Donald N Cook

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Innate immune control of pulmonary dendritic cell trafficking
    Donald N Cook
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Proc Am Thorac Soc 4:234-9. 2007
  2. ncbi request reprint Genetic regulation of endotoxin-induced airway disease
    Donald N Cook
    Department of Medicine, Duke University Medical Center, P O Box 2629, and the Durham VAMC, Durham, NC 27710, USA
    Genomics 83:961-9. 2004
  3. ncbi request reprint Toll-like receptors in the pathogenesis of human disease
    Donald N Cook
    Department of Medicine, Duke University Medical Center, and the Durham Veterans Administration Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 5:975-9. 2004
  4. pmc Spontaneous mutations in recombinant inbred mice: mutant toll-like receptor 4 (Tlr4) in BXD29 mice
    Donald N Cook
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 172:1751-5. 2006
  5. ncbi request reprint Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide
    Stavros Garantziotis
    Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
    Transplantation 84:1012-9. 2007
  6. ncbi request reprint The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation
    John W Hollingsworth
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Box 3221, Durham, NC 27710, USA
    Am J Respir Crit Care Med 171:806-13. 2005
  7. ncbi request reprint The role of Toll-like receptor 4 in environmental airway injury in mice
    John W Hollingsworth
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 170:126-32. 2004
  8. ncbi request reprint TLR4 signaling attenuates ongoing allergic inflammation
    John W Hollingsworth
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 176:5856-62. 2006
  9. ncbi request reprint Polymorphisms of the Toll-like receptors and human disease
    David A Schwartz
    Department of Medicine, Duke University Medical Center, The Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 41:S403-7. 2005
  10. pmc Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses
    Hideki Nakano
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Nat Immunol 10:394-402. 2009

