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Genomes and Genes | Donald N CookSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Innate immune control of pulmonary dendritic cell traffickingDonald N Cook
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Proc Am Thorac Soc 4:234-9. 2007..It is hoped that an improved understanding of these mechanisms will lead to novel DC-mediated therapeutic strategies to treat immune-related pulmonary disease...
Genetic regulation of endotoxin-induced airway diseaseDonald N Cook
Department of Medicine, Duke University Medical Center, P O Box 2629, and the Durham VAMC, Durham, NC 27710, USA
Genomics 83:961-9. 2004..Functional studies of these genes are expected to reveal important molecular mechanisms regulating the magnitude of biologic responses to LPS...- Toll-like receptors in the pathogenesis of human diseaseDonald N Cook
Department of Medicine, Duke University Medical Center, and the Durham Veterans Administration Medical Center, Durham, North Carolina 27710, USA
Nat Immunol 5:975-9. 2004..As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options... - Spontaneous mutations in recombinant inbred mice: mutant toll-like receptor 4 (Tlr4) in BXD29 miceDonald N Cook
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Genetics 172:1751-5. 2006..Our results also suggest that the frequency of such unidentified, spontaneously occurring mutations is an issue that should be considered when RI strains are used to identify QTL... - Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharideStavros Garantziotis
Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
Transplantation 84:1012-9. 2007..We have developed and pursued the hypothesis that local activation of pulmonary innate immunity through toll-like receptor (TLR)-4 is critical to the development of posttransplant alloimmune lung injury... - The role of Toll-like receptor 4 in environmental airway injury in miceJohn W Hollingsworth
Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
Am J Respir Crit Care Med 170:126-32. 2004..These data demonstrate in the mouse that the requirement of TLR4 for pulmonary inflammation depends on the nature of the toxin and appears specific to toxin and exposure conditions... - The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammationJohn W Hollingsworth
Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Box 3221, Durham, NC 27710, USA
Am J Respir Crit Care Med 171:806-13. 2005..These data demonstrate the critical role of hematopoietic cells and alveolar macrophages in initiating LPS-induced neutrophil recruitment from the vascular space to the airspace... - TLR4 signaling attenuates ongoing allergic inflammationJohn W Hollingsworth
Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 176:5856-62. 2006..Together, these findings show that low doses of endotoxin can have regulatory effects on allergic inflammation, particularly in the setting of ongoing allergen exposure... - Polymorphisms of the Toll-like receptors and human diseaseDavid A Schwartz
Department of Medicine, Duke University Medical Center, The Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
Clin Infect Dis 41:S403-7. 2005..These findings have resulted in new opportunities to study the pathogenesis of disease, identify subpopulations at greater risk of disease, and, potentially, identify novel therapeutic approaches... - Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responsesHideki Nakano
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Nat Immunol 10:394-402. 2009..We conclude that blood-derived inflammatory DCs are important in the development of T(H)1 immune responses... - The genetics of innate immunity in the lungDonald N Cook
Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
Chest 123:369S. 2003 - Toll-like receptors and the genetics of innate immunityDonald N Cook
Department of Medicine, Duke University Medical Center, Durham Veteran's Administration Medical Center (VAMC, Durham, North Carolina 27710, USA
Curr Opin Allergy Clin Immunol 3:523-9. 2003..This improved understanding promises to facilitate the future development of novel therapies for many different inflammatory diseases including asthma, sepsis and atherosclerosis... - CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infectionJeffrey W Tyner
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Med 11:1180-7. 2005..The antiapoptotic action of chemokine signaling may therefore allow scavengers to finally stop the host cell-to-cell infectious process... - A matrix for new ideas in pulmonary fibrosisDonald N Cook
Pulmonary and Critical Care Division, Department of Medicine, and the Department of Veterans Affairs Medical Center and Duke University Medical Center, Durham, North Carolina, USA
Am J Respir Cell Mol Biol 27:122-4. 2002 - The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivityGregory S Whitehead
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Am J Respir Crit Care Med 175:243-9. 2007..The D6 chemokine receptor can bind and scavenge several chemokines, including the T-helper 2 (Th2)-associated chemokines CCL17 and CCL22. Although D6 is constitutively expressed in the lung, its pulmonary function is unknown... - Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6Yeny Martinez de la Torre
Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rozzano, 20089 Milan, Italy
Proc Natl Acad Sci U S A 104:2319-24. 2007..Thus, the promiscuous decoy receptor for inflammatory CC chemokines D6 plays a nonredundant role in the protection against fetal loss caused by systemic inflammation and antiphospholipid antibodies... - Cutting edge: the silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitisLiping Liu
Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Immunol 177:17-21. 2006..CD11c(+) dendritic cells accumulated abnormally in cutaneous immunization sites of D6(-/-) mice. Surprisingly, D6, a "silent" chemokine receptor, supports immune response generation... - Control of microglial neurotoxicity by the fractalkine receptorAstrid E Cardona
Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute, Cleveland, Ohio 44195, USA
Nat Neurosci 9:917-24. 2006..Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX3CR1 antagonists could increase neuronal vulnerability... - Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host diseaseMiriam Merad
Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
Nat Med 10:510-7. 2004.... - Attenuation of allergen-induced responses in CCR6-/- mice is dependent upon altered pulmonary T lymphocyte activationSteven K Lundy
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 174:2054-60. 2005..Altogether, the defect in CCR6-/- mice appears to be primarily due to an alteration in T cell activation, but also appears to include local pulmonary APC defects... - The chemokine receptor D6 limits the inflammatory response in vivoThomas Jamieson
The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK
Nat Immunol 6:403-11. 2005..These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response... - The chemokine receptor CCR6 is an important component of the innate immune responseHaitao Wen
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Eur J Immunol 37:2487-98. 2007..These data illustrate that CCR6 deficiency alters the innate response via attenuating the hyperactive local and systemic inflammatory response during CLP-induced peritonitis... - Increased inflammation in mice deficient for the chemokine decoy receptor D6Yeny Martinez de la Torre
Institute of General Pathology, Medical Faculty, University of Milan, Milan, Italy
Eur J Immunol 35:1342-6. 2005..Thus, D6 is a decoy receptor structurally adapted and strategically located to tune tissue inflammation and control transfer of inflammatory chemokines to draining lymph nodes... - Impaired T cell function in RANTES-deficient miceYasuhiko Makino
Penn Center for Molecular Studies of Kidney Disease, Renal Electrolyte and Hypertension Division, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Immunol 102:302-9. 2002..Together, these data suggest that RANTES is required for normal T cell functions as well as for recruiting monocytes and T cells to sites of inflammation...