John Chute

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice
    John P Chute
    Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:2365-72. 2007
  2. ncbi request reprint Stem cell homing
    John P Chute
    Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Hematol 13:399-406. 2006
  3. pmc Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells
    John P Chute
    Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:11707-12. 2006
  4. ncbi request reprint A metabolic study of patients with lung cancer and hyponatremia of malignancy
    John P Chute
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Clin Cancer Res 12:888-96. 2006
  5. ncbi request reprint Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis
    John P Chute
    Division of Cellular Therapy, Department of Internal Medicine, Duke University, Durham, North Carolina 27710, USA
    Stem Cells 24:1315-27. 2006
  6. ncbi request reprint Soluble factors elaborated by human brain endothelial cells induce the concomitant expansion of purified human BM CD34+CD38- cells and SCID-repopulating cells
    John P Chute
    Stem Cell Biology Laboratory, Large Scale Biology Corporation, Vacaville, CA, USA
    Blood 105:576-83. 2005
  7. pmc Minireview: Nuclear receptors, hematopoiesis, and stem cells
    John P Chute
    Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Mol Endocrinol 24:1-10. 2010
  8. pmc Myeloablative intravenous busulfan/fludarabine conditioning does not facilitate reliable engraftment of dual umbilical cord blood grafts in adult recipients
    Mitchell E Horwitz
    Adult Stem Cell Transplant Program, Division of Cellular Therapy, Duke University School of Medicine, Durham, NC 27710, USA
    Biol Blood Marrow Transplant 14:591-4. 2008
  9. pmc Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation
    David A Rizzieri
    Duke University Medical Center, Department of Medicine, Division of Cellular Therapy, Durham, North Carloina, 27705, USA
    Biol Blood Marrow Transplant 16:1107-14. 2010
  10. ncbi request reprint Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury
    Garrett G Muramoto
    Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Blood Marrow Transplant 12:530-40. 2006

