Thomas Coffman

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production
    MyTrang Nguyen
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 169:4586-93. 2002
  2. ncbi request reprint Renal segmental microvascular responses to ANG II in AT1A receptor null mice
    Lisa M Harrison-Bernard
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 284:F538-45. 2003
  3. ncbi request reprint Impact of genetic background on nephropathy in diabetic mice
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Physiol Renal Physiol 290:F214-22. 2006
  4. ncbi request reprint Prostacyclin protects against elevated blood pressure and cardiac fibrosis
    Helene Francois
    Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705
    Cell Metab 2:201-7. 2005
  5. doi request reprint Kidney in hypertension: guyton redux
    Thomas M Coffman
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC, USA
    Hypertension 51:811-6. 2008
  6. doi request reprint Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death
    Matthew A Sparks
    Division of Nephrology and Department of Medicine, Duke University, Durham, NC 27710, USA
    Hypertension 61:166-73. 2013
  7. doi request reprint Under pressure: the search for the essential mechanisms of hypertension
    Thomas M Coffman
    Division of Nephrology, Department of Medicine, Cardiovascular Research Center, Duke University, Durham, North Carolina, USA
    Nat Med 17:1402-9. 2011
  8. pmc AT1 receptors in the collecting duct directly modulate the concentration of urine
    Johannes Stegbauer
    Department of Medicine, Division of Nephrology, Duke University Medical Center, MSRBII Room 2018, 106 Research Drive, Durham, NC 27710, USA
    J Am Soc Nephrol 22:2237-46. 2011
  9. pmc Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
    Steven D Crowley
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:17985-90. 2006
  10. ncbi request reprint Role for thromboxane receptors in angiotensin-II-induced hypertension
    Helene Francois
    Division of Nephrology, Department of Medicine, Duke University, and Durham VA Medical Centers, Durham, NC 27705, USA
    Hypertension 43:364-9. 2004

Research Grants

  1. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas M Coffman; Fiscal Year: 2010
  2. DUKE TRAINING GRANT IN NEPHROLOGY
    Thomas Coffman; Fiscal Year: 2007
  3. Angiogenic Signals in Diabetic Complications
    Thomas Coffman; Fiscal Year: 2007
  4. Prostaglandin E2 and Regulation of Kidney Function
    Thomas Coffman; Fiscal Year: 2009
  5. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas Coffman; Fiscal Year: 2007
  6. Prostaglandin E2 and Regulation of Kidney Function
    Thomas Coffman; Fiscal Year: 2007
  7. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas Coffman; Fiscal Year: 1999
  8. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas Coffman; Fiscal Year: 2003
  9. Duke-UNC-Stanford AMDC Unit
    Thomas Coffman; Fiscal Year: 2005
  10. Prostaglandin E2 and Regulation of Kidney Function
    Thomas M Coffman; Fiscal Year: 2010

Detail Information

Publications66

  1. ncbi request reprint Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production
    MyTrang Nguyen
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 169:4586-93. 2002
    ..Accordingly, these studies identify PGE(2)/EP(3) as a proinflammatory signaling pathway that promotes mast cell activation...
  2. ncbi request reprint Renal segmental microvascular responses to ANG II in AT1A receptor null mice
    Lisa M Harrison-Bernard
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 284:F538-45. 2003
    ....
  3. ncbi request reprint Impact of genetic background on nephropathy in diabetic mice
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Physiol Renal Physiol 290:F214-22. 2006
    ..Thus, among the strains and models tested, the DBA/2 genetic background and the Akita (Ins2(+/C96Y)) model may be the most useful platforms for model development...
  4. ncbi request reprint Prostacyclin protects against elevated blood pressure and cardiac fibrosis
    Helene Francois
    Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705
    Cell Metab 2:201-7. 2005
    ..Our data suggest that adjuvant therapy that blocks unrestrained Tx actions might protect against end-organ damage without affecting blood pressure in patients taking COX-2 inhibitors...
