaJohn A Crump
Division of Infectious Diseases and International Health, Department of Medicinea and Department of Pathology, Duke University, Durham, North Carolina, USA
J Clin Microbiol 50:138-41. 2012..Of 25 samples from patients with M. tuberculosis bacteremia, 9 (36.0%) were positive and 1 (1.5%) of 66 control samples was positive by NAAT. The NAAT shows promise, but modifications should focus on improving sensitivity... - Gender differences in the risk of HIV infection among persons reporting abstinence, monogamy, and multiple sexual partners in northern TanzaniaKeren Z Landman
Duke University Medical Center, Durham, North Carolina, USA
PLoS ONE 3:e3075. 2008..We examined the association between the number of sexual partners and the risk of HIV seropositivity among men and women presenting for HIV voluntary counseling and testing (VCT) in northern Tanzania... - Effect of trimethoprim-sulfamethoxazole prophylaxis on antimicrobial resistance of fecal Escherichia coli in HIV-infected patients in TanzaniaSusan C Morpeth
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Acquir Immune Defic Syndr 47:585-91. 2008..Trimethoprim-sulfamethoxazole (SXT) reduces morbidity and mortality among HIV-infected persons in Africa, but its impact on antimicrobial resistance is of concern... - Antiretroviral treatment literacy among HIV voluntary counseling and testing clients in Moshi, Tanzania, 2003 to 2005Keren Z Landman
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina 27710, USA
J Int Assoc Physicians AIDS Care (Chic) 6:24-6. 2007..Previous HIV testing was protective against low antiretroviral treatment literacy. These results support refocusing HIV education efforts and increasing synergy between HIV prevention and treatment programs... - Predicting mortality for paediatric inpatients where malaria is uncommonDana C Clifton
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Arch Dis Child 97:889-94. 2012..As the proportion of children living low malaria transmission areas in sub-Saharan Africa increases, approaches for identifying non-malarial severe illness need to be evaluated to improve child outcomes... - Validation, performance under field conditions, and cost-effectiveness of Capillus HIV-1/HIV-2 and determine HIV-1/2 rapid human immunodeficiency virus antibody assays using sequential and parallel testing algorithms in TanzaniaMeghan K Mayhood
Duke University Medical Center, Durham, North Carolina, USA
J Clin Microbiol 46:3946-51. 2008..64 per HIV diagnosis but missed 0.4% of HIV infections. A parallel testing algorithm cost $13.46 per HIV diagnosis but detected more HIV-infected clients... - Utility of rapid antibody tests to exclude HIV-1 infection among infants and children aged <18 months in a low-resource settingAnn M Buchanan
Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
J Clin Virol 55:244-9. 2012..Excluding HIV infection among infants and young children in resource-poor settings where nucleic acid amplification tests (NAAT) are not routinely available remains a considerable challenge... - Controlled comparison of BacT/Alert MB system, manual Myco/F lytic procedure, and isolator 10 system for diagnosis of Mycobacterium tuberculosis BacteremiaJohn A Crump
Box 102359, Duke University Medical Center, Durham, NC 27710, USA
J Clin Microbiol 49:3054-7. 2011..4920). M. tuberculosis bacteremia was detected more rapidly in a continuously monitored liquid blood culture system, but the mean time to positivity exceeded 3 weeks... - A cost-effectiveness analysis of alternative HIV retesting strategies in sub-saharan AfricaRichard C Waters
Duke Global Health Institute, Duke University, Durham, NC 27701, USA
J Acquir Immune Defic Syndr 56:443-52. 2011..Guidelines in sub-Saharan Africa on when HIV-seronegative persons should retest range from never to annually for lower-risk populations and from annually to every 3 months for high-risk populations... - Chikungunya and dengue fever among hospitalized febrile patients in northern TanzaniaJulian T Hertz
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Am J Trop Med Hyg 86:171-7. 2012..5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating... - Predicting CD4 lymphocyte count <200 cells/mm(3) in an HIV type 1-infected African populationSusan C Morpeth
Duke University Medical Center, Durham, North Carolina, 27710, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
AIDS Res Hum Retroviruses 23:1230-6. 2007.... - Prevalence and correlates of intimate partner violence among women attending HIV voluntary counseling and testing in northern Tanzania, 2005-2008Malavika Prabhu
Duke University Medical Center, Durham, NC 27710, USA
Int J Gynaecol Obstet 113:63-7. 2011..To investigate the prevalence and correlates of intimate partner violence (IPV) among women at an HIV voluntary counseling and testing (VCT) center in northern Tanzania... - Leptospirosis among hospitalized febrile patients in northern TanzaniaHolly M Biggs