Collaborators

Detail Information

Publications33

  1. pmc Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice
    John P Chute
    Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:2365-72. 2007
    ..These data suggest that reestablishment of endothelial cell activity can improve the hematopoietic recovery and survival of irradiated mice...
  2. ncbi request reprint Stem cell homing
    John P Chute
    Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Hematol 13:399-406. 2006
    ..This review discusses the latest progress in defining the molecular processes underlying stem cell homing and the specialized niches where stem cells reside...
  3. pmc Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells
    John P Chute
    Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:11707-12. 2006
    ..Modulation of ALDH activity and retinoid signaling is a previously unrecognized and effective strategy to amplify human HSCs...
  4. ncbi request reprint A metabolic study of patients with lung cancer and hyponatremia of malignancy
    John P Chute
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Clin Cancer Res 12:888-96. 2006
    ..We sought to distinguish patients with hyponatremia caused by elevated AVP versus those with ectopic atrial natriuretic peptide (ANP) via this detailed metabolic study...
  5. ncbi request reprint Molecular profile and partial functional analysis of novel endothelial cell-derived growth factors that regulate hematopoiesis
    John P Chute
    Division of Cellular Therapy, Department of Internal Medicine, Duke University, Durham, North Carolina 27710, USA
    Stem Cells 24:1315-27. 2006
    ..These data demonstrate the potential of primary HUBECs as a reservoir for the discovery of novel secreted proteins that regulate human hematopoiesis...
  6. ncbi request reprint Soluble factors elaborated by human brain endothelial cells induce the concomitant expansion of purified human BM CD34+CD38- cells and SCID-repopulating cells
    John P Chute
    Stem Cell Biology Laboratory, Large Scale Biology Corporation, Vacaville, CA, USA
    Blood 105:576-83. 2005
    ..These studies also demonstrate that HUBEC-elaborated soluble factors mediate a unique and potent expansion of human HSCs...
  7. pmc Minireview: Nuclear receptors, hematopoiesis, and stem cells
    John P Chute
    Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Mol Endocrinol 24:1-10. 2010
    ..Herein, we review in detail the function of specific NRs in controlling HSC and other stem cell fate and propose a framework through which these observations can be translated into therapeutic amplification of HSCs for clinical purposes...
  8. pmc Myeloablative intravenous busulfan/fludarabine conditioning does not facilitate reliable engraftment of dual umbilical cord blood grafts in adult recipients
    Mitchell E Horwitz
    Adult Stem Cell Transplant Program, Division of Cellular Therapy, Duke University School of Medicine, Durham, NC 27710, USA
    Biol Blood Marrow Transplant 14:591-4. 2008
    ..We conclude that the myeloablative conditioning regimen of once-daily intravenous busulfan with fludarabine provides insufficient immunosuppression to allow for engraftment of partially matched, dual umbilical cord blood grafts...
  9. pmc Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation
    David A Rizzieri
    Duke University Medical Center, Department of Medicine, Division of Cellular Therapy, Durham, North Carloina, 27705, USA
    Biol Blood Marrow Transplant 16:1107-14. 2010
    ..Future studies must assess whether the improved outcomes are the direct result of the high doses and improved NK cell function or other aspects of immune recovery...
  10. ncbi request reprint Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury
    Garrett G Muramoto
    Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Blood Marrow Transplant 12:530-40. 2006
    ....
  11. pmc Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors
    David A Rizzieri
    Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Invest 29:56-61. 2011
    ..The primary objective of this pilot study was to evaluate the feasibility of administering IL-2 following a T-cell-depleted nonmyeloablative hematopoietic stem cell transplant...
  12. doi request reprint Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity
    Garrett G Muramoto
    Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 28:523-34. 2010
    ..Pharmacologic inhibition of ALDH has therapeutic potential as a means to amplify ST-HSCs for transplantation purposes...
  13. ncbi request reprint Ex vivo culture with human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow
    John P Chute
    Stem Cell Biology Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health NIH, Navy Transplantation and Autoimmunity Branch, Bethesda, MD, USA
    Blood 100:4433-9. 2002
    ..These data demonstrate that human brain endothelial cells possess a unique hematopoietic activity that increases the repopulating capacity of adult human bone marrow...
  14. doi request reprint Bone marrow CD34+ cells expanded on human brain endothelial cells reconstitute lethally irradiated baboons in a variable manner
    Hiroto Araki
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago, IL, USA
    Leuk Lymphoma 51:1121-7. 2010
    ....
  15. pmc Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo
    Alice B Salter
    Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 113:2104-7. 2009
    ..These data demonstrate that allogeneic EPC infusions can augment hematopoiesis and suggest a relationship between BM microvascular recovery and hematopoietic reconstitution in vivo...
  16. pmc Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial
    Oana I Craciunescu
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 79:1248-55. 2011
    ..To describe renal shielding techniques and dosimetry in delivering total body irradiation (TBI) to patients with severe systemic sclerosis (SSc) enrolled in a hematopoietic stem cell transplant protocol...
  17. pmc Fludarabine-based nonmyeloablative stem cell transplantation for sickle cell disease with and without renal failure: clinical outcome and pharmacokinetics