  5. doi request reprint Kidney in hypertension: guyton redux
    Thomas M Coffman
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC, USA
    Hypertension 51:811-6. 2008
  6. doi request reprint Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death
    Matthew A Sparks
    Division of Nephrology and Department of Medicine, Duke University, Durham, NC 27710, USA
    Hypertension 61:166-73. 2013
    ..Thus, TP receptors in vascular smooth muscle cells play a major role in mediating the actions of thromboxane A(2) in TP agonist-induced shock, hypertension, and vascular remodeling of the aorta...
  7. doi request reprint Under pressure: the search for the essential mechanisms of hypertension
    Thomas M Coffman
    Division of Nephrology, Department of Medicine, Cardiovascular Research Center, Duke University, Durham, North Carolina, USA
    Nat Med 17:1402-9. 2011
    ..The intent of this review is to provide a sense of where the field is progressing, with an emphasis on work that sheds light on pathogenic mechanisms and that is therefore likely to inform new translational advances...
  8. pmc AT1 receptors in the collecting duct directly modulate the concentration of urine
    Johannes Stegbauer
    Department of Medicine, Division of Nephrology, Duke University Medical Center, MSRBII Room 2018, 106 Research Drive, Durham, NC 27710, USA
    J Am Soc Nephrol 22:2237-46. 2011
    ..In summary, these results demonstrate that AT(1A) receptors in epithelial cells of the collecting duct directly modulate aquaporin-2 levels and contribute to the concentration of urine...
  9. pmc Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
    Steven D Crowley
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:17985-90. 2006
    ..Further, they suggest that the major mechanism of action of RAS inhibitors in hypertension is attenuation of angiotensin II effects in the kidney...
  10. ncbi request reprint Role for thromboxane receptors in angiotensin-II-induced hypertension
    Helene Francois
    Division of Nephrology, Department of Medicine, Duke University, and Durham VA Medical Centers, Durham, NC 27705, USA
    Hypertension 43:364-9. 2004
    ..However, irrespective of genetic background, the TP receptor makes a robust contribution to the pathogenesis of angiotensin II-dependent hypertension...
  11. pmc Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 115:1092-9. 2005
    ..Thus, the regulation of blood pressure by the RAS is mediated by AT(1) receptors both within and outside the kidney...
  12. pmc A role for the thromboxane receptor in L-NAME hypertension
    Helene Francois
    Department of Medicine, Duke University Medical Center, Rm 2018 MSRB II, 106 Research Drive, Durham, NC 27710, USA
    Am J Physiol Renal Physiol 295:F1096-102. 2008
    ..01). Thus, in L-NAME hypertension, TP receptors contribute to elevated blood pressure and cardiac hypertrophy. In this model, TP receptors also provided unexpected protection against kidney injury...
  13. pmc The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background
    Carie S Facemire
    Department of Medicine, Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27710, USA
    Hypertension 55:531-8. 2010
    ..These data indicate that genetic background significantly modifies the BP response to mPGES1 deficiency. Exaggerated production of thromboxane may contribute to the robust hypertension and albuminuria in 129 mPGES1-deficient mice...
  14. pmc Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 116:2218-25. 2006
    ..Our data suggest that ACE2 is a functional component of the renin-angiotensin system, metabolizing Ang II and thereby contributing to regulation of blood pressure...
  15. ncbi request reprint In hypertension, the kidney rules
    Steven D Crowley
    Nephrology, VA Medical Center, Durham, NC 27705, USA
    Curr Hypertens Rep 9:148-53. 2007
    ..These findings, with previous experiments, clearly establish the critical role of the kidney in the pathogenesis of hypertension and its cardiovascular complications...
  16. pmc Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension
    Matthew A Sparks
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Room 2028 MSRB2, 106 Research Dr, Durham, NC 27710, USA
    Hypertension 57:577-85. 2011
    ..Thus, vascular AT(1A) receptors promote oxidative stress in the aortic wall but are not required for remodeling in angiotensin II-dependent hypertension...
  17. pmc Renal actions of RGS2 control blood pressure
    Susan B Gurley
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 21:1847-51. 2010
    ..These data support a critical role for the renal epithelium and/or vasculature as the final determinants of the intra-arterial pressure in hypertension...
