Research Topics
Species | R Edward ColemanSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancerDavid T Price
Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
J Urol 168:273-80. 2002..Overall the data from this study suggest that FCH is preferable to FDG for PET of prostate carcinoma and support the need for future validation studies in a larger number of subjects...
Impact of dedicated brain PET on intended patient management in participants of the national oncologic PET RegistryBruce E Hillner
Department of Internal Medicine, Virginia Commonwealth University, 1101 E Marshall St Room 7013, Richmond, VA 23298 0170, USA
Mol Imaging Biol 13:161-5. 2011..This study seeks to assess the impact of dedicated brain positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-D-glucose on intended management of patients with primary and metastatic brain tumors...
PET in lung cancer stagingR E Coleman
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Q J Nucl Med 45:231-4. 2001..PET is accurate in the staging of the mediastinum, adrenal glands, and the skeletal system. PET is not as accurate in the detection of brain metastases because of their small size and the normal cortical accumulation...
Is quantitation necessary for oncological PET studies? ForR Edward Coleman
Duke University Medical Center, Durham, NC 27710, USA
Eur J Nucl Med Mol Imaging 29:133-5. 2002
Positron emission tomography diagnosis of Alzheimer's diseaseR Edward Coleman
Department of Radiology, Duke University Medical Center, Box 3949, Durham, NC 27710, USA
Neuroimaging Clin N Am 15:837-46, x. 2005..Semiquantitative methods of image interpretation are available. Medicare covers FDG-PET imaging for the narrow indication of differentiation of possible AD from frontotemporal dementia...
Radiation dosimetry, pharmacokinetics, and safety of ultratrace Iobenguane I-131 in patients with malignant pheochromocytoma/paraganglioma or metastatic carcinoidR Edward Coleman
Division of Nuclear Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer Biother Radiopharm 24:469-75. 2009..These findings support the further development of Ultratrace 131I-MIBG for the treatment of neuroendocrine tumors, such as metastatic Pheo and carcinoid...
PET and PET/CT reports: observations from the National Oncologic PET RegistryR Edward Coleman
Department of Radiology, Duke University School of Medicine, Durham, North Carolina 27710, USA
J Nucl Med 51:158-63. 2010..Our objective was to identify core elements for inclusion in oncologic PET reports and to evaluate a sample of reports in the National Oncologic PET Registry database...
Value of FDG-PET scanning in management of lung cancerR Edward Coleman
Division of Nuclear Medicine, Department of Radiology, Duke University Medical School, Durham NC 27710, USA
Lancet 359:1361-2. 2002
FDG imagingR E Coleman
Duke University Medical Center, Box 3949, Durham, North Carolina 27710, USA
Nucl Med Biol 27:689-90. 2000..Semiquantitative indices such as the standardized uptake value may be used for research purposes to provide a quantitative parameter from the study...
Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6Michael R Zalutsky
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Nucl Med 49:30-8. 2008..The main goal of this study was to investigate the feasibility and safety of this approach in patients with recurrent malignant brain tumors...
A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boostDavid A Reardon
Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
Neuro Oncol 10:182-9. 2008..S. Food and Drug Administration has approved a trial randomizing newly diagnosed GBM patients to either our study regimen or standard XRT plus temozolomide...
Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study resultsDavid A Reardon
Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC, 27710, USA
J Clin Oncol 24:115-22. 2006..To assess the efficacy and toxicity of intraresection cavity iodine-131-labeled murine antitenascin monoclonal antibody 81C6 (131I-m81C6) among recurrent malignant brain tumor patients...
Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial resultsDavid A Reardon
Department of Surgery, The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina, USA
J Nucl Med 47:912-8. 2006....
Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusionsJohn H Sampson
Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
Neuro Oncol 9:343-53. 2007..6% of catheters. Routine use of this algorithm, and its further developments, should improve prospective selection of catheter trajectories, and thereby improve the efficacy of drugs delivered by this promising technique...
Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic ResonanceR Edward Coleman
Duke University Medical Center, Durham, North Carolina, USA
J Am Coll Radiol 2:568-84. 2005....
Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II studyGamal Akabani
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
J Nucl Med 46:1042-51. 2005..Further clinical studies are warranted to determine the effectiveness of (131)I-mu81C6 mAb based on a target dose of 44 Gy rather than a fixed administered activity...