Collaborators

Detail Information

Publications25

  1. pmc Innate immune control of pulmonary dendritic cell trafficking
    Donald N Cook
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Proc Am Thorac Soc 4:234-9. 2007
    ..It is hoped that an improved understanding of these mechanisms will lead to novel DC-mediated therapeutic strategies to treat immune-related pulmonary disease...
  2. ncbi request reprint Genetic regulation of endotoxin-induced airway disease
    Donald N Cook
    Department of Medicine, Duke University Medical Center, P O Box 2629, and the Durham VAMC, Durham, NC 27710, USA
    Genomics 83:961-9. 2004
    ..Functional studies of these genes are expected to reveal important molecular mechanisms regulating the magnitude of biologic responses to LPS...
  3. ncbi request reprint Toll-like receptors in the pathogenesis of human disease
    Donald N Cook
    Department of Medicine, Duke University Medical Center, and the Durham Veterans Administration Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 5:975-9. 2004
    ..As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options...
  4. pmc Spontaneous mutations in recombinant inbred mice: mutant toll-like receptor 4 (Tlr4) in BXD29 mice
    Donald N Cook
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 172:1751-5. 2006
    ..Our results also suggest that the frequency of such unidentified, spontaneously occurring mutations is an issue that should be considered when RI strains are used to identify QTL...
  5. ncbi request reprint Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide
    Stavros Garantziotis
    Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
    Transplantation 84:1012-9. 2007
    ..We have developed and pursued the hypothesis that local activation of pulmonary innate immunity through toll-like receptor (TLR)-4 is critical to the development of posttransplant alloimmune lung injury...
  6. ncbi request reprint The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation
    John W Hollingsworth
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Box 3221, Durham, NC 27710, USA
    Am J Respir Crit Care Med 171:806-13. 2005
    ..These data demonstrate the critical role of hematopoietic cells and alveolar macrophages in initiating LPS-induced neutrophil recruitment from the vascular space to the airspace...
  7. ncbi request reprint The role of Toll-like receptor 4 in environmental airway injury in mice
    John W Hollingsworth
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 170:126-32. 2004
    ..These data demonstrate in the mouse that the requirement of TLR4 for pulmonary inflammation depends on the nature of the toxin and appears specific to toxin and exposure conditions...
  8. ncbi request reprint TLR4 signaling attenuates ongoing allergic inflammation
    John W Hollingsworth
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 176:5856-62. 2006
    ..Together, these findings show that low doses of endotoxin can have regulatory effects on allergic inflammation, particularly in the setting of ongoing allergen exposure...
  9. ncbi request reprint Polymorphisms of the Toll-like receptors and human disease
    David A Schwartz
    Department of Medicine, Duke University Medical Center, The Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 41:S403-7. 2005
    ..These findings have resulted in new opportunities to study the pathogenesis of disease, identify subpopulations at greater risk of disease, and, potentially, identify novel therapeutic approaches...
  10. pmc Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses
    Hideki Nakano
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Nat Immunol 10:394-402. 2009
    ..We conclude that blood-derived inflammatory DCs are important in the development of T(H)1 immune responses...
  11. ncbi request reprint The genetics of innate immunity in the lung
    Donald N Cook
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 123:369S. 2003
  12. ncbi request reprint Toll-like receptors and the genetics of innate immunity
    Donald N Cook
    Department of Medicine, Duke University Medical Center, Durham Veteran s Administration Medical Center VAMC, Durham, North Carolina 27710, USA
    Curr Opin Allergy Clin Immunol 3:523-9. 2003
    ..This review summarizes recent work in which genetic approaches have been used to identify novel and important facets of Toll-like receptor function...
  13. pmc CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease
    JAMES M COGHILL
    Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Blood 122:825-36. 2013
    ..Collectively, our data indicate that a sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c(+) APCs. ..
  14. ncbi request reprint CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
    Jeffrey W Tyner
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 11:1180-7. 2005
    ..The antiapoptotic action of chemokine signaling may therefore allow scavengers to finally stop the host cell-to-cell infectious process...
  15. ncbi request reprint A matrix for new ideas in pulmonary fibrosis
    Donald N Cook
    Pulmonary and Critical Care Division, Department of Medicine, and the Department of Veterans Affairs Medical Center and Duke University Medical Center, Durham, North Carolina, USA
    Am J Respir Cell Mol Biol 27:122-4. 2002
  16. pmc Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6
    Yeny Martinez de la Torre
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rozzano, 20089 Milan, Italy
    Proc Natl Acad Sci U S A 104:2319-24. 2007
    ..Thus, the promiscuous decoy receptor for inflammatory CC chemokines D6 plays a nonredundant role in the protection against fetal loss caused by systemic inflammation and antiphospholipid antibodies...
  17. ncbi request reprint The chemokine receptor CCR6 is an important component of the innate immune response
    Haitao Wen
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Immunol 37:2487-98. 2007
    ..These data illustrate that CCR6 deficiency alters the innate response via attenuating the hyperactive local and systemic inflammatory response during CLP-induced peritonitis...
  18. pmc The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity
    Gregory S Whitehead
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:243-9. 2007
    ..The D6 chemokine receptor can bind and scavenge several chemokines, including the T-helper 2 (Th2)-associated chemokines CCL17 and CCL22. Although D6 is constitutively expressed in the lung, its pulmonary function is unknown...
  19. ncbi request reprint Cutting edge: the silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitis
    Liping Liu
    Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Immunol 177:17-21. 2006
    ..CD11c(+) dendritic cells accumulated abnormally in cutaneous immunization sites of D6(-/-) mice. Surprisingly, D6, a "silent" chemokine receptor, supports immune response generation...
  20. ncbi request reprint Control of microglial neurotoxicity by the fractalkine receptor
    Astrid E Cardona
    Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Nat Neurosci 9:917-24. 2006
    ..Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX3CR1 antagonists could increase neuronal vulnerability...
  21. ncbi request reprint Attenuation of allergen-induced responses in CCR6-/- mice is dependent upon altered pulmonary T lymphocyte activation
    Steven K Lundy
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 174:2054-60. 2005
    ..Altogether, the defect in CCR6-/- mice appears to be primarily due to an alteration in T cell activation, but also appears to include local pulmonary APC defects...
  22. ncbi request reprint The chemokine receptor D6 limits the inflammatory response in vivo
    Thomas Jamieson
    The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK
    Nat Immunol 6:403-11. 2005
    ..These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response...
  23. ncbi request reprint Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Med 10:510-7. 2004
    ....
  24. ncbi request reprint Increased inflammation in mice deficient for the chemokine decoy receptor D6
    Yeny Martinez de la Torre
    Institute of General Pathology, Medical Faculty, University of Milan, Milan, Italy
    Eur J Immunol 35:1342-6. 2005
    ..Thus, D6 is a decoy receptor structurally adapted and strategically located to tune tissue inflammation and control transfer of inflammatory chemokines to draining lymph nodes...
  25. ncbi request reprint Impaired T cell function in RANTES-deficient mice
    Yasuhiko Makino
    Penn Center for Molecular Studies of Kidney Disease, Renal Electrolyte and Hypertension Division, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Immunol 102:302-9. 2002
    ..Together, these data suggest that RANTES is required for normal T cell functions as well as for recruiting monocytes and T cells to sites of inflammation...