  18. ncbi request reprint Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency
    Thu H Le
    Department of Medicine, Duke University and Durham VA Medical Centers, 508 Fulton Street, Building 6, Room 1100, Durham, NC 27705, USA
    Hypertension 43:445-51. 2004
    ..By 2-point analysis, we found a region spanning 5 cM on chromosome 3, with significant linkage to the development of renal vascular lesions (LOD score: 3.3 to 3.8)...
  19. pmc Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2
    Hui Quan
    Department of Cell Biology, Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:4166-73. 2004
    ..001), a level virtually identical to that of the wild-type controls. These data suggest that the XT2 orphan transporter is involved in glycine reabsorption and that the absence of this transporter is sufficient to cause hypertension...
  20. pmc Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina, USA
    Am J Physiol Renal Physiol 298:F788-95. 2010
    ..Identification of these naturally occurring strain differences should prove useful for nephropathy modeling and may be exploited to allow identification of novel susceptibility alleles for albuminuria in diabetes...
  21. ncbi request reprint In hypertension, the kidney breaks your heart
    Steven D Crowley
    MSRB II, Room 2018, Duke University Medical Center, 106 Research Drive, Durham, NC 27710, USA
    Curr Cardiol Rep 10:470-6. 2008
    ..These findings, together with previous experiments, confirm the kidney's critical role in the pathogenesis of hypertension and its complications...
  22. ncbi request reprint Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice
    Liu Yang
    Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    J Hepatol 43:317-23. 2005
    ..Pharmacological blockade of the renin-angiotensin system (RAS) attenuates liver fibrogenesis in rats. Here, we provide genetic evidence implicating angiotensin type 1 (AT1) receptors in liver fibrogenesis...
  23. pmc Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA
    Am J Physiol Renal Physiol 295:F515-24. 2008
    ..These proinflammatory actions of ANG II seem to have a proclivity for inducing kidney injury while having negligible actions in the pathogenesis of cardiac hypertrophy...
  24. ncbi request reprint AT(1) receptors and control of blood pressure: the kidney and more
    Steven D Crowley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    Trends Cardiovasc Med 17:30-4. 2007
    ..However, the nature and relative contributions of these actions may differ in hypertension...
  25. ncbi request reprint Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice
    Xiaosen Ouyang
    Division of Nephrology, Dept of Medicine, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 289:F902-10. 2005
    ..In conclusion, the absence of the AT(1) receptor is associated with marked renal alterations in vasoactive, profibrotic, and immune mediators with an inflammatory pattern favoring a Th1 phenotype...
  26. ncbi request reprint The renin-angiotensin system and diabetic nephropathy
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
    Semin Nephrol 27:144-52. 2007
    ..We provide a general review of the RAS and its role in diabetic nephropathy...
  27. ncbi request reprint Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury
    Liming Wang
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    J Am Soc Nephrol 16:3611-22. 2005
    ..It is speculated that Galpha q-coupled signaling cascades may be important effector pathways mediating renal injury...
  28. pmc RGS2: a "turn-off" in hypertension
    Thu H Le
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Administration Medical Centers, Durham, North Carolina 27705, USA
    J Clin Invest 111:441-3. 2003
  29. pmc Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression
    Carie S Facemire
    Division of Nephrology, Department of Medicine, Duke University Medical Center, 106 Research Drive, Durham, NC 27710, USA
    Hypertension 54:652-8. 2009
    ..Interfering with this pathway is likely to be one mechanism underlying hypertension caused by antiangiogenic agents targeting VEGF...
  30. ncbi request reprint Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells
    Pierre Louis Tharaux
    Duke University and Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Immunol 171:96-105. 2003
    ..Thus, Rho GTPases acting through Rho kinase play a unique role in T cell activation during cellular immune responses by promoting structural rearrangements that are critical for T cell signaling...
  31. pmc Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis
    Steven D Crowley
    Department of Medicine, Division of Nephrology, Duke University Medical Center, and Durham VA Medical Center, Durham, North Carolina 27705, USA
    J Clin Invest 119:943-53. 2009
    ..Since AT1A-deficient lpr mice had low blood pressure, these findings suggest that activation of type 1 angiotensin receptors in the glomerulus is sufficient to accelerate renal injury and inflammation in the absence of hypertension...