Lexical and sublexical components of age-related changes in neural activation during visual word identificationWythe L Whiting
Duke University Medical Center, Durham, NC 27710, USA
J Cogn Neurosci 15:475-87. 2003..We conclude that aging affects the neural mechanisms supporting word identification performance although behavioral measures of this ability are generally constant as a function of age...
Regional cardiac sympathetic innervation early and late after transmyocardial laser revascularizationG Chad Hughes
Division of Cardiovascular Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Card Surg 19:21-7. 2004..The purpose of the present study was to evaluate regional myocardial sympathetic innervation both early (3 days) and late (6 months) after TMR...
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumorsJohn H Sampson
Division of Neurosurgery, Department of Surgery, Box 3050, Room 220 Sands Building, Duke University Medical Center, Durham, NC 27710, USA
Neuro Oncol 10:320-9. 2008..However, the potential efficacy of drugs delivered by this technique may be severely constrained by ineffective infusion in many patients...
Prognostic value of fluorine-18 fluorodeoxyglucose positron emission tomography imaging in patients with advanced-stage non-small-cell lung carcinomaJenny K Hoang
Department of Radiology, Duke University Medical Center, Erwin Rd, Durham, NC 27710, USA
J Clin Oncol 26:1459-64. 2008....
Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGFG Chad Hughes
Departments of Surgery and Medicine, Divisions of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC, USA
Ann Thorac Surg 77:812-8. 2004..This study expands on prior work by comparing the long-term proangiogenic effects of direct intramyocardial (IM) injection of bFGF, as well as IM and intravenous (IV) VEGF in a porcine model of chronic hibernating myocardium...
Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECTBennett B Chin
Department of Radiology, Duke University School of Medicine, Durham, NC 27710, USA
Radiology 245:440-8. 2007..To prospectively determine feasibility of evaluating murine left ventricular (LV) function with electrocardiographically (ECG)-gated blood pool single photon emission computed tomography (SPECT)...
Head and neck cancer: dedicated FDG PET/CT protocol for detection--phantom and initial clinical studiesYuka Yamamoto
Department of Radiology, Nuclear Medicine Division, Duke University Medical Center, Durham, NC, USA
Radiology 244:263-72. 2007....
Changes in plasma volume associated with mental stress ischemia in patients with coronary artery diseaseSimon L Bacon
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Int J Psychophysiol 61:143-8. 2006..Reduced plasma volume may be one mechanism by which mental stress may increase the risk for acute coronary events...
Increasing uptake time in FDG-PET: standardized uptake values in normal tissues at 1 versus 3 hBennett B Chin
Department of Radiology, Division of Nuclear Medicine, Duke University Medical Center, Durham, NC, USA
Mol Imaging Biol 11:118-22. 2009..Increasing FDG uptake in normal organs, however, may mitigate the beneficial effects of blood pool clearance. The purpose of this study is to determine the normal tissue and blood pool FDG uptake at 1 and 3 h after injection...
Clinical applications of PET in oncologyEric M Rohren
Department of Radiology, Duke University Medical Center, Rm 1410, Duke North, Erwin Rd, Durham, NC 27710, USA
Radiology 231:305-32. 2004..Other applications are being used clinically but have not been as carefully evaluated in the literature, and these applications may not be covered by third-party payers. The developing applications of PET are included in this review...
Clinical stage I non-small cell lung cancer including FDG-PET Imaging: sites and time to recurrenceJoerg Gauger
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Thorac Oncol 2:499-505. 2007..The purpose of this study was to determine the sites and time to recurrence in patients with clinical stage I NSCLC whose initial staging evaluation included conventional imaging and fluorodeoxyglucose-PET...
Predicting Cognitive Decline in Subjects at Risk for Alzheimer Disease by Using Combined Cerebrospinal Fluid, MR Imaging, and PET BiomarkersJennifer L Shaffer
Department of Radiology, Department of Psychiatry and Medicine, and Duke Institute for Brain Sciences, Duke University Medical Center, 2301 Erwin Rd, Box 3808, Durham, NC 27710 The Mind Research Network, Albuquerque, NM
Radiology 266:583-91. 2013..FDG PET appears to add the greatest prognostic information. © RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120010/-/DC1...
Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxinJohn H Sampson
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
AJR Am J Roentgenol 188:703-9. 2007..Our purpose was to test the hypothesis that hyperintense signal changes on T2-weighted images produced by such infusions can be used to track drug distribution...
