Steven D Crowley

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 115:1092-9. 2005
  2. pmc Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
    Steven D Crowley
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:17985-90. 2006
  3. ncbi request reprint AT(1) receptors and control of blood pressure: the kidney and more
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    Trends Cardiovasc Med 17:30-4. 2007
  4. ncbi request reprint Coronary steal from a left internal mammary artery coronary bypass graft by a left upper extremity arteriovenous hemodialysis fistula
    Steven D Crowley
    Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Kidney Dis 40:852-5. 2002
  5. pmc A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Box 103015, Duke University Medical Center, Durham, NC 27710, USA
    Hypertension 55:99-108. 2010
  6. doi request reprint Lymphocyte responses exacerbate angiotensin II-dependent hypertension
    Steven D Crowley
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1089-97. 2010
  7. ncbi request reprint In hypertension, the kidney breaks your heart
    Steven D Crowley
    MSRB II, Room 2018, Duke University Medical Center, 106 Research Drive, Durham, NC 27710, USA
    Curr Cardiol Rep 10:470-6. 2008
  8. pmc Role of AT₁ receptor-mediated salt retention in angiotensin II-dependent hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Am J Physiol Renal Physiol 301:F1124-30. 2011
  9. ncbi request reprint A Web-based compendium of clinical questions and medical evidence to educate internal medicine residents
    Steven D Crowley
    Division of Nephrology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Acad Med 78:270-4. 2003
  10. pmc Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA
    Am J Physiol Renal Physiol 295:F515-24. 2008