  32. ncbi request reprint Physiological impact of increased expression of the AT1 angiotensin receptor
    Thu H Le
    Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
    Hypertension 42:507-14. 2003
    ..The impact of enhanced AT1 receptor expression on blood pressure may be blunted by systemic compensatory responses and altered signal-effector coupling in the vasculature...
  33. doi request reprint Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, USA
    Exp Physiol 93:538-42. 2008
    ....
  34. ncbi request reprint Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection
    Roslyn B Mannon
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA
    Kidney Int 62:290-300. 2002
    ..Chronic rejection (CR) develops in these long surviving grafts. The pathologic features of CR in this model are similar to CR in human kidney grafts...
  35. pmc Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
    Keshava Rajagopal
    Department of Surgery, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:16284-9. 2006
    ..Such ligands may have potential as a novel class of therapeutic agents...
  36. ncbi request reprint Proinflammatory actions of thromboxane receptors to enhance cellular immune responses
    Dennis W Thomas
    Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC 27705, USA
    J Immunol 171:6389-95. 2003
    ..Specific inhibition of the TP receptor may provide a more precise approach to limit inflammation without some of the untoward effects associated with NSAIDs...
  37. pmc Increased blood pressure in mice lacking cytochrome P450 2J5
    Krairerk Athirakul
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    FASEB J 22:4096-108. 2008
    ..Together, our findings illustrate a sex-specific role for CYP2J5 in regulation of blood pressure, proximal tubular transport, and afferent arteriolar responsiveness via an estrogen-dependent mechanism...
  38. ncbi request reprint Role of microsomal prostaglandin E synthase 1 in the kidney
    Helene Francois
    Divisions of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina 27705, USA
    J Am Soc Nephrol 18:1466-75. 2007
    ..Moreover, there are significant gender differences in physiologic contributions of mPGES1 to control kidney function...
  39. pmc The renin-angiotensin system: it's all in your head
    Kelly K Parsons
    Division of Nephrology, Department of Medicine, Duke University School of Medicine, and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    J Clin Invest 117:873-6. 2007
    ....
  40. pmc Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection
    Anthony W Ashton
    Department of Medicine, Divisions of Cardiology and Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 204:929-40. 2007
    ..cruzi infection is possibly an important determinant of mortality and parasitism. A deeper understanding of the role of TXA(2) may result in novel therapeutic targets for a disease with limited treatment options...
  41. pmc A new cardiac MASTer switch for the renin-angiotensin system
    Thu H Le
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA
    J Clin Invest 116:866-9. 2006
    ..This discovery suggests a distinct pathway for activation of the RAS that may have a particular impact on the pathogenesis of chronic tissue injury as well as more acute pathology such as arrhythmias in the heart...
  42. ncbi request reprint A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice
    Thu H Le
    Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham 27705, USA
    Physiol Genomics 18:290-8. 2004
    ....
  43. pmc Prostanoids and blood pressure: which way is up?
    Helene Francois
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    J Clin Invest 114:757-9. 2004
    ..A new study suggests that PGI2 plays a critical role in stimulating renin release and promoting hypertension following renal artery stenosis...
  44. pmc A major role for the EP4 receptor in regulation of renin
    Carie S Facemire
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, USA
    Am J Physiol Renal Physiol 301:F1035-41. 2011
    ..Surprisingly, mPGES1 or mPGES2 are not required, suggesting other alternative mechanisms for generating PGE(2) in response to macula densa stimulation...
  45. pmc Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide
    Paulo N Rocha
    Division of Nephrology, Duke University, Durham VA Medical Centers, Durham, North Carolina 27705, USA
    Clin Diagn Lab Immunol 12:896-903. 2005
    ..These studies indicate that TXA(2) mediates a portion of apoptotic thymocyte death caused by LPS. The absence of an effect of global inhibition of prostanoid synthesis suggests a complex role for prostanoids in this model...
  46. pmc Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle
    Anne A Wooldridge
    Department of Pharmacology, Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:11850-9. 2008
    ..Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity...