    Mitchell E Horwitz
    Adult Stem Cell Transplant Program, Division of Cellular Therapy, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Biol Blood Marrow Transplant 13:1422-6. 2007
    ..We conclude that fludarabine-based nonmyeloablative allogeneic SCT for adult patients with SCD is feasible, even in the setting of ESRD...
  18. pmc Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture
    Rachid Safi
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    Mol Endocrinol 23:188-201. 2009
    ..These data indicate that the RAR/RXR heterodimer is a critical regulator of human HSC differentiation, and pharmacological modulation of RXR signaling prevents the loss of human HSCs that otherwise occurs in short-term culture...
  19. pmc Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
    Heather A Himburg
    Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina, USA
    Nat Med 16:475-82. 2010
    ..We identify the secreted growth factor pleiotrophin as a new regulator of both HSC expansion and regeneration...
  20. ncbi request reprint Quantitative analysis demonstrates expansion of SCID-repopulating cells and increased engraftment capacity in human cord blood following ex vivo culture with human brain endothelial cells
    John P Chute
    Stem Cell Biology Laboratory, Large Scale Biology Corporation, Vacaville, California, USA
    Stem Cells 22:202-15. 2004
    ..These studies indicate that the application of HUBEC coculture or HUBEC-conditioned media can potentially improve upon current strategies for the clinical expansion of CB stem cells...
  21. doi request reprint "Short course" bortezomib plus melphalan and prednisone as induction prior to transplant or as frontline therapy for nontransplant candidates in patients with previously untreated multiple myeloma
    Cristina Gasparetto
    Department of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    Biol Blood Marrow Transplant 16:70-7. 2010
    ..VMP did not negatively affect stem cell collection. Longer follow-up and prospective phase III trials are required to validate these initial observations...
  22. pmc Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates
    Benny J Chen
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e11056. 2010
    ..Our data demonstrate that rhGH promotes hematopoietic engraftment and immune recovery post the exposure of ionizing radiation and mitigates against the mortality from lethal irradiation even when administered after exposure...
  23. ncbi request reprint Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice
    John P Chute
    Large Scale Biology Corporation, Vacaville, Calif, USA
    Exp Hematol 32:308-17. 2004
    ..High-dose ionizing radiation can cause lethal myeloablation in exposed individuals. We examined whether ex vivo culture could rescue hematopoietic stem cells with repopulating capacity following harvest from lethally irradiated animals...
  24. pmc Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment
    Hao Wang
    Mandel Center for Hypertension and Atherosclerosis Research and the Cardiovascular Research Center, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 24:1263-73. 2013
    ..In summary, CD44(+) MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment. ..
  25. pmc Gene expression signatures that predict radiation exposure in mice and humans
    Holly K Dressman
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Med 4:e106. 2007
    ..The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure to ionizing radiation...
  26. pmc Underlying potential: cellular and molecular determinants of adult liver repair
    Anna Mae Diehl
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    J Clin Invest 123:1858-60. 2013
    ....
  27. pmc Radiation injury treatment network (RITN): healthcare professionals preparing for a mass casualty radiological or nuclear incident
    Joel R Ross
    Division of Cellular Therapy, Duke University, Durham, NC 27710, USA
    Int J Radiat Biol 87:748-53. 2011
    ..The ongoing efforts of radiation biologists, radiation oncologists, and health physicists can and should complement the efforts of RITN and government agencies...
  28. pmc Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles
    Sarah K Meadows
    Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 5:e11535. 2010
    ....
  29. ncbi request reprint Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution
    David A Rizzieri
    Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:690-7. 2007
    ..To allow a donor to be found for nearly all patients, we have used a nonmyeloablative conditioning regimen in conjunction with stem cells from a related donor with one fully mismatched HLA haplotype...
  30. pmc Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 458:776-9. 2009
    ....
  31. doi request reprint Nanoscale detection of ionizing radiation damage to DNA by atomic force microscopy
    Changhong Ke
    Center for Biologically Inspired Materials and Material Systems and Department of Mechanical, Engineering and Materials Science, Duke University, Durham, NC 27708, USA
    Small 4:288-94. 2008
    ..01 ng microL(-1)), which is beyond the capability of traditional techniques. AFM imaging can uniquely supplement traditional techniques for sensitive measurements of damage to DNA by ionizing radiation...
  32. pmc Gene expression signatures of radiation response are specific, durable and accurate in mice and humans
    Sarah K Meadows
    Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 3:e1912. 2008
    ..Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures...
  33. ncbi request reprint Rescue of hematopoietic stem cells following high-dose radiation injury using ex vivo culture on endothelial monolayers
    John P Chute
    Navy National Institute of Diabetes and Digestive and Kidney Diseases Transplantation and Autoimmunity Branch, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Mil Med 167:74-7. 2002
    ..1%; mean, 1.9%). These results demonstrate that a subpopulation of bone marrow stem cells are capable of surviving the effects of high-dose radiation if these cells are placed in coculture with endothelial cell monolayers...

Research Grants3