Detail Information

Publications22

  1. pmc Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 115:1092-9. 2005
    ..Thus, the regulation of blood pressure by the RAS is mediated by AT(1) receptors both within and outside the kidney...
  2. pmc Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
    Steven D Crowley
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:17985-90. 2006
    ..Further, they suggest that the major mechanism of action of RAS inhibitors in hypertension is attenuation of angiotensin II effects in the kidney...
  3. ncbi request reprint AT(1) receptors and control of blood pressure: the kidney and more
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    Trends Cardiovasc Med 17:30-4. 2007
    ..However, the nature and relative contributions of these actions may differ in hypertension...
  4. ncbi request reprint Coronary steal from a left internal mammary artery coronary bypass graft by a left upper extremity arteriovenous hemodialysis fistula
    Steven D Crowley
    Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Kidney Dis 40:852-5. 2002
    ..This phenomenon suggests the need to consider the impact of upper extremity access placement on blood flow to the left internal mammary artery in patients who previously have undergone placement of a coronary artery bypass graft...
  5. pmc A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Box 103015, Duke University Medical Center, Durham, NC 27710, USA
    Hypertension 55:99-108. 2010
    ....
  6. doi request reprint Lymphocyte responses exacerbate angiotensin II-dependent hypertension
    Steven D Crowley
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1089-97. 2010
    ..Thus, the absence of lymphocyte activity protects from hypertension by allowing blood pressure-induced sodium excretion, possibly via stimulation of eNOS- and COX-2-dependent pathways...
  7. ncbi request reprint In hypertension, the kidney breaks your heart
    Steven D Crowley
    MSRB II, Room 2018, Duke University Medical Center, 106 Research Drive, Durham, NC 27710, USA
    Curr Cardiol Rep 10:470-6. 2008
    ..These findings, together with previous experiments, confirm the kidney's critical role in the pathogenesis of hypertension and its complications...
  8. pmc Role of AT₁ receptor-mediated salt retention in angiotensin II-dependent hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Am J Physiol Renal Physiol 301:F1124-30. 2011
    ..These studies provide insight into precise mechanisms through which AT(1) receptor blockade influences the progression of hypertensive kidney disease...
  9. ncbi request reprint A Web-based compendium of clinical questions and medical evidence to educate internal medicine residents
    Steven D Crowley
    Division of Nephrology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Acad Med 78:270-4. 2003
    ..Residents benefited from questions previously searched by other residents, allowing them to address a wider spectrum of CQs during ward rotations...
  10. pmc Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA
    Am J Physiol Renal Physiol 295:F515-24. 2008
    ..These proinflammatory actions of ANG II seem to have a proclivity for inducing kidney injury while having negligible actions in the pathogenesis of cardiac hypertrophy...
  11. pmc Gene expression profiles linked to AT1 angiotensin receptors in the kidney
    Natalia A Makhanova
    Department of Medicine, Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina, USA
    Physiol Genomics 42:211-8. 2010
    ..This genome-wide assessment should facilitate identification of critical distal pathways linked to blood pressure regulation...
  12. pmc Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis
    Steven D Crowley
    Department of Medicine, Division of Nephrology, Duke University Medical Center, and Durham VA Medical Center, Durham, North Carolina 27705, USA
    J Clin Invest 119:943-53. 2009
    ..Since AT1A-deficient lpr mice had low blood pressure, these findings suggest that activation of type 1 angiotensin receptors in the glomerulus is sufficient to accelerate renal injury and inflammation in the absence of hypertension...
  13. pmc A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension
    Jian Dong Zhang
    Division of Nephrology, Departments of Medicine, Duke University Medical Center and Durham VA Medical Center, Durham, NC 27710, USA
    Circ Res 110:1604-17. 2012
    ..However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hypertension...
  14. ncbi request reprint In hypertension, the kidney rules
    Steven D Crowley
    Nephrology, VA Medical Center, Durham, NC 27705, USA
    Curr Hypertens Rep 9:148-53. 2007
    ..These findings, with previous experiments, clearly establish the critical role of the kidney in the pathogenesis of hypertension and its cardiovascular complications...
  15. pmc The role of type 1 angiotensin receptors on T lymphocytes in cardiovascular and renal diseases
    Jiandong Zhang
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, DUMC, Durham, NC 27710, USA
    Curr Hypertens Rep 15:39-46. 2013
    ..Future studies should illustrate how these discrepant functions of AT(1) receptors in target organs versus mononuclear cells can be exploited for the benefit of patients with recalcitrant hypertension and other cardiovascular diseases...
  16. pmc Recent advances involving the renin-angiotensin system
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
    Exp Cell Res 318:1049-56. 2012
    ..Further characterization of the diverse interactions between the RAS and other signaling pathways within specific tissues should lead to novel treatments for renal and cardiovascular disease...
  17. doi request reprint Kidney in hypertension: guyton redux
    Thomas M Coffman
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC, USA
    Hypertension 51:811-6. 2008
  18. pmc Classical Renin-Angiotensin system in kidney physiology
    Matthew A Sparks
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
    Compr Physiol 4:1201-28. 2014
    ....
  19. ncbi request reprint Effector mechanisms in transplant rejection
    Paulo N Rocha
    Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
    Immunol Rev 196:51-64. 2003
    ..In this review, we discuss these major effector pathways, focusing on their role in the pathogenesis of allograft rejection...
  20. ncbi request reprint Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells
    Pierre Louis Tharaux
    Duke University and Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Immunol 171:96-105. 2003
    ..Thus, Rho GTPases acting through Rho kinase play a unique role in T cell activation during cellular immune responses by promoting structural rearrangements that are critical for T cell signaling...
  21. pmc The cooperative roles of inflammation and oxidative stress in the pathogenesis of hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina
    Antioxid Redox Signal 20:102-20. 2014
    ..As effectors of the cell-mediated immune response, myeloid cells and T lymphocytes protect the host organism from infection by attacking foreign intruders with bursts of reactive oxygen species (ROS)...
  22. doi request reprint Prehypertension and chronic kidney disease: the ox or the plow?
    John P Middleton
    Division of Nephrology, Duke University, Durham, North Carolina 27705, USA
    Kidney Int 81:229-32. 2012
    ..Recent observations, including the report by Yano and colleagues, also suggest that prehypertension is an important risk factor for the development of chronic kidney disease...