3'-Deoxy-3'-[F-18]fluorothymidine positron emission tomography in patients with recurrent glioblastoma multiforme: comparison with Gd-DTPA enhanced magnetic resonance imagingYuka Yamamoto
Department of Radiology, Nuclear Medicine Division, Duke University Medical Center, Durham, NC, USA
Mol Imaging Biol 8:340-7. 2006....
Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery diseaseMichael A Babyak
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Am J Cardiol 105:25-8. 2010..7, (95% confidence interval 1.1 to 2.6, p = 0.011). In conclusion, reductions in the LVEF during mental stress are prospectively associated with adverse clinical outcomes...
Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing: a comparison with clinical and perfusion variablesS T Mast
Division of Cardiology, Department of Internal Medicine, Duke University Medical Center and Health Systems, Durham, North Carolina 27710, USA
J Nucl Med 42:871-7. 2001..In patients who cannot exercise and are undergoing noninvasive evaluation with pharmacologic stress testing and myocardial perfusion imaging, ejection fraction should be measured simultaneously for risk assessment optimization...
Adult age differences in visual word identification: functional neuroanatomy by positron emission tomographyDavid J Madden
Duke University Medical Center, Durham, NC 27710, USA
Brain Cogn 49:297-321. 2002....
Recommendations on the use of 18F-FDG PET in oncologyJames W Fletcher
Department of Radiology, Indiana Purdue University, Indiana University School of Medicine, Indianapolis, Indiana 46202 5253, USA
J Nucl Med 49:480-508. 2008..In addition, (18)F-FDG PET should be used to detect recurrence of breast, colorectal, head and neck, or thyroid cancer and of lymphoma...
A comparison of the diagnostic accuracy of 18F-FDG PET and CT in the characterization of solitary pulmonary nodulesJames W Fletcher
Department of Radiology, Indiana University School of Medicine, University Hospital, Indianapolis, Indiana 46202 5253, USA
J Nucl Med 49:179-85. 2008..Our objective was to compare CT and PET accuracy in veterans with SPN...
PET and brain tumor image fusionTerence Z Wong
Department of Radiology, Nuclear Medicine Division, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer J 10:234-42. 2004....
A comparative analysis of positron emission tomography and mediastinoscopy in staging non-small cell lung cancerGonzalo V Gonzalez-Stawinski
Division of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Thorac Cardiovasc Surg 126:1900-5. 2003..Cervical mediastinoscopy with lymph node biopsy remains the criterion standard for mediastinal staging...
Incremental prognostic power of single-photon emission computed tomographic myocardial perfusion imaging in patients with known or suspected coronary artery diseaseSalvador Borges-Neto
Department of Medicine Cardiology, Duke University Medical Center, Durham, NC 27710, USA
Am J Cardiol 95:182-8. 2005..This information may be useful for stratifying patients into multiple risk categories for future cardiovascular events and potentially guiding therapy...
Iodine -131 metaiodobenzylguanidine is an effective treatment for malignant pheochromocytoma and paragangliomaShawn D Safford
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Surgery 134:956-62; discussion 962-3. 2003..An initial dose of 500 mCi may be optimal. The benefit of (131)I-MIBG treatment for metastatic pheochromocytoma must also be weighed against its side effects...
Iodine-131 metaiodobenzylguanidine treatment for metastatic carcinoid. Results in 98 patientsShawn D Safford
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
Cancer 101:1987-93. 2004..Improved survival was predicted best by symptomatic response to 131I-MIBG treatment, but not by hormone or radiographic response...
Detection of primary breast carcinoma with a dedicated, large-field-of-view FDG PET mammography device: initial experienceEric L Rosen
Department of Radiology, Duke University Medical Center, Room 24244B, Hospital South, Durham, NC 27710, USA
Radiology 234:527-34. 2005..To prospectively assess a dedicated, large field of view positron emission tomography (PET) mammographic device for imaging primary breast carcinoma...
Prospective multicenter study of axillary nodal staging by positron emission tomography in breast cancer: a report of the staging breast cancer with PET Study GroupRichard L Wahl
Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Clin Oncol 22:277-85. 2004..To determine the accuracy of positron emission tomography with fluorine-18-labeled 2-fluoro-2-deoxy-d-glucose (FDG-PET) in detecting axillary nodal metastases in women with primary breast cancer...