  47. ncbi request reprint Targeting genes in the renin-angiotensin system
    Thu H Le
    Division of Nephrology and Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27710, USA
    Curr Opin Nephrol Hypertens 17:57-63. 2008
    ..In this review, we will highlight studies using this approach to uncover new perspectives on the physiology of the renin-angiotensin system...
  48. ncbi request reprint Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria
    Ariela Benigni
    Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy
    J Am Soc Nephrol 15:2666-74. 2004
    ..These findings provide a clear rationale for specifically targeting proteinuria in pharmacologic interventions of chronic nephropathies...
  49. ncbi request reprint A WNK in the kidney controls blood pressure
    Thomas M Coffman
    Nat Genet 38:1105-6. 2006
  50. ncbi request reprint Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice
    Heddwen L Brooks
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Hypertension 39:470-3. 2002
    ....
  51. ncbi request reprint Essential role of AT1A receptor in the development of 2K1C hypertension
    Ludek Cervenka
    Center for Experimental Cardiovascular Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Hypertension 40:735-41. 2002
    ..These results support the essential role of AT1A receptors in mediating 2K1C hypertension and support the hypothesis that augmented NO production serves as a counteracting system in this model of hypertension...
  52. doi request reprint Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors
    Florian Gembardt
    Department of Cardiology, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 22:3068-77. 2008
    ....
  53. ncbi request reprint Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor
    Paul Bridgman
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Box 80, 750 Washington St, Boston, MA 02111, USA
    Am J Physiol Heart Circ Physiol 289:H586-92. 2005
    ..Further work is necessary to explore the potential mechanisms underlying these gender-based differences...
  54. ncbi request reprint Heparin binding EGF is necessary for vasospastic response to endothelin
    Dominique Chansel
    INSERM U702 Hôpital Tenon Université Pierre et Marie Curie, Paris, France
    FASEB J 20:1936-8. 2006
    ..This functional cascade requires modulation of agonist-induced calcium transient by EGFR and PI3K with extremely fast kinetics, suggesting a novel paradigm for GPCR-mediated calcium signaling, which may offer future therapeutic targets...
  55. ncbi request reprint New mass spectrometric assay for angiotensin-converting enzyme 2 activity
    Khalid M Elased
    Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA
    Hypertension 47:1010-7. 2006
    ..This approach allows for the rapid screening for ACE2, which has applications in drug testing, high-throughput enzymatic assays, and identification of novel substrates/inhibitors of the renin-angiotensin system...
  56. ncbi request reprint Mouse models of diabetic nephropathy
    Matthew D Breyer
    Division of Nephrology and Department of Medicine, Vanderbilt University Medical School, S3223 MCN, Nashville, TN 37232, USA
    J Am Soc Nephrol 16:27-45. 2005
    ..Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnostic and therapeutic interventions in mice before testing in humans...
  57. ncbi request reprint Prevention of post-transplant cardiovascular disease--report and recommendations of an ad hoc group
    Andrew D Bostom
    Department of Surgery, University of Minnesota, MMC 328 Mayo, Minneapolis 55455, USA
    Am J Transplant 2:491-500. 2002
  58. ncbi request reprint Strategy for the development of a matched set of transport-competent, angiotensin receptor-deficient proximal tubule cell lines
    Philip G Woost
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    In Vitro Cell Dev Biol Anim 42:189-200. 2006
    ..Cell lines were amplified, yielding a virtually unlimited supply of highly differentiated, transport-competent, angiotensin receptor-deficient PCT cell lines...
  59. ncbi request reprint Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link?
    Susan E Quaggin
    J Am Soc Nephrol 18:364-6. 2007
  60. ncbi request reprint Prolonged survival of class II transactivator-deficient cardiac allografts
    W June Brickey
    University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Transplantation 74:1341-8. 2002
    ..CIITA also up-regulates MHC class I gene expression in vitro. Thus, disruption of a single factor, namely CIITA, represents an ideal strategy for reducing transplant rejection...
  61. ncbi request reprint Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice
    Charlotte Wagner
    Department of Physiology, University of Regensburg, 93040 Regensburg, Germany
    Pflugers Arch 447:214-22. 2003
    ..Our data suggest a marked divergence of renin and Cox-2 expression in the kidney cortex of C57Bl/6 mice with no clear evidence for a role of Cox-2-derived prostanoids from the macula densa in the regulation of renin expression...
