J A Cohn

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain
    L Daniel Howell
    Department of Medicine, Duke University and VA Medical Centers, Durham, NC 27710-3378, USA
    Biochem J 378:151-9. 2004
  2. ncbi The role of cystic fibrosis gene mutations in determining susceptibility to chronic pancreatitis
    Jonathan A Cohn
    Veterans Administration Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Gastroenterol Clin North Am 33:817-37, vii. 2004
  3. ncbi Are mutations in the cystic fibrosis gene important in chronic pancreatitis?
    J A Cohn
    Department of Medicine, Duke University, Durham, North Carolina, USA
    Surg Clin North Am 79:723-31, viii. 1999
  4. ncbi Reduced CFTR function and the pathobiology of idiopathic pancreatitis
    Jonathan A Cohn
    Veterans Administration and Duke University Medical Centers, Durham, NC 27710, USA
    J Clin Gastroenterol 39:S70-7. 2005
  5. ncbi The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis
    Jonathan A Cohn
    Veterans Administration Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Clin Lab Med 25:79-100. 2005
  6. ncbi Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers
    Jonathan A Cohn
    Department of Medicine, Durham Veterans Administration and Duke University Medical Center, Durham, North Carolina 27710, USA
    Hum Mutat 26:303-7. 2005
  7. ncbi Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments against the motion
    Jonathan A Cohn
    Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Can J Gastroenterol 17:53-5. 2003
  8. ncbi Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene
    Jonathan A Cohn
    Duke University and Veterans Administration Medical Centers, Durham, NC, USA
    J Investig Med 50:247S-255S. 2002
  9. ncbi Cystic fibrosis mutations and genetic predisposition to idiopathic chronic pancreatitis
    J A Cohn
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Med Clin North Am 84:621-31, ix. 2000
  10. ncbi Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations
    P G Noone
    Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Gastroenterology 121:1310-9. 2001

Research Grants

  1. The Cystic Fibrosis Gene and Chronic Pancreatitis
    Jonathan Cohn; Fiscal Year: 2007
  2. MOLECULAR BASIS OF SECRETORY DIARRHEA
    Jonathan Cohn; Fiscal Year: 2003
  3. The Cystic Fibrosis Gene and Chronic Pancreatitis
    Jonathan Cohn; Fiscal Year: 2009

Collaborators

Detail Information

Publications12

  1. ncbi Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain
    L Daniel Howell
    Department of Medicine, Duke University and VA Medical Centers, Durham, NC 27710-3378, USA
    Biochem J 378:151-9. 2004
    ..These findings suggest that during the activation of native CFTR, phosphorylation of the R domain by PKA can control the ability of the NBD1 domain to hydrolyse ATP and to interact with other NBD domains...
  2. ncbi The role of cystic fibrosis gene mutations in determining susceptibility to chronic pancreatitis
    Jonathan A Cohn
    Veterans Administration Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Gastroenterol Clin North Am 33:817-37, vii. 2004
    ..It summarizes recent studies on the relationship between CFTR mutations and pancreatitis, and it reviews several unresolved issues in the field...
  3. ncbi Are mutations in the cystic fibrosis gene important in chronic pancreatitis?
    J A Cohn
    Department of Medicine, Duke University, Durham, North Carolina, USA
    Surg Clin North Am 79:723-31, viii. 1999
    ..This article reviews the evidence that links mutations of this gene to unexplained pancreatitis, and discusses the implications of this for the evaluation, pathogenesis, classification, and possible prevention of pancreatitis...
  4. ncbi Reduced CFTR function and the pathobiology of idiopathic pancreatitis
    Jonathan A Cohn
    Veterans Administration and Duke University Medical Centers, Durham, NC 27710, USA
    J Clin Gastroenterol 39:S70-7. 2005
    ..These findings indicate that PSTI is a modifier gene for CFTR-related ICP and have implications for the diagnosis and pathogenesis of pancreatitis...
  5. ncbi The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis
    Jonathan A Cohn
    Veterans Administration Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Clin Lab Med 25:79-100. 2005
    ..It summarizes recent studies on the relationship between CFTR mutations and pancreatitis, and it reviews several unresolved issues in the field...
  6. ncbi Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers
    Jonathan A Cohn
    Department of Medicine, Durham Veterans Administration and Duke University Medical Center, Durham, North Carolina 27710, USA
    Hum Mutat 26:303-7. 2005
    ..Having two CFTR mutations imparts a higher relative risk, while having only one mutation imparts a higher attributable risk...
  7. ncbi Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments against the motion
    Jonathan A Cohn
    Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Can J Gastroenterol 17:53-5. 2003
    ....
  8. ncbi Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene
    Jonathan A Cohn
    Duke University and Veterans Administration Medical Centers, Durham, NC, USA
    J Investig Med 50:247S-255S. 2002
    ..These findings indicate that PSTI is a modifier gene for CFTR-related ICP and have implications for the classification, diagnosis, and pathogenesis of pancreatitis...
  9. ncbi Cystic fibrosis mutations and genetic predisposition to idiopathic chronic pancreatitis
    J A Cohn
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Med Clin North Am 84:621-31, ix. 2000
    ..This article summarizes the evidence associating these abnormal CFTR genotypes with idiopathic chronic pancreatitis and reviews the implications of this association for the pathogenesis, classification, and prevention of pancreatitis...
  10. ncbi Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations
    P G Noone
    Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Gastroenterology 121:1310-9. 2001
    ..The N34S PSTI mutation increased risk separately. Testing for pancreatitis-associated CFTR and PSTI genotypes may be useful in nonalcoholic pancreatitis...
  11. ncbi 5' exon replacement and repair by spliceosome-mediated RNA trans-splicing
    S Gary Mansfield
    Intronn, Inc, Gaithersburg, Maryland 20878, USA. Department of Medicine, Duke University Medical Center, Durham, North Carolina 27713, USA
    RNA 9:1290-7. 2003
    ..These studies demonstrate that (1) SMaRT can be used to reprogram the 5' end of mRNA, and (2) efficiency can be improved substantially...
  12. ncbi Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing
    Xiaoming Liu
    Department of Anatomy and Cell Biology, College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Nat Biotechnol 20:47-52. 2002
    ..These results provide functional evidence for SMaRT-mediated repair of mutant endogenous CFTR mRNA in intact polarized CF airway epithelial models...

Research Grants10

  1. The Cystic Fibrosis Gene and Chronic Pancreatitis
    Jonathan Cohn; Fiscal Year: 2007
    ..Thus, this project's general goals are to develop methods to identify health y individuals who are highly susceptible to CP and CP, and to work towards developing preventative therapy for these individuals. ..
  2. MOLECULAR BASIS OF SECRETORY DIARRHEA
    Jonathan Cohn; Fiscal Year: 2003
    ..Given the pivotal role of CFTR in the pathogenesis of diarrhea and CF this project has excellent prospects of leading to information of practical benefit in the treatment of these conditions. ..
  3. The Cystic Fibrosis Gene and Chronic Pancreatitis
    Jonathan Cohn; Fiscal Year: 2009
    ..Thus, this project's general goals are to develop methods to identify health y individuals who are highly susceptible to CP and CP, and to work towards developing preventative therapy for these individuals. ..