Department of Medicine and Department of Pathology, Duke University Medical Center, Durham, NC, USA
Am J Trop Med Hyg 85:275-81. 2011..001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic... - Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern TanzaniaMalavika Prabhu
Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
Clin Infect Dis 53:e8-15. 2011.... - Controlled comparison of BACTEC 13A, MYCO/F LYTIC, BacT/ALERT MB, and ISOLATOR 10 systems for detection of mycobacteremiaJohn A Crump
Clinical Microbiology Laboratory, Duke University Medical Center and Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
J Clin Microbiol 41:1987-90. 2003.... - Cost-effectiveness of free HIV voluntary counseling and testing through a community-based AIDS service organization in Northern TanzaniaNathan M Thielman
Division of Infectious Diseases and International Health, Duke University Medical Center, Box 3867, Durham, NC 27701, USA
Am J Public Health 96:114-9. 2006..72, $5.40, and $4.72, respectively. CONCLUSIONS: The provision of free VCT enhances both the number of clients testing per day and its cost-effectiveness in resource-limited settings... - Evaluation of a dried blood spot HIV-1 RNA program for early infant diagnosis and viral load monitoring at rural and remote healthcare facilitiesSarah M Lofgren
Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA
AIDS 23:2459-66. 2009..To assess technical and operational performance of a dried blood spot (DBS)-based HIV-1 RNA service for remote healthcare facilities in a low-income country... - Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settingsJohn A Bartlett
Duke University Medical Center, Durham, NC 27710, USA
AIDS 26:1345-54. 2012..To evaluate virologic response rates of lopinavir/ritonavir (LPV/r) monotherapy as second-line antiretroviral treatment (ART) among adults in resource-limited settings (RLSs)... - Capacity of health-care facilities to deliver HIV treatment and care services, Northern Tanzania, 2004Keren Z Landman
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Box 3867, Durham, NC 27710, USA
Int J STD AIDS 17:459-62. 2006..Laboratory facilities for ART monitoring were inadequate, and outpatient ART was limited... - Community-acquired bloodstream infections in Africa: a systematic review and meta-analysisElizabeth A Reddy
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Lancet Infect Dis 10:417-32. 2010..Improved clinical microbiology services and reassessment of empirical treatment guidelines that account for the epidemiology of bloodstream infections might contribute to better outcomes... - Establishment of haematological and immunological reference values for healthy Tanzanian children in Kilimanjaro RegionAnn M Buchanan
Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Trop Med Int Health 15:1011-21. 2010..To determine the normal haematological and immunological reference intervals for healthy Tanzanian children... - Invasive non-Typhi Salmonella disease in AfricaSusan C Morpeth
Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Infect Dis 49:606-11. 2009..Much work remains to be done to understand and control invasive non-Typhi Salmonella disease in sub-Saharan Africa... - Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replicationStephanie A Freel
Department of Surgery, Duke University Human Vaccine Institute, Durham, North Carolina, USA
J Virol 86:6835-46. 2012.... - Development, implementation, and impact of acceptability criteria for serologic tests for infectious diseasesJohn A Crump
Clinical Microbiology Laboratory, Duke University Medical Center, Duke University School of Medicine, Durham, North Carolina 27710, USA
J Clin Microbiol 42:881-3. 2004..001). We recommend that acceptability criteria be developed and applied to samples submitted to clinical microbiology laboratories for serologic testing... - Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individualsGeorgia D Tomaras
Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center, Box 2926, Durham, NC 27710, USA
J Virol 85:11502-19. 2011..The broadly reactive HIV-1 neutralization observed in some subjects is mediated by antibodies targeting several conserved regions on the HIV-1 envelope glycoprotein... - Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestorsMattia Bonsignori
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Virol 85:9998-10009. 2011..Thus, E.A244, B.9021, and AE.CM243 Envs are three potential immunogen candidates for studies aimed at defining strategies to induce V2/V3 conformational epitope-specific antibodies... - The global burden of typhoid feverJohn A Crump
Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, MS A 38, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Bull World Health Organ 82:346-53. 2004..To use new data to make a revised estimate of the global burden of typhoid fever, an accurate understanding of which is necessary to guide public health decisions for disease control and prevention efforts...