  62. ncbi request reprint ACE and ACE2 activity in diabetic mice
    Jan Wysocki
    Division of Nephrology Hypertension, The Feinberg School of Medicine, Northwestern University, Searle 10 475, 320 E Superior, Chicago, IL 60611, USA
    Diabetes 55:2132-9. 2006
    ....
  63. ncbi request reprint Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism
    Irving C Allen
    Curriculum in Genetics and Molecular Biology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 290:L526-33. 2006
    ..Furthermore, these findings demonstrate a unique pathway for TP regulation of homeostatic mechanisms in the airway and suggest a paradigm for the role of TXA2 in other organ systems...
  64. ncbi request reprint Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice
    Jean Jacques Boffa
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, School of Medicine, 6341 B MBRB, Chapel Hill, NC 27599 7545, USA
    J Am Soc Nephrol 15:2358-65. 2004
    ..These results demonstrate that renal vasoconstriction during endotoxemic shock induced by LPS is mediated by TP receptors as indicated by pharmacologic blockade and genetic disruption of TP receptors...
  65. ncbi request reprint COX-2-derived prostacyclin modulates vascular remodeling
    R Daniel Rudic
    The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Circ Res 96:1240-7. 2005
    ....
  66. ncbi request reprint Role of prostacyclin in the cardiovascular response to thromboxane A2
    Yan Cheng
    Center for Experimental Therapeutics, 153 Johnson Pavilion, 3620 Hamilton Walk, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Science 296:539-41. 2002
    ..This interplay may help explain the adverse cardiovascular effects associated with selective COX-2 inhibitors, which, unlike aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), inhibit PGI2 but not TxA2...

Research Grants23

  1. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas M Coffman; Fiscal Year: 2010
    ..abstract_text> ..
  2. DUKE TRAINING GRANT IN NEPHROLOGY
    Thomas Coffman; Fiscal Year: 2007
    ..Completion of this program should allow trainees to pursue careers as academicians conducting high-quality research in clinical and basic aspects of nephrology ..
  3. Angiogenic Signals in Diabetic Complications
    Thomas Coffman; Fiscal Year: 2007
    ..3. To define the consequences of altered angiogenic signaling on the development of albuminuria and nephropathy in diabetes. ..
  4. Prostaglandin E2 and Regulation of Kidney Function
    Thomas Coffman; Fiscal Year: 2009
    ..To identify the genes in the PGE2 pathway controlling renin expression and release. 2. To define the capacity of mPGE synthases to modulate kidney function. 3. To define the impact of PGE2 metabolism by 15-PGDH on renal functions. ..
  5. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas Coffman; Fiscal Year: 2007
    ..abstract_text> ..
  6. Prostaglandin E2 and Regulation of Kidney Function
    Thomas Coffman; Fiscal Year: 2007
    ..To identify the genes in the PGE2 pathway controlling renin expression and release. 2. To define the capacity of mPGE synthases to modulate kidney function. 3. To define the impact of PGE2 metabolism by 15-PGDH on renal functions. ..
  7. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas Coffman; Fiscal Year: 1999
    ..Specific Aim V: To define the contribution of the AgtrlB gene to blood pressure regulation, mice with targeted disruption of the AgtrlB gene will be studied. ..
  8. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas Coffman; Fiscal Year: 2003
    ..These studies will define the physiological importance of AT1 receptor signaling in the kidney and will compare the relative contribution of epithelial and vascular actions of AT1 receptors in regulating blood pressure. ..
  9. Duke-UNC-Stanford AMDC Unit
    Thomas Coffman; Fiscal Year: 2005
    ..We plan to share these technologies fully with other investigators to help accomplish the overall goals of the Mouse Models of Diabetic Complications Consortium. ..
  10. Prostaglandin E2 and Regulation of Kidney Function
    Thomas M Coffman; Fiscal Year: 2010
    ..We will explore the mechanism used by the EP4 receptor to raise blood pressure and will define its potential utility as a therapeutic target for the treatment of hypertension. ..