Practical approach to diagnostic CT combined with PETTerence Z Wong
Department of Radiology, Duke University Medical Center, Box 3949 Duke University Medical Center, Durham, NC 27710, USA
AJR Am J Roentgenol 188:622-9. 2007..Standardization of imaging protocols will become increasingly important as multiple-institution trials are developed for evaluation of present and future applications of PET/CT...
Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphomaDavid A Rizzieri
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Blood 104:642-8. 2004..These data demonstrate this radiopharmaceutical to be an encouraging agent for the treatment of lymphoma particularly if methods to protect the normal viscera are developed...
Regional brain activity correlates of nicotine dependenceJed E Rose
Department of Psychiatry, Duke University Medical Center, Durham, NC 27705, USA
Neuropsychopharmacology 32:2441-52. 2007..The results also highlight the likely role of thalamic gating processes as well as striatal reward and corticolimbic regulatory pathways in the maintenance of cigarette addiction...
Screening for cerebral metastases with FDG PET in patients undergoing whole-body staging of non-central nervous system malignancyEric M Rohren
Department of Radiology, Duke University Medical Center, Durham, NC, USA
Radiology 226:181-7. 2003....
Incidence and patterns of neuraxis metastases in children with diffuse pontine gliomaSridharan Gururangan
The Brain Tumor Center at Duke, Duke University Medical Center, Durham, NC 27710, USA
J Neurooncol 77:207-12. 2006..We performed a retrospective study of patients with diffuse pontine glioma (DPG) who suffered neuraxis metastasis (NM) and characterized the incidence, clinical features, radiologic findings, and patterns of disease dissemination...
Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracersT R DeGrado
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Nucl Med 42:1805-14. 2001..Preliminary PET studies on patients with prostate cancer and with breast cancer and brain tumor support further studies to evaluate the usefulness of FCH as an oncologic probe...
Combination of converging collimators for high-sensitivity brain SPECTRuben Ter-Antonyan
Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
J Nucl Med 50:1548-56. 2009..The reason for combining collimators is to ensure both high sensitivity and sufficient sampling without trading off spatial resolution...
Outcome prediction in patients at high risk for coronary artery disease: comparison between 99mTc tetrofosmin and 99mTc sestamibiSalvador Borges-Neto
Department of Medicine, Duke Clinical Research Institute and Drexel School of Medicine, Duke University Medical Center, PO Box 3949, Durham, NC 27710, USA
Radiology 232:58-65. 2004....
Quantitative effects of contrast enhanced CT attenuation correction on PET SUV measurementsTira Bunyaviroch
Department of Radiology, Nuclear Medicine Section, Duke University Medical Center, Durham, NC 27710, USA
Mol Imaging Biol 10:107-13. 2008..Newer CT-based attenuation correction (CTAC) algorithms have been developed to reduce these errors...
Prediction of death and nonfatal myocardial infarction in high-risk patients: a comparison between the Duke treadmill score, peak exercise radionuclide angiography, and SPECT perfusion imagingLawrence Liao
Cardiology Division, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Nucl Med 46:5-11. 2005..7, and 16.7, respectively). CONCLUSION: The DTS, perfusion SPECT, and RNA-EF are each significant predictors of cardiovascular events in high-risk patients. The optimal risk stratification of patients for CAD may include all 3 modalities...
Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case studyJohn H Sampson
Duke University Medical Center, Durham, NC 27710, USA
Neuro Oncol 7:90-6. 2005..This report describes a dramatic and sustained clinical and radiographic response in a patient with a bifrontal glioblastoma multiforme treated with intratumoral infusion of a novel targeted toxin, TP-38...
ProstaScint (capromab pendetide) imaging using hybrid gamma camera-CT technologyTerence Z Wong
Department of Radiology, Division of Nuclear Medicine, Duke University Medical Center, Box 3949, Durham, NC 27710, USA
AJR Am J Roentgenol 184:676-80. 2005
Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECTSreekanth Vemulapalli
Department of Medicine, Division of Cardiology, Duke University Medical Center, Box 3808 DUMC, Durham, NC 27710, USA
Radiology 242:198-207. 2007....
Receiver operating characteristic curves to assess predictors of radiation-induced symptomatic lung injuryPehr A Lind
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Int J Radiat Oncol Biol Phys 54:340-7. 2002..Additional studies are needed to better understand the dosimetric/functional determinants of radiation pneumonitis...
Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trialJames A Blumenthal
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
JAMA 293:1626-34. 2005..Observational studies have shown that psychosocial factors are associated with increased risk for cardiovascular morbidity and mortality, but the effects of behavioral interventions on psychosocial and medical end points remain uncertain...
Positron emission tomography imaging of brain tumorsTerence Z Wong
Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Box 3949, Durham, NC 27710, USA
Neuroimaging Clin N Am 12:615-26. 2002..These tracers may be useful in specific clinical situations, however, such as tumor localization for treatment planning or evaluation of low-grade tumors...
Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter studyP Murali Doraiswamy
Duke University Medical Center, Durham, NC, USA
Neurology 79:1636-44. 2012..We prospectively evaluated the prognostic utility of detecting Aβ pathology using florbetapir PET in subjects at risk for progressive cognitive decline...
Clinical oncologic positron emission tomography: an introductionTimothy G Turkington
Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Box 3949, DUMC, Durham, NC 27710, USA
Semin Roentgenol 37:102-9. 2002..Third-party payers now recognize the importance of PET imaging in multiple malignancies. The number of PET scans performed annually will continue to increase as the indications increase and the instrumentation is more available...
Mammotomography with pinhole incomplete circular orbit SPECTMartin P Tornai
Section of Nuclear Medicine, Department of Radiology, Duke University Medical Center, DUMC 3949, Durham, NC 27710, USA
J Nucl Med 44:583-93. 2003..Enhanced 3-dimensional imaging performance with very-high-stopping-power apertures is thought to ultimately yield improved sensitivities for lesion detection and identification in breast disease...
Neuroimaging and early diagnosis of Alzheimer disease: a look to the futureJeffrey R Petrella
Department of Radiology, Duke University Medical Center, Duke Hospital North, Rm 1513, Erwin Rd, Durham, NC 27710, USA
Radiology 226:315-36. 2003..PET ligands are in late-stage development for demonstration of amyloid plaques, and human studies have already begun. Functional MR-based memory challenge tests are in development as well...
Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the joint working group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic ResonanceR Edward Coleman
Duke University Medical Center, Durham, North Carolina, USA
J Nucl Med 46:1225-39. 2005....
Gated 99mTc-tetrofosmin and 18F-FDG studies: a comparison of single-acquisition and separate-acquisition protocolsRobert A Pagnanelli
Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
J Nucl Med Technol 30:175-8. 2002..The gated (99m)Tc-TET/(18)F-FDG DISA protocol can be both a reliable and an efficient way to evaluate myocardial function, perfusion, and viability...
Quantitative pulmonary single photon emission computed tomography for radiotherapy applicationsC Scarfone
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Med Phys 26:1579-88. 1999..SPECT has the potential to provide accurate estimates of lung activity distributions that, together with improved image quality, may be useful for the study and prediction of therapeutic response...
Pharmacokinetics and radiation dosimetry of 18F-fluorocholineTimothy R DeGrado
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Nucl Med 43:92-6. 2002..18F-Fluorocholine (fluoromethyl-dimethyl-2-hydroxyethylammonium [FCH]) has been developed as an oncologic probe for PET. This study evaluates the kinetics and radiation dosimetry of 18F-FCH using murine and human biodistribution data...
[18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastomaSridharan Gururangan
The Brain Tumor Center at Duke, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
Neurosurgery 55:1280-8; discussion 1288-9. 2004..We evaluated the [(18)F]fluorodeoxyglucose (FDG) accumulation during positron emission tomography (PET) in patients with medulloblastoma and examined the relationship of intensity of uptake with patient outcome after the initial scan...
Impact of computed tomography-positron emission tomography fusion in staging patients with thoracic malignanciesThomas A D'Amico
Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 74:160-3; discussion 163. 2002..Positron emission tomography (PET) has been demonstrated to improve staging in patients with thoracic malignancies. This study evaluates the ability of a new imaging technique to improve the spatial resolution and accuracy of PET...
Incidental detection of pigmented villonodular synovitis on FDG PETMehmet T Kitapci
Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Nucl Med 28:668-9. 2003....
PET studies of the influences of nicotine on neural systems in cigarette smokersJed E Rose
Veterans Affairs Medical Center, Durham, NC, USA
Am J Psychiatry 160:323-33. 2003..The effects of acute nicotine administration and smoking on brain function were investigated in two studies, with the primary goal of identifying neural systems that mediate these effects...
Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomasDavid A Reardon
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Clin Oncol 20:1389-97. 2002..To assess the efficacy and toxicity of intraresection cavity (131)I-labeled murine antitenascin monoclonal antibody 81C6 and determine its true response rate among patients with newly diagnosed malignant glioma...
Aging and attentional guidance during visual search: functional neuroanatomy by positron emission tomographyDavid J Madden
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Psychol Aging 17:24-43. 2002....
A comparison of mechanical and laser transmyocardial revascularization for induction of angiogenesis and arteriogenesis in chronically ischemic myocardiumG Chad Hughes
Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, North Carolina, USA
J Am Coll Cardiol 39:1220-8. 2002....
Variable-time positron emission tomography leg protocol to equalize noise for positron emission tomography/computed tomography acquisitionsJoshua M Wilson
Graduate Program in Medical Physics, Duke University, Durham, North Carolina, USA
Nucl Med Commun 32:868-72. 2011..Reducing the total scan time will limit the opportunity for motion, which can reduce imaging artefacts and improves image fusion, will improve a patient's experience, and will yield the biggest gains in time for the tallest patients...
Positron emission tomography with 2-deoxy-2-[(18)F]fluoro-D-glucose for evaluating local and distant disease in patients with cervical cancerTerence Z Wong
Departments of Radiology and Radiation Oncology, Duke University Medical Center, Durham, NC, USA
Mol Imaging Biol 6:55-62. 2004..To assess the accuracy of positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) for evaluating local and distant disease in patients with cervical cancer...
Depression and increased myocardial ischemic activity in patients with ischemic heart diseaseWei Jiang
Departments of Department ofPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am Heart J 146:55-61. 2003..The observed inverse association between higher level of depressive symptoms and ischemic activity needs to be further assessed in large samples...
Aging and recognition memory: changes in regional cerebral blood flow associated with components of reaction time distributionsD J Madden
Box 2980, Duke University Medical Center, Durham, NC 27710 USA
J Cogn Neurosci 11:511-20. 1999..The data suggest that the attentional demands of this task are relatively greater for older adults and consequently lead to the recruitment of additional neural systems during task performance...
Fractal texture analysis of perfusion lung scansG D Tourassi
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Comput Biomed Res 33:161-71. 2000..The average fractal dimension (FD) of normal ROIs was statistically significantly higher than that of abnormal ROIs. Furthermore, the FDs of abnormal ROIs with PE were significantly lower than the FDs of ROIs with OPD present...
Association of bone scintigraphic abnormalities with knee malalignment and painV B Kraus
Duke General Clinical Research Unit, Duke University Medical Center, Durham, NC 27710, USA
Ann Rheum Dis 68:1673-9. 2009..The information content of knee bone scintigraphy was evaluated, including pattern, localisation and intensity of retention relative to radiographic features of knee osteoarthritis, knee alignment and knee symptoms...
Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapyG Akabani
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
Int J Radiat Oncol Biol Phys 46:947-58. 2000....
Radioiodinated metaiodobenzylguanidine in the diagnosis and therapy of carcinoid tumorsM U Khan
Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, NC27710, USA
Q J Nucl Med Mol Imaging 52:441-54. 2008..In this article, we review the current state of the art in the diagnosis and treatment of carcinoid tumors as well as the role of MIBG in their diagnosis and management...
Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addictionJ E Rose
Nicotine Research Program, Duke University and V A Medical Center, Durham, NC 27705, USA
Drug Alcohol Depend 56:99-107. 1999..These results have significant implications for theories of addiction to nicotine as well as other drugs such as cocaine that may be subject to binding by lung tissue...
Emotional responsivity and transient myocardial ischemiaR A Carels
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Consult Clin Psychol 67:605-10. 1999..These results suggest that emotional responsivity may represent an individual difference characteristic that is associated with an increased likelihood of exhibiting myocardial ischemia in both the laboratory and the real-world setting...
Adult age differences in the functional neuroanatomy of verbal recognition memoryD J Madden
Center for the Study of Aging and Human Development, and Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Hum Brain Mapp 7:115-35. 1999....
Cerebellar activity and disturbed time sense after THCR J Mathew
Department of Psychiatry and Radiology, Duke University Medical Center, Box 3972, Durham, NC 27710, USA
Brain Res 797:183-9. 1998..The relationship between decreased cerebellar flow and impaired time sense is of interest because the cerebellum has been linked to an internal timing system...
Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial resultsD D Bigner
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
J Clin Oncol 16:2202-12. 1998..To determine the maximum-tolerated dose (MTD) of iodine 131 (131I)-labeled 81C6 monoclonal antibody (mAb) in brain tumor patients with surgically created resection cavities (SCRCs) and to identify any objective responses to this treatment...
Multifractal texture analysis of perfusion lung scans as a potential diagnostic tool for acute pulmonary embolismG D Tourassi
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
Comput Biol Med 31:15-25. 2001..Linear and non-linear decision models were evaluated for the diagnostic task. A consensus neural network significantly outperformed all decision models including the physicians...
Efficiency comparison between 99m Tc-tetrofosmin and 99m Tc-sestamibi myocardial perfusion studiesG C Ravizzini
Dept of Radiology (Nuclear Medicine, Duke University Medical Center, Durham, NC 27710, USA
Nucl Med Commun 23:203-8. 2002..These factors may be considered for efficiency improvement in nuclear cardiology laboratories using 99mTc perfusion tracers...
Multimodality nuclear medicine imaging in three-dimensional radiation treatment planning for lung cancer: challenges and prospectsM T Munley
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Lung Cancer 23:105-14. 1999..The utilization of accurate nuclear medicine image reconstruction techniques and TCT may improve the treatment planning process...
Poststress measurements of left ventricular function with gated perfusion SPECT: comparison with resting measurements by using a same-day perfusion-function protocolS Borges-Neto
Departments of Radiology Nuclear Medicine, Duke University Medical Center and Health Systems, Duke North Rm 1410, Durham, NC 27710, USA
Radiology 215:529-33. 2000....
Is chronically dysfunctional yet viable myocardium distal to a severe coronary stenosis hypoperfused?G C Hughes
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 72:163-8. 2001....
Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomasI Cokgor
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
J Clin Oncol 18:3862-72. 2000....
Positron emission tomography: brain tumors and lung cancerR J Hagge
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Radiol Clin North Am 39:871-81. 2001..Truly, FDG-PET has earned its place as the new standard of care in imaging non-small cell lung cancer...
Effects of specific activity on meta-[(131)I]iodobenzylguanidine kinetics in isolated rat heartT R DeGrado
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
Nucl Med Biol 25:59-64. 1998..5 nmol/g. Extrapolation of these results to human studies indicates that isotope-exchange-labeled [123I]MIBG has a specific activity sufficiently high to avoid mass effects on its heart retention...
Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancerT R DeGrado
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer Res 61:110-7. 2001..It is concluded that FCH closely mimics choline uptake by normal tissues and prostate cancer neoplasms. FCH is potentially useful as a PET tracer for detection and localization of prostate cancer and monitoring effects of therapy...
Radiation-induced pulmonary injury: symptomatic versus subclinical endpointsL B Marks
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Int J Radiat Biol 76:469-75. 2000..To assess the relationship between radiation (RT)-induced pulmonary symptoms and subclinical changes in pulmonary functions tests (PFT) and radiographs...
Prediction of myocardial perfusion abnormalities by quantitative regional function using a radionuclide angiography database: a comparison with wall motion analysisS Borges-Neto
Department of Radiology Nuclear Medicine, Duke University Medical Center and Health Systems, Durham, North Carolina 27710, USA
Clin Nucl Med 25:110-4. 2000..A new assessment of regional ejection fraction at rest and peak exercise by first-pass radionuclide angiography using a "normal" database file has been developed...
Can we predict radiation-induced changes in pulmonary function based on the sum of predicted regional dysfunction?M Fan
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
J Clin Oncol 19:543-50. 2001..To determine whether changes in whole-lung pulmonary function test (PFT) values are related to the sum of predicted radiation therapy (RT)-induced changes in regional lung perfusion...
Relating radiation-induced regional lung injury to changes in pulmonary function testsM Fan
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
Int J Radiat Oncol Biol Phys 51:311-7. 2001..Additional studies to clarify the relationship between regional and global lung injury are needed...
(18)F-fluorodeoxyglucose positron emission tomography and MR imaging findings in Rasmussen encephalitisD J Fiorella
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
AJNR Am J Neuroradiol 22:1291-9. 2001....
Comparison of [125I]HIPDm and [125I]iodoantipyrine in quantifying regional cerebral blood flow in ratsR E Albright
Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710
Stroke 19:1404-10. 1988....
